Find Endoxifen manufacturers, exporters & distributors on PharmaCompass

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ACTIVE PHARMA INGREDIENTS

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NDC API

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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Chemistry

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Also known as: 112093-28-4, Z-endoxifen, 4-hydroxy-n-desmethyltamoxifen, Endoxifen z-isomer, N-desmethyl-4-hydroxytamoxifen, (z)-endoxifen
Molecular Formula
C25H27NO2
Molecular Weight
373.5  g/mol
InChI Key
MHJBZVSGOZTKRH-IZHYLOQSSA-N
FDA UNII
46AF8680RC

Endoxifen
1 2D Structure

Endoxifen

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
2.1.2 InChI
InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24-
2.1.3 InChI Key
MHJBZVSGOZTKRH-IZHYLOQSSA-N
2.1.4 Canonical SMILES
CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3
2.1.5 Isomeric SMILES
CC/C(=C(\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)OCCNC)/C3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
46AF8680RC
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-hydroxy-n-demethyltamoxifen

2. 4-hydroxy-n-desmethyltamoxifen

3. 4-hydroxy-n-desmethyltamoxifen, (z)-isomer

4. Z-endoxifen

2.3.2 Depositor-Supplied Synonyms

1. 112093-28-4

2. Z-endoxifen

3. 4-hydroxy-n-desmethyltamoxifen

4. Endoxifen Z-isomer

5. N-desmethyl-4-hydroxytamoxifen

6. (z)-endoxifen

7. 110025-28-0

8. (z)-4-hydroxy-n-desmethyl Tamoxifen (mixture Of Isomers)

9. 4ohndtam

10. Nsc-749798

11. N-desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/z Mixture)

12. 4-hydroxy-n-desmethyl-tamoxifen

13. Chebi:80555

14. 46af8680rc

15. 4-[(z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

16. (z)-4-hydroxy-n-desmethyl Tamoxifen (contains Up To 10% E Isomer)

17. Unii-46af8680rc

18. 4-hydroxy-n-desmethyltamoxifen, (z)-isomer

19. 4-hydroxy-n-desmethyl Tamoxifen

20. (z)-4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

21. Endoxifenz-isomer

22. Phenol, 4-((1z)-1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenyl-1-buten-1-yl)-

23. Endoxifen(e/z=1:1)

24. Endoxifen [who-dd]

25. Chembl1093458

26. Schembl10107920

27. Gtpl10203

28. Dtxsid80149880

29. Ex-a645

30. Phenol, 4-[(1z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-

31. Bcp15866

32. Ex-a1970

33. 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

34. Bdbm50435003

35. Hy-18719e

36. Nsc746494

37. Nsc749798

38. Nsc777380

39. Zinc22056306

40. Nsc 749798

41. Nsc-746494

42. Nsc-777380

43. Ncgc00386714-01

44. Ac-36810

45. Be172975

46. Bs-42369

47. B7481

48. Cs-0028594

49. (z)-4-hydroxy-n-desmethyl Tamoxifen (endoxifen)

50. A894656

51. N-desmethyl-4-hydroxytamoxifen, Mixture Of Isomers

52. 4-hydroxy-n-desmethyl Tamoxifen ((e/z)-endoxifen)

53. J-002363

54. W-200834

55. Q27149598

56. N-desmethyl-4-hydroxy Tamoxifen(approx. 1:1 E/z Mixture)

57. (z)-4-hydroxy-n-desmethyl Tamoxifen(contains Up To 10% E Isomer)

58. (e/z)-4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol

59. (z)-4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol

60. 4-[(~{z})-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol

61. N-desmethyl-4-hydroxytamoxifen, Mixture Of Isomers, Analytical Standard

62. (e/z)-4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol

63. 4-[(1z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol

64. N-methyl-2-[4-[(e)-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]ethanamine

65. Phenol, 4-(1-(4-(2-(methylamino)ethoxy]phenyl)-2-phenyl-1-butenyl)-, (z)-

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 373.5 g/mol
Molecular Formula C25H27NO2
XLogP36.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count8
Exact Mass373.204179104 g/mol
Monoisotopic Mass373.204179104 g/mol
Topological Polar Surface Area41.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity467
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Metabolism/Metabolites

Endoxifen has known human metabolites that include Endoxifen O-glucuronide and Endoxifen O-sulfate.

Endoxifen is a known human metabolite of 4-Hydroxytamoxifen and N-Desmethyltamoxifen.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


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Looking for 110025-28-0 / Endoxifen API manufacturers, exporters & distributors?

Endoxifen manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Endoxifen API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Endoxifen manufacturer or Endoxifen supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Endoxifen manufacturer or Endoxifen supplier.

PharmaCompass also assists you with knowing the Endoxifen API Price utilized in the formulation of products. Endoxifen API Price is not always fixed or binding as the Endoxifen Price is obtained through a variety of data sources. The Endoxifen Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Endoxifen

Synonyms

112093-28-4, Z-endoxifen, 4-hydroxy-n-desmethyltamoxifen, Endoxifen z-isomer, N-desmethyl-4-hydroxytamoxifen, (z)-endoxifen

Cas Number

110025-28-0

Unique Ingredient Identifier (UNII)

46AF8680RC

Endoxifen Manufacturers

A Endoxifen manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Endoxifen, including repackagers and relabelers. The FDA regulates Endoxifen manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Endoxifen API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Endoxifen Suppliers

A Endoxifen supplier is an individual or a company that provides Endoxifen active pharmaceutical ingredient (API) or Endoxifen finished formulations upon request. The Endoxifen suppliers may include Endoxifen API manufacturers, exporters, distributors and traders.

Endoxifen GMP

Endoxifen Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Endoxifen GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Endoxifen GMP manufacturer or Endoxifen GMP API supplier for your needs.

Endoxifen CoA

A Endoxifen CoA (Certificate of Analysis) is a formal document that attests to Endoxifen's compliance with Endoxifen specifications and serves as a tool for batch-level quality control.

Endoxifen CoA mostly includes findings from lab analyses of a specific batch. For each Endoxifen CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Endoxifen may be tested according to a variety of international standards, such as European Pharmacopoeia (Endoxifen EP), Endoxifen JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Endoxifen USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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