Find Endurobol manufacturers, exporters & distributors on PharmaCompass

Endurobol

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 NDC API, 1 Listed Suppliers

1 API Suppliers
1 NDC API
1 Listed Suppliers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 317318-70-0, Gw501516, Gw 501516, Gw-501516, Gsk-516, Cardarine

Molecular Formula

C₂₁H₁₈F₃NO₃S₂

Molecular Weight

453.5 g/mol

InChI Key

YDBLKRPLXZNVNB-UHFFFAOYSA-N

FDA UNII

7I2HA1NU22

Cardarine (GW-501516) is a peroxisome proliferator-activator receptor-delta agonist for the potential treatment of dyslipidemia. Cardarine has been investigated for the treatment of Obesity, Lipid Disorders, and Cardiovascular Disease.

1 2D Structure

Endurobol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid

2.1.2 InChI

InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)

2.1.3 InChI Key

YDBLKRPLXZNVNB-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)OCC(=O)O

2.2 Other Identifiers

2.2.1 UNII

7I2HA1NU22

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Cardarine

2. Gw 1516

3. Gw 501516

4. Gw-1516

5. Gw-501516

6. Gw1516

7. Gw501516

2.3.2 Depositor-Supplied Synonyms

1. 317318-70-0

2. Gw501516

3. Gw 501516

4. Gw-501516

5. Gsk-516

6. Cardarine

7. Gw1516

8. Gw 1516

9. Unii-7i2ha1nu22

10. Gw-1516

11. 2-(4-((2-(4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic Acid

12. 2-(2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methyl)thio)phenoxy)acetic Acid

13. 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic Acid

14. Gw-516

15. Chembl38943

16. 7i2ha1nu22

17. {2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic Acid

18. Chebi:73726

19. 2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic Acid

20. Gw501,516

21. Gw 501,516

22. Gw-501,516

23. Gsk 516

24. Gw501516 (endurobol)

25. Schembl68714

26. 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid

27. Mls006010753

28. Endurobol;gw501516

29. Gtpl2687

30. Dtxsid3041037

31. Bdbm28661

32. Ex-a723

33. Hms3674c03

34. Hms3744o09

35. Bcp21491

36. Zinc1549989

37. Mfcd09033000

38. Pdsp1_000255

39. Pdsp2_000254

40. S5615

41. Akos015965103

42. Ccg-269268

43. Cs-0438

44. Db05416

45. Ex-3881

46. Sb19569

47. Gw501516(g)

48. Gw501516(gsk-516)

49. Ncgc00241455-01

50. Ncgc00241455-02

51. Ncgc00241455-08

52. Ac-23001

53. Hy-10838

54. Smr004701706

55. Am20040157

56. A26949

57. Gw501516, >=98% (hplc)

58. 318g700

59. 6t-0058

60. Benzenesulfonylchloride,4-(2-methylpropyl)-(9ci)

61. J-018519

62. Q5515069

63. Brd-k14880289-001-01-4

64. (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-thiazol-5-yl)methyl)thio)phenoxy)acetic Acid

65. {2-methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic Acid, Analytical Standard

66. {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic Acid

67. 2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic Acid;gw 501516

68. 2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-yl}methyl)sulfanyl]phenoxy}acetic Acid

69. 7t1

70. Acetic Acid, (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-

71. Acetic Acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]-

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₁₈F₃NO₃S₂
Molecular Weight	453.5 g/mol
XLogP3	5.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	453.06802027 g/mol
Monoisotopic Mass	453.06802027 g/mol
Topological Polar Surface Area	113 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	572
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Investigated for use/treatment in hyperlipidemia.

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

This drug regulates fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. Overexpression of PPARdelta using a transgenic murine model promotes an increase of muscle oxidative capability. It also plays a major role in the metabolic adaptations to western diet characterized by an excessive amount of saturated fat.

API SUPPLIERS