Find Eniluracil manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 59989-18-3, 5-ethynyluracil, 5-ethynylpyrimidine-2,4(1h,3h)-dione, 5-ethynyl-1h-pyrimidine-2,4-dione, Gw776c85, 776c85
Molecular Formula
C6H4N2O2
Molecular Weight
136.11  g/mol
InChI Key
JOZGNYDSEBIJDH-UHFFFAOYSA-N
FDA UNII
2E2W0W5XIU

Eniluracil
Eniluracil is an orally-active fluoropyrimidine analogue. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil (5-FU) in the liver. Co-administration of ethynyluracil permits the oral administration of 5-FU.
1 2D Structure

Eniluracil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-ethynyl-1H-pyrimidine-2,4-dione
2.1.2 InChI
InChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)
2.1.3 InChI Key
JOZGNYDSEBIJDH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C#CC1=CNC(=O)NC1=O
2.2 Other Identifiers
2.2.1 UNII
2E2W0W5XIU
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-ethynyluracil

2. 776c85

3. Compound 776c

4. Gw776c85

2.3.2 Depositor-Supplied Synonyms

1. 59989-18-3

2. 5-ethynyluracil

3. 5-ethynylpyrimidine-2,4(1h,3h)-dione

4. 5-ethynyl-1h-pyrimidine-2,4-dione

5. Gw776c85

6. 776c85

7. 5-ethynyl-2,4(1h,3h)-pyrimidinedione

8. 5-ethynyl-2-hydroxypyrimidin-4(1h)-one

9. 5-ethynyl-6-hydroxypyrimidin-2(1h)-one

10. 5-ethynyl-2,4(1h,3h)pyrimidinedione

11. 2e2w0w5xiu

12. Chembl355200

13. Compound 776c

14. 5-ethynylpyrimidine-2,4(1h,3h)-dione.

15. 776-c-85

16. Eniluracil [usan]

17. 5-ethynylpyrimidine-2,4-diol

18. Unii-2e2w0w5xiu

19. 5-ethynyl-2-hydroxypyrimidin-4(3h)-one

20. 5-ethynyl-4-hydroxypyrimidin-2(1h)-one

21. Eniluracil [usan:inn:ban]

22. 2,4(1h,3h)-pyrimidinedione, 5-ethynyl-

23. 5-ethynyl-uracil

24. Y3g

25. Eniluracil [mi]

26. Eniluracil [inn]

27. Eniluracil (usan/inn)

28. Eniluracil [mart.]

29. Eniluracil [who-dd]

30. Schembl37817

31. Zinc5467

32. Dtxsid10208696

33. Chebi:177783

34. Hms3745i03

35. Bdbm50124202

36. Geo-02731

37. Gw-776

38. Mfcd00871973

39. Nsc687296

40. Zb1821

41. Akos006240058

42. Akos016009479

43. Adh-300004

44. Db03516

45. Nsc-687296

46. As-66226

47. Hy-10533

48. Cs-0002630

49. E1096

50. Ft-0667865

51. D03998

52. T72682

53. A857850

54. Q27094456

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 136.11 g/mol
Molecular Formula C6H4N2O2
XLogP3-0.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass136.027277375 g/mol
Monoisotopic Mass136.027277375 g/mol
Topological Polar Surface Area58.2 Ų
Heavy Atom Count10
Formal Charge0
Complexity269
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of cancer in combination with 5-fluorouracil.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Eniluracil is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor, designed to enhance activity of chemotaxic agents. It is under investigation by Adherex, under license from GlaxoSmithKline, for the treatment of cancer in combination with 5-fluorouracil (5-FU).


5.2 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


5.3 Mechanism of Action

Normally, 5-FU is rapidly broken down in the body by an enzyme known as dihydropyrimidine dehydrogenase (DPD). Eniluracil irreversibly inhibits DPD, thereby substantially slowing the breakdown of 5-FU and prolonging exposure of the tumor cells to the drug.


ABOUT THIS PAGE

Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty