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1. 5-ethynyluracil
2. 776c85
3. Compound 776c
4. Gw776c85
1. 59989-18-3
2. 5-ethynyluracil
3. 5-ethynylpyrimidine-2,4(1h,3h)-dione
4. 5-ethynyl-1h-pyrimidine-2,4-dione
5. Gw776c85
6. 776c85
7. 5-ethynyl-2,4(1h,3h)-pyrimidinedione
8. 5-ethynyl-2-hydroxypyrimidin-4(1h)-one
9. 5-ethynyl-6-hydroxypyrimidin-2(1h)-one
10. 5-ethynyl-2,4(1h,3h)pyrimidinedione
11. 2e2w0w5xiu
12. Chembl355200
13. Compound 776c
14. 5-ethynylpyrimidine-2,4(1h,3h)-dione.
15. 776-c-85
16. Eniluracil [usan]
17. 5-ethynylpyrimidine-2,4-diol
18. Unii-2e2w0w5xiu
19. 5-ethynyl-2-hydroxypyrimidin-4(3h)-one
20. 5-ethynyl-4-hydroxypyrimidin-2(1h)-one
21. Eniluracil [usan:inn:ban]
22. 2,4(1h,3h)-pyrimidinedione, 5-ethynyl-
23. 5-ethynyl-uracil
24. Y3g
25. Eniluracil [mi]
26. Eniluracil [inn]
27. Eniluracil (usan/inn)
28. Eniluracil [mart.]
29. Eniluracil [who-dd]
30. Schembl37817
31. Zinc5467
32. Dtxsid10208696
33. Chebi:177783
34. Hms3745i03
35. Bdbm50124202
36. Geo-02731
37. Gw-776
38. Mfcd00871973
39. Nsc687296
40. Zb1821
41. Akos006240058
42. Akos016009479
43. Adh-300004
44. Db03516
45. Nsc-687296
46. As-66226
47. Hy-10533
48. Cs-0002630
49. E1096
50. Ft-0667865
51. D03998
52. T72682
53. A857850
54. Q27094456
Molecular Weight | 136.11 g/mol |
---|---|
Molecular Formula | C6H4N2O2 |
XLogP3 | -0.7 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 1 |
Exact Mass | 136.027277375 g/mol |
Monoisotopic Mass | 136.027277375 g/mol |
Topological Polar Surface Area | 58.2 Ų |
Heavy Atom Count | 10 |
Formal Charge | 0 |
Complexity | 269 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
For the treatment of cancer in combination with 5-fluorouracil.
Eniluracil is an orally active dihydropyrimidine dehydrogenase (DPD) inhibitor, designed to enhance activity of chemotaxic agents. It is under investigation by Adherex, under license from GlaxoSmithKline, for the treatment of cancer in combination with 5-fluorouracil (5-FU).
Enzyme Inhibitors
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Normally, 5-FU is rapidly broken down in the body by an enzyme known as dihydropyrimidine dehydrogenase (DPD). Eniluracil irreversibly inhibits DPD, thereby substantially slowing the breakdown of 5-FU and prolonging exposure of the tumor cells to the drug.
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