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    Chemistry

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    Also known as: 130929-57-6, Comtess, Comtan, Entacaponum, Or-611, Entacapona
    Molecular Formula
    C14H15N3O5
    Molecular Weight
    305.29  g/mol
    InChI Key
    JRURYQJSLYLRLN-BJMVGYQFSA-N
    FDA UNII
    4975G9NM6T
    Entacapone
    Entacapone is a nitrocatechol compound with anti-parkinsonian property. Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), which catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure including dihydroxyphenylalanine (DOPA), catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. When administered in conjunction with dopaminergic agents such as L-DOPA, entacapone prevents the metabolism and inactivation of adjunct drugs, thereby increasing the bioavailability of these compounds by facilitating their passage across the blood-brain barrier.
    Entacapone is a Catechol-O-Methyltransferase Inhibitor. The mechanism of action of entacapone is as a Catechol O-Methyltransferase Inhibitor.
    1 2D Structure

    Entacapone

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
    2.1.2 InChI
    InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
    2.1.3 InChI Key
    JRURYQJSLYLRLN-BJMVGYQFSA-N
    2.1.4 Canonical SMILES
    CCN(CC)C(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O)[O-])C#N
    2.1.5 Isomeric SMILES
    CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N
    2.2 Other Identifiers
    2.2.1 UNII
    4975G9NM6T
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-cyano-n,n-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide

    2. Comtan

    3. Comtess

    4. Or 611

    5. Or-611

    2.3.2 Depositor-Supplied Synonyms

    1. 130929-57-6

    2. Comtess

    3. Comtan

    4. Entacaponum

    5. Or-611

    6. Entacapona

    7. (e)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethylacrylamide

    8. 116314-67-1

    9. Entacapone Teva

    10. Entacapone Orion

    11. (e)-alpha-cyano-n,n-diethyl-3,4-dihydroxy-5-nitrocinnamamide

    12. (e)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethylprop-2-enamide

    13. (2e)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethylprop-2-enamide

    14. Chembl953

    15. 2-propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethyl-

    16. Chebi:4798

    17. 2-cyano-n,n-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide

    18. N,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) Acrylamide

    19. 4975g9nm6t

    20. (2e)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethyl-2-propenamide

    21. Entacaponum [inn-latin]

    22. Entacapone Sodium

    23. Entacapona [inn-spanish]

    24. Ncgc00164555-01

    25. Entacom

    26. 2-propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethyl-, (2e)-

    27. Dsstox_cid_26439

    28. Dsstox_rid_81615

    29. Dsstox_gsid_46439

    30. Or 611

    31. (e)-entacapone

    32. (~{e})-2-cyano-~{n},~{n}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide

    33. Comtan (tn)

    34. Cas-130929-57-6

    35. Sr-05000001452

    36. (e)-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-n,n-diethyl-prop-2-enamide

    37. Unii-4975g9nm6t

    38. Com-998

    39. Entacapone [usan:usp:inn:ban]

    40. Entacapone [mi]

    41. Entacapone [inn]

    42. Entacapone [jan]

    43. Entacapone [usan]

    44. (e)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethyl-2-propenamide

    45. Entacapone [vandf]

    46. Entacapone [mart.]

    47. Entacapone [usp-rs]

    48. Entacapone [who-dd]

    49. Schembl34504

    50. Schembl34505

    51. Bidd:gt0026

    52. Entacapone [ema Epar]

    53. 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethyl-2-propenamide

    54. Entacapone (jp17/usp/inn)

    55. Gtpl6647

    56. Dtxsid5046439

    57. Entacapone [orange Book]

    58. Schembl13596593

    59. Hsdb 8251

    60. Entacapone [ep Monograph]

    61. Entacapone [usp Monograph]

    62. Hms2089o16

    63. Hms3713b20

    64. Hms3885k09

    65. Or611

    66. Stalevo Component Entacapone

    67. Corbilta Component Entacapone

    68. Ex-a1130

    69. Tox21_112184

    70. Ac-393

    71. Bdbm50108879

    72. Mfcd00866580

    73. S3147

    74. Zinc35342787

    75. Akos015907685

    76. Akos015965009

    77. Entacapone Component Of Stalevo

    78. Tox21_112184_1

    79. Bcp9000645

    80. Ccg-213064

    81. Cs-1266

    82. Db00494

    83. Entacapone Component Of Corbilta

    84. Ncgc00164555-02

    85. Ncgc00164555-03

    86. Ncgc00164555-10

    87. Hy-14280

    88. E0961

    89. Sw199035-2

    90. C07943

    91. D00781

    92. Ab01275450-01

    93. Ab01275450_02

    94. Ab01275450_03

    95. 929e576

    96. A806167

    97. A922031

    98. Q416444

    99. J-005902

    100. J-008069

    101. Sr-05000001452-1

    102. Sr-05000001452-2

    103. Sr-05000001452-3

    104. Brd-k83636919-001-01-4

    105. Levodopa/carbidopa/entacapone Orion Component Entacapone

    106. (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

    107. Entacapone Component Of Levodopa/carbidopa/entacapone Orion

    108. (e)-.alpha.-cyano-n,n-diethyl-3,4-dihydroxy-5-nitrocinnamamide

    109. (e)-n, N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide

    110. (e)-2-cyano-n,n-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide

    111. 2-propenamide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethyl-,(2e)-

    112. Pd9

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 305.29 g/mol
    Molecular Formula C14H15N3O5
    XLogP32.1
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count4
    Exact Mass305.10117059 g/mol
    Monoisotopic Mass305.10117059 g/mol
    Topological Polar Surface Area130 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity500
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameComtan
    PubMed HealthEntacapone (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelComtan (entacapone) is available as tablets containing 200-mg entacapone.Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinson's Disease as an adjunct to levodopa/carbidopa therapy. It is a nitrocatec..
    Active IngredientEntacapone
    Dosage FormTablet
    RouteOral
    Strength200mg
    Market StatusPrescription
    CompanyOrion Pharma

    2 of 4  
    Drug NameEntacapone
    PubMed HealthEntacapone (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelEntacapone is available as tablets containing 200-mg entacapone.Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinsons Disease as an adjunct to levodopa/carbidopa therapy. It is a nitrocatechol struc...
    Active IngredientEntacapone
    Dosage FormTablet
    RouteOral
    Strength200mg
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Sun Pharma Global

    3 of 4  
    Drug NameComtan
    PubMed HealthEntacapone (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelComtan (entacapone) is available as tablets containing 200-mg entacapone.Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinson's Disease as an adjunct to levodopa/carbidopa therapy. It is a nitrocatec..
    Active IngredientEntacapone
    Dosage FormTablet
    RouteOral
    Strength200mg
    Market StatusPrescription
    CompanyOrion Pharma

    4 of 4  
    Drug NameEntacapone
    PubMed HealthEntacapone (By mouth)
    Drug ClassesAntiparkinsonian
    Drug LabelEntacapone is available as tablets containing 200-mg entacapone.Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinsons Disease as an adjunct to levodopa/carbidopa therapy. It is a nitrocatechol struc...
    Active IngredientEntacapone
    Dosage FormTablet
    RouteOral
    Strength200mg
    Market StatusPrescription
    CompanyMylan Pharms; Wockhardt; Sun Pharma Global

    4.2 Therapeutic Uses

    Antiparkinson Agents; Enzyme Inhibitors

    National Library of Medicine's Medical Subject Headings. Entacapone. Online file (MeSH, 2015). Available from, as of May 1, 2015: https://www.nlm.nih.gov/mesh/2014/mesh_browser/MBrowser.html

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health(NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Entacapone is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of July 18, 2015: https://clinicaltrials.gov/search/intervention=entacapone

    Comtan is indicated as an adjunct to levodopa and carbidopa to treat end-of-dose "wearing-off" in patients with Parkinson's disease. /Included in US product label/

    NIH; DailyMed. Current Medication Information for Comtan (Entacapone) Tablet, Film Coated (Updated: July 2014). Available from, as of June 4, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1aceb59-9be8-43b8-83d6-81e05e4b51e4

    Stalevo, a combination drug consisting of levodopa, carbidopa (dopa decarboxylase inhibitor), and entacapone (catechol-O-methyltransferase-COMT inhibitor) is indicated for the treatment of Parkinson's disease. Stalevo can be used: to substitute (with equivalent strengths of each of the three components) carbidopa/levodopa and entacapone previously administered as individual products. To replace carbidopa/levodopa therapy (without entacapone) when patients experience the signs and symptoms of end-of-dose "wearing-off" and when they have been taking a total daily dose of levodopa of 600 mg or less and have not been experiencing dyskinesias. /Included in US product label/

    NIH; DailyMed. Current Medication Information for Stalevo (Carbidopa, Levodopa and Entacapone) Tablet, Film Coated (Updated: August 2014). Available from, as of May 4, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5edfc3e7-f80d-47ee-897a-c02ff4eb3e74

    Parkinson's disease (PD) is a neurodegenerative disorder characterized by a variety of motor symptoms including freezing of gait (FOG), in which walking is transiently halted as if the patient's feet were 'glued to the ground'. Treatment of FOG is still challenging. Although L-threo-3,4-dihydroxyphenylserine (L-DOPS), a precursor of noradrenaline, has been on the market in Japan because of its beneficial effect for FOG, clinical use of L-DOPS has been far from satisfying. However, the fact that there were some responders to L-DOPS encouraged us to hypothesize that the enhancement of L-DOPS concentration in the brain by the co-administration of L-DOPS and a catechol-O-methyl transferase (COMT) inhibitor, which is expected to interrupt L-DOPS metabolism in the peripheral circulation, would be beneficial for FOG. Based on our hypothesis, we conducted a preliminary study with a small number of participants with FOG. Of the 16 PD patients with FOG who completed this study, group 1 (n=6) received L-DOPS co-administered with entacapone, which is a COMT inhibitor used worldwide as an anti-parkinson drug, group 2 (n=5) received entacapone alone, and group 3 (n=5) received L-DOPS alone. Only the patients in group 1 showed a significant improvement in FOG. Moreover, the beneficial effect was observed only in patients with levodopa-resistant FOG. This result supports our hypothesis, at least in patients with levodopa-resistant FOG, and shows that the co-administration of L-DOPS and entacapone could be a new strategy for FOG treatment.

    PMID:23265352 Fukada K et al; Med Hypotheses 80 (2): 209-12 (2013)

    4.3 Drug Warning

    Diarrhea was reported in 10% of patients receiving entacapone in clinical studies, and about 2% of patients required discontinuance of the drug because of diarrhea. Diarrhea generally was of mild to moderate intensity, but severe diarrhea, which required hospitalization, may occur rarely. Diarrhea generally occurs during the first 4-12 weeks of entacapone therapy, but may occur as early as the first week or as late as several months following initiation of entacapone therapy. Diarrhea generally resolved following discontinuance of the drug.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 2649

    Findings from an FDA-conducted meta-analysis suggest that patients receiving combined therapy with levodopa, carbidopa, and entacapone may be at increased risk of cardiovascular events (i.e., myocardial infarction, stroke, cardiovascular death) compared with those receiving levodopa-carbidopa. The meta-analysis combined cardiovascular-related findings from 15 clinical trials that compared the combination of levodopa, carbidopa, and entacapone with levodopa-carbidopa and found a small but statistically significant increase in the risk of cardiovascular events in those receiving the levodopa, carbidopa, and entacapone regimen (relative risk: 2.46). However, the increased risk was driven largely by data from a single trial (STRIDE-PD); when this trial was removed from the analysis, the results were no longer significant. Various factors make it difficult to draw firm conclusions from this meta-analysis. Many of the trials included in the analysis had a duration of less than 6 months (possibly not long enough to detect cardiovascular risk) and were not specifically designed to evaluate cardiovascular safety. In addition, the majority of patients had preexisting cardiovascular risk factors. At this time, FDA has not concluded that combined therapy with levodopa, carbidopa, and entacapone is associated with an increased risk of cardiovascular events and is continuing to review the available data related to this safety concern. Patients currently receiving entacapone as an adjunct to levodopa-carbidopa (either separately or as a fixed-combination preparation) should continue to take the drugs as prescribed unless otherwise instructed by a clinician. Cardiac function should be monitored regularly in such patients, particularly in those with a history of cardiovascular disease.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 2648

    Dopaminergic therapy in Parkinson's disease patients has been associated with orthostatic hypotension. Entacapone enhances levodopa bioavailability and, therefore, might be expected to increase the occurrence of orthostatic hypotension. In controlled studies, approximately 1.2% and 0.8% of 200 mg entacapone and placebo patients, respectively, reported at least one episode of syncope. Reports of syncope were generally more frequent in patients in both treatment groups who had an episode of documented hypotension.

    NIH; DailyMed. Current Medication Information for Comtan (Entacapone) Tablet, Film Coated (Updated: July 2014). Available from, as of June 4, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1aceb59-9be8-43b8-83d6-81e05e4b51e4

    Postmarketing reports indicate that patients may experience new or worsening mental status and behavioral changes, which may be severe, including psychotic-like behavior during Comtan treatment or after starting or increasing the dose of Comtan. Other drugs prescribed to improve the symptoms of Parkinson's disease can have similar effects on thinking and behavior. Abnormal thinking and behavior can cause paranoid ideation, delusions, hallucinations, confusion, disorientation, aggressive behavior, agitation, and delirium. Psychotic-like behaviors were also observed during the clinical development of Comtan. Patients with a major psychotic disorder should ordinarily not be treated with Comtan because of the risk of exacerbating psychosis. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of Comtan.

    NIH; DailyMed. Current Medication Information for Comtan (Entacapone) Tablet, Film Coated (Updated: July 2014). Available from, as of June 4, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1aceb59-9be8-43b8-83d6-81e05e4b51e4

    For more Drug Warnings (Complete) data for ENTACAPONE (22 total), please visit the HSDB record page.

    4.4 Drug Indication

    Used as an adjunct to levodopa / carbidopa in the symptomatic treatment of patients with idiopathic Parkinson's Disease who experience the signs and symptoms of end-of-dose "wearing-off".

    FDA Label

    Entacapone is indicated as an adjunct to standard preparations of levodopa / benserazide or levodopa / carbidopa for use in adult patients with Parkinson's disease and end-of-dose motor fluctuations, who cannot be stabilised on those combinations.

    Entacapone is indicated as an adjunct to standard preparations of levodopa / benserazide or levodopa / carbidopa for use in patients with Parkinson's disease and end-of-dose motor fluctuations, who cannot be stabilised on those combinations.

    Entacapone is indicated as an adjunct to standard preparations of levodopa / benserazide or levodopa / carbidopa for use in adult patients with Parkinson's disease and end-of-dose motor fluctuations, who cannot be stabilised on those combinations.

    Entacapone is indicated as an adjunct to standard preparations of levodopa / benserazide or levodopa / carbidopa for use in adult patients with Parkinson's disease and end-of-dose motor fluctuations, who cannot be stabilised on those combinations.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Entacapone is structurally and pharmacologically related to tolcapone, but unlike tolcapone, is not associated with hepatotoxicity. Entacapone is used in the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa therapy. Entacapone selectively and reversiblly inhibits catechol-O-methyltransferase (COMT). In mammals, COMT is distributed throughout various organs with the highest activities in the liver and kidney. COMT also occurs in the heart, lung, smooth and skeletal muscles, intestinal tract, reproductive organs, various glands, adipose tissue, skin, blood cells and neuronal tissues, especially in glial cells. COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated metabolites. COMT is responsible for the elimination of biologically active catechols and some other hydroxylated metabolites. In the presence of a decarboxylase inhibitor, COMT becomes the major metabolizing enzyme for levodopa, catalyzing the it to 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD) in the brain and periphery.

    5.2 MeSH Pharmacological Classification

    Catechol O-Methyltransferase Inhibitors

    Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE. (See all compounds classified as Catechol O-Methyltransferase Inhibitors.)

    Antiparkinson Agents

    Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    ENTACAPONE
    5.3.2 FDA UNII
    4975G9NM6T
    5.3.3 Pharmacological Classes
    Catechol-O-Methyltransferase Inhibitor [EPC]; Catechol O-Methyltransferase Inhibitors [MoA]
    5.4 ATC Code

    N04BX02

    N04BX02

    N04BX02

    N04BX02

    N - Nervous system

    N04 - Anti-parkinson drugs

    N04B - Dopaminergic agents

    N04BX - Other dopaminergic agents

    N04BX02 - Entacapone

    5.5 Absorption, Distribution and Excretion

    Absorption

    Entacapone is rapidly absorbed (approximately 1 hour). The absolute bioavailability following oral administration is 35%.

    Route of Elimination

    Entacapone is almost completely metabolized prior to excretion, with only a very small amount (0.2% of dose) found unchanged in urine. As only about 10% of the entacapone dose is excreted in urine as parent compound and conjugated glucuronide, biliary excretion appears to be the major route of excretion of this drug.

    Volume of Distribution

    20 L

    Clearance

    850 mL/min

    In rats and in humans, the absolute bioavailability was dose-dependent and ranged from 20% to 55%, following single dose of 10, 65 and 400 mg/kg, in rats and from 29% to 49%, following single dose of 5, 25, 50, 100, 200, 400 and 800 mg, in humans.

    European Medicines Agency (EMA), Committee for Medicinal Products for Human Use (CHMP), European Public Assessment Report (EPAR): Comtan (Entacapone), Scientific Discussion p.4 (2005). Available from, as of June 5, 2015: https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000171/WC500033075.pdf

    Absorption of unchanged entacapone after single oral administration is quite rapid both in rats and in dogs. Two peaks in plasma concentrations, occurring at 5-15 minutes and at 3-5 hours post dose, were found in rats indicating that entacapone is subject to enterohepatic circulation and a single peak at 3 hours was found in dogs. A transformation of entacapone to its (Z)-isomer took place in both species studied, the transformation being minimal in rats but quite noticeable in dogs.

    European Medicines Agency (EMA), Committee for Medicinal Products for Human Use (CHMP), European Public Assessment Report (EPAR): Comtan (Entacapone), Scientific Discussion p.4 (2005). Available from, as of June 5, 2015: https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000171/WC500033075.pdf

    /MILK/ In animal studies, entacapone was excreted into maternal rat milk.

    NIH; DailyMed. Current Medication Information for Comtan (Entacapone) Tablet, Film Coated (Updated: July 2014). Available from, as of June 4, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1aceb59-9be8-43b8-83d6-81e05e4b51e4

    In rats and dogs, entacapone metabolites are predominantly excreted in the feces (two thirds as glucuronide or sulfate conjugates) and one third in the urine with less than 1.5% of the dose as unchanged entacapone. After the first hour 30-45% of the dose was recovered in the bile, with an enterohepatic circulation accounting for about 10% of the given radioactivity.

    European Medicines Agency (EMA), Committee for Medicinal Products for Human Use (CHMP), European Public Assessment Report (EPAR): Comtan (Entacapone), Scientific Discussion p.4 (2005). Available from, as of June 5, 2015: https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000171/WC500033075.pdf

    For more Absorption, Distribution and Excretion (Complete) data for ENTACAPONE (8 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Metabolized via isomerization to the cis-isomer, followed by direct glucuronidation of the parent and cis-isomer.

    In rats and dogs, entacapone metabolites are predominantly excreted in the feces (two thirds as glucuronide or sulfate conjugates) and one third in the urine with less than 1.5% of the dose as unchanged entacapone. After the first hour 30-45% of the dose was recovered in the bile, with an enterohepatic circulation accounting for about 10% of the given radioactivity.

    European Medicines Agency (EMA), Committee for Medicinal Products for Human Use (CHMP), European Public Assessment Report (EPAR): Comtan (Entacapone), Scientific Discussion p.4 (2005). Available from, as of June 5, 2015: https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000171/WC500033075.pdf

    Entacapone is extensively metabolised in the liver in all species including humans, the main metabolic pathway being glucuronidation, sulfation and isomerisation from (E)- to (Z)-isomer (active metabolite). Similar pathways across species are the reduction of the C-C double bond of the side chain (less important in rat and in man) and the hydrolysis to 3,4-dihydroxy-5-nitrobenzaldehyde. The dissimilarities consists of amide N-dealkylation, nitro reduction and O-methylation (only in rats), amide hydrolysis and nitrile hydrolysis (only in dogs) and oxidative hydrolysis of one of the ethyl groups of the diethylamide group (only in man).

    European Medicines Agency (EMA), Committee for Medicinal Products for Human Use (CHMP), European Public Assessment Report (EPAR): Comtan (Entacapone), Scientific Discussion p.4 (2005). Available from, as of June 5, 2015: https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000171/WC500033075.pdf

    Entacapone is almost completely metabolized prior to excretion, with only a very small amount (0.2% of dose) found unchanged in urine. The main metabolic pathway is isomerization to the cis-isomer, followed by direct glucuronidation of the parent and cis-isomer; the glucuronide conjugate is inactive.

    NIH; DailyMed. Current Medication Information for Comtan (Entacapone) Tablet, Film Coated (Updated: July 2014). Available from, as of June 4, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1aceb59-9be8-43b8-83d6-81e05e4b51e4

    Entacapone undergoes extensive metabolism, mainly in the liver. The main metabolic pathway of entacapone in humans is the isomerization to the cis-isomer, followed by direct glucuronidation of the parent and cis-isomer; the glucuronide conjugate is inactive.

    Health Canada; Product Monograph for Comtan (Entacapone), Drug Identification Number (DIN): 02243763 (Date of Revision: November 18, 2013). Available from, as of June 5, 2015: https://webprod5.hc-sc.gc.ca/dpd-bdpp/start-debuter.do?lang=eng

    Entacapone has known human metabolites that include Entacapone 3-o-glucuronide.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.7 Biological Half-Life

    0.4-0.7 hour

    The elimination of entacapone is biphasic, with an elimination half-life of 0.4 hour to 0.7 hour based on the beta-phase and 2.4 hours based on the gamma-phase.

    NIH; DailyMed. Current Medication Information for Comtan (Entacapone) Tablet, Film Coated (Updated: July 2014). Available from, as of June 4, 2015: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b1aceb59-9be8-43b8-83d6-81e05e4b51e4

    The overall elimination half-life of entacapone ranged from 30 minutes to 1 hour in dogs and from 1.5 to 3 hours in man.

    European Medicines Agency (EMA), Committee for Medicinal Products for Human Use (CHMP), European Public Assessment Report (EPAR): Comtan (Entacapone), Scientific Discussion p.4 (2005). Available from, as of June 5, 2015: https://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000171/WC500033075.pdf

    5.8 Mechanism of Action

    The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in peripheral tissues, altering the plasma pharmacokinetics of levodopa. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to a greater reduction in the manifestations of parkinsonian syndrome.

    Comtan (entacapone) is a reversible, selective and mainly peripherally acting inhibitor of catechol-O-methyltransferase (COMT). Comtan has no antiparkinsonian effect of its own and is designed for concomitant administration with levodopa preparations. COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a cathecol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, epinephrine) and their hydroxylated metabolites. In the presence of a dopa decarboxylase (DDC) inhibitor, COMT becomes the major enzyme which is responsible for the metabolism of levodopa to 3-methoxy-4-hydroxy-l-phenylalanine (3-OMD). The mechanism of action of entacapone is believed to be related to its ability to inhibit COMT and thereby alter the plasma pharmacokinetics of levodopa. When administered with levodopa and a DDC inhibitor (carbidopa or benserazide), entacapone decreases the degradation of levodopa in the peripheral tissues further by inhibiting the metabolism of levodopa to 3-OMD through the COMT pathway. This leads to more sustained plasma concentrations of levodopa. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain leading to greater effects on the signs and symptoms of Parkinson's Disease. The higher levodopa levels also lead to increased levodopa adverse effects, sometimes requiring a decrease in the dose of levodopa.

    Health Canada; Product Monograph for Comtan (Entacapone), Drug Identification Number (DIN): 02243763 (Date of Revision: November 18, 2013). Available from, as of June 5, 2015: https://webprod5.hc-sc.gc.ca/dpd-bdpp/start-debuter.do?lang=eng

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    Fermion Oy

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LIFESCIENCES","supplierCountry":"INDIA","foreign_port":"SANTOS","customer":"EMS","customerCountry":"BRAZIL","quantity":"1050.00","actualQuantity":"1050","unit":"KGS","unitRateFc":"250","totalValueFC":"260282.4","currency":"USD","unitRateINR":20662.5,"date":"31-May-2024","totalValueINR":"21695625","totalValueInUsd":"260282.4","indian_port":"Hyderabad ICD","hs_no":"29269000","bill_no":"1321331","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad ICD","supplierAddress":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE), Hyderabad","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717957800,"product":"ENTACAPONE","address":"SANALI INFO PARK, A BLOCK","city":"ROAD NO.2, BANJARA HILLS, HYDERABAD","supplier":"NEULAND LABORATORIES","supplierCountry":"INDIA","foreign_port":"BANGKOK","customer":"UNISON LABORATORIES CO. ","customerCountry":"THAILAND","quantity":"240.00","actualQuantity":"240","unit":"KGS","unitRateFc":"195","totalValueFC":"45765.5","currency":"USD","unitRateINR":15918.64625,"date":"10-Jun-2024","totalValueINR":"3820475.1","totalValueInUsd":"45765.5","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"1549460","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"THAILAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"SANALI INFO PARK, A BLOCK, ROAD NO.2, BANJARA HILLS, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718303400,"product":"ENTACAPONE","address":"SANALI INFO PARK, A BLOCK","city":"ROAD NO.2, BANJARA HILLS, HYDERABAD","supplier":"NEULAND LABORATORIES","supplierCountry":"INDIA","foreign_port":"YELGRAD (BEOGRAD)","customer":"FHI ZDRAVLJE A.D","customerCountry":"SERBIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"190","totalValueFC":"199157.8","currency":"EUR","unitRateINR":16625.574000000001,"date":"14-Jun-2024","totalValueINR":"16625574","totalValueInUsd":"199157.8","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"1669419","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SERBIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"SANALI INFO PARK, A BLOCK, ROAD NO.2, BANJARA HILLS, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719253800,"product":"ENTACAPONE PH.EUR","address":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE)","city":"Hyderabad","supplier":"COHANCE LIFESCIENCES","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"ILKO ILAC SAN VE TIC A\/KONYA","customerCountry":"TURKEY","quantity":"160.00","actualQuantity":"160","unit":"KGS","unitRateFc":"115","totalValueFC":"17825.6","currency":"USD","unitRateINR":9300.4249999999993,"date":"25-Jun-2024","totalValueINR":"1488068","totalValueInUsd":"17825.6","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"1940318","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE), Hyderabad","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719253800,"product":"ENTACAPONE PH.EUR","address":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE)","city":"Hyderabad","supplier":"COHANCE LIFESCIENCES","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"ILKO ILAC SAN VE TIC A\/KONYA","customerCountry":"TURKEY","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"115","totalValueFC":"55726.6","currency":"USD","unitRateINR":9304.0519999999997,"date":"25-Jun-2024","totalValueINR":"4652026","totalValueInUsd":"55726.6","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"1941067","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE), Hyderabad","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719426600,"product":"ENTACAPONE PH.EUR","address":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE)","city":"Hyderabad","supplier":"COHANCE LIFESCIENCES","supplierCountry":"INDIA","foreign_port":"BUDAPEST,","customer":"TEVA PHARMACEUTICAL INDUSTRIES","customerCountry":"HUNGARY","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"140","totalValueFC":"40619.8","currency":"USD","unitRateINR":11303.064133333333,"date":"27-Jun-2024","totalValueINR":"3390919.24","totalValueInUsd":"40619.8","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"1985323","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE), Hyderabad","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719513000,"product":"ENTACAPONE","address":"SANALI INFO PARK, A BLOCK","city":"ROAD NO.2, BANJARA HILLS, HYDERABAD","supplier":"NEULAND LABORATORIES","supplierCountry":"INDIA","foreign_port":"KARACHI -","customer":"GETZ PHARMA RESEARCH PVT. LTD","customerCountry":"PAKISTAN","quantity":"21.00","actualQuantity":"21","unit":"KGS","unitRateFc":"240","totalValueFC":"4887.3","currency":"USD","unitRateINR":19427.857142857141,"date":"28-Jun-2024","totalValueINR":"407985","totalValueInUsd":"4887.3","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"2013855","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"SANALI INFO PARK, A BLOCK, ROAD NO.2, BANJARA HILLS, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722277800,"product":"ENTACAPONE PH.EUR","address":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE)","city":"Hyderabad","supplier":"COHANCE LIFESCIENCES","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"ABDI IBRAHIM","customerCountry":"TURKEY","quantity":"420.00","actualQuantity":"420","unit":"KGS","unitRateFc":"135","totalValueFC":"55540.7","currency":"USD","unitRateINR":11054.056428571428,"date":"30-Jul-2024","totalValueINR":"4642703.7","totalValueInUsd":"55540.7","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"2814893","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE), Hyderabad","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725042600,"product":"ENTACAPONE USP","address":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE)","city":"Hyderabad","supplier":"COHANCE LIFESCIENCES","supplierCountry":"INDIA","foreign_port":"SHANGHAI - PU DONG","customer":"ANYANG WANTAI PHARMACEUTICALS CO.,","customerCountry":"CHINA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"330","totalValueFC":"8118.4","currency":"USD","unitRateINR":27238.3184,"date":"31-Aug-2024","totalValueINR":"680957.96","totalValueInUsd":"8118.4","indian_port":"Hyderabad Air","hs_no":"29269000","bill_no":"3647452","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"Plot No. 26 & 27, Technocrat Industrial Estate (TIE), Hyderabad","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727029800,"product":"ENTACAPONE PH.EUR","address":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"TAIPEI","customer":"DARD CHEM & PHARM CO. LTD","customerCountry":"TAIWAN","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"370","totalValueFC":"9083.3","currency":"USD","unitRateINR":30447.68,"date":"23-Sep-2024","totalValueINR":"761192","totalValueInUsd":"9083.3","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"4275620","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA, HYDERABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727375400,"product":"ENTACAPONE USP","address":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA","city":"HYDERABAD","supplier":"HETERO DRUGS","supplierCountry":"INDIA","foreign_port":"BANGKOK","customer":"CAMBER PHARMACEUTICAL CO. LTD.","customerCountry":"THAILAND","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"8250","totalValueFC":"6073.8","currency":"THB","unitRateINR":20359.799999999999,"date":"27-Sep-2024","totalValueINR":"508995","totalValueInUsd":"6073.8","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"4402941","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"THAILAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"HETERO HOUSE,H.NO.8-3-166\/7\/1ERRAGADDA, HYDERABAD","customerAddress":""}]
    15-Jan-2021
    27-Sep-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 200MG

    USFDA APPLICATION NUMBER - 20796

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    DOSAGE - TABLET;ORAL - 12.5MG;200MG;50MG

    USFDA APPLICATION NUMBER - 21485

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    DOSAGE - TABLET;ORAL - 18.75MG;200MG;75MG

    USFDA APPLICATION NUMBER - 21485

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    DOSAGE - TABLET;ORAL - 25MG;200MG;100MG

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    DOSAGE - TABLET;ORAL - 31.25MG;200MG;125MG

    USFDA APPLICATION NUMBER - 21485

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    DOSAGE - TABLET;ORAL - 37.5MG;200MG;150MG

    USFDA APPLICATION NUMBER - 21485

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    DOSAGE - TABLET;ORAL - 50MG;200MG;200MG

    USFDA APPLICATION NUMBER - 21485

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    01

    Brand Name : Comtan

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    CPHI Middle east
    Not Confirmed

    Brand Name : Comtan

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    Company :

    Entacapone

    Drug Cost (USD) : 47,766

    Year : 2022

    Prescribers :

    Prescriptions : 35

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    02

    Brand Name : Entacapone

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    Entacapone

    Drug Cost (USD) : 27,406,308

    Year : 2022

    Prescribers : 24049

    Prescriptions : 119869

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    03

    Brand Name : Comtan

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    Company :

    Entacapone

    Drug Cost (USD) : 109,958

    Year : 2021

    Prescribers : 18

    Prescriptions : 96

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    04

    Brand Name : Entacapone

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    Brand Name : Entacapone

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    Company :

    Entacapone

    Drug Cost (USD) : 25,916,248

    Year : 2021

    Prescribers : 24034

    Prescriptions : 119936

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    05

    Brand Name : Entacapone

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    Company :

    Entacapone

    Drug Cost (USD) : 28,790,103

    Year : 2020

    Prescribers : 23329

    Prescriptions : 127359

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    Brand Name : Comtan

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    Company :

    Entacapone

    Drug Cost (USD) : 244,939

    Year : 2020

    Prescribers : 42

    Prescriptions : 233

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    07

    Brand Name : Comtan

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    Company :

    Entacapone

    Drug Cost (USD) : 437,531

    Year : 2019

    Prescribers : 62

    Prescriptions : 366

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    08

    Brand Name : Entacapone

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    Company :

    Entacapone

    Drug Cost (USD) : 31,207,608

    Year : 2019

    Prescribers : 23717

    Prescriptions : 138141

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    09

    Brand Name : Comtan

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    Company :

    Entacapone

    Drug Cost (USD) : 580,297

    Year : 2018

    Prescribers : 79

    Prescriptions : 495

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    10

    Brand Name : Entacapone

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    Company :

    Entacapone

    Drug Cost (USD) : 41,739,252

    Year : 2018

    Prescribers : 23548

    Prescriptions : 148985

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    01

    Brand Name : COMTAN

    Finland
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    Antibody Engineering
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    ORION PHARMA

    Entacapone

    Dosage Form : TABLET;ORAL

    Dosage Strength : 200MG

    Price Per Pack :

    Published in :

    Country : USA

    RX/OTC/DISCN : RX

    Fermion Orion Company Banner

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    02

    Brand Name : Comtess

    Finland
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    Antibody Engineering
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    Orion Corporation Orion Pharma

    Entacapone

    Dosage Form : Antic-calc Tablet, Film Coated

    Dosage Strength : 200 mg

    Price Per Pack (Euro) : 52.877

    Published in :

    Country : Norway

    RX/OTC/DISCN :

    Fermion Orion Company Banner

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    03

    Brand Name : Comtess

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    Antibody Engineering
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    Orion Corporation Orion Pharma

    Entacapone

    Dosage Form : Antic-calc Tablet, Film Coated

    Dosage Strength : 200 mg

    Price Per Pack (Euro) : 84.953

    Published in :

    Country : Norway

    RX/OTC/DISCN :

    Fermion Orion Company Banner

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    04

    Brand Name : CORBILTA

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    ORION CORPORATION

    Etilevodopa; Carbidopa; Entacapone

    Dosage Form : Film-Coated Tablet

    Dosage Strength : 100 mg + 25 mg + 200 mg

    Price Per Pack (Euro) : 57.86

    Published in :

    Country : Italy

    RX/OTC/DISCN :

    Fermion Orion Company Banner

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    05

    Brand Name : STALEVO

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    ORION CORPORATION

    Etilevodopa; Carbidopa; Entacapone

    Dosage Form : Film-Coated Tablet

    Dosage Strength : 100 mg + 25 mg + 200 mg

    Price Per Pack (Euro) : 110.22

    Published in :

    Country : Italy

    RX/OTC/DISCN :

    Fermion Orion Company Banner

    Portfolio PDF

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    06

    Brand Name : CORBILTA

    Finland
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    Antibody Engineering
    Not Confirmed

    ORION CORPORATION

    Etilevodopa; Carbidopa; Entacapone

    Dosage Form : Film-Coated Tablet

    Dosage Strength : 200 mg/50 mg/200 mg

    Price Per Pack (Euro) : 57.86

    Published in :

    Country : Italy

    RX/OTC/DISCN :

    Fermion Orion Company Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

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    Website

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    07

    Brand Name : STALEVO

    Finland
    arrow
    Antibody Engineering
    Not Confirmed

    ORION CORPORATION

    Etilevodopa; Carbidopa; Entacapone

    Dosage Form : Film-Coated Tablet

    Dosage Strength : 200 mg/50 mg/200 mg

    Price Per Pack (Euro) : 110.22

    Published in :

    Country : Italy

    RX/OTC/DISCN :

    Fermion Orion Company Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    08

    Brand Name : CORBILTA

    Finland
    arrow
    Antibody Engineering
    Not Confirmed

    ORION CORPORATION

    Etilevodopa; Carbidopa; Entacapone

    Dosage Form : Film-Coated Tablet

    Dosage Strength : 50 mg/12.5 mg/200 mg

    Price Per Pack (Euro) : 57.86

    Published in :

    Country : Italy

    RX/OTC/DISCN :

    Fermion Orion Company Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    09

    Brand Name : STALEVO

    Finland
    arrow
    Antibody Engineering
    Not Confirmed

    ORION CORPORATION

    Etilevodopa; Carbidopa; Entacapone

    Dosage Form : Film-Coated Tablet

    Dosage Strength : 50 mg/12.5 mg/200 mg

    Price Per Pack (Euro) : 110.22

    Published in :

    Country : Italy

    RX/OTC/DISCN :

    Fermion Orion Company Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    10

    Brand Name : CORBILTA

    Finland
    arrow
    Antibody Engineering
    Not Confirmed

    ORION CORPORATION

    Etilevodopa; Carbidopa; Entacapone

    Dosage Form : Film-Coated Tablet

    Dosage Strength : 75 mg/18.75 mg/200 mg

    Price Per Pack (Euro) : 57.86

    Published in :

    Country : Italy

    RX/OTC/DISCN :

    Fermion Orion Company Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    Only 10 entries up to this point, click to access all click full view read-more
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    Annual Reports

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    01

    Brand Name : Comtan

    Entacapone

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    CPHI Middle east
    Not Confirmed

    Brand Name : Comtan

    Switzerland
    arrow
    CPHI Middle east
    Not Confirmed

    Novartis

    Entacapone

    Main Therapeutic Indication : Neuroscience/Mental Health

    Currency : USD

    2014 Revenue in Millions : -7.50%

    2013 Revenue in Millions :

    Growth (%) :

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    02

    Brand Name : Comtan/Stalevo

    Entacapone

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    CPHI Middle east
    Not Confirmed

    Brand Name : Comtan/Stalevo

    Switzerland
    arrow
    CPHI Middle east
    Not Confirmed

    Novartis

    Entacapone

    Main Therapeutic Indication : Neuroscience and Mental Health

    Currency : USD

    2015 Revenue in Millions : 371

    2014 Revenue in Millions : 294

    Growth (%) : -21%

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    Market Place

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    APIs

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    india-flag.png
    Entacapone API needed in India [ENA20403]
    A company that focuses strongly on development and manufacturing of products in various specialties including antibiotics, anti-allergic, anti-inflammatory, anti-hypertensive, antacids, anti-infective, anti-malarial & respiratory is looking for suppliers of Entacapone API for development purposes. The suppliers must support this enquiry with ODMF & CoA.
    30 Aug 2024

    Reply

    30 Aug 2024

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    Reply Comment (4)

    30 Aug 2024

    Russia-big.png
    Entacapone (100 kg) API needed in Russia [ENA19224]
    A company that focuses on providing consultancy services to pharmaceutical companies is looking for suppliers of Entacapone (100 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    21 Mar 2024

    Reply

    21 Mar 2024

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    Reply Comment (9)

    21 Mar 2024

    Iran.png
    Various APIs needed in Iran [ENA12317]
    A company that deals in the manufacturing of a variety of solid pharmaceutical products such as tablets, coated tablets and capsules is looking for suppliers of Various APIs for commercial purpose. 1. Levodopa (2.2 MT) API 2. Carbidopa (200 kg) API 3. Entacapone (2 MT) API
    05 Jan 2022

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    05 Jan 2022

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    Reply Comment (8)

    05 Jan 2022

    india-flag.png
    USP Grade Entacapone (1 kg) & IP Grade Timolol Maleate APIs needed in India [ENA08955]
    Ami Jyot International, a chemical distributor based in India is looking for suppliers of USP Grade Entacapone (1 kg) & IP Grade Timolol Maleate APIs. Interested suppliers can contact them via their email: amijyot.international@gmail.com.
    31 Oct 2020

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    31 Oct 2020

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    Reply Comment (4)

    31 Oct 2020

    Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

    Patents & EXCLUSIVITIES

    Check the patents & exclusivity for this product

    Health Canada Patents

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    read-more

    01

    Gowling Strathy & Henderson

    Entacapone
    arrow
    CPHI Middle east
    Not Confirmed

    Gowling Strathy & Henderson

    Canada
    arrow
    CPHI Middle east
    Not Confirmed

    Patent Expiration Date : 2012-03-28

    Date Granted : 1995-03-28

    Entacapone

    Brand Name : COMTAN

    Patent Number : 1334967

    Filing Date : 1987-11-27

    Strength per Unit : 200mg

    Dosage Form : Tablet

    Human Or VET : Human

    Route of Administration : Oral

    Patent Expiration Date : 2012-03-28

    Date Granted : 1995-03-28

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    02

    Gowling Strathy & Henderson

    Entacapone
    arrow
    CPHI Middle east
    Not Confirmed

    Gowling Strathy & Henderson

    Canada
    arrow
    CPHI Middle east
    Not Confirmed

    Patent Expiration Date : 2019-09-13

    Date Granted : 2008-01-29

    Entacapone

    Brand Name : COMTAN

    Patent Number : 2342634

    Filing Date : 1999-09-13

    Strength per Unit : 200mg

    Dosage Form : Tablet

    Human Or VET : Human

    Route of Administration : Oral

    Patent Expiration Date : 2019-09-13

    Date Granted : 2008-01-29

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    REF. STANDARDS & IMPURITIES

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