Find Entinostat manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 209783-80-2, Ms-275, Sndx-275, Entinostat (ms-275), Ms 275, Ms-27-275
Molecular Formula
C21H20N4O3
Molecular Weight
376.4  g/mol
InChI Key
INVTYAOGFAGBOE-UHFFFAOYSA-N
FDA UNII
1ZNY4FKK9H

Entinostat
Entinostat is a synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.
1 2D Structure

Entinostat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
2.1.2 InChI
InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
2.1.3 InChI Key
INVTYAOGFAGBOE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3
2.2 Other Identifiers
2.2.1 UNII
1ZNY4FKK9H
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ms 27-275

2. Ms 275

3. Ms-27-275

4. Ms-275

5. N-(2-aminophenyl)-4-(n-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide

6. Sndx-275

2.3.2 Depositor-Supplied Synonyms

1. 209783-80-2

2. Ms-275

3. Sndx-275

4. Entinostat (ms-275)

5. Ms 275

6. Ms-27-275

7. Sndx 275

8. Pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate

9. Ms 27-275

10. Ms275

11. Entinostat (ms-275,sndx-275)

12. 1zny4fkk9h

13. Bay 86-5274

14. N-(2-aminophenyl)-4-(n-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide

15. Pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

16. Chembl27759

17. Pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate

18. Nsc706995

19. Bay86-5274

20. Nsc-706995

21. Pyridin-3-ylmethyl 4-(2-aminophenylcarbamoyl)benzylcarbamate

22. Ms-275-27

23. Carbamic Acid, N-((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3- Pyridinylmethyl Ester

24. Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl Ester

25. Pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate.

26. Pyridin-3-ylmethyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate

27. N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic Acid 3-pyridinylmethyl Ester

28. Entinostatum

29. N-(2-aminophenyl)-4-[n-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzamide

30. Entinostat, Free Base

31. Entinostat [inn]

32. Entinostat [jan]

33. Entinostat [usan:inn]

34. Unii-1zny4fkk9h

35. Entinostat [usan]

36. Ms-275 - Entinostat

37. 3-pyridinylmethyl ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)carbamate

38. Benzamide-type Inhibitor, 3

39. Carbamic Acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3-pyridinylmethyl Ester

40. Entinostat [who-dd]

41. Mls006010183

42. Entinostat (jan/usan/inn)

43. Schembl148309

44. Gtpl7007

45. Dtxsid0041068

46. Bdbm19410

47. Ex-a038

48. Chebi:132082

49. Bcpp000155

50. Hms3426g07

51. Hms3648k12

52. Hms3654o11

53. Hms3744o17

54. Act06782

55. Amy31163

56. Bcp01824

57. Zinc1488870

58. Mfcd08272435

59. Nsc756642

60. S1053

61. Entinostat (ms-275;sndx-275)

62. 3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

63. Akos024262667

64. N-(2-aminophenyl)-4-[n-(pyridin-3-yl-methoxycarbonyl)aminomethyl]benzamide

65. Ac-8968

66. Bcp9000967

67. Carbamic Acid, 3-pyridinylmethyl Ester

68. Ccg-208680

69. Cs-0511

70. Db11841

71. Entinostat (ms-275, Sndx-275)

72. Nsc 706995

73. Nsc-756642

74. Sb16665

75. Carbamic Acid, [[4-[[(2-aminophenyl)carbaonyl]phenyl]methyl]-, 3-pyridinylmethyl Ester

76. Ncgc00165833-01

77. Ncgc00165833-02

78. Ncgc00165833-03

79. Ncgc00165833-04

80. Ncgc00165833-11

81. Ncgc00165833-13

82. 442532-99-2

83. As-17906

84. Bp-25653

85. Hy-12163

86. Nci60_038022

87. Smr004458705

88. Ms-275, A Hdac1 And Hdac3 Inhibitor

89. Zk 244894

90. E1454

91. Ft-0667871

92. Sw219667-1

93. Ec-000.2117

94. D09338

95. 783m802

96. A815057

97. Ms-275,entinostat, Sndx-275, Ms-27-275

98. Sr-01000946382

99. Q1281020

100. Sr-01000946382-1

101. W-201831

102. Brd-k77908580-001-02-1

103. Brd-k77908580-001-04-7

104. (pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate

105. Pyridin-3-ylmethyl4-((2-aminophenyl)carbamoyl)benzylcarbamate

106. N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-3-pyridinylmethyl Ester, Carbamic Acid

107. N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamic Acid 3-pyridinylmethyl Ester

108. Pyridin-3-ylmethyl ((4-((2-aminophenyl)carbamoyl)phenyl)methyl)carbamate

109. Sndx 275;3-pyridylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 376.4 g/mol
Molecular Formula C21H20N4O3
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass376.15354051 g/mol
Monoisotopic Mass376.15354051 g/mol
Topological Polar Surface Area106 Ų
Heavy Atom Count28
Formal Charge0
Complexity508
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Histone Deacetylase Inhibitors

Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. (See all compounds classified as Histone Deacetylase Inhibitors.)


Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


4.2 ATC Code

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01X - Other antineoplastic agents

L01XH - Histone deacetylase (hdac) inhibitors

L01XH05 - Entinostat


Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Entinostat Manufacturers

A Entinostat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Entinostat, including repackagers and relabelers. The FDA regulates Entinostat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Entinostat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Entinostat Suppliers

A Entinostat supplier is an individual or a company that provides Entinostat active pharmaceutical ingredient (API) or Entinostat finished formulations upon request. The Entinostat suppliers may include Entinostat API manufacturers, exporters, distributors and traders.

click here to find a list of Entinostat suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Entinostat USDMF

A Entinostat DMF (Drug Master File) is a document detailing the whole manufacturing process of Entinostat active pharmaceutical ingredient (API) in detail. Different forms of Entinostat DMFs exist exist since differing nations have different regulations, such as Entinostat USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Entinostat DMF submitted to regulatory agencies in the US is known as a USDMF. Entinostat USDMF includes data on Entinostat's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Entinostat USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Entinostat suppliers with USDMF on PharmaCompass.

Entinostat GMP

Entinostat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Entinostat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Entinostat GMP manufacturer or Entinostat GMP API supplier for your needs.

Entinostat CoA

A Entinostat CoA (Certificate of Analysis) is a formal document that attests to Entinostat's compliance with Entinostat specifications and serves as a tool for batch-level quality control.

Entinostat CoA mostly includes findings from lab analyses of a specific batch. For each Entinostat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Entinostat may be tested according to a variety of international standards, such as European Pharmacopoeia (Entinostat EP), Entinostat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Entinostat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty