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    Also known as: 50-98-6, (-)-ephedrine hydrochloride, L-ephedrine hydrochloride, 1-ephedrine hydrochloride, Ephedrine hcl, Ephedrine (hydrochloride)
    Molecular Formula
    C10H16ClNO
    Molecular Weight
    201.69  g/mol
    InChI Key
    BALXUFOVQVENIU-GNAZCLTHSA-N
    FDA UNII
    NLJ6390P1Z
    Ephedrine Hydrochloride
    A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
    1 2D Structure

    Ephedrine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C10H15NO.ClH/c1-8(11-2)10(12)9-6-4-3-5-7-9;/h3-8,10-12H,1-2H3;1H/t8-,10-;/m0./s1
    2.1.3 InChI Key
    BALXUFOVQVENIU-GNAZCLTHSA-N
    2.1.4 Canonical SMILES
    CC(C(C1=CC=CC=C1)O)NC.Cl
    2.1.5 Isomeric SMILES
    C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    NLJ6390P1Z
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ephedrine

    2. Ephedrine Erythro Isomer

    3. Ephedrine Renaudin

    4. Ephedrine Sulfate

    5. Erythro Isomer Of Ephedrine

    6. Hydrochloride, Ephedrine

    7. Renaudin, Ephedrine

    8. Sal Phedrine

    9. Sal-phedrine

    10. Salphedrine

    11. Sulfate, Ephedrine

    2.3.2 Depositor-Supplied Synonyms

    1. 50-98-6

    2. (-)-ephedrine Hydrochloride

    3. L-ephedrine Hydrochloride

    4. 1-ephedrine Hydrochloride

    5. Ephedrine Hcl

    6. Ephedrine (hydrochloride)

    7. Nlj6390p1z

    8. Nsc-759611

    9. Ephedronguent

    10. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol Hydrochloride

    11. Altusin

    12. Dsstox_cid_25825

    13. Dsstox_rid_81156

    14. Dsstox_gsid_45825

    15. Ephedrinium Chloride

    16. L-ephedrine, Hydrochloride

    17. (-)-ephedrin Hydrochloride

    18. Cas-50-98-6

    19. Einecs 200-074-6

    20. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;hydrochloride

    21. Unii-nlj6390p1z

    22. Ephedrine Hydrochloride [usan:ban:jan]

    23. Ncgc00094665-01

    24. Rezipres

    25. (1r,2s)-(-)-ephedrine Hydrochloride

    26. Ephedrini Hydrochloridum

    27. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid [german]

    28. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

    29. Ec 200-074-6

    30. Schembl22822

    31. Ephedrine Hydrochloride (tn)

    32. Ephedrine Hydrochloride Racemic

    33. N-methyl-beta-oxy-beta-phenylisopropylaminhydrochlorid

    34. Chembl2146102

    35. Dtxsid1045825

    36. Chebi:31541

    37. Hy-b1195a

    38. Str01942

    39. Ephedrine Hydrochloride [mi]

    40. Tox21_111310

    41. Ephedrine Hydrochloride (jp17/usp)

    42. Ephedrine Hydrochloride [jan]

    43. Akos015895154

    44. Tox21_111310_1

    45. Ccg-229523

    46. Cs-4803

    47. Ephedrine Hydrochloride [mart.]

    48. Ephedrine Hydrochloride [vandf]

    49. Nsc 759611

    50. Benzenemethanol, .alpha.-[(1s)-1-(methylamino)ethyl]-, Hydrochloride, (.alpha.r)-

    51. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride, (alphar)-

    52. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, Hydrochloride, (theta-(theta,s))-

    53. Ephedrine Hydrochloride [usp-rs]

    54. Ephedrine Hydrochloride [who-dd]

    55. Ephedrine Hydrochloride [who-ip]

    56. Ncgc00015408-03

    57. (1r,2s)-(-)-ephedrinehydrochloride

    58. Ephedrine Hydrochloride [ep Impurity]

    59. Ephedrine Hydrochloride [orange Book]

    60. (-)-ephedrine Hydrochloride [who-ip]

    61. (1r,2s)-(-)-ephedrine Hydrochloride, 99%

    62. Ephedrine Hydrochloride [ep Monograph]

    63. D01386

    64. Ephedrine Hydrochloride [usp Monograph]

    65. Ephedrini Hydrochloridum [who-ip Latin]

    66. 066e127

    67. Q27284939

    68. (1r,2s)-ephedrine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    69. Ephedrine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    70. (r-(r*,s*))-.alpha.-(1-(methylamino)ethyl)benzenemethanol Hydrochloride [who-ip]

    71. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, Hydrochloride, (r-(r*,s*))-

    72. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, Hydrochloride (1:1), (alphar)-

    73. Ephedrine Hydrochloride, Drug Precursor, European Pharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 201.69 g/mol
    Molecular Formula C10H16ClNO
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count3
    Exact Mass201.0920418 g/mol
    Monoisotopic Mass201.0920418 g/mol
    Topological Polar Surface Area32.3 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity121
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic Agents

    Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Central Nervous System Stimulants

    A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Adrenergic beta-Agonists [MoA]; Increased Norepinephrine Activity [PE]; Norepinephrine Releasing Agent [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]

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    13-Jan-2021
    29-Nov-2024
    KGS
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    Average Price (USD/KGS)

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    ABOUT THIS PAGE

    Ephedrine Hydrochloride Manufacturers

    A Ephedrine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ephedrine Hydrochloride, including repackagers and relabelers. The FDA regulates Ephedrine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ephedrine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ephedrine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ephedrine Hydrochloride Suppliers

    A Ephedrine Hydrochloride supplier is an individual or a company that provides Ephedrine Hydrochloride active pharmaceutical ingredient (API) or Ephedrine Hydrochloride finished formulations upon request. The Ephedrine Hydrochloride suppliers may include Ephedrine Hydrochloride API manufacturers, exporters, distributors and traders.

    click here to find a list of Ephedrine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ephedrine Hydrochloride USDMF

    A Ephedrine Hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Ephedrine Hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Ephedrine Hydrochloride DMFs exist exist since differing nations have different regulations, such as Ephedrine Hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ephedrine Hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Ephedrine Hydrochloride USDMF includes data on Ephedrine Hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ephedrine Hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ephedrine Hydrochloride suppliers with USDMF on PharmaCompass.

    Ephedrine Hydrochloride JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Ephedrine Hydrochloride Drug Master File in Japan (Ephedrine Hydrochloride JDMF) empowers Ephedrine Hydrochloride API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Ephedrine Hydrochloride JDMF during the approval evaluation for pharmaceutical products. At the time of Ephedrine Hydrochloride JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Ephedrine Hydrochloride suppliers with JDMF on PharmaCompass.

    Ephedrine Hydrochloride KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Ephedrine Hydrochloride Drug Master File in Korea (Ephedrine Hydrochloride KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ephedrine Hydrochloride. The MFDS reviews the Ephedrine Hydrochloride KDMF as part of the drug registration process and uses the information provided in the Ephedrine Hydrochloride KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Ephedrine Hydrochloride KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ephedrine Hydrochloride API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Ephedrine Hydrochloride suppliers with KDMF on PharmaCompass.

    Ephedrine Hydrochloride CEP

    A Ephedrine Hydrochloride CEP of the European Pharmacopoeia monograph is often referred to as a Ephedrine Hydrochloride Certificate of Suitability (COS). The purpose of a Ephedrine Hydrochloride CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ephedrine Hydrochloride EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ephedrine Hydrochloride to their clients by showing that a Ephedrine Hydrochloride CEP has been issued for it. The manufacturer submits a Ephedrine Hydrochloride CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ephedrine Hydrochloride CEP holder for the record. Additionally, the data presented in the Ephedrine Hydrochloride CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ephedrine Hydrochloride DMF.

    A Ephedrine Hydrochloride CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ephedrine Hydrochloride CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Ephedrine Hydrochloride suppliers with CEP (COS) on PharmaCompass.

    Ephedrine Hydrochloride WC

    A Ephedrine Hydrochloride written confirmation (Ephedrine Hydrochloride WC) is an official document issued by a regulatory agency to a Ephedrine Hydrochloride manufacturer, verifying that the manufacturing facility of a Ephedrine Hydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ephedrine Hydrochloride APIs or Ephedrine Hydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Ephedrine Hydrochloride WC (written confirmation) as part of the regulatory process.

    click here to find a list of Ephedrine Hydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

    Ephedrine Hydrochloride NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ephedrine Hydrochloride as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Ephedrine Hydrochloride API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Ephedrine Hydrochloride as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Ephedrine Hydrochloride and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ephedrine Hydrochloride NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Ephedrine Hydrochloride suppliers with NDC on PharmaCompass.

    Ephedrine Hydrochloride GMP

    Ephedrine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ephedrine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ephedrine Hydrochloride GMP manufacturer or Ephedrine Hydrochloride GMP API supplier for your needs.

    Ephedrine Hydrochloride CoA

    A Ephedrine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Ephedrine Hydrochloride's compliance with Ephedrine Hydrochloride specifications and serves as a tool for batch-level quality control.

    Ephedrine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Ephedrine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ephedrine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Ephedrine Hydrochloride EP), Ephedrine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ephedrine Hydrochloride USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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