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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 12 USDMF, 1 EU WC, 7 NDC API, 6 Listed Suppliers, $ API Reference Price

15 API Suppliers
12 USDMF
1 EU WC
7 NDC API
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

6 Drugs in Development

6 Drugs in Development

FINISHED DOSAGE FORMULATIONS

26 FDF Dossiers, 21 FDA Orange Book, 1 Canada, 2 South Africa, 2 Listed Dossiers

26 FDF Dossiers
21 FDA Orange Book
1 Canada
2 South Africa
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INTRAVENOUS - 25MG/5ML (5MG/ML), SOLUTION;INTRAVENOUS - 50MG/ML (50MG/ML)

drugProductComposition
SOLUTION;INTRAVENOUS - 25MG/5ML (5MG/ML)
SOLUTION;INTRAVENOUS - 50MG/ML (50MG/ML)

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 5 SPI Pharma, 2 Seqens, 7 DKSH, 5 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 11 Gangwal Healthcare, 4 ACG Worldwide, 6 Actylis, 1 Aeon Procare, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 20 BASF, 10 Corel Pharma Chem, 3 DFE Pharma, 1 Finar, 8 Gangwal Chemicals, 7 Ideal Cures Pvt Ltd, 3 Ingredion Pharma Solutions, 17 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 11 Microlex e.U, 2 Nomisma Healthcare, 3 Novo Excipients, 2 Pharmatrans-Sanaq, 5 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 23 Roquette, 7 Seppic, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 The Dow Chemical Company, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

55 Fillers, Diluents & Binders, 52 Coating Systems & Additives, 31 Controlled & Modified Release, 27 Direct Compression, 25 Thickeners and Stabilizers, 21 Disintegrants & Superdisintegrants, 18 Granulation, 16 Lubricants & Glidants, 13 Solubilizers, 12 Co-Processed Excipients, 10 Taste Masking, 10 Film Formers & Plasticizers, 9 Empty Capsules, 9 Topical, 7 Chewable & Orodispersible Aids, 7 Parenteral, 5 API Stability Enhancers, 4 Vegetarian Capsules, 4 Coloring Agents, 4 Emulsifying Agents, 3 Rheology Modifiers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 32 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
32 NEWS #PharmaBuzz

MARKET PLACE

2 APIs, 2 FDF Dossiers

marketPlace
2 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

10 US Patents

patents
10 US Patents

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

otherSolutions
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 67

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

6DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

207 RELATED EXCIPIENT COMPANIES

342EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Ephedrine sulphate, Isofedrol, Akovaz, 134-72-5, Corphedra, Ephedrine sulfate [usp]

Molecular Formula

C₂₀H₃₂N₂O₆S

Molecular Weight

428.5 g/mol

InChI Key

CAVQBDOACNULDN-KHFUBBAMSA-N

FDA UNII

U6X61U5ZEG

A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

1 2D Structure

Ephedrine Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric acid

2.1.2 InChI

InChI=1S/2C10H15NO.H2O4S/c2*1-8(11-2)10(12)9-6-4-3-5-7-9;1-5(2,3)4/h2*3-8,10-12H,1-2H3;(H2,1,2,3,4)/t2*8-,10-;/m00./s1

2.1.3 InChI Key

CAVQBDOACNULDN-KHFUBBAMSA-N

2.1.4 Canonical SMILES

CC(C(C1=CC=CC=C1)O)NC.CC(C(C1=CC=CC=C1)O)NC.OS(=O)(=O)O

2.1.5 Isomeric SMILES

C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.OS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

U6X61U5ZEG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Ephedrine

2. Ephedrine Erythro Isomer

3. Ephedrine Hydrochloride

4. Ephedrine Renaudin

5. Erythro Isomer Of Ephedrine

6. Hydrochloride, Ephedrine

7. Renaudin, Ephedrine

8. Sal Phedrine

9. Sal-phedrine

10. Salphedrine

11. Sulfate, Ephedrine

2.3.2 Depositor-Supplied Synonyms

1. Ephedrine Sulphate

2. Isofedrol

3. Akovaz

4. 134-72-5

5. Corphedra

6. Ephedrine Sulfate [usp]

7. U6x61u5zeg

8. (-)-ephedrine Sulfate (2:1) (salt)

9. 134-72-5 (sulfate)

10. (-)-ephedrine Hemisulfate

11. Nci-c55652

12. Ephedrine Sulfate (usp)

13. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alphar)-, Sulfate (2:1) (salt)

14. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric Acid

15. L-ephedrine Sulfate

16. Unii-u6x61u5zeg

17. Expansyl

18. Ccris 1351

19. Ephedrini Sulfas

20. Pazo Ointment

21. Franol Plus

22. Franol-plus

23. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol Sulfate (2:1) (salt)

24. Pazo Suppositories

25. Corphedra (tn)

26. Emerphed (tn)

27. Einecs 205-154-4

28. Akovaz (tn)

29. Emerphed

30. Ephedrine L- Sulfate

31. 1-phenyl-2-methylamine-propanol-1-sulfate

32. Ec 205-154-4

33. Schembl41262

34. (1r,2s)-1-phenyl-2-methylaminopropanol-1 Sulfate

35. Ephedrine Sulfate [mi]

36. 1-alpha-(1-(methylamino)ethyl)benzyl Alcohol Sulfate

37. Chembl1523964

38. Dtxsid6020565

39. Ephedrine Sulfate [vandf]

40. Ephedrine Sulfate [mart.]

41. Ephedrine Sulfate [usp-rs]

42. Ephedrine Sulfate [who-dd]

43. Ephedrine Sulfate [who-ip]

44. (-)-erythro-1-hydroxy-2-(methylamino)-1-phenylpropane Sulfate

45. Bdbm50480314

46. Akos015901652

47. Ephedrine Sulfate [orange Book]

48. Ephedrini Sulfas [who-ip Latin]

49. Ephedrine Sulfate [usp Monograph]

50. Ncgc00093901-01

51. Ephedrine Sulfate (2:1) (salt), (-)-

52. Eu-0100501

53. D04018

54. E 3250

55. Q27290771

56. Ephedrine Sulphate 1.0 Mg/ml In Methanol (as Free Base)

57. Bis((r-(r*,s*))-beta-hydroxy-alpha-methylphenethyl)methylammonium Sulphate

58. Bis((r-(r*,s*))-beta-hydroxy-alpha-methylphenethyl)methylammonium) Sulphate

59. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alphar)-, Sulfate (2:1)

60. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (r-(r*,s*))-, Sulfate (2:1) (salt)

61. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (theta-(theta,s))-, Sulfate (2:1) (salt)

62. (r-(r*,s*))-.alpha.-(1-(methylamino)ethyl)benzenemethanol Sulfate (2:1) (salt) [who-ip]

63. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, (r-(r*,s*))-, Sulfate (2:1) (salt)

2.4 Create Date

2005-07-19

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₃₂N₂O₆S
Molecular Weight	428.5 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	6
Exact Mass	428.19810792 g/mol
Monoisotopic Mass	428.19810792 g/mol
Topological Polar Surface Area	148 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	202
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic Agents

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

Central Nervous System Stimulants

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

4.2 FDA Pharmacological Classification

4.2.1 Pharmacological Classes

Adrenergic beta-Agonists [MoA]; Increased Norepinephrine Activity [PE]; Norepinephrine Releasing Agent [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]

API SUPPLIERS

01

Malladi Drugs & Pharmaceuticals Li...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Malladi is a leader in Ephedrine, Pseudoephedrine Salts & Phenylephrine HCl // USFDA, EDQM, ANSM, KFDA, and TGA inspected.

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India

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USDMF

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CEP/COS JDMF EU-WC NDC

KDMF VMF Others AUDIT

02

Pharm-RX Chemical

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Pharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

Contact Supplier

U.S.A

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Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

03

Nortec Quimica

Brazil

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Nortec Quimica is the largest API manufacturer in Latin America.

Contact Supplier

Brazil

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Embio Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

05

Siegfried AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

06

Siegfried AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

07

elm-plastic GmbH

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

08

Catalytica

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

09

Avon Organics Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

10

Krebs Biochemicals & Industries Lt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

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API Reference Price

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MAHARASTRA","supplier":"EMBIO LIMITED","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"TO THE ORDER OF","customerCountry":"SWITZERLAND","quantity":"275.00","actualQuantity":"275","unit":"KGS","unitRateFc":"67","totalValueFC":"16958.9","currency":"USD","unitRateINR":5172.6788727272724,"date":"31-Aug-2024","totalValueINR":"1422486.69","totalValueInUsd":"16958.9","indian_port":"Bombay Air","hs_no":"29394200","bill_no":"3634217","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"501, SENTINEL, HIRANANDANI GARDENS, POWAI, MUMBAI. MAHARASTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"PSEUDOEPHEDRINE SULFATE USP BATCH NO:900724 MFG DT:AUGUST 2024 EXP\/RETEST DT.JULY2029","address":"501, SENTINEL, HIRANANDANI GARDENS","city":"POWAI, MUMBAI. MAHARASTRA","supplier":"EMBIO LIMITED","supplierCountry":"INDIA","foreign_port":"SINGAPORE","customer":"TO THE ORDER OF","customerCountry":"SINGAPORE","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"68","totalValueFC":"3297.2","currency":"USD","unitRateINR":5526.1631999999991,"date":"10-Sep-2024","totalValueINR":"276308.16","totalValueInUsd":"3297.2","indian_port":"Bombay Air","hs_no":"29394200","bill_no":"3891597","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"501, SENTINEL, HIRANANDANI GARDENS, POWAI, MUMBAI. MAHARASTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"PSEUDOEPHEDRINE SULPHATE USP (NOC NO.PC-EXP-11001\/2024 DT.30.07.2024)","address":"NO.9, G.S.T. 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ROAD","city":"CHENNAI, TAMIL NADU","supplier":"MALLADI DRUGS & PHARMACEUTICALS LIMITED","supplierCountry":"INDIA","foreign_port":"COLOMBO","customer":"TO THE ORDER OF","customerCountry":"SRI LANKA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1000","totalValueFC":"882.9","currency":"USD","unitRateINR":74189,"date":"18-Oct-2024","totalValueINR":"74189","totalValueInUsd":"882.9","indian_port":"Madras Air","hs_no":"29394100","bill_no":"4918630","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SRI LANKA","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"NO.9, G.S.T. ROAD, CHENNAI, TAMIL NADU","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666204200,"product":"(FOC) - EPHEDRINE SULFATE PWD P - 100635 - 21452025","address":"NO.54\/1, BOODIHAL,,NELAMANGALA,","city":"BENGALURU,KARNATAKA","supplier":"SIEGFRIED AG","supplierCountry":"GERMANY","foreign_port":"NA","customer":"SOMERSET THERAPEUTICS LIMITED","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1450","totalValueFC":"7264.6","currency":"USD","unitRateINR":"119552.5","date":"20-Oct-2022","totalValueINR":"597762.5","totalValueInUsd":"7264.6","indian_port":"BANGALORE AIR","hs_no":"29394100","bill_no":"2970765","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"NO.54\/1, BOODIHAL,,NELAMANGALA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721932200,"product":"EPHEDRINE SULFATE USP","address":"6-3-865\/1\/2, FLAT NO.201,","city":"HYDERABAD, ANDHRA PRADESH","supplier":"SIEGFRIED AG","supplierCountry":"SWITZERLAND","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"GLAND PHARMA LTD","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15000","unit":"GMS","unitRateFc":"1.5","totalValueFC":"24951.8","currency":"EUR","unitRateINR":"139.1","date":"26-Jul-2024","totalValueINR":"2085750","totalValueInUsd":"24951.8","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"4706824","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"UNTERE BRUHLSTRASSE 44800 ZOFINGENSWITZERLAND CH","customerAddress":"6-3-865\/1\/2, FLAT NO.201,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION;INTRAVENOUS - 25MG/5ML (5MG...DOSAGE - SOLUTION;INTRAVENOUS - 25MG/5ML (5MG/ML)

USFDA APPLICATION NUMBER - 208289

DOSAGE - SOLUTION;INTRAVENOUS - 50MG/ML (50MG...DOSAGE - SOLUTION;INTRAVENOUS - 50MG/ML (50MG/ML)

USFDA APPLICATION NUMBER - 208289

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Fillers, Diluents & Binders

Coating Systems & Additives

Controlled & Modified Release

Direct Compression

Thickeners and Stabilizers

Disintegrants & Superdisintegrants

Granulation

Lubricants & Glidants

Solubilizers

Co-Processed Excipients

Taste Masking

Film Formers & Plasticizers

Empty Capsules

Topical

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers

12 USDMF

1 EU WC

7 NDC API

6 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

6 Drugs in Development

FINISHED DOSAGE FORMULATIONS

26 FDF Dossiers

21 FDA Orange Book

1 Canada

2 South Africa

2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INTRAVENOUS - 25MG/5ML (5MG/ML)

SOLUTION;INTRAVENOUS - 50MG/ML (50MG/ML)

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7 DKSH

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11 Gangwal Healthcare

4 ACG Worldwide

6 Actylis

1 Aeon Procare

7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

20 BASF

10 Corel Pharma Chem

3 DFE Pharma

1 Finar

8 Gangwal Chemicals

7 Ideal Cures Pvt Ltd

3 Ingredion Pharma Solutions

17 Kerry

3 Kima Chemical

6 Lonza Capsugel

11 Microlex e.U

2 Nomisma Healthcare

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2 Qualicaps

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7 Seppic

5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

10 Sigachi Industries

2 The Dow Chemical Company

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EXCIPIENTS BY APPLICATIONS

55 Fillers, Diluents & Binders

52 Coating Systems & Additives

31 Controlled & Modified Release

27 Direct Compression

25 Thickeners and Stabilizers

21 Disintegrants & Superdisintegrants

18 Granulation

16 Lubricants & Glidants

13 Solubilizers

12 Co-Processed Excipients

10 Taste Masking

10 Film Formers & Plasticizers

9 Empty Capsules

9 Topical

7 Chewable & Orodispersible Aids

7 Parenteral

5 API Stability Enhancers

4 Vegetarian Capsules

4 Coloring Agents

4 Emulsifying Agents