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    Chemistry

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    Also known as: L-adrenaline, Adrenaline, L-epinephrine, 51-43-4, Adrenalin, Levoepinephrine
    Molecular Formula
    C9H13NO3
    Molecular Weight
    183.20  g/mol
    InChI Key
    UCTWMZQNUQWSLP-VIFPVBQESA-N
    Epinephrine
    The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
    Epinephrine is an alpha-Adrenergic Agonist, and beta-Adrenergic Agonist, and Catecholamine. The mechanism of action of epinephrine is as an Adrenergic alpha-Agonist, and Adrenergic beta-Agonist.
    1 2D Structure

    Epinephrine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
    2.1.2 InChI
    InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
    2.1.3 InChI Key
    UCTWMZQNUQWSLP-VIFPVBQESA-N
    2.1.4 Canonical SMILES
    CNCC(C1=CC(=C(C=C1)O)O)O
    2.1.5 Isomeric SMILES
    CNC[C@@H](C1=CC(=C(C=C1)O)O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

    2. Acetate, Epinephrine

    3. Adrenaline

    4. Adrenaline Acid Tartrate

    5. Adrenaline Bitartrate

    6. Adrenaline Hydrochloride

    7. Epifrin

    8. Epinephrine Acetate

    9. Epinephrine Bitartrate

    10. Epinephrine Hydrochloride

    11. Epinephrine Hydrogen Tartrate

    12. Epitrate

    13. Lyophrin

    14. Medihaler-epi

    2.2.2 Depositor-Supplied Synonyms

    1. L-adrenaline

    2. Adrenaline

    3. L-epinephrine

    4. 51-43-4

    5. Adrenalin

    6. Levoepinephrine

    7. Nephridine

    8. (-)-epinephrine

    9. Adnephrine

    10. Chelafrin

    11. Epinefrina

    12. Epinephran

    13. Epirenan

    14. Epipen

    15. (-)-adrenaline

    16. Adrenal

    17. Epifrin

    18. Renoform

    19. Vasoconstrictine

    20. Primatene Mist

    21. Bronkaid Mist

    22. Sus-phrine

    23. Hypernephrin

    24. Renostypticin

    25. Supracapsulin

    26. Supranephrane

    27. Suprarenaline

    28. Adrenalinum

    29. Adrenine

    30. Glauposine

    31. Hemisine

    32. Hemostasin

    33. Hemostatin

    34. Levorenin

    35. Levorenine

    36. Lyophrin

    37. Mucidrina

    38. Nieraline

    39. Paranephrin

    40. Renaglandin

    41. Renaleptine

    42. Renalina

    43. Scurenaline

    44. Simplene

    45. Styptirenal

    46. Takamina

    47. Twinject

    48. Vasotonin

    49. Bosmin

    50. Exadrin

    51. Tonogen

    52. (r)-adrenaline

    53. Adrin

    54. (-)-(r)-epinephrine

    55. L-epirenamine

    56. Antiasthmatique

    57. Esphygmogenina

    58. Methylarterenol

    59. Supranephrine

    60. Adrenamine

    61. Adrenapax

    62. Adrenasol

    63. Adrenodis

    64. Adrenohorma

    65. Adrenosan

    66. Adrenutol

    67. Astmahalin

    68. Astminhal

    69. Balmadren

    70. Bernarenin

    71. Biorenine

    72. Brevirenin

    73. Bronkaid

    74. Drenamist

    75. Dylephrin

    76. Glaucosan

    77. Glycirenan

    78. Haemostasin

    79. Haemostatin

    80. Hektalin

    81. Hyporenin

    82. Intranefrin

    83. Isoptoepinal

    84. Kidoline

    85. Myosthenine

    86. Sindrenina

    87. Soladren

    88. Sphygmogenin

    89. Stryptirenal

    90. Supradin

    91. Supranefran

    92. Supranol

    93. Takamine

    94. Tokamina

    95. Vasodrine

    96. Corisol

    97. Glaucon

    98. Mytrate

    99. Suprel

    100. Asthma-nefrin

    101. Asmatane Mist

    102. 4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

    103. L(-)-epinephrine

    104. Sympathin I

    105. (r)-epinephrine

    106. Asthma Meter Mist

    107. Epiglaufrin

    108. Adrenalin-medihaler

    109. Levorenen

    110. Eppy

    111. Dyspne-inhal

    112. R-(-)-epinephrine

    113. Adrenalin In Oil

    114. Epinefrin [czech]

    115. Epinephrinum

    116. Epinefrin

    117. Renostyptin

    118. Surrenine

    119. Susphrine

    120. Citanest Forte

    121. 1-epinephrine

    122. 1-adrenalin

    123. Epipen Jr.

    124. Vaponefrin

    125. (r)-(-)-adrenaline

    126. Rcra Waste Number P042

    127. L-epinephrine (synthetic)

    128. Adrenalina [dcit]

    129. Adrenatrate

    130. Epinefrina [inn-spanish]

    131. Epinephrinum [inn-latin]

    132. Metanephrin

    133. Renaglandulin

    134. Renostypricin

    135. Vasoconstrictor

    136. Epirenin

    137. Renagladin

    138. Surenine

    139. Vasoton

    140. L-adrenalin

    141. R-adrenaline

    142. Suprarenin

    143. Methylaminoethanolcatechol

    144. Auvi-q

    145. (r)-(-)-epinephrine

    146. L-methylaminoethanolcatechol

    147. D-adrenaline

    148. Sus-phrine Sulfite-free

    149. Lyodrin

    150. Symjepi

    151. (r)-(-)-adnephrine

    152. L-epinehphrine

    153. (r)-(-)-epirenamine

    154. L-1-(3,4-dihydroxyphenyl)-2-methylaminoethanol

    155. 4-[(1r)-1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

    156. (-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzyl Alcohol

    157. Rcra Waste No. P042

    158. 1,2-benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (r)-

    159. Adrenalin (tn)

    160. Micronefrin

    161. Epitrate

    162. Levo-methylaminoethanolcatechol

    163. (-)-r-epinephrine

    164. Racepinefrine, (r)-

    165. Ai3-19015

    166. Adrenalin Chloride

    167. Sus-phrine Sulphite-free

    168. Lopac-e-4642

    169. 1,2-benzenediol, 4-[(1r)-1-hydroxy-2-(methylamino)ethyl]-

    170. 1-1-(3,4-dihydroxyphenyl)-2-methylaminoethanol

    171. Chembl679

    172. Ykh834o4bh

    173. Adrenan

    174. Adrine

    175. D-epinephrine

    176. (r)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

    177. D-epifrin

    178. Chebi:28918

    179. Benzyl Alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (-)-

    180. Asthmanefrin

    181. Nsc-62786

    182. 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

    183. Ncgc00015417-01

    184. Ncgc00142615-03

    185. Ncgc00142615-08

    186. Adrenalina

    187. 1,2-benzenediol, 4-((1r)-1-hydroxy-2-(methylamino)ethyl)-

    188. 1,2-benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (theta)-

    189. Dsstox_cid_2986

    190. Adrenaline (l-adrenaline)

    191. Dsstox_rid_76819

    192. Dsstox_gsid_22986

    193. Rac Epinephrine

    194. (-)-3,4-dihydroxy-a-[2-(methylamino)ethyl]benzyl Alcohol

    195. Adrenaclick

    196. Exadri

    197. 1,2-benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, (r)-

    198. Epipen E Z Pen

    199. L-epinephine

    200. Asthmahaler Mist

    201. Epi E Z Pen Jr

    202. Ana-guard

    203. Ana-kit

    204. Cas-51-43-4

    205. Epipen Ez Pen

    206. L-adrenaline Base

    207. (-)-adrenalin

    208. Twinject 0.3

    209. Epi Ez Pen Jr

    210. Adrop

    211. Epinephrine [usan:inn:jan]

    212. Epipen Auto-injector

    213. Ccris 4812

    214. Twinject 0.15

    215. Auvi-q Auto-injector

    216. Epipen Jr

    217. Hsdb 4289

    218. Bronkaid Suspension Mist

    219. Einecs 200-098-7

    220. Nsc 62786

    221. Epipen Jr. Auto-injector

    222. Unii-ykh834o4bh

    223. (r)-4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol

    224. Epinephrin

    225. Levoreninum

    226. Anapen

    227. Nsc62786

    228. 4-((1r)-1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

    229. Bupivacaine Hcl And Epinephrine

    230. Benzyl Alcohol, 3,4-dihydroxy-.alpha.-[(methylamino)methyl]-, (-)-

    231. Benzyl Alcohol, 3,4-dihydroxy-.alpha.-((methylamino)methyl)-, (-)-

    232. Epinephrine [usp:inn:ban:jan]

    233. Ale

    234. Iop

    235. Epinephrine (usp)

    236. Epipen (tn)

    237. Nchembio747-comp9

    238. Twinject 0.30

    239. Adrenaline/epinephrine

    240. Adrenaline (jp15)

    241. Adrenaline (jp17)

    242. Epitrate (salt/mix)

    243. Auvi-q (tn)

    244. Adrenaline [jan]

    245. Epinephrine (usp/inn)

    246. Epinephrine [mi]

    247. Epinephrine [inn]

    248. Adrenalinum [hpus]

    249. Epinephrine [hsdb]

    250. Bmse000316

    251. 4-[1-hydroxy-2-(methylamino)ethyl]-1,2-benzenediol #

    252. Adrenaline [mart.]

    253. Citanest Forte (salt/mix)

    254. L-adrenaline (epinephrine)

    255. Schembl3814

    256. 3,4-dihydroxy-.alpha.-((methylamino)methyl)benzyl Alcohol

    257. Epinephrine [usp-rs]

    258. Epinephrine [who-dd]

    259. Epinephrine [who-ip]

    260. Gtpl479

    261. Bidd:gt0119

    262. E4250_sigma

    263. Adrenaline [ep Impurity]

    264. Dtxsid5022986

    265. Bdbm44818

    266. Cid_6852374

    267. Hy-b0447b

    268. Zinc39089

    269. Adrenaline [ep Monograph]

    270. Component Of E-pilo (salt/mix)

    271. Epinephrine [orange Book]

    272. Hms3884h06

    273. Epinephrine [usp Monograph]

    274. 104655-05-2

    275. Bcp09042

    276. Epinephrinum [who-ip Latin]

    277. Tox21_111562

    278. Bdbm50029050

    279. Hsci1_000215

    280. Pdsp1_001120

    281. Pdsp2_001104

    282. S2522

    283. 51-43-4 (free Base)

    284. Octocaine Component Epinephrine

    285. Akos024283500

    286. Iontocaine Component Epinephrine

    287. Tox21_111562_1

    288. Ccg-204593

    289. D29a657

    290. Db00668

    291. Sdccgsbi-0050486.p002

    292. Smp1_000227

    293. (-)-epinephrine, >=97.0% (nt)

    294. Epinephrine Component Of Octocaine

    295. Ncgc00142615-01

    296. Ncgc00142615-04

    297. Ncgc00142615-05

    298. Ncgc00142615-06

    299. Ncgc00142615-07

    300. Ncgc00142615-09

    301. Ncgc00142615-18

    302. Ac-13188

    303. Ac-31211

    304. As-13813

    305. Epinephrine Component Of Iontocaine

    306. 4,5-beta-trihydroxy-n-methylphenethylamine

    307. A0173

    308. Sw219274-1

    309. (-)-epinephrine;l-adrenaline;(-)-adrenalin

    310. C00788

    311. D00095

    312. D88222

    313. Ab00573227-11

    314. Ab00573227-12

    315. Ab00573227-13

    316. Ab00573227_14

    317. Ab00573227_15

    318. Q132621

    319. 4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol

    320. Q-200601

    321. Sr-01000075267-8

    322. Noradrenaline Tartrate Impurity A [ep Impurity]

    323. 4-[(1r)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol

    324. Lidosite Topical System Kit Component Epinephrine

    325. Z2686405805

    326. (-)-3,4-dihydroxy-a-[(methylamino)methyl]-benzyl Alcohol

    327. Adrenaline, European Pharmacopoeia (ep) Reference Standard

    328. Epinephrine Component Of Lidosite Topical System Kit

    329. (-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-benzyl Alcohol

    330. (-)-3,4-dihydroxy-alpha-[2-(methylamino)ethyl]benzyl Alcohol

    331. 4-[(1r)-1-hydroxy-2-(methylamino)ethyl]pyrocatechol;tartaric Acid

    332. (-)-3,4-dihydroxy-.alpha.-((methylamino)methyl)benzyl Alcohol

    333. Adrenaline With Impurity F, European Pharmacopoeia (ep) Reference Standard

    334. 2,3-dihydroxybutanedioic Acid;4-[(1r)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

    335. 2,3-bis(oxidanyl)butanedioic Acid;4-[(1r)-2-(methylamino)-1-oxidanyl-ethyl]benzene-1,2-diol

    2.3 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 183.20 g/mol
    Molecular Formula C9H13NO3
    XLogP3-1.4
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass183.08954328 g/mol
    Monoisotopic Mass183.08954328 g/mol
    Topological Polar Surface Area72.7 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity154
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 16  
    Drug NameAdrenalin
    PubMed HealthEpinephrine (Into the nose)
    Drug ClassesDecongestant
    Drug LabelAdrenalin (epinephrine injection, USP) is a clear, colorless, sterile solution containing 1 mg/mL (1:1000) epinephrine, packaged as 1 mL of solution in a single-use clear glass vial or 30 mL of solution in a multiple-dose amber glass vial. In the 1...
    Active IngredientEpinephrine hydrochloride
    Dosage FormInjectable
    RouteIntramuscular, intraocular, subcutaneous; Intramuscular, subcutaneous
    Strengtheq 1mg base/ml (eq 1mg base/ml); eq 30mg base/30ml (eq 1mg base/ml)
    Market StatusPrescription
    CompanyPar Sterile Products

    2 of 16  
    Drug NameAuvi-q
    PubMed HealthEpinephrine (Injection)
    Drug ClassesAnaphylaxis Agent, Anesthetic Adjunct, Bronchodilator, Vasopressor
    Drug LabelAuviQ (epinephrine injection, USP) 0.3 mg and 0.15 mg is an auto-injector and a combination product containing drug and device components.AuviQ includes audible (electronic voice instructions, beeps) and visible (LED lights) cues for use.Ea...
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strengtheq 0.15mg/delivery; eq 0.3mg/delivery
    Market StatusPrescription
    CompanySanofi Aventis Us

    3 of 16  
    Drug NameEpinephrine
    PubMed HealthEpinephrine
    Drug ClassesAnaphylaxis Agent, Anesthetic Adjunct, Antiglaucoma, Bronchodilator, Decongestant, Vasopressor
    Drug LabelEach EpiPen Auto-Injector delivers a single dose of 0.3 mg epinephrine injection, USP, 1:1000 (0.3 mL) in a sterile solution. Each EpiPen Jr Auto-Injector delivers a single dose of 0.15 mg epinephrine injection, USP, 1:2000 (0.3 mL) in a sterile...
    Active IngredientEpinephrine hydrochloride
    Dosage FormSolution
    RouteIv (infusion)
    Strengtheq 1mg base/ml (eq 1mg base/ml)
    Market StatusPrescription
    CompanyBelcher Pharms

    4 of 16  
    Drug NameEpipen
    PubMed HealthEpinephrine
    Drug ClassesAnaphylaxis Agent, Anesthetic Adjunct, Antiglaucoma, Bronchodilator, Decongestant, Vasopressor
    Drug LabelEach EpiPen Auto-Injector delivers a single dose of 0.3 mg epinephrine injection, USP, 1:1000 (0.3 mL) in a sterile solution. Each EpiPen Jr Auto-Injector delivers a single dose of 0.15 mg epinephrine injection, USP, 1:2000 (0.3 mL) in a sterile...
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strength0.3mg/delivery
    Market StatusPrescription
    CompanyMylan Speclt

    5 of 16  
    Drug NameEpipen jr.
    Drug LabelEpiPen (epinephrine injection, USP) 0.3 mg and EpiPen Jr (epinephrine injection, USP) 0.15 mg are auto-injectors and combination products containing drug and device components.Each EpiPen Auto-Injector, 0.3 mg delivers a single dose of 0.3 mg epineph...
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strength0.15mg/delivery
    Market StatusPrescription
    CompanyMylan Speclt

    6 of 16  
    Drug NameSeptocaine
    Active IngredientArticaine hydrochloride; epinephrine bitartrate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 0.0085mg base/1.7ml (4%; eq 0.01mg base/ml); eq 0.017mg base/1.7ml (4%; 4%; eq 0.005mg base/ml)
    Market StatusPrescription
    CompanyDeproco

    7 of 16  
    Drug NameTwinject 0.15
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strengtheq 0.15mg/delivery
    Market StatusPrescription
    CompanyAmedra Pharms

    8 of 16  
    Drug NameTwinject 0.3
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strengtheq 0.3mg/delivery
    Market StatusPrescription
    CompanyAmedra Pharms

    9 of 16  
    Drug NameAuvi-q
    PubMed HealthEpinephrine (Injection)
    Drug ClassesAnaphylaxis Agent, Anesthetic Adjunct, Bronchodilator, Vasopressor
    Drug LabelAuviQ (epinephrine injection, USP) 0.3 mg and 0.15 mg is an auto-injector and a combination product containing drug and device components.AuviQ includes audible (electronic voice instructions, beeps) and visible (LED lights) cues for use.Ea...
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strengtheq 0.15mg/delivery; eq 0.3mg/delivery
    Market StatusPrescription
    CompanySanofi Aventis Us

    10 of 16  
    Drug NameEpinephrine
    PubMed HealthEpinephrine
    Drug ClassesAnaphylaxis Agent, Anesthetic Adjunct, Antiglaucoma, Bronchodilator, Decongestant, Vasopressor
    Drug LabelEach EpiPen Auto-Injector delivers a single dose of 0.3 mg epinephrine injection, USP, 1:1000 (0.3 mL) in a sterile solution. Each EpiPen Jr Auto-Injector delivers a single dose of 0.15 mg epinephrine injection, USP, 1:2000 (0.3 mL) in a sterile...
    Active IngredientEpinephrine hydrochloride
    Dosage FormSolution
    RouteIv (infusion)
    Strengtheq 1mg base/ml (eq 1mg base/ml)
    Market StatusPrescription
    CompanyBelcher Pharms

    11 of 16  
    Drug NameEpipen
    PubMed HealthEpinephrine
    Drug ClassesAnaphylaxis Agent, Anesthetic Adjunct, Antiglaucoma, Bronchodilator, Decongestant, Vasopressor
    Drug LabelEach EpiPen Auto-Injector delivers a single dose of 0.3 mg epinephrine injection, USP, 1:1000 (0.3 mL) in a sterile solution. Each EpiPen Jr Auto-Injector delivers a single dose of 0.15 mg epinephrine injection, USP, 1:2000 (0.3 mL) in a sterile...
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strength0.3mg/delivery
    Market StatusPrescription
    CompanyMylan Speclt

    12 of 16  
    Drug NameEpipen jr.
    Drug LabelEpiPen (epinephrine injection, USP) 0.3 mg and EpiPen Jr (epinephrine injection, USP) 0.15 mg are auto-injectors and combination products containing drug and device components.Each EpiPen Auto-Injector, 0.3 mg delivers a single dose of 0.3 mg epineph...
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strength0.15mg/delivery
    Market StatusPrescription
    CompanyMylan Speclt

    13 of 16  
    Drug NameSeptocaine
    Active IngredientArticaine hydrochloride; epinephrine bitartrate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 0.0085mg base/1.7ml (4%; eq 0.01mg base/ml); eq 0.017mg base/1.7ml (4%; 4%; eq 0.005mg base/ml)
    Market StatusPrescription
    CompanyDeproco

    14 of 16  
    Drug NameTwinject 0.15
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strengtheq 0.15mg/delivery
    Market StatusPrescription
    CompanyAmedra Pharms

    15 of 16  
    Drug NameTwinject 0.3
    Active IngredientEpinephrine
    Dosage FormInjectable
    RouteIntramuscular, subcutaneous
    Strengtheq 0.3mg/delivery
    Market StatusPrescription
    CompanyAmedra Pharms

    16 of 16  
    Drug NameAdrenalin
    PubMed HealthEpinephrine (Into the nose)
    Drug ClassesDecongestant
    Drug LabelAdrenalin (epinephrine injection, USP) is a clear, colorless, sterile solution containing 1 mg/mL (1:1000) epinephrine, packaged as 1 mL of solution in a single-use clear glass vial or 30 mL of solution in a multiple-dose amber glass vial. In the 1...
    Active IngredientEpinephrine hydrochloride
    Dosage FormInjectable
    RouteIntramuscular, intraocular, subcutaneous; Intramuscular, subcutaneous
    Strengtheq 1mg base/ml (eq 1mg base/ml); eq 30mg base/30ml (eq 1mg base/ml)
    Market StatusPrescription
    CompanyPar Sterile Products

    4.2 Therapeutic Uses

    Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic Agonists; Bronchodilator Agents; Mydriatics; Sympathomimetics; Vasoconstrictor Agents

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Epinephrine is the drug of choice in the emergency treatment of severe acute anaphylactic reactions including anaphylactic shock. Symptoms such as urticaria, pruritus, angioedema, and swelling of the lips, eyelids, and tongue which may result from reactions to drugs, sera, insect stings, food, or other allergens may be relieved by epinephrine. Epinephrine should be given to all patients with signs of systemic reactions, particularly hypotension, airway swelling, or definite breathing difficulty. Circulatory support during anaphylactic shock requires rapid volume resuscitation and vasopressor therapy to support blood pressure; epinephrine is the drug of choice for the treatment of both vasodilation/hypotension and cardiac arrest associated with anaphylaxis. /Included in US product label/

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 1389

    Epinephrine may be added to solutions of some local anesthetics to decrease the rate of vascular absorption of the anesthetic, thereby localizing anesthesia and prolonging the duration of anesthesia; the risk of systemic toxicity from the local anesthetic is also decreased. Epinephrine may be applied topically to control superficial bleeding from arterioles or capillaries in the skin, mucous membranes, or other tissues. Bleeding from larger vessels is not controllable by topical application of epinephrine. /Included in US product label/

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 1390

    Epinephrine is used for its a-adrenergic stimulatory effects to increase blood flow in advanced cardiovascular life support (ACLS) during cardiopulmonary resuscitation (CPR). The principal beneficial effects of the drug in patients with cardiac arrest result from increases in aortic diastolic blood pressure and in myocardial and cerebral blood flow during resuscitation. The value and safety of the beta-adrenergic effects of epinephrine are controversial because they may increase myocardial work and reduce subendocardial perfusion. Epinephrine remains a drug of choice and a high priority for ACLS in cardiac arrest to facilitate return of spontaneous circulation. /Included in US product label/

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 1389

    For more Therapeutic Uses (Complete) data for EPINEPHRINE (15 total), please visit the HSDB record page.

    4.3 Drug Warning

    Epinephrine should not be used in cardiogenic shock because it increases myocardial oxygen demand, nor should it be used in hemorrhagic or traumatic shock.

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 1389

    Vet: epinephrine injection (1:1000): do not use in acute hypotension produced by phenothiazine derived tranquilizers, since further depression of blood pressure can occur. Do not use when cyclopropane or halogenated anesthetics are used because of possible cardiac collapse. Do not use in treatment of vascular shock. Do not use in patients known to be sensitive to epinephrine ... Use with caution in hyperthyroid animals; animals being treated with thyroid, digitalis, or mercurial diuretics. Do not use injection if it is brown or contains a precipitate.

    Aronson, C.E. (ed.). Veterinary Pharmaceuticals & Biologicals, 1980-1981. Media, Pa.: Harwal Publishing Co., 1980., p. 16-48

    A prospective study where topical epinephrine was used on burn and non-burn patients and five patients served as controls without epinephrine usage. Catecholamine concentrations were measured and to estimate the systemic effects of epinephrine, serum lactate and pyruvate concentrations were analyzed and perioperative haemodynamic changes recorded. Compared to the baseline values, there was a significant increase in the heart rate, serum epinephrine and lactate concentrations and LP-ratios in the burn patients and an increase in the epinephrine concentrations in the non-burn patients at 1 and 2 h. Epinephrine and lactate concentrations and LP-ratios were also higher in the burn patients compared to the other groups. Altogether, there were no changes in the control group. This study showed that the use of topical epinephrine has systemic effects on hemodynamics and serum epinephrine concentrations. Increased epinephrine concentrations in burn patients suggest increased absorption properties in these patients. The increased lactate concentrations and LP-ratios suggest tissue ischaemia, likely in skin.

    PMID:19481869 Papp AA et al; Burns 35 (6): 832-9 (2009).

    Some manufacturers state that epinephrine is contraindicated for parenteral use during the second stage of labor; parenteral administration of the drug to maintain blood pressure during spinal anesthesia for delivery can cause acceleration of fetal heart rate and should not be used in obstetric patients when maternal systolic/diastolic blood pressure exceeds 130/80 mm Hg. Epinephrine should be administered cautiously by oral inhalation to pregnant patients. Epinephrine should be used during pregnancy only if the potential benefits justify the possible risks to the fetus. There is some evidence that epidural administration of lidocaine with epinephrine during labor is safe.

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 1393

    For more Drug Warnings (Complete) data for EPINEPHRINE (21 total), please visit the HSDB record page.

    4.4 Minimum/Potential Fatal Human Dose

    The minimum lethal human dose by subcutaneous injection is estimated as 4 mg.

    Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 548

    4.5 Drug Indication

    Epinephrine injection is indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which include bees, wasps, hornets, yellow jackets and fire ants) and biting insects (e.g., triatoma, mosquitos), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media) and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. Injectable epinephrine is intended for immediate/urgent administration in patients, who are found to be at increased risk for anaphylaxis, including individuals with a history of anaphylaxis. Selection of the appropriate dosage strength is determined according to body weight. Epinephrine's cardiac effects may be of use in restoring cardiac rhythm in cardiac arrest due to various causes but is not used in cardiac failure or in hemorrhagic, traumatic, or cardiogenic shock. Epinephrine is used as a hemostatic agent. It is also used in treating mucosal congestion of hay fever, rhinitis, and acute sinusitis; to relieve bronchial asthmatic paroxysms; in syncope due to complete heart block or carotid sinus hypersensitivity; for symptomatic relief of serum sickness, urticaria, angioneurotic edema; for resuscitation in cardiac arrest following anesthetic accidents; in simple (open angle) glaucoma; for relaxation of uterine musculature and to inhibit uterine contractions. Epinephrine injection can be utilized to prolong the action of local anesthetics. In addition to the above, epinephrine is used as an over the counter (OTC) agent for the intermittent symptoms of asthma, such as wheezing, tightness of chest and shortness of breath. It is also used for the maintenance of mydriasis during intraocular surgery.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Epinephrine is a sympathomimetic drug. It causes an adrenergic receptive mechanism on effector cells and mimics all actions of the sympathetic nervous system except those on the facial arteries and sweat glands. Important effects of epinephrine include increased heart rate, myocardial contractility, and renin release via beta-1 receptors. Beta-2 effects produce bronchodilation which may be useful as an adjunct treatment of asthma exacerbations as well as vasodilation, tocolysis, and increased aqueous humor production. In croup, nebulized epinephrine is associated with both clinically and statistically significant transient reduction of croup symptoms 30 minutes post-treatment. Epinephrine also alleviates pruritus, urticaria, and angioedema and may be helpful in relieving gastrointestinal and genitourinary symptoms associated with anaphylaxis because of its relaxing effects on the smooth muscle of the stomach, intestine, uterus, and urinary bladder.

    5.2 MeSH Pharmacological Classification

    Adrenergic alpha-Agonists

    Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    Adrenergic beta-Agonists

    Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    Mydriatics

    Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    EPINEPHRINE
    5.3.2 FDA UNII
    YKH834O4BH
    5.3.3 Pharmacological Classes
    Adrenergic beta-Agonists [MoA]; Catecholamine [EPC]; Catecholamines [CS]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]
    5.4 ATC Code

    C01CA24

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    A - Alimentary tract and metabolism

    A01 - Stomatological preparations

    A01A - Stomatological preparations

    A01AD - Other agents for local oral treatment

    A01AD01 - Epinephrine

    B - Blood and blood forming organs

    B02 - Antihemorrhagics

    B02B - Vitamin k and other hemostatics

    B02BC - Local hemostatics

    B02BC09 - Epinephrine

    C - Cardiovascular system

    C01 - Cardiac therapy

    C01C - Cardiac stimulants excl. cardiac glycosides

    C01CA - Adrenergic and dopaminergic agents

    C01CA24 - Epinephrine

    R - Respiratory system

    R01 - Nasal preparations

    R01A - Decongestants and other nasal preparations for topical use

    R01AA - Sympathomimetics, plain

    R01AA14 - Epinephrine

    R - Respiratory system

    R03 - Drugs for obstructive airway diseases

    R03A - Adrenergics, inhalants

    R03AA - Alpha- and beta-adrenoreceptor agonists

    R03AA01 - Epinephrine

    S - Sensory organs

    S01 - Ophthalmologicals

    S01E - Antiglaucoma preparations and miotics

    S01EA - Sympathomimetics in glaucoma therapy

    S01EA01 - Epinephrine

    5.5 Absorption, Distribution and Excretion

    Absorption

    Following I.V. (intravenous) injection, epinephrine disappears rapidly from the blood stream. Subcutaneously or I.M. (intramuscular) administered epinephrine has a rapid onset and short duration of action. Subcutaneous (SC) administration during asthmatic attacks may produce bronchodilation within 5 to 10 minutes, and maximal effects may occur within 20 minutes. The drug becomes fixed in the tissues rapidly,.

    Route of Elimination

    The majority of the dose of epinephrine is seen excreted in the urine,. About 40% of a parenteral dose of epinephrine is excreted in urine as metanephrine, 40% as VMA, 7% as 3-methoxy-4-hydroxyphenoglycol, 2% as 3,4-dihydroxymandelic acid, and the rest as acetylated derivatives. These metabolites are excreted mainly as the sulfate conjugates and, to a lesser extent, the glucuronide conjugates. Only small amounts of the drug are excreted completely unchanged.

    Clearance

    Intravenous injection produces an immediate and intensified response. Following intravenous injection, epinephrine disappears rapidly from the blood stream.

    Following topical application of radiolabeled epinephrine to the eye in rabbits, highest concentrations of the drug in tissues and fluids other than the eye occurred in the pituitary gland, with lower concentrations in the intestine, fat, adrenal gland, kidney, heart, lung, spleen, ovary, pancreas, liver, uterus, muscle, brain, and serum. In humans, systemically absorbed epinephrine crosses the placenta but not the blood-brain barrier. Systemically absorbed epinephrine distributes into milk.

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 2926

    Epinephrine is not effective after oral admin because it is rapidly conjugated and oxidized in GI mucosa and liver. Absorption from sc tissues occurs slowly because of local vasoconstriction ... Absorption is more rapid after im than after sc injection ... Epinephrine is rapidly inactivated in the body.

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 247

    In a prospective, randomized, five-way crossover study in rabbits, ... plasma epinephrine concentrations /were measured/ before, and at intervals up to 180 min after epinephrine administration by intramuscular or subcutaneous injection, or by inhalation, with intravenous epinephrine and intramuscular saline as the positive and negative controls, respectively. Maximum plasma epinephrine concentrations were higher, and occurred more rapidly, after intramuscular injection than after subcutaneous injection or inhalation, and were 7719+/-3943 (S.E.M.) pg/mL at 32.5+/-6.6 min, 2692+/-863 pg/mL at 111.7+/-30.8 min and 1196+/-369 pg/mL at 45. 8+/-19.2 min, respectively. Intravenous injection of epinephrine resulted in a plasma concentration of 3544+/-422 pg/mL at 5 min, and an elimination half-life (t(1/2)) of 11.0+/-2.5 min. In the saline control study, the endogenous epinephrine concentration peaked at 518+/-142 pg/mL. CONCLUSION: In this model, absorption of epinephrine was significantly faster after intramuscular injection than after subcutaneous injection or inhalation. The extent of absorption was satisfactory after both intramuscular and subcutaneous injections. Neither the rate nor the extent of absorption was satisfactory after administration by inhalation.

    PMID:10870098 Gu X et al; Biopharm Drug Dispos 20 (8): 401-5 (1999).

    3 groups of 5 greyhounds received 1.5 ug/kg epinephrine 1:200,000 in either lidocaine 0.5%, bupivacaine 0.5% or 0.9% saline. Dogs were anesthetized and 40% of the allocated epinephrine solution was infiltrated beneath the perianal skin and each of the 4 quadrants of the rectal mucosa was injected with the remainder of the solution. Plasma epinephrine, lidocaine, bupivacaine, lactate, glucose and potassium concn were measured at 1, 2, 5, 10 and 30 min following infiltration. Peak plasma epinephrine concn were recorded 2 min following rectal mucosal infiltration in all 3 groups. Plasma epinephrine concn were significantly higher (p < 0.01) in the lidocaine group at 1 and 2 min following infiltration. Both plasma bupivacaine and lidocaine peaked 10 min after infiltration and thereafter tended to decr towards baseline concn. Plasma bupivacaine concn were significantly higher (p < 0.01) than plasma lidocaine concn throughout the study period. There were no significant differences in metabolic or biochemical indices within or between the 3 groups. However, both plasma glucose and lactate concn were elevated and peaked 10 min after infiltration, while plasma potassium concn remained unchanged throughout the study period. Heart rate in the bupivacaine group was significantly reduced at 30 min following infiltration (p < 0.05). There were no significant differences observed in the mean arterial and pulse pressures among the 3 groups.

    PMID:2758538 Flynn N et al; Can J Anaesth 36 (4): 397-401 (1989)

    Epinephrine is well absorbed after subcutaneous or IM injection; absorption can be hastened by massaging the injection site. Both rapid and prolonged absorption occur after subcutaneous injection of the longer-acting aqueous suspension (no longer commercially available in the US). Epinephrine also is absorbed following endotracheal administration, although serum concentrations achieved may be only 10% of those with an equivalent IV dose.. After oral inhalation of epinephrine in the usual dosage, absorption is slight and the effects of the drug are restricted mainly to the respiratory tract. Absorption increases somewhat when larger doses are inhaled, and systemic effects may occur.

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 1394

    5.6 Metabolism/Metabolites

    Epinephrine is rapidly inactivated mainly by enzymic transformation to metanephrine or normetanephrine, either of which is then conjugated and excreted in the urine in the form of both sulfates and glucuronides. Either sequence results in the formation of 3-methoxy-4- hydroxy-mandelic acid(vanillylmandelic acid, VMA) which is shown to be detectable in the urine. Epinephrine is rapidly inactivated in the body mostly by the enzymes COMT (catechol-O-methyltransferase) and MAO (monoamine oxidase). The liver is abundant in the above enzymes, and is a primary, although not essential, tissue in the degradation process.

    The pharmacologic actions of epinephrine are terminated mainly by uptake and metabolism in sympathetic nerve endings. Circulating drug is metabolized in the liver and other tissues by a combination of reactions involving the enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). The major metabolites are metanephrine and 3-methoxy-4-hydroxymandelic acid (vanillylmandelic acid, VMA) both of which are inactive. About 40% of a parenteral dose of epinephrine is excreted in urine as metanephrine, 40% as VMA, 7% as 3-methoxy-4-hydroxyphenoglycol, 2% as 3,4-dihydroxymandelic acid, and the remainder as acetylated derivatives. These metabolites are excreted mostly as the sulfate conjugates and, to a lesser extent, the glucuronide conjugates. Only small amounts of the drug are excreted unchanged.

    American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 1394

    Circulating epinephrine is metabolized in the liver and is taken up into adrenergic neurons and metabolized by MAO and catechol-O-methyltransferase to metadrenaline, sulfate conjugates, and hydroxy derivatives of mandelic acid.

    Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 548

    Epinephrine has known human metabolites that include Epinephrine sulfate.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.7 Biological Half-Life

    The plasma half-life is approximately 2-3 minutes. However, when administered by subcutaneous or intramuscular injection, local vasoconstriction may delay absorption so that epinephrine's effects may last longer than the half-life suggests.

    Elimination half life is 1 minute.

    Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 548

    5.8 Mechanism of Action

    Epinephrine acts on alpha and beta-adrenergic receptors. Epinephrine acts on alpha and beta receptors and is the strongest alpha receptor activator. Through its action on alpha-adrenergic receptors, epinephrine minimizes the vasodilation and increased the vascular permeability that occurs during anaphylaxis, which can cause the loss of intravascular fluid volume as well as hypotension. Epinephrine relaxes the smooth muscle of the bronchi and iris and is a histamine antagonist, rendering it useful in treating the manifestations of allergic reactions and associated conditions. This drug also produces an increase in blood sugar and increases glycogenolysis in the liver. Through its action on beta-adrenergic receptors, epinephrine leads to bronchial smooth muscle relaxation that helps to relieve bronchospasm, wheezing, and dyspnea that may occur during anaphylaxis.

    The mechanism of rise in blood pressure ... is threefold: a direct myocardial stimulation that increases the strength of ventricular contraction (positive inotropic action), an increased heart rate (positive chronotropic action), vasoconstriction in many vascular beds, especially in precapillary resistance vessels of skin, mucosa, and kidney, along with marked constriction of veins.

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 243

    ... Epinephrine affects respiration primarily by relaxing bronchial muscle. It has a powerful bronchodilator action, most evident when bronchial muscle is contracted because of disease, as in bronchial asthma, or in response to drugs or various autacoids. In such situations, epinephrine has a striking therapeutic effect as a physiological antagonist to substances that cause bronchoconstriction. The beneficial effects of epinephrine in asthma also may arise from inhibition of antigen-induced release of inflammatory mediators from mast cells, and to a lesser extent from diminution of bronchial secretions and congestion within the mucosa. Inhibition of mast cell secretion is mediated by beta2 receptors, while the effects on the mucosa are mediated by alpha receptors

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 11th ed. New York, NY: McGraw-Hill, 2006., p. 246

    The electrophysiologic effects of circulating epinephrine in humans were examined in four study groups of 10 subjects each. In 10 subjects without structural heart disease (Group 1) and in 10 patients with coronary disease or dilated cardiomyopathy (Group 2) epinephrine infusion at 25 and 50 ng/kg body weight per min for 14 min resulted in an elevation of the plasma epinephrine concentration in the physiologic range. In both groups it produced a dose-dependent decrease in the effective refractory period of the atrium, atrioventricular node and ventricle and improvement in atrioventricular node conduction. Epinephrine facilitated the induction of sustained ventricular tachycardia in 3 of the 20 subjects. In Group 3, a beta-adrenergic blocking dose of propranolol was added to the infusion of 50 ng/kg per min of epinephrine. Propranolol not only reversed the effects of epinephrine, but also lengthened these variables compared with baseline values. In group 4, propranolol was administered first, followed by 50 ng/kg per min of epinephrine. Propranolol alone slowed atrioventricular node conduction and mildly prolonged the refractory periods. In the presence of beta-blockade, epinephrine had no effect on atrioventricular node properties but resulted in a lengthening of the atrial and ventricular effective refractory periods. In conclusion, epinephrine in physioloic doses shortens the effective refractory period of the atrium, atrioventricular node and ventricle, improves atrioventricular node conduction and may facilitate the induction of sustained ventricular tachycardia. The overall electrophysiologic effects of epinephrine result from stimulation of beta-receptors. Stimulation of alpha-receptors by epinephrine has no effect on the atrioventricular node but prolongs the effective refractory period of the atrium and ventricle, partially offsetting the shortening of refractory periods mediated by beta-receptor stimulation.

    PMID:2835408 Morady F et al; J Am Coll Cardiol 11 (6): 1235-44 (1988)

    Epinephrine plays a key role in the control of vasomotor tone; however, the participation of the NO/cGMP pathway in response to beta-adrenoceptor activation remains controversial. To evaluate the involvement of the endothelium in the vascular response to epinephrine, we assessed NO production, endothelial NO synthase phosphorylation, and tissue accumulation of cGMP in the perfused arterial mesenteric bed of rat. Epinephrine elicited a concentration-dependent increase in NO (EC(50) of 45.7 pM), which was coupled to cGMP tissue accumulation. Both NO and cGMP production were blocked by either endothelium removal (saponin) or NO synthase inhibition (N(omega)-nitro-L-arginine). Blockade of beta(1)- and beta(2)-adrenoceptors with 1 microM propranolol or beta(3)-adrenoceptor with 10 nM SR 59230A displaced rightward the concentration-NO production curve evoked by epinephrine. Selective stimulation of beta(1)-, beta(2)-, or beta(3)-adrenoceptors also resulted in NO and cGMP production. Propranolol (1 microM) inhibited the rise in NO induced by isoproterenol or the beta(2)-adrenoceptor agonists salbutamol, terbutaline, or fenoterol. Likewise, 10 nM SR 59230A reduced the effects of the beta(3)-adrenoceptor agonists BRL 37344, CGP 12177, SR 595611A, or pindolol. The NO production induced by epinephrine and BRL 37344 was associated with the activation of the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of eNOS in serine 1177. In addition, in anaesthetized rats, bolus administration of isoproterenol, salbutamol, or BRL 37344 produced NO-dependent reductions in systolic blood pressure. These findings indicate that beta(1)-, beta(2)-, and beta(3)-adrenoceptors are coupled to the NO/cGMP pathway, highlighting the role of the endothelium in the vasomotor action elicited by epinephrine and related beta-adrenoceptor agonists.

    PMID:19429833 Figueroa XF et al; Am J Physiol Heart Circ Physiol 297 (1): H134-43 (2009)

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E-2675 BATCH# 5241-013A2 (QTY 25 GRMS)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"VIATRIS","supplierCountry":"CANADA","foreign_port":"TORONTO","customer":"VIATRIS","customerCountry":"INDIA","quantity":"0.03","actualQuantity":"25","unit":"GMS","unitRateFc":"118","totalValueFC":"2225.5","currency":"CAD","unitRateINR":"7398.6","date":"30-Jan-2024","totalValueINR":"184965","totalValueInUsd":"2225.5","indian_port":"Bangalore Air","hs_no":"29379090","bill_no":"9895545","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"TORONTO","supplierAddress":"85 Advance Road, Etobicoke Ontario,Canada, M8Z 2S6SDNF Canada","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1712169000,"product":"EPINEPHRINE","address":"MUMBAI CENTRAL,","city":"MUMBAI, MAHARASHTRA.","supplier":"TRANSO-PHARM HANDELS GMBH","supplierCountry":"GERMANY","foreign_port":"HAMBURG - FUHLSBUETT","customer":"CIPLA","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"100","unit":"GMS","unitRateFc":"34","totalValueFC":"3766.1","currency":"EUR","unitRateINR":"3145","date":"04-Apr-2024","totalValueINR":"314500","totalValueInUsd":"3766.1","indian_port":"Bombay Air","hs_no":"29379019","bill_no":"2868112","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"HAMBURG - FUHLSBUETT","supplierAddress":"BUELTBEK 522962 SIEKSDNF GERMANY","customerAddress":"MUMBAI CENTRAL,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1712169000,"product":"EPINEPHRINE","address":"MUMBAI CENTRAL,","city":"MUMBAI, MAHARASHTRA.","supplier":"TRANSO-PHARM HANDELS GMBH","supplierCountry":"GERMANY","foreign_port":"HAMBURG","customer":"CIPLA","customerCountry":"INDIA","quantity":"1.96","actualQuantity":"1960","unit":"GMS","unitRateFc":"37.4","totalValueFC":"73816.3","currency":"USD","unitRateINR":"3145","date":"04-Apr-2024","totalValueINR":"6164200","totalValueInUsd":"73816.3","indian_port":"Indore-EPZ\/SEZ","hs_no":"29379019","bill_no":"1002309","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"HAMBURG","supplierAddress":"N\/A","customerAddress":"MUMBAI CENTRAL,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1712514600,"product":"EPINEPHRINE BASE UN 2811 TOXIC SOLID, ORGANIC, N.O.S. (EPINEPHRINE BASE) 6.1, II","address":"159, C.S.T. ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"CAMBREX CORPORATION","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"24012.2","totalValueFC":"24254.5","currency":"USD","unitRateINR":"2025432","date":"08-Apr-2024","totalValueINR":"2025432","totalValueInUsd":"24254.5","indian_port":"M\/s MAHARASHTRA AIRPORT DEVELOPMENTCOMPANYLIMITED","hs_no":"29379090","bill_no":"1000685","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"159, C.S.T. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719426600,"product":"NOREPINEPHRINE BITARTRATE\/NORADRENALINE TARTRATE UN 2811 TOXIC SOLID ,ORGANIC, N.O.S.-BATCH # 0840104","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"CAMBREX CORPORATION","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"VIATRIS","customerCountry":"INDIA","quantity":"6.46","actualQuantity":"6.46","unit":"KGS","unitRateFc":"22000","totalValueFC":"148193.5","currency":"USD","unitRateINR":"1915032.7","date":"27-Jun-2024","totalValueINR":"12371111.05","totalValueInUsd":"148193.5","indian_port":"Bangalore Air","hs_no":"29379090","bill_no":"4214921","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"Via E. Curiel, 34 - 20067 Paullo MISDNFSDNF Italy","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731263400,"product":"EPINEPHRINE BASE UN 2811 TOXIC SOLID, ORGANIC, N.O.S.(EPINEPHRINE BASE) 6.1, II","address":"159, C.S.T. ROAD,","city":"MUMBAI,MAHARASHTRA","supplier":"CAMBREX CORPORATION","supplierCountry":"ITALY","foreign_port":"MALPENSA APT\/MILANO","customer":"LUPIN LTD","customerCountry":"INDIA","quantity":"0.15","actualQuantity":"0.15","unit":"KGS","unitRateFc":"60000","totalValueFC":"9086.6","currency":"USD","unitRateINR":"5112000","date":"11-Nov-2024","totalValueINR":"766800","totalValueInUsd":"9086.6","indian_port":"M\/s MAHARASHTRA AIRPORT DEVELOPMENTCOMPANYLIMITED","hs_no":"29379090","bill_no":"6613372","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MALPENSA APT\/MILANO","supplierAddress":"Via E. Curiel Paullo MI SDNF Italy","customerAddress":"159, C.S.T. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1732559400,"product":"EPINEPHRINE BASE (300G)","address":"H NO.141, SILPA BRINDAVAN,","city":"KUKATPALLY, HYDERABAD, AP.","supplier":"TRANSO-PHARM USA LLC","supplierCountry":"TAIWAN","foreign_port":"HAMBURG - FUHLSBUETT","customer":"ORBICULAR PHARMACEUTICAL TECHNOLOGIES ","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"0.3","unit":"KGS","unitRateFc":"47500","totalValueFC":"14412.4","currency":"USD","unitRateINR":"4054125","date":"26-Nov-2024","totalValueINR":"1216237.5","totalValueInUsd":"14412.4","indian_port":"Hyderabad Air","hs_no":"29379019","bill_no":"6899355","productDescription":"API","marketType":"REGULATED MARKET","country":"TAIWAN","selfForZScoreResived":"Pharma Grade","supplierPort":"HAMBURG - FUHLSBUETT","supplierAddress":"716 Dekalb Pike #329 Blue Bell, PA 19422 SDNF United States","customerAddress":"H NO.141, SILPA BRINDAVAN,"}]
    11-Feb-2021
    26-Nov-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    FDF Dossiers

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    01

    Ethypharm

    France
    arrow
    CPhI WW Frankfurt
    Booth #5.0D100
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothEthypharm is an international Pharma company with European roots manufacturing and commercializing essential drugs all over the world.

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    Flag France
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : France

    Adrenaline

    Brand Name :

    Dosage Form : Ampoule

    Dosage Strength : 1MG/1ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : France

    Ethypharm

    Portfolio PDF

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    Virtual Booth

    Digital Content

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    02

    Ethypharm

    France
    arrow
    CPhI WW Frankfurt
    Booth #5.0D100
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothEthypharm is an international Pharma company with European roots manufacturing and commercializing essential drugs all over the world.

    Contact Supplier Contact Supplier
    Flag France
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : France

    Adrenaline

    Brand Name :

    Dosage Form : Pre-filled Syringe

    Dosage Strength : 1MG/10ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : France

    Ethypharm

    Portfolio PDF

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    Virtual Booth

    Digital Content

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    03

    Belmar Pharma Solutions

    U.S.A
    Antibody Engineering
    Not Confirmed
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    Belmar Pharma Solutions

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : DISCN

    Registration Country : USA

    EPINEPHRINE; LIDOCAINE HYDROCHLORIDE

    Brand Name : LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 0.01MG/ML;2%

    Packaging :

    Approval Date : 1982-01-01

    Application Number : 80757

    Regulatory Info : DISCN

    Registration Country : USA

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    Portfolio PDF

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    Virtual Booth

    Digital Content

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    04

    Fresenius Kabi USA

    U.S.A
    Antibody Engineering
    Not Confirmed
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    Fresenius Kabi USA

    U.S.A
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    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : RX

    Registration Country : USA

    EPINEPHRINE; LIDOCAINE HYDROCHLORIDE

    Brand Name : XYLOCAINE W/ EPINEPHRINE

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 0.005MG/ML;1%

    Packaging :

    Approval Date : 1986-11-13

    Application Number : 6488

    Regulatory Info : RX

    Registration Country : USA

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    05

    Galenica MA

    Morocco
    Antibody Engineering
    Not Confirmed
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    Galenica MA

    Morocco
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag Morocco
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Italy

    Mepivacaine; Epinephrine

    Brand Name : Carbosen With Adrenaline \"Strong\"

    Dosage Form :

    Dosage Strength : 50 Ampoules 2 Ml 20 Mg/Ml + 10 Mcg/Ml  

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

    blank

    Portfolio PDF

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    Virtual Booth

    Digital Content

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    06

    Galenica MA

    Morocco
    Antibody Engineering
    Not Confirmed
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    Galenica MA

    Morocco
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag Morocco
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Italy

    Mepivacaine; Epinephrine

    Brand Name : Carbosen With Adrenaline

    Dosage Form :

    Dosage Strength : 100 Vials 20 Ml 20 Mg/Ml + 5 Mcg/Ml  

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

    blank

    Portfolio PDF

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    Virtual Booth

    Digital Content

    Website

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    07

    Galenica MA

    Morocco
    Antibody Engineering
    Not Confirmed
    arrow

    Galenica MA

    Morocco
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag Morocco
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Italy

    Mepivacaine; Epinephrine

    Brand Name : Carbosen With Adrenaline

    Dosage Form :

    Dosage Strength : 50 Ampoules 5 Ml 20 Mg/Ml + 5Mcg/Ml  

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

    blank

    Portfolio PDF

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    Virtual Booth

    Digital Content

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    08

    Hospira, Inc.

    U.S.A
    Antibody Engineering
    Not Confirmed
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    Hospira, Inc.

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : DISCN

    Registration Country : USA

    EPINEPHRINE; LIDOCAINE HYDROCHLORIDE

    Brand Name : LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE

    Dosage Form : INJECTABLE;INJECTION

    Dosage Strength : 0.01MG/ML;2%

    Packaging :

    Approval Date : 2008-05-12

    Application Number : 78772

    Regulatory Info : DISCN

    Registration Country : USA

    blank

    Portfolio PDF

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    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    09

    Infugen Pharma

    India
    Antibody Engineering
    Not Confirmed
    arrow

    Infugen Pharma

    India
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    Post an Enquiry Post an Enquiry
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : India

    Epinephrine

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 1MG/ML

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : India

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    10

    Sterling Spa

    Italy
    Antibody Engineering
    Not Confirmed
    arrow

    Sterling Spa

    Italy
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag Italy
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : DISCN

    Registration Country : USA

    EPINEPHRINE

    Brand Name : BRONKAID MIST

    Dosage Form : AEROSOL, METERED;INHALATION

    Dosage Strength : 0.25MG/INH

    Packaging :

    Approval Date : 1982-01-01

    Application Number : 16803

    Regulatory Info : DISCN

    Registration Country : USA

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    Virtual Booth

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INTRAMUSCULAR, SUBCUTANEO...DOSAGE - INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS - 0.15MG/DELIVERY

    USFDA APPLICATION NUMBER - 19430

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    DOSAGE - INJECTABLE;INTRAMUSCULAR, SUBCUTANEO...DOSAGE - INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS - 0.3MG/DELIVERY

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