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    Also known as: Ergotamine tartrate, Ergotamine bitartrate, 379-79-3, Schembl8045, Akos015897172, Ac-14836
    Molecular Formula
    C37H41N5O11
    Molecular Weight
    731.7  g/mol
    InChI Key
    NMTWKEWYQXZGCI-DDLCCZDQSA-N
    Ergotamine Tartrate
    A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.
    1 2D Structure

    Ergotamine Tartrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (6aR,9R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;2,3-dihydroxybutanedioic acid
    2.1.2 InChI
    InChI=1S/C33H35N5O5.C4H6O6/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;5-1(3(7)8)2(6)4(9)10/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39);1-2,5-6H,(H,7,8)(H,9,10)/t21-,25-,26+,27+,32-,33+;/m1./s1
    2.1.3 InChI Key
    NMTWKEWYQXZGCI-DDLCCZDQSA-N
    2.1.4 Canonical SMILES
    CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C.C(C(C(=O)O)O)(C(=O)O)O
    2.1.5 Isomeric SMILES
    C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@H]5CN([C@@H]6CC7=CNC8=CC=CC(=C78)C6=C5)C.C(C(C(=O)O)O)(C(=O)O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Cornutamine

    2. Ergo Kranit

    3. Ergo Sanol

    4. Ergo-kranit

    5. Ergodryl Mono

    6. Ergomar

    7. Ergostat

    8. Ergotamine

    9. Ergotamine Tartrate

    10. Ergotamine Tartrate (2:1)

    11. Ergotaminine

    12. Gynergen

    13. Lingraine

    14. Mono, Ergodryl

    15. Tartrate, Ergotamine

    2.2.2 Depositor-Supplied Synonyms

    1. Ergotamine Tartrate

    2. Ergotamine Bitartrate

    3. 379-79-3

    4. Schembl8045

    5. Akos015897172

    6. Ac-14836

    2.3 Create Date
    2007-05-07
    3 Chemical and Physical Properties
    Molecular Weight 731.7 g/mol
    Molecular Formula C37H41N5O11
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count7
    Exact Mass731.28025714 g/mol
    Monoisotopic Mass731.28025714 g/mol
    Topological Polar Surface Area233 Ų
    Heavy Atom Count53
    Formal Charge0
    Complexity1350
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameErgomar
    PubMed HealthErgotamine Tartrate (By mouth)
    Drug ClassesAntimigraine
    Active IngredientErgotamine tartrate
    Dosage FormTablet
    RouteSublingual
    Strength2mg
    Market StatusPrescription
    CompanyRosedale Therapeutic

    2 of 2  
    Drug NameErgomar
    PubMed HealthErgotamine Tartrate (By mouth)
    Drug ClassesAntimigraine
    Active IngredientErgotamine tartrate
    Dosage FormTablet
    RouteSublingual
    Strength2mg
    Market StatusPrescription
    CompanyRosedale Therapeutic

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic alpha-1 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)

    Analgesics, Non-Narcotic

    A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

    Oxytocics

    Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157) (See all compounds classified as Oxytocics.)

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Ergotamines [CS]; Ergotamine Derivative [EPC]

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RUZYNE","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"KGS","unitRateFc":"3600","totalValueFC":"14541.5","currency":"USD","unitRateINR":"303480","date":"26-Jun-2024","totalValueINR":"1213920","totalValueInUsd":"14541.5","indian_port":"Bombay Air","hs_no":"29396210","bill_no":"4196455","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"OSTRAVSKA 305\/29,KOMAROV OPAVA 74770SDNF CZECH REPUBLIC","customerAddress":"CADILA CORPORATE CAMPUS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719340200,"product":"ERGOTAMINE TARTRATE","address":"CADILA CORPORATE CAMPUS","city":"AHMEDABAD, GUJARAT","supplier":"TEVA PHARMACEUTICAL INDUSTRIES","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"CADILA PHARMACEUTICALS","customerCountry":"INDIA","quantity":"4.13","actualQuantity":"4.13","unit":"KGS","unitRateFc":"3600","totalValueFC":"15014.1","currency":"USD","unitRateINR":"303480","date":"26-Jun-2024","totalValueINR":"1253372.4","totalValueInUsd":"15014.1","indian_port":"Bombay Air","hs_no":"29396210","bill_no":"4196455","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - 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    13-Mar-2021
    26-Oct-2024
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 100MG;1MG

    USFDA APPLICATION NUMBER - 84294

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    DOSAGE - SUPPOSITORY;RECTAL - 100MG;2MG

    USFDA APPLICATION NUMBER - 86557

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    USP

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    ABOUT THIS PAGE

    Ergotamine Tartrate Manufacturers

    A Ergotamine Tartrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ergotamine Tartrate, including repackagers and relabelers. The FDA regulates Ergotamine Tartrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ergotamine Tartrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ergotamine Tartrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ergotamine Tartrate Suppliers

    A Ergotamine Tartrate supplier is an individual or a company that provides Ergotamine Tartrate active pharmaceutical ingredient (API) or Ergotamine Tartrate finished formulations upon request. The Ergotamine Tartrate suppliers may include Ergotamine Tartrate API manufacturers, exporters, distributors and traders.

    click here to find a list of Ergotamine Tartrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ergotamine Tartrate USDMF

    A Ergotamine Tartrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Ergotamine Tartrate active pharmaceutical ingredient (API) in detail. Different forms of Ergotamine Tartrate DMFs exist exist since differing nations have different regulations, such as Ergotamine Tartrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ergotamine Tartrate DMF submitted to regulatory agencies in the US is known as a USDMF. Ergotamine Tartrate USDMF includes data on Ergotamine Tartrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ergotamine Tartrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ergotamine Tartrate suppliers with USDMF on PharmaCompass.

    Ergotamine Tartrate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Ergotamine Tartrate Drug Master File in Japan (Ergotamine Tartrate JDMF) empowers Ergotamine Tartrate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Ergotamine Tartrate JDMF during the approval evaluation for pharmaceutical products. At the time of Ergotamine Tartrate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Ergotamine Tartrate suppliers with JDMF on PharmaCompass.

    Ergotamine Tartrate CEP

    A Ergotamine Tartrate CEP of the European Pharmacopoeia monograph is often referred to as a Ergotamine Tartrate Certificate of Suitability (COS). The purpose of a Ergotamine Tartrate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ergotamine Tartrate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ergotamine Tartrate to their clients by showing that a Ergotamine Tartrate CEP has been issued for it. The manufacturer submits a Ergotamine Tartrate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ergotamine Tartrate CEP holder for the record. Additionally, the data presented in the Ergotamine Tartrate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ergotamine Tartrate DMF.

    A Ergotamine Tartrate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ergotamine Tartrate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Ergotamine Tartrate suppliers with CEP (COS) on PharmaCompass.

    Ergotamine Tartrate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ergotamine Tartrate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Ergotamine Tartrate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Ergotamine Tartrate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Ergotamine Tartrate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ergotamine Tartrate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Ergotamine Tartrate suppliers with NDC on PharmaCompass.

    Ergotamine Tartrate GMP

    Ergotamine Tartrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ergotamine Tartrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ergotamine Tartrate GMP manufacturer or Ergotamine Tartrate GMP API supplier for your needs.

    Ergotamine Tartrate CoA

    A Ergotamine Tartrate CoA (Certificate of Analysis) is a formal document that attests to Ergotamine Tartrate's compliance with Ergotamine Tartrate specifications and serves as a tool for batch-level quality control.

    Ergotamine Tartrate CoA mostly includes findings from lab analyses of a specific batch. For each Ergotamine Tartrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ergotamine Tartrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Ergotamine Tartrate EP), Ergotamine Tartrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ergotamine Tartrate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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