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1. 3-o-decyl-2-deoxy-6-o-(2-deoxy-3-o-(3-methoxydecyl)-6-o-methyl-2-((1-oxo-11-octadecenyl)amino)-4-o-phosphonoglucopyranosyl)-2-((1,3-dioxotetradecyl)amino)-1-(dihydroxy Phosphate)glucopyranose
1. 185955-34-4
2. Eritoran [inn]
3. E5564
4. Chembl501259
5. Chebi:68609
6. 551541vi0y
7. [(2r,3r,4r,5s,6r)-4-decoxy-5-hydroxy-6-[[(2r,3r,4r,5s,6r)-4-[(3r)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(z)-octadec-11-enoyl]amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)oxan-2-yl] Dihydrogen Phosphate
8. 3-o-decyl-2-deoxy-6-o-[2-deoxy-3-o-[(3r)-3-methoxydecyl]-6-o-methyl-2-[[(11z)-1-oxo-11-octadecenyl]amino]-4-o-phosphono-beta-d-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-alpha-d-glucopyranose1-(dihydrogenphosphat
9. 3-o-decyl-2-deoxy-6-o-{2-deoxy-3-o-[(3r)-3-methoxydecyl]-6-o-methyl-2-[(11e)-octadec-11-enoylamino]-4-o-phosphonato-beta-d-glucopyranosyl}-2-[(3-oxotetradecanoyl)amino]-1-o-phosphono-alpha-d-glucopyranose
10. 3-o-decyl-2-deoxy-6-o-{2-deoxy-3-o-[(3r)-3-methoxydecyl]-6-o-methyl-2-[(11z)-octadec-11-enoylamino]-4-o-phosphono-beta-d-glucopyranosyl}-2-[(3-oxotetradecanoyl)amino]-1-o-phosphono-alpha-d-glucopyranose
11. B1287
12. Unii-551541vi0y
13. Eritoran [mi]
14. Eritoran [who-dd]
15. E5564; Eritoran
16. Gtpl4919
17. Schembl10042156
18. Dtxsid60873217
19. Ex-a5458
20. Bdbm50274760
21. Db04933
22. 3-o-decyl-2-deoxy-6-o-(2-deoxy-3-o-(3-methoxydecyl)-6-o-methyl-2-((1-oxo-11-octadecenyl)amino)-4-o-phosphonoglucopyranosyl)-2-((1,3-dioxotetradecyl)amino)-1-(dihydroxy Phosphate)glucopyranose
23. Q5389586
24. .alpha.-d-glucopyranose, 3-o-decyl-2-deoxy-6-o-(2-deoxy-3-o-((3r)-3-methoxydecyl)-6-o-methyl-2-(((11z)-1-oxo-11-octadecenyl)amino)-4-o-phosphono-.beta.-d-glucopyranosyl)-2-((1,3-dioxotetradecyl)amino)-, 1-(dihydrogen Phosphate)
25. [(2r,3s,4r,5r,6r)-6-[[(2r,3s,4r,5r,6r)-4-decoxy-3-hydroxy-5-(3-oxotetradecanoylamino)-6-phosphonooxyoxan-2-yl]methoxy]-4-[(3r)-3-methoxydecoxy]-2-(methoxymethyl)-5-[[(z)-octadec-11-enoyl]amino]oxan-3-yl] Dihydrogen Phosphate
26. 3-o-decyl-2-deoxy-6-o-(2-deoxy-3-o-((3r)-3-methoxydecyl)-6-o-methyl-2-((11z)-octadec-11-enoylamino)-4-o-phosphono-.beta.-d-glucopyranosyl)-2-((3-oxotetradecanoyl)amino)-1-o-phosphono-.alpha.-d-glucopyranose
| Molecular Weight | 1313.7 g/mol |
|---|---|
| Molecular Formula | C66H126N2O19P2 |
| XLogP3 | 15.4 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 19 |
| Rotatable Bond Count | 59 |
| Exact Mass | 1312.84300379 g/mol |
| Monoisotopic Mass | 1312.84300379 g/mol |
| Topological Polar Surface Area | 294 Ų |
| Heavy Atom Count | 89 |
| Formal Charge | 0 |
| Complexity | 1900 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 11 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Investigated for use/treatment in sepsis and septicemia.
Sepsis
Eritoran has been shown to down-regulate the intracellular generation of pro-inflammatory cytokines IL-6 and TNF-alpha in human monocytes.
50.4 to 62.7 hours
Eritoran is a toll-like receptor 4 inhibitor.
Drugs in Development
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A Eritoran manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Eritoran, including repackagers and relabelers. The FDA regulates Eritoran manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Eritoran API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Eritoran supplier is an individual or a company that provides Eritoran active pharmaceutical ingredient (API) or Eritoran finished formulations upon request. The Eritoran suppliers may include Eritoran API manufacturers, exporters, distributors and traders.
Eritoran Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Eritoran GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Eritoran GMP manufacturer or Eritoran GMP API supplier for your needs.
A Eritoran CoA (Certificate of Analysis) is a formal document that attests to Eritoran's compliance with Eritoran specifications and serves as a tool for batch-level quality control.
Eritoran CoA mostly includes findings from lab analyses of a specific batch. For each Eritoran CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Eritoran may be tested according to a variety of international standards, such as European Pharmacopoeia (Eritoran EP), Eritoran JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Eritoran USP).
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