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Synopsis

Chemistry

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Also known as: Omeprazole magnesium, 161973-10-0, Prilosec otc, H 168/68 magnesium, 95382-33-5, Omeprazole (as magnesium)
Molecular Formula
C34H36MgN6O6S2
Molecular Weight
713.1  g/mol
InChI Key
KWORUUGOSLYAGD-UHFFFAOYSA-N
FDA UNII
426QFE7XLK

Esomeprazole Magnesium
The S-isomer of omeprazole.
1 2D Structure

Esomeprazole Magnesium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
2.1.2 InChI
InChI=1S/2C17H18N3O3S.Mg/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h2*5-8H,9H2,1-4H3;/q2*-1;+2
2.1.3 InChI Key
KWORUUGOSLYAGD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]
2.2 Other Identifiers
2.2.1 UNII
426QFE7XLK
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Esomeprazole

2. Esomeprazole Potassium

3. Esomeprazole Sodium

4. Esomeprazole Strontium

5. Esomeprazole Strontium Anhydrous

6. Nexium

7. Strontium, Esomeprazole

2.3.2 Depositor-Supplied Synonyms

1. Omeprazole Magnesium

2. 161973-10-0

3. Prilosec Otc

4. H 168/68 Magnesium

5. 95382-33-5

6. Omeprazole (as Magnesium)

7. 426qfe7xlk

8. Magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

9. Esomeprazole Magnesium Salt

10. Unii-426qfe7xlk

11. Omeprazole Magnesium [usan]

12. Omeprazole Magnesium [usan:usp]

13. Prilosec Otc (tn)

14. Esomeprazole(magnesium)

15. Omeprazole Magnesium Salt

16. Omeprazole Magnesium (usp)

17. Mls001165732

18. Schembl722792

19. Esomeprazole Magnesium (nexium)

20. Chembl1567328

21. Chebi:94401

22. H-168/68 Magnesium

23. Hms2878h13

24. Omeprazole Magnesium [vandf]

25. Mfcd06798050

26. Omeprazole Magnesium [mart.]

27. Omeprazole Magnesium [usp-rs]

28. Omeprazole Magnesium [who-dd]

29. Akos015896379

30. Akos025402081

31. Omeprazole Magnesium Salt [mi]

32. As-75082

33. Omeprazole Magnesium [orange Book]

34. Smr000550477

35. Omeprazole Magnesium [ep Monograph]

36. Omeprazole Magnesium [usp Impurity]

37. Omeprazole Magnesium [usp Monograph]

38. Ft-0657297

39. Sw220306-1

40. Talicia Component Omeprazole Magnesium

41. D05259

42. Omeprazole Magnesium Component Of Talicia

43. A810316

44. J-014249

45. Q-100195

46. Q27166253

47. 5-methoxy-1h-1,3-benzimidazol-2-yl (4-methoxy-3,5-dimethyl-2-pyridinyl)methyl Sulfoxide

48. (rs)-5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole, Magnesium Salt (2:1)

49. 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole, Magnesium Salt

50. 5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole, Magnesium Salt (2:1)

51. Magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]benzimidazol-1-ide;esomeprazole Magnesium(random Configuration)

52. Magnesium(2+) 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1h-1,3-benzodiazol-1-ide 6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1h-1,3-benzodiazol-1-ide

53. Magnesium, Bis(6-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl-.kappa.o)-1h-benzimidazolato-.kappa.n3)-, (t-4)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 713.1 g/mol
Molecular Formula C34H36MgN6O6S2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count14
Rotatable Bond Count10
Exact Mass712.1988169 g/mol
Monoisotopic Mass712.1988169 g/mol
Topological Polar Surface Area163 Ų
Heavy Atom Count49
Formal Charge0
Complexity453
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameEsomeprazole magnesium
PubMed HealthEsomeprazole
Drug ClassesGastric Acid Secretion Inhibitor, Gastrointestinal Agent
Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active IngredientEsomeprazole magnesium
Dosage FormCapsule, delayed release
Routeoral
Strength40mg; 20mg
Market StatusTentative Approval
CompanyRanbaxy

2 of 6  
Drug NameNexium
Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active IngredientEsomeprazole magnesium
Dosage FormCapsule, delayed rel pellets; For suspension, delayed release
RouteOral
Strengtheq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
Market StatusPrescription
CompanyAstrazeneca

3 of 6  
Drug NameOmeprazole magnesium
Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active IngredientOmeprazole magnesium
Dosage FormCapsule, delayed release
RouteOral
Strengtheq 20mg base
Market StatusOver the Counter
CompanyDr Reddys Labs

4 of 6  
Drug NameEsomeprazole magnesium
PubMed HealthEsomeprazole
Drug ClassesGastric Acid Secretion Inhibitor, Gastrointestinal Agent
Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active IngredientEsomeprazole magnesium
Dosage FormCapsule, delayed release
Routeoral
Strength40mg; 20mg
Market StatusTentative Approval
CompanyRanbaxy

5 of 6  
Drug NameNexium
Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active IngredientEsomeprazole magnesium
Dosage FormCapsule, delayed rel pellets; For suspension, delayed release
RouteOral
Strengtheq 5mg base/packet; eq 20mg base/packet; eq 20mg base; eq 40mg base; eq 10mg base/packet; eq 40mg base/packet; eq 2.5mg base/packet
Market StatusPrescription
CompanyAstrazeneca

6 of 6  
Drug NameOmeprazole magnesium
Drug LabelThe active ingredient in NEXIUM (esomeprazole magnesium) Delayed-Release Capsules and NEXIUM (esomeprazole magnesium) For Delayed-Release Oral Suspension is bis(5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole...
Active IngredientOmeprazole magnesium
Dosage FormCapsule, delayed release
RouteOral
Strengtheq 20mg base
Market StatusOver the Counter
CompanyDr Reddys Labs

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Ulcer Agents

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)


Proton Pump Inhibitors

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Proton Pump Inhibitor [EPC]; Proton Pump Inhibitors [MoA]; Cytochrome P450 2C19 Inhibitors [MoA]

API Reference Price

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01-Jan-2021
31-Dec-2024
KGS
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Average Price (USD/KGS)

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - CAPSULE, DELAYED RELEASE;ORAL - EQ 2...DOSAGE - CAPSULE, DELAYED RELEASE;ORAL - EQ 20MG BASE

USFDA APPLICATION NUMBER - 204655

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DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - ...DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - EQ 20MG BASE

USFDA APPLICATION NUMBER - 21153

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DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - ...DOSAGE - CAPSULE, DELAYED REL PELLETS;ORAL - EQ 40MG BASE

USFDA APPLICATION NUMBER - 21153

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DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 2.5MG BASE/PACKET

USFDA APPLICATION NUMBER - 21957

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DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 20MG BASE/PACKET

USFDA APPLICATION NUMBER - 21957

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DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 40MG BASE/PACKET

USFDA APPLICATION NUMBER - 21957

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DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL...DOSAGE - FOR SUSPENSION, DELAYED RELEASE;ORAL - EQ 5MG BASE/PACKET

USFDA APPLICATION NUMBER - 21957

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DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20...DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE;375MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22511

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DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20...DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE;500MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 22511

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Esomeprazole Magnesium Dihydrate Manufacturers

A Esomeprazole Magnesium Dihydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Esomeprazole Magnesium Dihydrate, including repackagers and relabelers. The FDA regulates Esomeprazole Magnesium Dihydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Esomeprazole Magnesium Dihydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Esomeprazole Magnesium Dihydrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Esomeprazole Magnesium Dihydrate Suppliers

A Esomeprazole Magnesium Dihydrate supplier is an individual or a company that provides Esomeprazole Magnesium Dihydrate active pharmaceutical ingredient (API) or Esomeprazole Magnesium Dihydrate finished formulations upon request. The Esomeprazole Magnesium Dihydrate suppliers may include Esomeprazole Magnesium Dihydrate API manufacturers, exporters, distributors and traders.

click here to find a list of Esomeprazole Magnesium Dihydrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Esomeprazole Magnesium Dihydrate USDMF

A Esomeprazole Magnesium Dihydrate DMF (Drug Master File) is a document detailing the whole manufacturing process of Esomeprazole Magnesium Dihydrate active pharmaceutical ingredient (API) in detail. Different forms of Esomeprazole Magnesium Dihydrate DMFs exist exist since differing nations have different regulations, such as Esomeprazole Magnesium Dihydrate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Esomeprazole Magnesium Dihydrate DMF submitted to regulatory agencies in the US is known as a USDMF. Esomeprazole Magnesium Dihydrate USDMF includes data on Esomeprazole Magnesium Dihydrate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Esomeprazole Magnesium Dihydrate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Esomeprazole Magnesium Dihydrate suppliers with USDMF on PharmaCompass.

Esomeprazole Magnesium Dihydrate JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Esomeprazole Magnesium Dihydrate Drug Master File in Japan (Esomeprazole Magnesium Dihydrate JDMF) empowers Esomeprazole Magnesium Dihydrate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Esomeprazole Magnesium Dihydrate JDMF during the approval evaluation for pharmaceutical products. At the time of Esomeprazole Magnesium Dihydrate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Esomeprazole Magnesium Dihydrate suppliers with JDMF on PharmaCompass.

Esomeprazole Magnesium Dihydrate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Esomeprazole Magnesium Dihydrate Drug Master File in Korea (Esomeprazole Magnesium Dihydrate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Esomeprazole Magnesium Dihydrate. The MFDS reviews the Esomeprazole Magnesium Dihydrate KDMF as part of the drug registration process and uses the information provided in the Esomeprazole Magnesium Dihydrate KDMF to evaluate the safety and efficacy of the drug.

After submitting a Esomeprazole Magnesium Dihydrate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Esomeprazole Magnesium Dihydrate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Esomeprazole Magnesium Dihydrate suppliers with KDMF on PharmaCompass.

Esomeprazole Magnesium Dihydrate CEP

A Esomeprazole Magnesium Dihydrate CEP of the European Pharmacopoeia monograph is often referred to as a Esomeprazole Magnesium Dihydrate Certificate of Suitability (COS). The purpose of a Esomeprazole Magnesium Dihydrate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Esomeprazole Magnesium Dihydrate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Esomeprazole Magnesium Dihydrate to their clients by showing that a Esomeprazole Magnesium Dihydrate CEP has been issued for it. The manufacturer submits a Esomeprazole Magnesium Dihydrate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Esomeprazole Magnesium Dihydrate CEP holder for the record. Additionally, the data presented in the Esomeprazole Magnesium Dihydrate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Esomeprazole Magnesium Dihydrate DMF.

A Esomeprazole Magnesium Dihydrate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Esomeprazole Magnesium Dihydrate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Esomeprazole Magnesium Dihydrate suppliers with CEP (COS) on PharmaCompass.

Esomeprazole Magnesium Dihydrate WC

A Esomeprazole Magnesium Dihydrate written confirmation (Esomeprazole Magnesium Dihydrate WC) is an official document issued by a regulatory agency to a Esomeprazole Magnesium Dihydrate manufacturer, verifying that the manufacturing facility of a Esomeprazole Magnesium Dihydrate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Esomeprazole Magnesium Dihydrate APIs or Esomeprazole Magnesium Dihydrate finished pharmaceutical products to another nation, regulatory agencies frequently require a Esomeprazole Magnesium Dihydrate WC (written confirmation) as part of the regulatory process.

click here to find a list of Esomeprazole Magnesium Dihydrate suppliers with Written Confirmation (WC) on PharmaCompass.

Esomeprazole Magnesium Dihydrate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Esomeprazole Magnesium Dihydrate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Esomeprazole Magnesium Dihydrate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Esomeprazole Magnesium Dihydrate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Esomeprazole Magnesium Dihydrate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Esomeprazole Magnesium Dihydrate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Esomeprazole Magnesium Dihydrate suppliers with NDC on PharmaCompass.

Esomeprazole Magnesium Dihydrate GMP

Esomeprazole Magnesium Dihydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Esomeprazole Magnesium Dihydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Esomeprazole Magnesium Dihydrate GMP manufacturer or Esomeprazole Magnesium Dihydrate GMP API supplier for your needs.

Esomeprazole Magnesium Dihydrate CoA

A Esomeprazole Magnesium Dihydrate CoA (Certificate of Analysis) is a formal document that attests to Esomeprazole Magnesium Dihydrate's compliance with Esomeprazole Magnesium Dihydrate specifications and serves as a tool for batch-level quality control.

Esomeprazole Magnesium Dihydrate CoA mostly includes findings from lab analyses of a specific batch. For each Esomeprazole Magnesium Dihydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Esomeprazole Magnesium Dihydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Esomeprazole Magnesium Dihydrate EP), Esomeprazole Magnesium Dihydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Esomeprazole Magnesium Dihydrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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