IM Injection: When conjugated with aryl and alkyl groups for parenteral administration, the rate of absorption of oily preparations is slowed with a prolonged duration of action, such that a single intramuscular injection of estradiol valerate or estradiol cypionate is absorbed over several weeks. Natazia: After oral administration of estradiol valerate, cleavage to 17-estradiol and valeric acid takes place during absorption by the intestinal mucosa or in the course of the first liver passage. This gives rise to estradiol and its metabolites, estrone and other metabolites. Maximum serum estradiol concentrations of 73.3 pg/mL are reached at a median of approximately 6 hours (range: 1.512 hours) and the area under the estradiol concentration curve [AUC(024h)] was 1301 pgh/mL after single ingestion of a tablet containing 3 mg estradiol valerate under fasted condition on Day 1 of the 28-day sequential regimen.

Estradiol, estrone and estriol are excreted in the urine along with glucuronide and sulfate conjugates.

Molecular Formula	C₂₃H₃₂O₃
Molecular Weight	356.5 g/mol
XLogP3	6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	356.23514488 g/mol
Monoisotopic Mass	356.23514488 g/mol
Topological Polar Surface Area	46.5 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	518
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

1 of 4
Drug Name	Delestrogen
PubMed Health	Estradiol (Injection)
Drug Classes	Endocrine-Metabolic Agent, Musculoskeletal Agent
Drug Label	DELESTROGEN (estradiol valerate injection, USP) contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to pale yellow. Formulations (per mL): 10 mg estradiol valerate...
Active Ingredient	Estradiol valerate
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml; 40mg/ml; 10mg/ml
Market Status	Prescription
Company	Par Sterile Products

2 of 4
Drug Name	Estradiol valerate
Drug Label	Estradiol valerate injection, USP contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to pale yellow. Formulations (per mL): 10 mg estradiol valerate in a vehicle co...
Active Ingredient	Estradiol valerate
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml; 40mg/ml; 10mg/ml
Market Status	Prescription
Company	Luitpold; Sandoz

3 of 4
Drug Name	Delestrogen
PubMed Health	Estradiol (Injection)
Drug Classes	Endocrine-Metabolic Agent, Musculoskeletal Agent
Drug Label	DELESTROGEN (estradiol valerate injection, USP) contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to pale yellow. Formulations (per mL): 10 mg estradiol valerate...
Active Ingredient	Estradiol valerate
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml; 40mg/ml; 10mg/ml
Market Status	Prescription
Company	Par Sterile Products

4 of 4
Drug Name	Estradiol valerate
Drug Label	Estradiol valerate injection, USP contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to pale yellow. Formulations (per mL): 10 mg estradiol valerate in a vehicle co...
Active Ingredient	Estradiol valerate
Dosage Form	Injectable
Route	Injection
Strength	20mg/ml; 40mg/ml; 10mg/ml
Market Status	Prescription
Company	Luitpold; Sandoz

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