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Chemistry

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Also known as: 50-27-1, Oestriol, Trihydroxyestrin, Aacifemine, Estratriol, Ovestin
Molecular Formula
C18H24O3
Molecular Weight
288.4  g/mol
InChI Key
PROQIPRRNZUXQM-ZXXIGWHRSA-N
FDA UNII
FB33469R8E

Estriol
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
1 2D Structure

Estriol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
2.1.2 InChI
InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
2.1.3 InChI Key
PROQIPRRNZUXQM-ZXXIGWHRSA-N
2.1.4 Canonical SMILES
CC12CCC3C(C1CC(C2O)O)CCC4=C3C=CC(=C4)O
2.1.5 Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@H]([C@@H]2O)O)CCC4=C3C=CC(=C4)O
2.2 Other Identifiers
2.2.1 UNII
FB33469R8E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol

2. (16beta,17beta)-estra-1,3,5(10)-triene-3,16,17-triol

3. 16 Alpha Hydroxy Estradiol

4. 16-alpha-hydroxy-estradiol

5. 16alpha,17beta Estriol

6. 16alpha,17beta-estriol

7. 16beta Hydroxy Estradiol

8. 16beta-hydroxy-estradiol

9. Epiestriol

10. Estra-1,3,5(10)-triene-3,16beta,17beta-triol

11. Ovestin

2.3.2 Depositor-Supplied Synonyms

1. 50-27-1

2. Oestriol

3. Trihydroxyestrin

4. Aacifemine

5. Estratriol

6. Ovestin

7. Ovestrion

8. Destriol

9. Tridestrin

10. Theelol

11. Oestratriol

12. Orestin

13. Holin

14. 16alpha-hydroxyestradiol

15. Ortho-gynest

16. Deuslon-a

17. Hemostyptanon

18. Hormomed

19. Klimoral

20. Oestriolum

21. Orgastyptin

22. Overstin

23. Thulol

24. Triovex

25. 16alpha,17beta-estriol

26. Gynaesan

27. Hormonin

28. Stiptanon

29. Synapause

30. Triodurin

31. Estriel

32. Trihydroxyoestrin

33. Follicular Hormone Hydrate

34. 16-alpha-hydroxyestradiol

35. Estriolo [italian]

36. 16alpha-hydroxyoestradiol

37. 16alpha,17beta-oestriol

38. 16-alpha,17-beta-estriol

39. 16-alpha,17-beta-oestriol

40. Colpogyn

41. Estriolo

42. Incurin

43. 16alpha-hydroxy-17beta-estradiol

44. Estriol, Unconjugated

45. (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol

46. 16-alpha-hydroxyoestradiol

47. Deuslon A

48. Nsc-12169

49. 3,16alpha,17beta-estriol

50. 3,16-alpha,17-beta-estriol

51. 3,16-alpha,17-beta-oestriol

52. 16.alpha.-hydroxyestradiol

53. 16.alpha.,17.beta.-estriol

54. 3,16alpha,17beta-trihydroxy-1,3,5(10)-estratriene

55. 16.alpha.-estriol

56. Chlorapatite

57. Gynasan

58. Ovesterin

59. 1,3,5-estratriene-3beta,16alpha,17beta-triol

60. Ovo-vinces

61. 1,3,5-oestratriene-3beta,16alpha,17beta-triol

62. A 13610

63. Klimax E

64. Estra-1,3,5(10)-trien-3,16alpha,17beta-triol

65. Oestra-1,3,5(10)-triene-3,16alpha,17beta-triol

66. 16.alpha.-hydroxyoestradiol

67. 3,16alpha,17beta-trihydroxy-delta-1,3,5-oestratriene

68. 3,16-alpha,17-beta-trihydroxy-delta-1,3,5-estratriene

69. 3,16-alpha,17-beta-trihydroxy-delta-1,3,5-oestratriene

70. 3,16-alpha,17-beta-trihydroxyestra-1,3,5(10)-triene

71. 3,16-alpha,17-beta-trihydroxyoestra-1,3,5(10)-triene

72. (16alpha,17beta)-oestra-1,3,5(10)-triene-3,16,17-triol

73. 1,3,5(10)-estratriene-3,16alpha,17beta-triol

74. 16.alpha.,17.beta.-oestriol

75. 1,3,5(10)-estratriene-3,16-alpha,17beta-triol

76. Chebi:27974

77. Estra-1,3,5(10)-triene-3,16alpha,17beta-triol

78. Oestra-1,3,5(10)-triene-3,16-alpha,17-beta-triol

79. 3,16alpha,17beta-trihydroxy-delta(1,3,5)-estratriene

80. (8r,9s,13s,14s,16r,17r)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

81. Oe3

82. 16.alpha.-hydroxy-17.beta.-estradiol

83. 16-epiestriol

84. Fb33469r8e

85. Nsc12169

86. Estra-1,3,5(10)-triene-3,16,17-triol, (16a,17b)-

87. Estra-1,3,5(10)-triene-3,16,17-triol

88. Dsstox_cid_2366

89. Dsstox_rid_76559

90. Dsstox_gsid_22366

91. 1306-04-3

92. 3,16.alpha.,17.beta.-estriol

93. Mfcd00003691

94. 16a-hydroxyestradiol

95. Folicular Hormone

96. (1s,10r,11s,13r,14r,15s)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol

97. 3,17.beta.-estriol

98. Ccris 284

99. Estriel (tn)

100. 16-hydroxyestradiol

101. Oestriol [steroidal Oestrogens]

102. Estra-1,3,5(10)-triene-3,16,17-triol, (16.alpha.,17.beta.)-

103. Hsdb 3590

104. Sr-01000721851

105. Einecs 200-022-2

106. Nsc 12169

107. 1,3,5(10)-estratriene-3,16.alpha.,17.beta.-triol

108. Estra-1,3,5(10)-trien-3,16.alpha.,17.beta.-triol

109. Estra-1,3,5(10)-triene-3,16.alpha.,17.beta.-triol

110. 1,3,5(10)-estratriene-3,16,17-triol

111. 1,3,5-estratriene-3.beta.,16-.alpha.,17-.beta.-triol

112. 1,3,5-oestratriene-3-.beta.,16.alpha.,17.beta.-triol

113. 3,16.alpha.,17.beta.-trihydroxy-1,3,5(10)-estratriene

114. 3,16.alpha.,17.beta.-trihydroxyestra-1,3,5(10)-triene

115. Brn 2508172

116. Oestra-1,3,5(10)-triene-3,16.alpha., 17.beta.-triol

117. 3,16.alpha.,17.beta.-trihydroxy-.delta.-1,3,5-estratriene

118. Ovestinon

119. Trimesta

120. 3,16.alpha.,17.beta.-trihydroxy-.delta.-1,3,5-oestratriene

121. Oestriol.

122. Unii-fb33469r8e

123. (16.alpha.,17.beta.)-estra-1,3,5(10)-triene-3,16,17-triol

124. (16.alpha.,17.beta.)-oestra-1,3,5(10)-triene-3,16,17-triol

125. Estriol [usp:inn:ban:jan]

126. 3,16-.alpha.,17-.beta.-oestriol

127. Estra-1,3,5(10)-triene-3,16,17-triol, (16alpha,17beta)-

128. Holin V

129. Cas-50-27-1

130. 16a-estriol

131. Ncgc00166111-01

132. (8r,9s,13s,14s,16r,17r)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,16,17-triol

133. 16a,17b-estriol

134. Estriol, 98%

135. Estriol [hsdb]

136. Estriol, >=97%

137. Estriol [jan]

138. Estriol [mi]

139. 3,16a,17b-estriol

140. Estriol [mart.]

141. Prestwick0_001096

142. Prestwick1_001096

143. Prestwick2_001096

144. Prestwick3_001096

145. Estriol (jp17/usp)

146. E0218

147. Estriol [usp-rs]

148. Estriol [who-dd]

149. Epitope Id:140131

150. 1,3,5(10)-estratrien-3,16.alpha.,17.beta.-triol

151. Estra-1,3,5(10)-triene-3,16-.alpha., L7-.beta.-triol

152. Schembl78033

153. Bspbio_001172

154. Estriol [green Book]

155. 3,16-.alpha.,17-.beta.-trihydroxyoestra-1,3,5(10)-triene

156. 4-06-00-07550 (beilstein Handbook Reference)

157. Mls000069812

158. Bidd:er0124

159. Spbio_003056

160. Estriol [ep Monograph]

161. Bpbio1_001290

162. Chembl193482

163. Gtpl2821

164. Estriol [usp Monograph]

165. Dtxsid9022366

166. Estriol 1.0 Mg/ml In Methanol

167. Hms1571k14

168. Hms2090e20

169. Hms2098k14

170. Hms2234a18

171. Hms3715k14

172. Hms3884p19

173. Bcp23357

174. Hy-b0412

175. Zinc3815418

176. Estriol 100 Microg/ml In Methanol

177. Tox21_112320

178. Tox21_301604

179. Bdbm50410506

180. Lmst02010003

181. S2466

182. Estriol [ema Epar Veterinary]

183. Estriol 1000 Microg/ml In Methanol

184. Akos015894926

185. Tox21_112320_1

186. Bcp9000661

187. Ccg-221096

188. Db04573

189. Estriol 100 Microg/ml In Acetonitrile

190. Estriol, Purum, >=97.0% (hplc)

191. Fd12050

192. Smp1_000122

193. Ncgc00166111-02

194. Ncgc00179277-01

195. Ncgc00255193-01

196. Ncgc00274080-01

197. As-13735

198. Estriol, Meets Usp Testing Specifications

199. Smr000059210

200. Bcp0726000219

201. Ab00514045

202. B1507

203. Estriol, Vetranal(tm), Analytical Standard

204. Wln: L E5 B666ttt&j E1 Fq Gq Oq

205. C05141

206. D00185

207. Estra-1,3,5(10)-triene-3,16a,17b-triol

208. 1,3,5-estratriene-3b,16a,17b-triol

209. 3,16a,17b-trihydroxyestra-1,3,5(10)-triene

210. 3,17.beta.-trihydroxy-1,3,5(10)-estratriene

211. 3,17.beta.-trihydroxyestra-1,3,5(10)-triene

212. Ab00514045-08

213. Ab00514045-09

214. Ab00514045_10

215. (16.alpha.,3,5(10)-triene-3,16,17-triol

216. 003e691

217. Q409721

218. 3,17.beta.-trihydroxy-.delta.-1,3,5-estratriene

219. 3,17.beta.-trihydroxy-.delta.-1,3,5-oestratriene

220. Q-201072

221. Sr-01000721851-3

222. Sr-01000721851-4

223. 1,5(10)-estratriene-3,16.alpha., 17.beta.-triol

224. 1,5(10)-estratriene-3,16.alpha.,17.beta.-triol

225. 3,16alpha,17beta-trihydroxyestra-1,3,5(10)-triene

226. Brd-k17016787-001-03-5

227. Brd-k17016787-001-16-7

228. Estra-1,5(10)-trien-3,16.alpha.,17.beta.-triol

229. Estra-1,5(10)-triene-3,16.alpha.,17.beta.-triol

230. 1,5-estratriene-3.beta.,16-.alpha.,17-.beta.-triol

231. 1,5-oestratriene-3-.beta.,16.alpha.,17.beta.-triol

232. 13b-methyl-1,3,5(10)-gonatriene-3,16a,17b-triol

233. Estra-1,5(10)-trien-3,16.alpha., 17.beta.-triol

234. Estra-1,5(10)-triene-3,16.alpha., 17.beta.-triol

235. Estriol, European Pharmacopoeia (ep) Reference Standard

236. Oestra-1,5(10)-triene-3,16.alpha., 17.beta.-triol

237. Oestra-1,5(10)-triene-3,16.alpha.,17.beta.-triol

238. 6ec6f23b-a991-4606-8bc7-146d915dab31

239. Estriol, United States Pharmacopeia (usp) Reference Standard

240. (16a,17b)-estra-1,3,5(10)-triene-3,16,17-triol

241. (s)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic Acidt-butyl Ester

242. Estra-1(10),2,4-triene-3,16,17-triol, (16alpha,17beta)-

243. Estra-1,5(10)-triene-3,16,17-triol, (16.alpha.,17.beta.)-

244. (9beta,13alpha,16beta,17beta)-estra-1(10),2,4-triene-3,16,17-triol

245. 13.beta.-methyl-1,3,5(10)-gonatriene-3,16.alpha.,17.beta.-triol

246. Estriol For System Suitability, European Pharmacopoeia (ep) Reference Standard

247. Estriol Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

248. (13s,16r,17r)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,16,17-triol

249. (8r,13s,16r,17r)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,16,17-triol

250. (8r,9s,13s,14s,16r,17r)-13-methyl-6,7,8,9,11,12,14,15,16, 17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 288.4 g/mol
Molecular Formula C18H24O3
XLogP32.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass288.17254462 g/mol
Monoisotopic Mass288.17254462 g/mol
Topological Polar Surface Area60.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity411
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

/Estriol is indicated as/ hormone replacement therapy for treatment of atrophic vaginitis and kraurosis in post-menopausal women.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


/Estriol is indicated for the/ treatment of pruritus vulvae and dyspareunia associated with atrophic vaginal epithelium.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


4.2 Drug Warning

Gynest Cream is not indicated during pregnancy. If pregnancy occurs during use of Gynest Cream, treatment should be withdrawn immediately.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


Gynest Cream contains arachis oil (peanut oil) and should not be applied by patients known to be allergic to peanuts. As there is a possible relationship between allergy to peanuts and allergy to soya, patients with soya allergy should also avoid Gynest Cream.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


Before initiating or re-instituting HRT, a complete personal and family medical history should be taken. Physical (including pelvic and breast) examination should be guided by this and by the contra-indications and warnings for use. During treatment, periodic check-ups are recommended of a frequency and nature adapted to the individual woman. Women should be advised what changes in their breasts should be reported to their doctor or nurse. Investigations, including mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


The risk of endometrial hyperplasia and carcinoma is increased when systemic estrogens are administered alone for prolonged periods of time. The endometrial safety of long-term or repeated use of topical vaginal estrogens is uncertain. Therefore, if repeated, treatment should be reviewed at least annually, with a special consideration given to any symptoms of endometrial hyperplasia or carcinoma.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


For more Drug Warnings (Complete) data for ESTRIOL (40 total), please visit the HSDB record page.


4.3 Drug Indication

Used as a test to determine the general health of an unborn fetus.


The treatment of hormone-dependent urinary incontinence due to sphincter mechanism incompetence in ovariohysterectomised bitches.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.


5.2 ATC Code

QG03CA04


G03CA04

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


G - Genito urinary system and sex hormones

G03 - Sex hormones and modulators of the genital system

G03C - Estrogens

G03CA - Natural and semisynthetic estrogens, plain

G03CA04 - Estriol


G - Genito urinary system and sex hormones

G03 - Sex hormones and modulators of the genital system

G03C - Estrogens

G03CC - Estrogens, combinations with other drugs

G03CC06 - Estriol


5.3 Absorption, Distribution and Excretion

Estriol is readily absorbed following intravaginal application. Peak serum estriol concentrations are generally observed within 2 hours following intravaginal application and remain elevated for 6 hours.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


Systemic bioavailability on vaginal administration is better than after oral administration. Intravaginal application of 1 mg estriol in women with senile atrophy of the vaginal epithelium results in serum levels similar to those seen after oral administration of 10 mg estriol.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


Plasma estriol levels increased from <90pmol/L (26 pg/mL) about fifty fold over a few hours after intravaginal administration of Gynest Cream. Eight to ten hours after administration, 50% of women still had estriol levels above 90pmol/L (26 pg/mL).

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


Estriol circulates with the blood, about 14% free, 8% bound to SHBG and the rest bound to albumin.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


More than 95% of estriol is excreted in the urine, predominantly in the form of glucuronides.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


5.4 Metabolism/Metabolites

Primary metabolites of estriol include the 16-alpha-glucuronide, 3-glucuronide, 3-sulfate and 3-sulfate 16-alpha-glucuronide.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


The metabolic disposition of estrogens includes oxidative metabolism (largely hydroxylation) and conjugative metabolism by glucuronidation, sulfonation and/or O-methylation. Estradiol is converted to estrone by a 17beta-hydroxysteroid dehydrogenase; the estrone produced is further metabolized to 16alpha-hydroxyoestrone and then to estriol.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V91 145 (2007)


Estriol is a common metabolite of estrone and estradiol-17-beta in animals and in humans. Estriol is excreted in humans as conjugated and unconjugated 2-hydroxy estriol after 2-hydroxylation.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V21 336 (1979)


5.5 Mechanism of Action

Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. The drug interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estriol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.


... Synthetic estriol, is chemically and biologically identical to endogenous human estriol. Estriol, a weak estrogen, is a natural metabolite of estradiol, the predominant estrogen. Estriol exerts estrogenicity by binding to estrogen receptors, present in the female genital tract. Estriol, oral or vaginal, similar to estradiol, corrects lowered proliferation and abnormal physiology in the atrophic vaginal epithelium seen in estrogen deficient states, such as after natural or surgical menopause. In contrast, the histology of the endometrium after using Gynest Cream rarely shows minor signs of proliferation in previously atrophic endometria.

Datapharm Communications Ltd; Electronic Medicines Compendium (eMC), Summary of Product Characteristics (SPC) for Gynest 0.01% w/w Cream (Last updated June 2009). Available from, as of March 16, 2011: https://www.medicines.org.uk/EMC/medicine/24108/SPC/Gynest+0.01++w+w+Cream/


Estrogens have an important role in the reproductive, skeletal, cardiovascular, and central nervous systems in women, and act principally by regulating gene expression. Biologic response is initiated when estrogen binds to a ligand-binding domain of the estrogen receptor resulting in a conformational change that leads to gene transcription through specific estrogen response elements (ERE) of target gene promoters; subsequent activation or repression of the target gene is mediated through 2 distinct transactivation domains (ie, AF-1 and AF-2) of the receptor. The estrogen receptor also mediates gene transcription using different response elements (ie, AP-1) and other signal pathways. Recent advances in the molecular pharmacology of estrogen and estrogen receptors have resulted in the development of selective estrogen receptor modulators (eg, clomiphene, raloxifene, tamoxifen, toremifene), agents that bind and activate the estrogen receptor but that exhibit tissue-specific effects distinct from estrogen. Tissue-specific estrogen-agonist or -antagonist activity of these drugs appears to be related to structural differences in their estrogen receptor complex (eg, specifically the surface topography of AF-2 for raloxifene) compared with the estrogen (estradiol)-estrogen receptor complex. A second estrogen receptor also has been identified, and existence of at least 2 estrogen receptors (ER-alpha, ER-beta) may contribute to the tissue-specific activity of selective modulators. While the role of the estrogen receptor in bone, cardiovascular tissue, and the CNS continues to be studied, emerging evidence indicates that the mechanism of action of estrogen receptors in these tissues differs from the manner in which estrogen receptors function in reproductive tissue. /Estrogen General Statement/

American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3130


Intracellular cytosol-binding proteins for estrogens have been identified in estrogen-responsive tissues including the female genital organs, breasts, pituitary, and hypothalamus. The estrogen-binding protein complex (ie, cytosol-binding protein and estrogen) distributes into the cell nucleus where it stimulates DNA, RNA, and protein synthesis. The presence of these receptor proteins is responsible for the palliative response to estrogen therapy in women with metastatic carcinoma of the breast. /Estrogen General Statement/

American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3130


Estrogens have generally favorable effects on blood cholesterol and phospholipid concentrations. Estrogens reduce LDL-cholesterol and increase HDL-cholesterol concentrations in a dose-related manner. The decrease in LDL-cholesterol concentrations associated with estrogen therapy appears to result from increased LDL catabolism, while the increase in triglyceride concentrations is caused by increased production of large, triglyceride-rich, very-low-density lipoproteins (VLDLs); changes in serum HDL-cholesterol concentrations appear to result principally from an increase in the cholesterol and apolipoprotein A-1 content of HDL2- and a slight increase in HDL3-cholesterol. /Estrogen General Statement/

American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3130


For more Mechanism of Action (Complete) data for ESTRIOL (12 total), please visit the HSDB record page.


API SUPPLIERS

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Transo-Pharm Handels GmbH

Germany

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Aspen API

Netherlands

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Bayer AG

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Bayer AG

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Merck & Co

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Merck & Co

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ASG Biochem

India

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China

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China

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USDMF

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Aspen Oss Bv

Netherlands
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 12141

Submission : 1996-09-23

Status : Active

Type : II

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Proquina Sa

Germany

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Proquina Sa

Germany
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 12476

Submission : 1997-04-18

Status : Inactive

Type : II

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Diosynth Bv

United Kingdom

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Diosynth Bv

United Kingdom
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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 3837

Submission : 1980-05-21

Status : Inactive

Type : II

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Organon Inc

U.S.A

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Organon Inc

U.S.A
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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 1407

Submission : 1969-08-12

Status : Inactive

Type : II

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R0-CEP 2020-208 - Rev 01
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2022-11-25
1203
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ASPEN OSS B.V. Oss NL

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Certificate Number : R0-CEP 2020-208 - Rev 01

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Type : Chemical

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Certificate Number : R1-CEP 1999-179 - Rev 05

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Certificate Number : R1-CEP 2003-160 - Rev 05

Status : Valid

Issue Date : 2021-09-24

Type : Chemical

Substance Number : 1203

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Certificate Number : R1-CEP 2013-277 - Rev 01

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Estriol

Registration Number : 218MF10506

Registrant's Address : Kloosterstraat 6, 5349 AB Oss, the Netherlands

Initial Date of Registration : 2006-05-15

Latest Date of Registration : 2024-11-13

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EU WC

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ASG Biochem

India
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Estriol EP

Date of Issue : 2021-05-05

Valid Till : 2024-05-05

Written Confirmation Number : WC-0497

Address of the Firm : Ganganagar, 24Parganas (North)700312 West bengal

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NDC API

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Aspen Oss B.V.

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ESTRIOL

NDC Package Code : 60870-0259

Start Marketing Date : 1980-04-25

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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BePharma
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ESTRIOL

NDC Package Code : 43647-234

Start Marketing Date : 2019-04-01

End Marketing Date : 2026-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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ESTRIOL

NDC Package Code : 71052-032

Start Marketing Date : 2017-02-01

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (50g/50g)

Marketing Category : BULK INGREDIENT

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ESTRIOL

NDC Package Code : 76420-049

Start Marketing Date : 2017-02-10

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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Hapila GmbH

Germany
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Hapila GmbH

Germany
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ESTRIOL

NDC Package Code : 71448-0001

Start Marketing Date : 2017-06-01

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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BePharma
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ESTRIOL

NDC Package Code : 62991-2159

Start Marketing Date : 2015-08-18

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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N.V. Organon

U.S.A
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N.V. Organon

U.S.A
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ESTRIOL

NDC Package Code : 12860-0259

Start Marketing Date : 1980-04-25

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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BePharma
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ESTRIOL

NDC Package Code : 82393-108

Start Marketing Date : 2021-12-13

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT FOR HUMAN P...

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09

BePharma
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ESTRIOL

NDC Package Code : 44132-007

Start Marketing Date : 2012-08-06

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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BePharma
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ESTRIOL

NDC Package Code : 49452-2794

Start Marketing Date : 1994-05-01

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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01

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Virtual BoothTranso-Pharm GmbH works globally to supply Active Pharmaceutical Ingredients adhering to the highest quality & GMP standards.

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Estriol

About the Company : Founded in 1987, Transo-Pharm is a fully licensed and certified global distributor of pharmaceutical components for the health and veterinary industries. The company supports its c...

Founded in 1987, Transo-Pharm is a fully licensed and certified global distributor of pharmaceutical components for the health and veterinary industries. The company supports its customers throughout the complete lifecycle of APIs, from product development to market research, sourcing, import-export and sales. Transo-Pharm offers a diverse range of products. It qualifies manufacturers for full compliance and serves both as a valuable sourcing agent for its clients and a regulatory marketing agent for API manufacturers. It has offices in Shanghai, Hong Kong, Singapore, the United States, and an affiliated office in Mumbai.
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Aspen API

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Estriol

About the Company : Aspen API is the cooperative entity formed by Aspen Oss in the Netherlands and Fine Chemicals Corporation in South Africa. With quality, compliance, and teamwork at its core, Aspen...

Aspen API is the cooperative entity formed by Aspen Oss in the Netherlands and Fine Chemicals Corporation in South Africa. With quality, compliance, and teamwork at its core, Aspen API works tirelessly to deliver top-quality APIs to clients worldwide. Aspen API has a portfolio of over 58 high-quality APIs, including high potency, oncology, peptides, narcotics, analgesics, botanical extractions, and biochemicals. Aspen API places a strong emphasis on sustainability. It employs eco-friendly technologies and solvents in its chemical processes, ensuring responsible and environmentally conscious manufacturing.
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ASG Biochem

India
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ASG Biochem

India
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Estriol

About the Company : ASG Biochem Private Limited at Ganganagar near Kolkata, West Bengal, India, is a bulk API manufacturing company of the New Delhi based diversified APEEJAY STYA GROUP. The unit acqu...

ASG Biochem Private Limited at Ganganagar near Kolkata, West Bengal, India, is a bulk API manufacturing company of the New Delhi based diversified APEEJAY STYA GROUP. The unit acquired from AKZO NOBEL N.V., the Netherlands in 2004 is engaged in the synthesis of specialized APIs, in particular, hormones and intermediates.The unit has global exports including intermediates / penultimates to the European Union apart from supply to internal Group companies. In addition, the plant also holds ISO 9001-2008 and ISO 14001:2004 certification from DNV, the Netherlands.The unit has Japan accreditation for manufacturing APIs.
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Estriol

About the Company : Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Ex...

Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Excipients, Herbal extracts, Formulation of Chinese & Western Medicine. With abundant economic strength, the group has successfully developed to a pharmaceutical group enterprise wich intergrets operation of medicine & related products, processing & manufacturing, and importation & exportation together.
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Estriol

About the Company : Nanjing Bold Chemical Co., Ltd. is a high-tech enterprise dedicated to product development, production, sales and supply chain management in the field of pharmaceutical chemistry. ...

Nanjing Bold Chemical Co., Ltd. is a high-tech enterprise dedicated to product development, production, sales and supply chain management in the field of pharmaceutical chemistry. Our products and services mainly include a full range of functional pharmaceutical excipients, APIs, pharmaceutical intermediates, custom synthesis of new chemical substances and other related fields. Designed to provide customers globally with systematic product resources. We are available in various pharmaceutical excipients, APIs and pharmaceutical intermediates that comply with USP, EP, JP, and ChP standards.
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Estriol

About the Company : With the high technology and excellent services, Xianju pharma earned a top worldwide reputation for quality in pharmaceutical industry. Xianju pharma has dedicated to scientific r...

With the high technology and excellent services, Xianju pharma earned a top worldwide reputation for quality in pharmaceutical industry. Xianju pharma has dedicated to scientific research since we were established in 1972.We developed over 100 Active Pharmaceutical Ingredients and finished formulations from then on , becoming a leader of steroids and hormones manufacturing in China. Xianju pharma has full of confidence to be a global supplier of active pharmaceutical ingredients with customized solid state specifications and unparalleled intellectual property that accomplishment our cooperation.
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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1635445800,"product":"E1877-VAR ESTRIOL 16A-(B-D-GLUCURONIDE)(","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINKROAD,INDL.AREA,ANEKAL TQ,","city":"BANGALORE","supplier":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"MERCK GROUP","customerCountry":"UNITED STATES","quantity":"0.00","actualQuantity":"0.2","unit":"GMS","unitRateFc":"155535.8","totalValueFC":"413.8","currency":"INR","unitRateINR":155000,"date":"29-Oct-2021","totalValueINR":"31000","totalValueInUsd":"413.8","indian_port":"BANGALORE AIR","hs_no":"29379090","bill_no":"5675637","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINKROAD,INDL.AREA,ANEKAL TQ,, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1635445800,"product":"E1877-VAR ESTRIOL 16A-(B-D-GLUCURONIDE)(","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINKROAD,INDL.AREA,ANEKAL TQ,","city":"BANGALORE","supplier":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"MERCK GROUP","customerCountry":"UNITED STATES","quantity":"0.00","actualQuantity":"0.3","unit":"GMS","unitRateFc":"155535.1","totalValueFC":"627.4","currency":"INR","unitRateINR":156666.66666666669,"date":"29-Oct-2021","totalValueINR":"47000","totalValueInUsd":"627.4","indian_port":"BANGALORE AIR","hs_no":"29379090","bill_no":"5675637","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINKROAD,INDL.AREA,ANEKAL TQ,, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1657477800,"product":"E1877-VAR - ESTRIOL 16A-(B-D-GLUCURONIDE","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N","city":"BANGALORE","supplier":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"MERCK GROUP","customerCountry":"UNITED STATES","quantity":"0.00","actualQuantity":"0.2","unit":"GMS","unitRateFc":"98362.1","totalValueFC":"251.5","currency":"INR","unitRateINR":100000,"date":"11-Jul-2022","totalValueINR":"20000","totalValueInUsd":"251.5","indian_port":"BANGALORE AIR","hs_no":"29379090","bill_no":"2748107","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1657477800,"product":"E1877-VAR - ESTRIOL 16A-(B-D-GLUCURONIDE","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N","city":"BANGALORE","supplier":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"MERCK GROUP","customerCountry":"UNITED STATES","quantity":"0.00","actualQuantity":"0.3","unit":"GMS","unitRateFc":"98362.1","totalValueFC":"377.3","currency":"INR","unitRateINR":100000,"date":"11-Jul-2022","totalValueINR":"30000","totalValueInUsd":"377.3","indian_port":"BANGALORE AIR","hs_no":"29379090","bill_no":"2748107","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1657477800,"product":"E1877-VAR - ESTRIOL 16A-(B-D-GLUCURONIDE","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N","city":"BANGALORE","supplier":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"MERCK GROUP","customerCountry":"UNITED STATES","quantity":"0.00","actualQuantity":"0.5","unit":"GMS","unitRateFc":"98362.1","totalValueFC":"616.2","currency":"INR","unitRateINR":98000,"date":"11-Jul-2022","totalValueINR":"49000","totalValueInUsd":"616.2","indian_port":"BANGALORE AIR","hs_no":"29379090","bill_no":"2748107","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BANGALORE AIR","supplierAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N, BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720463400,"product":"E1877-VAR - ESTRIOL 16A-(B-D-GLUCURONIDE) (6000 MG)","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK","city":"BANGALORE","supplier":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"CHICAGO O\\'HARE INT\\'L","customer":"SIGMA - ALDRICH MANUFACTURING LLC","customerCountry":"UNITED STATES","quantity":"0.01","actualQuantity":"6","unit":"GMS","unitRateFc":"107023.1","totalValueFC":"7646","currency":"INR","unitRateINR":106523.09833333333,"date":"09-Jul-2024","totalValueINR":"639138.59","totalValueInUsd":"7646","indian_port":"Bangalore Air","hs_no":"29372300","bill_no":"2291425","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK, BANGALORE","customerAddress":""},{"dataSource":"API Import","activeIngredients":"ESTRIOL","year":"2021","qtr":"Q1","strtotime":1616697000,"product":"ESTRIOL RAW MATERIAL (SAMPLE FOR RESEARCH AND ANALYSIS , FOC)","address":"A-8, II FLOOR AISHYWARYA COMPLEXRUKMINIPURI COLONY DR.A S RAO NAGAR","city":"HYDERABAD.AP","supplier":"ASPEN API","supplierCountry":"GERMANY","foreign_port":"HAMBURG - FUHLSBUETT","customer":"ALPHAMED FORMULATIONS PRIVATE ","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"12","unit":"GMS","unitRateFc":"13.9","totalValueFC":"202","currency":"EUR","unitRateINR":"1225.8","date":"26-Mar-2021","totalValueINR":"14709.51","totalValueInUsd":"202","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"3314501","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"HAMBURG - FUHLSBUETT","supplierAddress":"","customerAddress":"A-8, II FLOOR AISHYWARYA COMPLEXRUKMINIPURI COLONY DR.A S RAO NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1638383400,"product":"FE22836 ESTRIOL","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N","city":"BANGALORE","supplier":"BIOSYNTH AG","supplierCountry":"CHINA","foreign_port":"LONDON METROPOLITAN","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.17","actualQuantity":"0.165","unit":"KGS","unitRateFc":"8690","totalValueFC":"1490.6","currency":"USD","unitRateINR":"681372.5","date":"02-Dec-2021","totalValueINR":"112426.46","totalValueInUsd":"1490.6","indian_port":"BANGALORE AIR","hs_no":"29372300","bill_no":"6507555","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"LONDON METROPOLITAN","supplierAddress":"","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723141800,"product":"ESTRIOL MICRONIZED (FOR TESTING PURPOSE)","address":"NO.18,DR NAIR ROAD, T NAGAR,","city":"CHENNAI","supplier":"ASPEN API","supplierCountry":"NETHERLANDS","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"STERIL-GENE LIFE SCIENCES (P) LTD","customerCountry":"INDIA","quantity":"0.08","actualQuantity":"80","unit":"GMS","unitRateFc":"25","totalValueFC":"2199.6","currency":"EUR","unitRateINR":"2306.3","date":"09-Aug-2024","totalValueINR":"184500","totalValueInUsd":"2199.6","indian_port":"Madras Air","hs_no":"29372300","bill_no":"4963426","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Micronized","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"KLOOSTERSTRAAT 6 5349 AB OSSTHE NETHERLANDSSDNF NETHERLANDS","customerAddress":"NO.18,DR NAIR ROAD, T NAGAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1735497000,"product":"ESTRIOL MICRONIZED (F.O.C. - SAMPLE) ESTRIOL MICRONIZED (F.O.C. - SAMPLE)","address":"13, SURYODAYA MILL ESTATE,","city":"MUMBAI ,MAHARASHTRA","supplier":"ASPEN API","supplierCountry":"NETHERLANDS","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"PREGNA INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"50","unit":"GMS","unitRateFc":"14.1","totalValueFC":"712.3","currency":"USD","unitRateINR":"1210.5","date":"30-Dec-2024","totalValueINR":"60525","totalValueInUsd":"712.3","indian_port":"Bombay Air","hs_no":"29372300","bill_no":"7519136","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Micronized","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"Kloosterstraat 6 5349 AB Oss SDNF SDNF NETHERLANDS","customerAddress":"13, SURYODAYA MILL ESTATE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736188200,"product":"ESTRIOL (50-27-1) ESTRIOL (50-27-1)","address":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ","city":"AMRITSAR,PUNJAB","supplier":"M\/S. SUNDAY BIOTECH CO.LTD","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"KWALITY PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"100","unit":"GMS","unitRateFc":"5","totalValueFC":"502.2","currency":"USD","unitRateINR":"433","date":"07-Jan-2025","totalValueINR":"43300","totalValueInUsd":"502.2","indian_port":"Delhi Air","hs_no":"29339990","bill_no":"7651642","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"ADD: ROOM 202,BUILDING 5,NANYI DISTRICT NO.99 XUEFU STREET,LICHENG DISTRICT,QUANZHOU CITY FUJIAN PR CHINA","customerAddress":"VILLAGE NAG KALAN,MAJITHA ROAD,MAJ"}]
26-Mar-2021
07-Jan-2025
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
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Number of Transactions

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FDF Dossiers

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01

Aspen API

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

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Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Oestriol Aspen

Dosage Form : TABLET

Dosage Strength : 1 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

02

Aspen API

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : TABLETT

Dosage Strength : 1 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

03

Aspen API

Netherlands
  • fda
  • EDQM
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Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : VAGINALKRÄM

Dosage Strength : 1 MG/G

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

04

Aspen API

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : TABLETT

Dosage Strength : 2 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

05

Aspen API

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : VAGITORIUM

Dosage Strength : 0,5 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

06

Aspen API

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Norway

Estriol

Brand Name : Ovest Erin

Dosage Form : Antic-calc Tablet

Dosage Strength : 1 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

Aspen API Comapny Banner

07

Aspen API

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Norway

Estriol

Brand Name : Ovest Erin

Dosage Form : Antic-calc Tablet

Dosage Strength : 2 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

Aspen API Comapny Banner

08

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BePharma
Not Confirmed

Estriolum

Brand Name : Ovestin

Dosage Form : Tabl

Dosage Strength : 1mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Aspen API Comapny Banner

09

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BePharma
Not Confirmed

Estriolum

Brand Name : Ovestin

Dosage Form : Vag Cr M Applicator

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Aspen API Comapny Banner

10

arrow
BePharma
Not Confirmed

Estriol

Brand Name : Ovestin

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Aspen API Comapny Banner
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Europe

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01

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Oestriol Aspen

Dosage Form : TABLET

Dosage Strength : 1 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

02

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : TABLETT

Dosage Strength : 1 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

03

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : VAGINALKRÄM

Dosage Strength : 1 MG/G

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

04

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : TABLETT

Dosage Strength : 2 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

05

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

estriol

Brand Name : Ovesterin

Dosage Form : VAGITORIUM

Dosage Strength : 0,5 MG

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Aspen API Comapny Banner

06

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Norway

Estriol

Brand Name : Ovest Erin

Dosage Form : Antic-calc Tablet

Dosage Strength : 1 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

Aspen API Comapny Banner

07

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
Digital Content Digital Content

Regulatory Info :

Registration Country : Norway

Estriol

Brand Name : Ovest Erin

Dosage Form : Antic-calc Tablet

Dosage Strength : 2 mg

Packaging : Blister

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

Aspen API Comapny Banner

08

arrow
BePharma
Not Confirmed

Estriolum

Brand Name : Ovestin

Dosage Form : Tabl

Dosage Strength : 1mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Aspen API Comapny Banner

09

arrow
BePharma
Not Confirmed

Estriolum

Brand Name : Ovestin

Dosage Form : Tabl

Dosage Strength : 1mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Aspen API Comapny Banner

10

arrow
BePharma
Not Confirmed

Estriolum

Brand Name : Ovestin

Dosage Form : Ovula

Dosage Strength : 0.5mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

Aspen API Comapny Banner
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Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Australia

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01

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BePharma
Not Confirmed

Estriol

Brand Name : Ovestin

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Aspen API Comapny Banner

02

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BePharma
Not Confirmed

Estriol

Brand Name : Ovestin Ovula

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Aspen API Comapny Banner

03

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BePharma
Not Confirmed

Estriol

Brand Name : Ovestin Ovula

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

Aspen API Comapny Banner

04

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BePharma
Not Confirmed

Estriol

Brand Name : Ovestin

Dosage Form :

Dosage Strength :

Packaging : 1

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Australia

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South Africa

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01

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BePharma
Not Confirmed

Estriol

Brand Name : Synapause Vaginal Cream

Dosage Form : VCR

Dosage Strength : 0.1g/100g

Packaging : 15X1g/100g

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

Aspen API Comapny Banner

02

Adcock Ingram Limited

South Africa
BePharma
Not Confirmed
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Adcock Ingram Limited

South Africa
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BePharma
Not Confirmed

Estriol

Brand Name : GYNOFLOR

Dosage Form : VAT

Dosage Strength : 0.03mg

Packaging : 12X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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03

Adcock Ingram Limited

South Africa
BePharma
Not Confirmed
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Adcock Ingram Limited

South Africa
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BePharma
Not Confirmed

Estriol

Brand Name : Synapause-E3

Dosage Form : TAB

Dosage Strength : 2mg

Packaging : 30X1mg

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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Regulatory FDF Prices

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01

Brand Name : Ovest Erin

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

Flag Netherlands
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RX/OTC/DISCN :

Estriol

Dosage Form : Antic-calc Tablet

Dosage Strength : 1 mg

Price Per Pack (Euro) : 16.5

Published in :

Country : Norway

RX/OTC/DISCN :

Aspen API Comapny Banner

02

Brand Name : Ovestin

South Africa
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BePharma
Not Confirmed

Estriol

Dosage Form : Tabl

Dosage Strength : 1mg

Price Per Pack (Euro) : 3.73

Published in :

Country : Switzerland

RX/OTC/DISCN : Class B

Aspen API Comapny Banner

03

Brand Name : Ovest Erin

Netherlands
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothAspen API. More than just an API™

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RX/OTC/DISCN :

Estriol

Dosage Form : Antic-calc Tablet

Dosage Strength : 2 mg

Price Per Pack (Euro) : 26.301

Published in :

Country : Norway

RX/OTC/DISCN :

Aspen API Comapny Banner

04

Brand Name : Ovestin

South Africa
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BePharma
Not Confirmed

Estriol

Dosage Form : Ovula

Dosage Strength : 0.5mg

Price Per Pack (Euro) : 4.79

Published in :

Country : Switzerland

RX/OTC/DISCN : Class B

Aspen API Comapny Banner

05

Brand Name : Ovestin

South Africa
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BePharma
Not Confirmed

Estriol

Dosage Form : Tabl

Dosage Strength : 1mg

Price Per Pack (Euro) : 10.01

Published in :

Country : Switzerland

RX/OTC/DISCN : Class B

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Brand Name : Ovestin

South Africa
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Estriol

Dosage Form : Vag Cr M Applicator

Dosage Strength :

Price Per Pack (Euro) : 8.27

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Country : Switzerland

RX/OTC/DISCN : Class B

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Brand Name : Ovestin

U.S.A
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Brand Name : Ovestin

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Estriol

Dosage Form :

Dosage Strength : 20 Cpr 1 Mg  

Price Per Pack (Euro) : 4.64

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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Brand Name : Colpogyn

Italy
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Brand Name : Colpogyn

Italy
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Estriol

Dosage Form : Oestriol 1Mg 20 Units Use Gyneco...

Dosage Strength : 20 ov vag 1 mg

Price Per Pack (Euro) : 7.85

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Country : Italy

RX/OTC/DISCN : Class A

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Brand Name : Trofogin

Italy
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Brand Name : Trofogin

Italy
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Estriol

Dosage Form : Oestriol 30G Cream Gynecological...

Dosage Strength : cream vag 30 g + 6 applic

Price Per Pack (Euro) : 3.98

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Country : Italy

RX/OTC/DISCN : Class A

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Brand Name : Donaflor

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Estriol

Dosage Form :

Dosage Strength : 12 Cpr Vag 50 Mg + 30 Mcg

Price Per Pack (Euro) : 16.5

Published in :

Country : Italy

RX/OTC/DISCN : Class C

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EDQM

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EDQM, Council of Europe

Estriol impurity A

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Estriol impurity A

CAS Number : N/A

Quantity Per Vial : 20 mg

Sale Unit : 1

Order Code : E1680005

Batch No : 2

Price (€) : 79

Storage : +5°C ± 3°C

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Estriol

CAS Number : 50-27-1

Quantity Per Vial : 50 mg

Sale Unit : 1

Order Code : E1680000

Batch No : 3

Price (€) : 79

Storage : +5°C ± 3°C

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Estriol (100 mg)

CAS Number : 50-27-1

Quantity Per Vial : 100

Sale Unit : mg

Price : $245.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

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Code/Batch No : Catalog #1254508 / R110J0

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Estriol Related Compound A (25 mg) (Estra- 1,...

CAS Number : 246021-20-5

Quantity Per Vial : 25

Sale Unit : mg

Price : $730.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

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Code/Batch No : Catalog #1254519 / F07960

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ABOUT THIS PAGE

Looking for 50-27-1 / Estriol API manufacturers, exporters & distributors?

Estriol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Estriol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Estriol manufacturer or Estriol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Estriol manufacturer or Estriol supplier.

PharmaCompass also assists you with knowing the Estriol API Price utilized in the formulation of products. Estriol API Price is not always fixed or binding as the Estriol Price is obtained through a variety of data sources. The Estriol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Estriol

Synonyms

50-27-1, Oestriol, Trihydroxyestrin, Aacifemine, Estratriol, Ovestin

Cas Number

50-27-1

Unique Ingredient Identifier (UNII)

FB33469R8E

About Estriol

A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.

Estriol Manufacturers

A Estriol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Estriol, including repackagers and relabelers. The FDA regulates Estriol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Estriol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Estriol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Estriol Suppliers

A Estriol supplier is an individual or a company that provides Estriol active pharmaceutical ingredient (API) or Estriol finished formulations upon request. The Estriol suppliers may include Estriol API manufacturers, exporters, distributors and traders.

click here to find a list of Estriol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Estriol USDMF

A Estriol DMF (Drug Master File) is a document detailing the whole manufacturing process of Estriol active pharmaceutical ingredient (API) in detail. Different forms of Estriol DMFs exist exist since differing nations have different regulations, such as Estriol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Estriol DMF submitted to regulatory agencies in the US is known as a USDMF. Estriol USDMF includes data on Estriol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Estriol USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Estriol suppliers with USDMF on PharmaCompass.

Estriol JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Estriol Drug Master File in Japan (Estriol JDMF) empowers Estriol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Estriol JDMF during the approval evaluation for pharmaceutical products. At the time of Estriol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Estriol suppliers with JDMF on PharmaCompass.

Estriol CEP

A Estriol CEP of the European Pharmacopoeia monograph is often referred to as a Estriol Certificate of Suitability (COS). The purpose of a Estriol CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Estriol EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Estriol to their clients by showing that a Estriol CEP has been issued for it. The manufacturer submits a Estriol CEP (COS) as part of the market authorization procedure, and it takes on the role of a Estriol CEP holder for the record. Additionally, the data presented in the Estriol CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Estriol DMF.

A Estriol CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Estriol CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Estriol suppliers with CEP (COS) on PharmaCompass.

Estriol WC

A Estriol written confirmation (Estriol WC) is an official document issued by a regulatory agency to a Estriol manufacturer, verifying that the manufacturing facility of a Estriol active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Estriol APIs or Estriol finished pharmaceutical products to another nation, regulatory agencies frequently require a Estriol WC (written confirmation) as part of the regulatory process.

click here to find a list of Estriol suppliers with Written Confirmation (WC) on PharmaCompass.

Estriol NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Estriol as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Estriol API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Estriol as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Estriol and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Estriol NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Estriol suppliers with NDC on PharmaCompass.

Estriol GMP

Estriol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Estriol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Estriol GMP manufacturer or Estriol GMP API supplier for your needs.

Estriol CoA

A Estriol CoA (Certificate of Analysis) is a formal document that attests to Estriol's compliance with Estriol specifications and serves as a tool for batch-level quality control.

Estriol CoA mostly includes findings from lab analyses of a specific batch. For each Estriol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Estriol may be tested according to a variety of international standards, such as European Pharmacopoeia (Estriol EP), Estriol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Estriol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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