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Estrogens Conjugated

Symbiotec Conjugated Estrogens

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Jai Radhe Sales is your partner for all your sourcing needs.

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xyz-pharma-m-2024-10-07

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Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

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Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

17 API Suppliers, 14 USDMF, 1 CEP/COS, 2 EU WC, 1 KDMF, 7 NDC API, 4 Listed Suppliers, $ API Reference Price

17 API Suppliers
14 USDMF
1 CEP/COS
2 EU WC
1 KDMF
7 NDC API
4 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

108 FDF Dossiers, 38 FDA Orange Book, 44 Europe, 10 Canada, 14 South Africa, 2 Listed Dossiers

108 FDF Dossiers
38 FDA Orange Book
44 Europe
10 Canada
14 South Africa
2 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - EQ 20MG BASE;0.45MG, TABLET;ORAL - 0.3MG, TABLET;ORAL - 0.45MG, TABLET;ORAL - 0.625MG, TABLET;ORAL - 0.9MG, TABLET;ORAL - 1.25MG

drugProductComposition
TABLET;ORAL - EQ 20MG BASE;0.45MG
TABLET;ORAL - 0.3MG
TABLET;ORAL - 0.45MG
TABLET;ORAL - 0.625MG
TABLET;ORAL - 0.9MG
TABLET;ORAL - 1.25MG

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 2 DKSH, 1 Jai Radhe Sales, 3 Faran Shimi Pharmaceutical, 10 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 5 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 11 BASF, 11 Corel Pharma Chem, 4 DFE Pharma, 1 Finar, 8 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 30 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 10 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 15 Roquette, 13 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 3 The Dow Chemical Company, 2 Vasa Pharmachem, 1 Vertellus

EXCIPIENTS BY APPLICATIONS

57 Fillers, Diluents & Binders, 45 Coating Systems & Additives, 27 Direct Compression, 27 Controlled & Modified Release, 18 Thickeners and Stabilizers, 16 Granulation, 15 Solubilizers, 15 Co-Processed Excipients, 13 Film Formers & Plasticizers, 10 Topical, 10 Lubricants & Glidants, 10 Disintegrants & Superdisintegrants, 10 Taste Masking, 8 Parenteral, 6 Chewable & Orodispersible Aids, 5 Emulsifying Agents, 5 Empty Capsules, 4 Vegetarian Capsules, 4 API Stability Enhancers, 4 Coloring Agents, 3 Rheology Modifiers, 3 Surfactant & Foaming Agents

DIGITAL CONTENT

5 DATA COMPILATION #PharmaFlow, 10 NEWS #PharmaBuzz

media
5 DATA COMPILATION #PharmaFlow
10 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

50 Finished Drug Prices, 5 Annual Reports

globalSalesInformation
50 Finished Drug Prices
5 Annual Reports

MARKET PLACE

12 APIs, 1 FDF Dossiers

marketPlace
12 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 US Patents

patents
4 US Patents

REF. STANDARDS & IMPURITIES

3 EDQM

otherSolutions
3 EDQM

Symbiotec Conjugated Estrogens

Synopsis

ACTIVE PHARMA INGREDIENTS

17

API Suppliers

14

USDMF

1

CEP/COS

CEP/COS Certifications

0

JDMF

2

EU WC

1

KDMF

7

NDC API

0

VMF

4

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 1,062

MARKET PLACE

12

API

1

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

108

FDF Dossiers

38

FDA Orange Book

FDA (Orange Book)

44

Europe

10

Canada

0

Australia

14

South Africa

2

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

3

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

4

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

5

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

10

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

2,829

Finished Drug Prices

186 RELATED EXCIPIENT COMPANIES

315EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sodium estrone sulfate, Estrone sodium sulfate, 438-67-5, Estrone sodium sulphate, Estrone 3-sulfate sodium salt, Conestoral

Molecular Formula

C₁₈H₂₁NaO₅S

Molecular Weight

372.4 g/mol

InChI Key

VUCAHVBMSFIGAI-ZFINNJDLSA-M

FDA UNII

6K6FDA543A

Conjugated Estrogens

1 2D Structure

Conjugated Estrogens

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfate

2.1.2 InChI

InChI=1S/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14-,15-,16+,18+;/m1./s1

2.1.3 InChI Key

VUCAHVBMSFIGAI-ZFINNJDLSA-M

2.1.4 Canonical SMILES

CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)[O-].[Na+]

2.1.5 Isomeric SMILES

C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

6K6FDA543A

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Estrone Sulfate

2. Estrone Sulfate, 14c-labeled

3. Estrone Sulfate, 16-(14)c-labeled

4. Estrone Sulfate, Ammonium Salt

5. Estrone Sulfate, Potassium Salt

6. Estrone Sulfate, Sodium Salt

7. Estrone-3-sulfate

8. Evex

9. Oestrone Sulphate

10. Potassium Estrone Sulfate

11. Sodium Estrone Sulfate

2.3.2 Depositor-Supplied Synonyms

1. Sodium Estrone Sulfate

2. Estrone Sodium Sulfate

3. 438-67-5

4. Estrone Sodium Sulphate

5. Estrone 3-sulfate Sodium Salt

6. Conestoral

7. Hyhorin

8. Morestin

9. Estrone Sulfate Sodium

10. Par Estro

11. Estrone Sulfate Sodium Salt

12. Estrone-3-sulfate Sodium Salt

13. Sodium Estrone Sulphate

14. Sodium Estrone 3-sulfate

15. Oestrone-3-sulphate Sodium Salt

16. Estrogenic Substances (conjugated)

17. Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, Sodium Salt

18. 6k6fda543a

19. Chebi:8389

20. 17-oxoestra-1,3,5(10)-trien-3-yl Sodium Sulfate

21. Nsc-18313

22. Estrone Sulfate (sodium)

23. Sodium;[(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Sulfate

24. Sodium Estrone-3-sulfate

25. 1,3,5(10)-estratrien-3-ol-17-one Sulphate, Sodium Salt

26. Smr000058772

27. Einecs 207-120-4

28. Nsc 18313

29. Unii-6k6fda543a

30. Conjugated Estrogens: Sodium Estrone Sulfate

31. Estrone3-sulfatesodiumsalt

32. Sodium (8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta(a)phenanthren-3-yl Sulfate

33. Sodium (8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthren-3-yl Sulfate

34. Sodium 17-oxoestra-1(10),2,4-trien-3-yl Sulfate

35. Estrone, Hydrogen Sulfate, Sodium Salt

36. Schembl4616

37. Mls000069757

38. Mls001424259

39. Chembl2106240

40. Dtxsid00860005

41. Dtxsid70881181

42. Hms2052j05

43. Hms2232j23

44. Discontinued. See E889070

45. Akos015967195

46. Estrone Sodium Sulfate [vandf]

47. Ccg-101163

48. Hy-113293b

49. Nc00413

50. Estrone Sodium Sulfate [who-dd]

51. Cs-0108249

52. D00312

53. Q4118295

54. Sodium 17-oxoestra-1,3,5(10)-trien-3-yl Sulfate

55. Estrone 3-sulfate Sodium Salt, Stabilized With Tris

56. Estra-1,3,5(10)-trien-17-one 3-(sulfooxy) Sodium Salt

57. Sodium [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Sulfate

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₁NaO₅S
Molecular Weight	372.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	372.10073922 g/mol
Monoisotopic Mass	372.10073922 g/mol
Topological Polar Surface Area	91.9 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	630
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Premarin
PubMed Health	Conjugated Estrogens (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Musculoskeletal Agent
Drug Label	Premarin Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average com...
Active Ingredient	Estrogens, conjugated
Dosage Form	Tablet; Cream; Injectable
Route	oral; Injection; Oral; Topical, vaginal
Strength	25mg/vial; 0.45mg; 1.25mg; 0.625mg/gm; 0.625mg; 0.9mg; 0.3mg
Market Status	Prescription
Company	Wyeth Pharms

2 of 2
Drug Name	Premarin
PubMed Health	Conjugated Estrogens (By mouth)
Drug Classes	Endocrine-Metabolic Agent, Musculoskeletal Agent
Drug Label	Premarin Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average com...
Active Ingredient	Estrogens, conjugated
Dosage Form	Tablet; Cream; Injectable
Route	oral; Injection; Oral; Topical, vaginal
Strength	25mg/vial; 0.45mg; 1.25mg; 0.625mg/gm; 0.625mg; 0.9mg; 0.3mg
Market Status	Prescription
Company	Wyeth Pharms

API SUPPLIERS

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USDMF

01

Symbiotec Pharmalab Private Ltd

India

CPhI India 2024

Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

Contact Supplier

Contact Supplier

India

Digital Content

Esterified Estrogens Usp

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 27920

Submission : 2014-02-19

Status : Active

Type : II

Symbiotec Pharmalab

Product Web Link

Digital Content

Corporate PDF

02

Aspen Oss Bv

Netherlands

CPhI India 2024

Aspen API. More than just an API.

Contact Supplier

Contact Supplier

Netherlands

Digital Content

Conjugated Estrogens Type Cn

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 34883

Submission : 2020-06-09

Status : Active

Type : II

Aspen API Comapny Banner

Product Web Link

Digital Content

03

Nv Organon

U.S.A

Pharmtech & Ingredients

Not Confirmed

04

Organon Inc

U.S.A

Pharmtech & Ingredients

Not Confirmed

05

Plantex Ltd Chemical And Pharmaceuti...

Israel

Pharmtech & Ingredients

Not Confirmed

06

Teva Pharmaceutical Industries Ltd

Israel

Pharmtech & Ingredients

Not Confirmed

07

Teva Pharmaceutical Industries Ltd

Israel

Pharmtech & Ingredients

Not Confirmed

08

Ayerst Laboratories Inc Div American...

U.S.A

Pharmtech & Ingredients

Not Confirmed

09

Organics Div La Grange Inc

Country

Pharmtech & Ingredients

Not Confirmed

10

Natural Biologics Llc

Country

Pharmtech & Ingredients

Not Confirmed

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CEP/COS

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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Lead Product(s) : Conjugated Estrogens

Therapeutic Area : Obstetrics/Gynecology (Women’s Health)

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Avion Pharmaceuticals

Deal Size : Undisclosed

Deal Type : Partnership

Aspen Concludes Strategic Partnership with U.S-Based Avion Pharmaceuticals

Details : Avion Pharmaceuticals gets exclusive rights to relaunch Cenestin® in the USA. Cenestin® is the only plant-derived mixture of nine conjugated estrogens indicated for treatment of moderate to severe symptoms of vasomotor, and vulvar and vaginal atrophy d...

Brand Name : Cenestin

Molecule Type : Small molecule

Upfront Cash : Undisclosed

November 12, 2020

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FDF Dossiers

01

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC A

Brand Name : CENESTIN

Dosage Form : TABLET;ORAL

Dosage Strength : 0.3MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 2002-06-21

Application Number : 20992

Regulatory Info : DISCN

Registration Country : USA

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02

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC A

Brand Name : CENESTIN

Dosage Form : TABLET;ORAL

Dosage Strength : 0.625MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 1999-03-24

Application Number : 20992

Regulatory Info : DISCN

Registration Country : USA

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03

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC A

Brand Name : CENESTIN

Dosage Form : TABLET;ORAL

Dosage Strength : 0.9MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 1999-03-24

Application Number : 20992

Regulatory Info : DISCN

Registration Country : USA

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04

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC A

Brand Name : CENESTIN

Dosage Form : TABLET;ORAL

Dosage Strength : 1.25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 2000-03-13

Application Number : 20992

Regulatory Info : DISCN

Registration Country : USA

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05

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC A

Brand Name : CENESTIN

Dosage Form : TABLET;ORAL

Dosage Strength : 0.45MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 2004-02-05

Application Number : 20992

Regulatory Info : DISCN

Registration Country : USA

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06

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC B

Brand Name : ENJUVIA

Dosage Form : TABLET;ORAL

Dosage Strength : 0.3MG

Packaging :

Approval Date : 2004-12-20

Application Number : 21443

Regulatory Info : DISCN

Registration Country : USA

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07

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC B

Brand Name : ENJUVIA

Dosage Form : TABLET;ORAL

Dosage Strength : 0.45MG

Packaging :

Approval Date : 2004-12-20

Application Number : 21443

Regulatory Info : DISCN

Registration Country : USA

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08

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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Contact Supplier

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South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC B

Brand Name : ENJUVIA

Dosage Form : TABLET;ORAL

Dosage Strength : 0.625MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 2004-05-10

Application Number : 21443

Regulatory Info : DISCN

Registration Country : USA

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09

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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Contact Supplier

Contact Supplier

South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC B

Brand Name : ENJUVIA

Dosage Form : TABLET;ORAL

Dosage Strength : 1.25MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 2004-05-10

Application Number : 21443

Regulatory Info : DISCN

Registration Country : USA

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10

Aspen Pharmacare Holdings

South Africa

Pharmtech & Ingredients

Not Confirmed

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Contact Supplier

Contact Supplier

South Africa

Digital Content

Regulatory Info : DISCN

Registration Country : USA

ESTROGENS, CONJUGATED SYNTHETIC B

Brand Name : ENJUVIA

Dosage Form : TABLET;ORAL

Dosage Strength : 0.9MG

Packaging :

Approval Date : 2007-04-27

Application Number : 21443

Regulatory Info : DISCN

Registration Country : USA

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FDA Orange Book

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Europe

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Canada

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South Africa

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Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 20MG BASE;0.45MG

USFDA APPLICATION NUMBER - 22247

DOSAGE - TABLET;ORAL - 0.3MG

USFDA APPLICATION NUMBER - 4782

DOSAGE - TABLET;ORAL - 0.45MG

USFDA APPLICATION NUMBER - 4782

DOSAGE - TABLET;ORAL - 0.625MG

USFDA APPLICATION NUMBER - 4782

DOSAGE - TABLET;ORAL - 0.9MG

USFDA APPLICATION NUMBER - 4782

DOSAGE - TABLET;ORAL - 1.25MG

USFDA APPLICATION NUMBER - 4782

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REF. STANDARDS & IMPURITIES

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EDQM

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