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    Chemistry

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    Also known as: Ethamsylate, 2624-44-4, Cyclonamine, Aglumin, Dicynene, Ethamsylate [usan]
    Molecular Formula
    C10H17NO5S
    Molecular Weight
    263.31  g/mol
    InChI Key
    HBGOLJKPSFNJSD-UHFFFAOYSA-N
    FDA UNII
    24YL531VOH
    Ethamsylate
    Benzenesulfonate derivative used as a systemic hemostatic.
    1 2D Structure

    Ethamsylate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2,5-dihydroxybenzenesulfonic acid;N-ethylethanamine
    2.1.2 InChI
    InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3
    2.1.3 InChI Key
    HBGOLJKPSFNJSD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCNCC.C1=CC(=C(C=C1O)S(=O)(=O)O)O
    2.2 Other Identifiers
    2.2.1 UNII
    24YL531VOH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Altodor

    2. Cyclonamine

    3. Dicinone

    4. Dicynene

    5. Dicynone

    6. Ethamsylate

    7. Hemo 141

    2.3.2 Depositor-Supplied Synonyms

    1. Ethamsylate

    2. 2624-44-4

    3. Cyclonamine

    4. Aglumin

    5. Dicynene

    6. Ethamsylate [usan]

    7. Md 141

    8. Etamsilate

    9. E 141

    10. Etamsylate [inn]

    11. Diethylamine 2,5-dihydroxybenzenesulfonate

    12. Diethylamine Dobesilate

    13. Benzenesulfonic Acid, 2,5-dihydroxy-, Compd. With N-ethylethanamine (1:1)

    14. 24yl531voh

    15. 2,5-dihydroxybenzenesulfonic Acid N-ethylethanamine (1:1)

    16. Altodor

    17. Benzenesulfonic Acid, 2,5-dihydroxy-, Compd. With Diethylamine

    18. 2,5-dihydroxybenzenesulfonic Acid Compound With Diethylamine (1:1)

    19. Md-141

    20. Ethamsylate (usan)

    21. Diethylammonium 2,5-dihydroxybenzenesulfonate

    22. Ncgc00017041-01

    23. Ciclonamina

    24. Dicynone

    25. Eselin

    26. Cas-2624-44-4

    27. E-141

    28. 2,5-dihydroxybenzenesulfonic Acid N-ethylethanamine

    29. 2,5-dihydroxybenzenesulfonic Acid;n-ethylethanamine

    30. Ciclonamina [italian]

    31. Etamsilato

    32. Etamsylatum

    33. Etamsylatum [inn-latin]

    34. Etamsilato [inn-spanish]

    35. Einecs 220-090-7

    36. Unii-24yl531voh

    37. Etamsylate,(s)

    38. Diethylammonium Cyclohexadien-4-ol-1-one-4-sulfonate

    39. Diidroxi-1,4-benzenesulfonato-3-di-etilammonium [italian]

    40. 2,5-dihydroxybenzenesulfonic Acid Compd. With N-ethylethanamine

    41. Etamsylate (jan/inn)

    42. Etamsylate [jan]

    43. Ethamsylate [mi]

    44. 1-hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic Acid Compd. With Diethylamine

    45. Etamsylate [mart.]

    46. Diidroxi-1,4-benzenesulfonato-3-di-etilammonium

    47. Dsstox_cid_25559

    48. Dsstox_rid_80956

    49. Etamsilate [who-dd]

    50. Dsstox_gsid_45559

    51. Schembl34303

    52. Chembl1514715

    53. Dtxsid4045559

    54. Chebi:31563

    55. Amy8982

    56. Etamsylate [ep Monograph]

    57. C18e8

    58. Hms1571k11

    59. Hms2098k11

    60. Hms3652i22

    61. Hms3715k11

    62. Bcp12254

    63. Hy-b1074

    64. Tox21_110752

    65. Mfcd00867499

    66. S4152

    67. Akos005267176

    68. Benzenesulfonic Acid, 2,5-dihydroxy-, Compd. With N-ethylethanamine(1:1)

    69. Ccg-221015

    70. Cs-4630

    71. Db13483

    72. Ks-1169

    73. Ncgc00017041-02

    74. Ncgc00017041-04

    75. Ac-32031

    76. Etamsylate 100 Microg/ml In Acetonitrile

    77. Diethylamine 2,5-dihydroxy Benzene Sulfonate

    78. E1145

    79. Ft-0668047

    80. Sw197271-3

    81. D01282

    82. F20533

    83. 624e444

    84. A847477

    85. Sr-01000838306

    86. Q2000876

    87. Sr-01000838306-2

    88. W-107184

    89. 2,5-dihydroxybenzene- Sulfonic Acid Diethylamine Salt

    90. 2,5-dihydroxybenzenesulfonic Acid N-ethylethanamine Salt

    91. 2,5-dihydroxybenzenesulfonic Acidn-ethylethanamine (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 263.31 g/mol
    Molecular Formula C10H17NO5S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count3
    Exact Mass263.08274382 g/mol
    Monoisotopic Mass263.08274382 g/mol
    Topological Polar Surface Area115 Ų
    Heavy Atom Count17
    Formal Charge0
    Complexity252
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Hemostatics

    Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure. (See all compounds classified as Hemostatics.)

    4.2 ATC Code

    B02BX01

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    B - Blood and blood forming organs

    B02 - Antihemorrhagics

    B02B - Vitamin k and other hemostatics

    B02BX - Other systemic hemostatics

    B02BX01 - Etamsylate

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    ESTEVE QUIMICA S.A. Barcelona ES

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    Etamsylate, Code 0122-P54 - Code 0122-P57

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    R1-CEP 1997-070 - Rev 08
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    Chemical
    2019-11-22
    1204
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    Etamsylate, Code 0122-P54 - Code 0122-P57

    Certificate Number : R1-CEP 1997-070 - Rev 08

    Status : Valid

    Issue Date : 2019-11-22

    Type : Chemical

    Substance Number : 1204

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      R1-CEP 2008-317 - Rev 04
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      1204
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      Etamsylate

      Certificate Number : R1-CEP 2008-317 - Rev 04

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      Issue Date : 2022-10-28

      Type : Chemical

      Substance Number : 1204

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      Etamsylate (EP)

      Date of Issue : 2022-06-08

      Valid Till : 2025-07-07

      Written Confirmation Number : WC-0104

      Address of the Firm : #125 & 126, Sipcot Industrial Complex, Hosur-635 126, Tamilnadu 

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      About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

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      [{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715279400,"product":"ETHAMSYLATE BP","address":"233 BHARAT INDUSTRIAL ESTATE,L B S","city":"BHANDUP,MAHARASHTRA","supplier":"RASINO DRUGS PRIVATE ","supplierCountry":"INDIA","foreign_port":"LAPAZ","customer":"LABORATORIOS ABD LTDA","customerCountry":"BOLIVIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"190","totalValueFC":"506.4","currency":"USD","unitRateINR":8442.4799999999996,"date":"10-May-2024","totalValueINR":"42212.4","totalValueInUsd":"506.4","indian_port":"Bombay Air","hs_no":"29211990","bill_no":"9772231","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BOLIVIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"233 BHARAT INDUSTRIAL ESTATE,L B S, BHANDUP,MAHARASHTRA","customerAddress":""}]
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      Registration Country : Italy

      Ethamsylate

      Brand Name : Dicynone

      Dosage Form :

      Dosage Strength : 20 Cpr 250 Mg  

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      Registration Country : Italy

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      Ethamsylate

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      Etamsylatum

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      Ethamsylate

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      BP Grade Etamsylate (50 kg) API needed in India [ENA13559]
      A company that specializes in manufacturing and marketing of various finished formulations is looking for suppliers of BP Grade Etamsylate (50 kg) API for commercial purpose. The suppliers must support this enquiry with GMP & CoA.
      07 May 2022

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      07 May 2022

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      07 May 2022

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      Etamsylate (MOQ) API needed in India [ENA13197]
      A pharmaceutical manufacturing company that deals in beta-lactam, non beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Etamsylate (MOQ) API for commercial purpose. The suppliers must support this enquiry with CoA.
      04 Apr 2022

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      04 Apr 2022

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      04 Apr 2022

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      USP/IP/BP Grade Aminophylline Dihydrate & other APIs needed in India [ENA05643]
      A pharmaceutical company with its main focus in manufacturing and supplying a wide range of pharmaceutical products is looking for suppliers of below mentioned APIs. The material should be of at least 3-4 years shelf life. 1. Aminophylline Dihydrate- 2.1 kg 2. Amoxicillin and Clavulanate Potassium (Sterile)- 7.1 kg 3. Azithromycin Dihydrate- 125 kg 4. Beclomethasone Dipropionate- 0.75 kg 5. Benzocaine- 15 kg 6. Calcium D-Saccharate- 20 kg 7. Ceftriaxone Sodium (Sterile)- 108 kg 8. Cefuroxime Sodium (Sterile)- 8.1 kg 9. Cholecalciferol- 1075 g 10. Clotrimazole- 44 kg 11. Cloxacillin Sodium (Sterile)- 19.5 kg 12. Ephedrine HCl- 3 kg 13. Erythromycin Stearate- 315 kg 14. Ethamsylate- 25 kg 15. Ethyl Oleate- 565 kg 16. Fluconazole- 86 kg 17. Gentamicin Sulphate- 75 kg 18. Hydrocortisone Sodium Succinate (Sterile)- 55 kg 19. Itraconazole Pellets (40%) 200mg- 80 kg 20. Lansoprazole Enteric Coated Pellets 30mg- 100 kg 21. Lidocaine HCl- 60 kg 22. Maltodextrin- 2 kg 23. Nandrolone Decanoate- 1.2 kg 24. Nefopam HCl- 2 kg 25. Neomycin Sulfate- 18 kg 26. Oxetacaine- 2.1 kg 27. Piroxicam- 2.5 kg 28. Sodium Metabisulphite- 60 kg 29. Sulbactam Sodium (Sterile)- 45 kg 30. Tranexamic Acid- 100 kg 31. Roxithromycin- 143 kg 32. Mefenamic Acid- 500 kg 33. Metronidazole Benzoate- 350 kg
      01 Nov 2019

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      01 Nov 2019

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      01 Nov 2019

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      Ethamsylate API (5 MT) needed in Poland [ENA04654]
      A leading trading company dealing in extracts, active substances for medicine, veterinary additives is looking for suppliers of Ethamsylate API (5 MT). The supplier must support this enquiry with CoA and CEP.
      19 Jul 2019

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      19 Jul 2019

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      19 Jul 2019

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