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    Also known as: Ethynylestradiol, 57-63-6, Ethinylestradiol, Ethynyl estradiol, Ethinyloestradiol, 17-ethinylestradiol
    Molecular Formula
    C20H24O2
    Molecular Weight
    296.4  g/mol
    InChI Key
    BFPYWIDHMRZLRN-SLHNCBLASA-N
    FDA UNII
    423D2T571U
    Ethinyl Estradiol
    A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
    Ethinyl estradiol is an Estrogen. The mechanism of action of ethinyl estradiol is as an Estrogen Receptor Agonist.
    1 2D Structure

    Ethinyl Estradiol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
    2.1.2 InChI
    InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
    2.1.3 InChI Key
    BFPYWIDHMRZLRN-SLHNCBLASA-N
    2.1.4 Canonical SMILES
    CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O
    2.1.5 Isomeric SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=C3C=CC(=C4)O
    2.2 Other Identifiers
    2.2.1 UNII
    423D2T571U
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-

    2. Estinyl

    3. Estradiol, Ethinyl

    4. Estradiol, Ethynyl

    5. Ethinyl Estradiol Hemihydrate

    6. Ethinyl Estradiol, (8 Alpha)-isomer

    7. Ethinyl Estradiol, (8 Alpha,17 Alpha)-isomer

    8. Ethinyl Estradiol, (8 Alpha,9 Beta,13 Alpha,14 Beta)-isomer

    9. Ethinyl Estradiol, (9 Beta,17 Alpha)-isomer

    10. Ethinyl Oestradiol Effik

    11. Ethinyl-oestradiol Effik

    12. Ethinylestradiol Jenapharm

    13. Ethinyloestradiol

    14. Ethynyl Estradiol

    15. Hemihydrate, Ethinyl Estradiol

    16. Jenapharm, Ethinylestradiol

    17. Lynoral

    18. Microfollin

    19. Microfollin Forte

    20. Progynon C

    2.3.2 Depositor-Supplied Synonyms

    1. Ethynylestradiol

    2. 57-63-6

    3. Ethinylestradiol

    4. Ethynyl Estradiol

    5. Ethinyloestradiol

    6. 17-ethinylestradiol

    7. Estinyl

    8. 17alpha-ethynylestradiol

    9. Ginestrene

    10. Lynoral

    11. Progynon C

    12. Ethinoral

    13. Eticyclin

    14. Eticyclol

    15. Etinestrol

    16. Etinestryl

    17. Etinoestryl

    18. Etistradiol

    19. Follicoral

    20. Novestrol

    21. Orestralyn

    22. Spanestrin

    23. Amenoron

    24. Dyloform

    25. Ertonyl

    26. Estigyn

    27. Estoral

    28. Estorals

    29. Ethidol

    30. Feminone

    31. Inestra

    32. Linoral

    33. Menolyn

    34. Oradiol

    35. Primogyn

    36. Esteed

    37. Neo-estrone

    38. Primogyn C

    39. Primogyn M

    40. Nogest-s

    41. Eston-e

    42. Palonyl

    43. Perovex

    44. 17alpha-ethinylestradiol

    45. 17-ethynylestradiol

    46. Diogyn E

    47. Chee-o-genf

    48. Chee-o-gen

    49. 17-ethinyl-3,17-estradiol

    50. Ethynyloestradiol

    51. 17-ethinyl-3,17-oestradiol

    52. 17-ethynyloestradiol

    53. Estoral (orion)

    54. 17alpha-ethinyl Estradiol

    55. Diognat-e

    56. Diogyn-e

    57. Eticylol

    58. Kolpolyn

    59. Orestrayln

    60. Ylestrol

    61. Anovlar

    62. Etivex

    63. 17a-ethynylestradiol

    64. Progynon M

    65. Ethinylestradiolum

    66. Estradiol, 17-ethynyl-

    67. Nsc-10973

    68. Ethinyl Estradiol [usp]

    69. 17.alpha.-ethinylestradiol

    70. 17.alpha.-ethynylestradiol

    71. Estoral [orion]

    72. 17.alpha.-ethynyloestradiol

    73. Microfollin

    74. 17a-ethinylestradiol

    75. 17 Alpha-ethinyestradiol

    76. Ethinyl Estradiol (usp)

    77. Diprol

    78. (8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    79. Ee

    80. Chembl691

    81. 17-alpha-ethynyl Estradiol

    82. 17.alpha.-ethinyl-17.beta.-estradiol

    83. Ethinyl-oestranol

    84. 17.alpha.-ethynyl-17.beta.-oestradiol

    85. Norinyl

    86. Mls000028479

    87. Aethinyloestradiolum

    88. Chebi:4903

    89. Ee2

    90. Estopherol

    91. Prosexol

    92. Ethinyl E2

    93. 17.alpha.-ethynylestradiol-l7.beta.

    94. 423d2t571u

    95. (8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol

    96. 17.alpha.-ethynyloestradiol-17.beta.

    97. Estoral (van)

    98. (17beta)-17-ethynylestra-1(10),2,4-triene-3,17-diol

    99. Aethinyoestradiol [german]

    100. Ncgc00091533-04

    101. Etinilestradiol

    102. Certostat

    103. Smr000058319

    104. 19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17a)-

    105. Etinilestradiolo

    106. Dsstox_cid_576

    107. Aethinyoestradiol

    108. 19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17.alpha.)-

    109. Etinilestradiol [inn-spanish]

    110. Ee(sub 2)

    111. Ethinylestradiolum [inn-latin]

    112. Etinilestradiolo [dcit]

    113. 17alpha-ethynyloestradiol

    114. Dsstox_rid_75668

    115. 17-alpha-ethynylestradiol

    116. Dsstox_gsid_20576

    117. 17alpha-ethynylestra-1,3,5(10)-triene-3,17beta-diol

    118. 17alpha-ethinyl-estra-1,3,5(10)-triene-3,17beta-diol

    119. 17-ethynyl-3,17-dihydroxy-1,3,5-oestratriene

    120. 19-nor-17.alpha.-pregna-1,3,5(10)-trien-20-yne-3,17-diol

    121. 17alpha-ethinylestradiol-17beta

    122. Ethinylestradiol [inn:ban:jan]

    123. 17-alpha-ethynylestradiol-17-beta

    124. Cas-57-63-6

    125. 17-alpha-ethinyl-17-beta-estradiol

    126. (1s,10r,11s,14r,15s)-14-ethynyl-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol

    127. 17-alpha-ethynyl-17-beta-oestradiol

    128. Component Of Oracon

    129. Component Of Ortrel

    130. Ccris 286

    131. Estinyl (tn)

    132. Component Of Demulen

    133. Hsdb 3587

    134. Einecs 200-342-2

    135. Mfcd00003690

    136. Ovulen-21

    137. Ovulen-28

    138. Estra-1,5(10)-triene-3,17.beta.-diol, 17-ethynyl-

    139. Estra-1,5[10]-triene-3,17.beta.-diol, 17-ethynyl-

    140. Brn 2419975

    141. Ethinyloestradiol [steroidal Oestrogens]

    142. Ylestol

    143. 19-nor-17.alpha.-pregna-1,5(10)-trien-20-yne-3,17-diol

    144. 19-nor-17.alpha.-pregna-1,5[10]-trien-20-yne-3,17-diol

    145. Ai3-52941

    146. Ethinyl-estradiol

    147. Ethynyl-estradiol

    148. Unii-423d2t571u

    149. 17alpha-ethinyl-17beta-estradiol

    150. 19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-

    151. Component Of Ovral

    152. 3wf

    153. Levlen (salt/mix)

    154. Oracon (salt/mix)

    155. Ortrel (salt/mix)

    156. 17-alpha-ethynyl-1,3,5-oestratriene-3,17-beta-diol

    157. Anovlar (salt/mix)

    158. Desogen (salt/mix)

    159. 17a-ethynyloestradiol

    160. Estoral {[orion]}

    161. 17alpha-ethinylestra-1,3,5(10)-triene-3,17beta-diol

    162. 17alpha-ethinyloestra-1,3,5(10)-triene-3,17beta-diol

    163. Nordette (salt/mix)

    164. Secrovin (salt/mix)

    165. 17-alpha-ethinylestra-1,3,5(10)-triene-3,17-beta-diol

    166. 17-alpha-ethynyl-1,3,5(10)-estratriene-3,17-beta-diol

    167. Seasonale (salt/mix)

    168. Triphasil (salt/mix)

    169. 17-alpha-ethinyloestra-1,3,5(10)-triene-3,17-beta-diol

    170. 17-alpha-ethynyl-1,3,5(10)-oestratriene-3,17-beta-diol

    171. 17alpha-ethinyl-3,17-dihydroxy-delta(sup1,3,5)-estratriene

    172. 17alpha-ethinyl-3,17-dihydroxy-delta(sup1,3,5)oestratriene

    173. 3,17beta-dihydroxy-17alpha-ethynyl-1,3,5(10)-estratriene

    174. 3,17beta-dihydroxy-17alpha-ethynyl-1,3,5(10)-oestratriene

    175. Estopherol (salt/mix)

    176. Estra-1,3,5(10)-triene-3,17beta-diol, 17alpha-ethynyl-

    177. Seasonique (salt/mix)

    178. 17-alpha-ethinyl-3,17-dihydroxy-delta(sup 1,3,5)-estratriene

    179. 17-ethynylestradiol Ram

    180. 19-nor-17alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol

    181. 3,17-beta-dihydroxy-17-alpha-ethynyl-1,3,5(10)-estratriene

    182. 3,17-beta-dihydroxy-17-alpha-ethynyl-1,3,5(10)-oestratriene

    183. Estra-1,3,5(10)-triene-3,17-beta-diol, 17-alpha-ethynyl-

    184. Ortho Evra (salt/mix)

    185. Tri-levlen (salt/mix)

    186. (17-alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17,diol

    187. 17alpha-ethinyl-delta(sup1,3,5(10))oestratriene-3,17-beta -diol

    188. 17alpha-ethynyloestradiol-17beta; 17beta-estradiol, 17-ethynyl-

    189. 19-nor-17-alpha-pregna-1,3,5(10)-triene-20-yne-3,17-diol

    190. Opera_id_1808

    191. 17a-ethynylestradiol-l7b

    192. 17-alpha-ethinyl-delta(sup 1,3,5(10))oestratriene-3,17-beta-diol

    193. Ortho-cyclen (salt/mix)

    194. 17a-ethynyloestradiol-17b

    195. Schembl4071

    196. 17a-ethinyl-17b-estradiol

    197. 17a-ethynyl-17b-oestradiol

    198. Mls000758274

    199. Mls001424011

    200. Bidd:er0162

    201. Ethinylestradiol [inn]

    202. Ethinylestradiol [jan]

    203. Ethinyl Estradiol [mi]

    204. Ethinylestradiol (jp17/inn)

    205. Ethinylestradiol [inci]

    206. Gtpl7071

    207. Sgcut00127

    208. 17alpha-ethynyl-1,3,5(10)-estratriene-3,17beta-diol

    209. Dtxsid5020576

    210. Ethinyl Estradiol [hsdb]

    211. Ethinylestradiol [mart.]

    212. Ethinyl Estradiol [vandf]

    213. Ethinylestradiol [who-dd]

    214. Ethinylestradiol [who-ip]

    215. Hms2051i19

    216. Hms2235j09

    217. Hms3715j09

    218. 17alpha-ethynylestradiol, >=98%

    219. Ethinyl Estradiol [usp-rs]

    220. (17alpha)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol

    221. 17.beta.-estradiol, 17-ethynyl-

    222. 19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol

    223. Hy-b0216

    224. Nsc10973

    225. To_000048

    226. Zinc3812897

    227. Tox21_111147

    228. Tox21_201291

    229. Tox21_300413

    230. Bdbm50187243

    231. Ethinyl Estradiol [ema Epar]

    232. Lmst02010036

    233. S1625

    234. 17

    235. A-ethynylestradiol;ethynylestradiol

    236. Akos015894925

    237. Tox21_111147_1

    238. Yaz Component Ethinyl Estradiol

    239. Ac-2169

    240. Ccg-100819

    241. Db00977

    242. Ethinyl Estradiol [orange Book]

    243. Ethinylestradiol [ep Monograph]

    244. Ks-5257

    245. Nc00069

    246. 17.alpha.-ethinyl-3,3,5)oestratriene

    247. Beyaz Component Ethinyl Estradiol

    248. Ovral Component Ethinyl Estradiol

    249. Zovia Component Ethinyl Estradiol

    250. 17.alpha.-ethinyl-3,3,5)-estratriene

    251. Alesse Component Ethinyl Estradiol

    252. Aviane Component Ethinyl Estradiol

    253. Ethinyl Estradiol [usp Monograph]

    254. Ethinylestradiolum [who-ip Latin]

    255. Femhrt Component Ethinyl Estradiol

    256. Kariva Component Ethinyl Estradiol

    257. Kelnor Component Ethinyl Estradiol

    258. Levora Component Ethinyl Estradiol

    259. Lybrel Component Ethinyl Estradiol

    260. Ncgc00091533-01

    261. Ncgc00091533-05

    262. Ncgc00091533-07

    263. Ncgc00091533-08

    264. Ncgc00091533-09

    265. Ncgc00091533-10

    266. Ncgc00254514-01

    267. Ncgc00258843-01

    268. Portia Component Ethinyl Estradiol

    269. Preven Component Ethinyl Estradiol

    270. Twirla Component Ethinyl Estradiol

    271. Vienva Component Ethinyl Estradiol

    272. Volnea Component Ethinyl Estradiol

    273. Xulane Component Ethinyl Estradiol

    274. Yasmin Component Ethinyl Estradiol

    275. Bekyree Component Ethinyl Estradiol

    276. Desogen Component Ethinyl Estradiol

    277. Enskyce Component Ethinyl Estradiol

    278. Ethinyl Estradiol Component Of Yaz

    279. Kurvelo Component Ethinyl Estradiol

    280. Lessina Component Ethinyl Estradiol

    281. Levlite Component Ethinyl Estradiol

    282. Nci60_000234

    283. Norinyl Component Ethinyl Estradiol

    284. Pimtrea Component Ethinyl Estradiol

    285. Safyral Component Ethinyl Estradiol

    286. Trivora Component Ethinyl Estradiol

    287. Velivet Component Ethinyl Estradiol

    288. Viorele Component Ethinyl Estradiol

    289. Vyfemla Component Ethinyl Estradiol

    290. Altavera Component Ethinyl Estradiol

    291. Annovera Component Ethinyl Estradiol

    292. Aranelle Component Ethinyl Estradiol

    293. Brevicon Component Ethinyl Estradiol

    294. Cryselle Component Ethinyl Estradiol

    295. Cyclessa Component Ethinyl Estradiol

    296. Elifemme Component Ethinyl Estradiol

    297. Enpresse Component Ethinyl Estradiol

    298. Isibloom Component Ethinyl Estradiol

    299. Levonest Component Ethinyl Estradiol

    300. Marlissa Component Ethinyl Estradiol

    301. Mircette Component Ethinyl Estradiol

    302. Nordette Component Ethinyl Estradiol

    303. Nuvaring Component Ethinyl Estradiol

    304. Orsythia Component Ethinyl Estradiol

    305. Previfem Component Ethinyl Estradiol

    306. Quasense Component Ethinyl Estradiol

    307. Setlakin Component Ethinyl Estradiol

    308. Sprintec Component Ethinyl Estradiol

    309. Taytulla Component Ethinyl Estradiol

    310. Ethinyl Estradiol Component Of Beyaz

    311. Ethinyl Estradiol Component Of Ovral

    312. Introvale Component Ethinyl Estradiol

    313. Quartette Component Ethinyl Estradiol

    314. Seasonale Component Ethinyl Estradiol

    315. Triphasil Component Ethinyl Estradiol

    316. Ethinyl Estradiol Component Of Alesse

    317. Ethinyl Estradiol Component Of Desogen

    318. Ethinyl Estradiol Component Of Femhrt

    319. Ethinyl Estradiol Component Of Kariva

    320. Ethinyl Estradiol Component Of Kelnor

    321. Ethinyl Estradiol Component Of Levlite

    322. Ethinyl Estradiol Component Of Lybrel

    323. Ethinyl Estradiol Component Of Preven

    324. Ethinyl Estradiol Component Of Safyral

    325. Ethinyl Estradiol Component Of Twirla

    326. Ethinyl Estradiol Component Of Velivet

    327. Ethinyl Estradiol Component Of Yasmin

    328. Femcon Fe Component Ethinyl Estradiol

    329. Ortho-cept Component Ethinyl Estradiol

    330. Seasonique Component Ethinyl Estradiol

    331. 17-ethynyl-3-17-dihydroxy-1,5-oestratriene

    332. 17alpha-ethynylestradiol, >=98.0% (hplc)

    333. Ethinyl Estradiol Component Of Altavera

    334. Ethinyl Estradiol Component Of Annovera

    335. Ethinyl Estradiol Component Of Aranelle

    336. Ethinyl Estradiol Component Of Cryselle

    337. Ethinyl Estradiol Component Of Cyclessa

    338. Ethinyl Estradiol Component Of Levonest

    339. Ethinyl Estradiol Component Of Mircette

    340. Ethinyl Estradiol Component Of Nuvaring

    341. Ethinyl Estradiol Component Of Previfem

    342. Ethinyl Estradiol Component Of Quasense

    343. Ethinyl Estradiol Component Of Setlakin

    344. Ethinyl Estradiol Component Of Sprintec

    345. Norquest Fe Component Ethinyl Estradiol

    346. C07534

    347. D00554

    348. Estrostep Fe Component Ethinyl Estradiol

    349. Ethinyl Estradiol Component Of Femcon Fe

    350. Ethinyl Estradiol Component Of Introvale

    351. Ethinyl Estradiol Component Of Seasonale

    352. H11762

    353. Loseasonique Component Ethinyl Estradiol

    354. Tri-previfem Component Ethinyl Estradiol

    355. Tri-sprintec Component Ethinyl Estradiol

    356. 17-ethynyl-3-17-dihydroxy-1,3,5-oestratriene

    357. Ab00441335-11

    358. Ab00441335_12

    359. Ethinyl Estradiol Component Of Ortho-cept

    360. Ethinyl Estradiol Component Of Seasonique

    361. Tri-legest Fe Component Ethinyl Estradiol

    362. Wln: L E5 B666ttt&j E1 Fq F1uu1 Oq

    363. 003e690

    364. Ethinyl Estradiol Component Of Estrostep Fe

    365. Ethinyl Estradiol Component Of Loseasonique

    366. Ethinyl Estradiol Component Of Norquest Fe

    367. Ethinyl Estradiol Component Of Tri-previfem

    368. Ethinyl Estradiol Component Of Tri-sprintec

    369. Lo Loestrin Fe Component Ethinyl Estradiol

    370. Lo Minastrin Fe Component Ethinyl Estradiol

    371. Q415563

    372. Sr-01000721903

    373. Tri Lo Sprintec Component Ethinyl Estradiol

    374. 17-ethynylestra-1,3,5(10)-triene-3,17beta-diol

    375. 17a-ethinylestradiol 100 Microg/ml In Acetonitrile

    376. Ethinyl Estradiol Component Of Lo Loestrin Fe

    377. Ethinyl Estradiol Component Of Tri-legest Fe

    378. Minastrin 24 Fe Component Ethinyl Estradiol

    379. Ortho Tri-cyclen Component Ethinyl Estradiol

    380. Q-201076

    381. Sr-01000721903-3

    382. 17-ethynyloestra-1,5(10)-triene-3,17.beta.-diol

    383. 17.alpha.-ethynyl-1,5-estratriene-3,17.beta.-diol

    384. 17.alpha.-ethynyl-1,5-oestratriene-3,17.beta.-diol

    385. 17a-ethinylestradiol 100 Microg/ml In Methanol/water

    386. 17alpha-ethinyl-1,3,5(10)-estratriene-3,17-diol

    387. Brd-k48195008-001-19-9

    388. Ethinyl Estradiol Component Of Ortho Tri-cyclen

    389. Ethinyl Estradiol Component Of Tri Lo Sprintec

    390. 17-ethynyloestra-1,3,5(10)-triene-3,17.beta.-diol

    391. 17.alpha.-ethinyl-1,3,5(10)-estratriene-3,17-diol

    392. Z1541638513

    393. 17.alpha.-ethinylestra-1,5(10)-triene-3,17.beta.-diol

    394. 17.alpha.-ethinyloestra-1,5(10)-triene-3,17.beta.-diol

    395. 17.alpha.-ethynylestra-1,5(10)-triene-3,17.beta.-diol

    396. 17.alpha.-ethynyloestra-1,5(10)-triene-3,17.beta.-diol

    397. 17.alpha.-ethinylestra-1,3,5(10)-triene-3,17.beta.-diol

    398. 17.alpha.-ethinyloestra-1,3,5(10)-triene-3,17.beta.-diol

    399. 17.alpha.-ethynyl-1,3,5(10)-estratriene-3,17.beta.-diol

    400. 17.alpha.-ethynyl-1,3,5(10)-oestratriene-3,17.beta.-diol

    401. 17.alpha.-ethynylestra-1,3,5(10)-triene-3,17.beta.-diol

    402. 17.alpha.-ethynyloestra-1,3,5(10)-triene-3,17.beta.-diol

    403. 17alpha-ethynylestradiol, Vetranal(tm), Analytical Standard

    404. 19-nor-17.alpha.-pregna-1,5(10)-trien-2-yne-3,17-diol

    405. Estra-1,5(10)-triene-3,17.beta.-diol, 17.alpha.-ethynyl-

    406. 17.alpha.-ethinyl-3,17-dihydroxy-.delta.(sup1,3,5)-estratriene

    407. 17.alpha.-ethinyl-3,17-dihydroxy-.delta.(sup1,3,5)oestratriene

    408. 19-nor-17.alpha.-pregna-1,3,5(10)-trien-20-yn-3,17-diol

    409. 19-norpregna-1,5(10)-trien-20-yne-3,17-diol, (17.alpha.)-

    410. 3,17.beta.-dihydroxy-17.alpha.-ethynyl-1,3,5(10)-estratriene

    411. 3,17.beta.-dihydroxy-17.alpha.-ethynyl-1,3,5(10)-oestratriene

    412. Estra-1,3,5(10)-triene-3,17.beta.-diol, 17.alpha.-ethynyl-

    413. Ethinylestradiol, European Pharmacopoeia (ep) Reference Standard

    414. 17.alpha.-ethinyl-.delta.(sup1,3,5(10))oestratriene-3,17-.beta. -diol

    415. 17.alpha.-ethinyl-.delta.(sup1,5(10))oestratriene-3,17-.beta.-diol

    416. 19-nor-17.alpha.-pregna-1,3,5(10)-trien-20-yne-3,17.beta.-diol

    417. Ethinyl Estradiol, United States Pharmacopeia (usp) Reference Standard

    418. (9beta,13alpha,14beta,17alpha)-17-ethynylestra-1(10),2,4-triene-3,17-diol

    419. Ethinyl Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material

    420. Ethinylestradiol For System Suitability, European Pharmacopoeia (ep) Reference Standard

    421. 1050678-65-3

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 296.4 g/mol
    Molecular Formula C20H24O2
    XLogP33.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count1
    Exact Mass296.177630004 g/mol
    Monoisotopic Mass296.177630004 g/mol
    Topological Polar Surface Area40.5 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity505
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Estrogens

    National Library of Medicine's Medical Subject Headings online file (MeSH, 2009)

    Ethinyl estradiol /is indicated in combination with an oral progestin/ for the prevention of pregnancy in women who elect to use this product as a method of contraception. /Included in US product label/

    US Natl Inst Health; DailyMed. Current Medication Information CESIA (desogestrel and ethinyl estradiol) kit (February 2009). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=9373

    Femhrt (norethindrone acetate/ethinyl estradiol) is indicated in women with an intact uterus for the treatment of moderate to severe vasomotor symptoms associated with the menopause. /Included in US product label/

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    Femhrt (norethindrone acetate/ethinyl estradiol) is indicated in women with an intact uterus for the prevention of postmenopausal osteoporosis. When prescribing solely for the prevention of postmenopausal osteoporosis, therapy should only be considered for women at significant risk of osteoporosis. Non-estrogen medications should be carefully considered. /Included in US product label/

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    Ethinyl estradiol is used frequently in combination with progestins for oral contraception.

    Briggs, G.G, R.K. Freeman, S.J. Yaffe. A Reference Guide to Fetal and Neonatal Risk. Drugs in Pregnancy and Lactation. 4th ed. Baltimore, MD: Williams & Wilkins 1994., p. 354

    4.2 Drug Warning

    /BOXED WARNING/ WARNING: Estrogens and progestins should not be used for the prevention of cardiovascular disease or dementia. The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown whether this finding applies to younger postmenopausal women. Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER: Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures, including endometrial sampling when indicated, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is no evidence that the use of "natural" estrogens results in a different endometrial risk profile than synthetic estrogens at equivalent estrogen doses.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    Other doses of oral conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    FDA Pregnancy Risk Category: X /CONTRAINDICATED IN PREGNANCY. Studies in animals and or humans, or investigational or post-marketing reports, have demonstrated positive evidence of fetal abnormalities or risk which clearly outweighs any possible benefit to the patient./

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    For more Drug Warnings (Complete) data for ETHINYLESTRADIOL (38 total), please visit the HSDB record page.

    4.3 Drug Indication

    Ethinylestradiol is combined with other drugs for use as a contraceptive, premenstrual dysphoric disorder, moderate acne, moderate to severe vasomotor symptoms of menopause, prevention of postmenopausal osteoporosis.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Ethinylestradiol is a synthetic estrogen that decreases luteinizing hormone to decrease endometrial vascularization, and decreases gonadotrophic hormone to prevent ovulation. It has a long duration of action as it is taken once daily, and a wide therapeutic index as overdoses are generally not associated with serious adverse effects. Patients should be counselled regarding the risks of thrombotic events.

    5.2 MeSH Pharmacological Classification

    Contraceptives, Oral, Hormonal

    Oral contraceptives which owe their effectiveness to hormonal preparations. (See all compounds classified as Contraceptives, Oral, Hormonal.)

    Estrogens

    Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. (See all compounds classified as Estrogens.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    ETHINYL ESTRADIOL
    5.3.2 FDA UNII
    423D2T571U
    5.3.3 Pharmacological Classes
    Mechanisms of Action [MoA] - Estrogen Receptor Agonists
    5.4 ATC Code

    G03AA07

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    G - Genito urinary system and sex hormones

    G03 - Sex hormones and modulators of the genital system

    G03C - Estrogens

    G03CA - Natural and semisynthetic estrogens, plain

    G03CA01 - Ethinylestradiol

    L - Antineoplastic and immunomodulating agents

    L02 - Endocrine therapy

    L02A - Hormones and related agents

    L02AA - Estrogens

    L02AA03 - Ethinylestradiol

    5.5 Absorption, Distribution and Excretion

    Absorption

    A 30g oral dose of ethinylestradiol reaches a Cmax of 74.135.6pg/mL, with a Tmax of 1.50.5h, and an AUC of 487.4166.6pg\*h/mL. A 1.2mg dose delivered via a patch reaches a Cmax of 28.810.3pg/mL, with a Tmax of 8631h, and an AUC of38951423pg\*h/mL.

    Route of Elimination

    Ethinylestradiol is 59.2% eliminated in the urine and bile, while 2-3% is eliminated in the feces. Over 90% of ethinylestradiol is eliminated as the unchanged parent drug.

    Volume of Distribution

    A 30g oral dose has an apparent volume of distribution of 625.3228.7L and a 1.2mg topical dose has an apparent volume of distribution of 11745.315934.8L.

    Clearance

    Ethinylestradiol has an intravenous clearance of 16.47L/h, and an estimated renal clearance of approximately 2.1L/h. A 30g oral dose has a clearance of 58.019.8L/h and a 1.2mg topical dose has a clearance of 303.5100.5L/h.

    Ethinyl estradiol is rapidly and almost completely absorbed. When the lowest and highest tablet strengths, 0.100 mg desogestrel/0.025 mg ethinyl estradiol and 0.150 mg desogestrel/0.025 mg ethinyl estradiol, were compared to solution, the relative bioavailability of ethinyl estradiol was 92% and 98%, respectively.

    US Natl Inst Health; DailyMed. Current Medication Information CESIA (desogestrel and ethinyl estradiol) kit (February 2009). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=9373

    The distribution of exogenous estrogens is similar to that of endogenous estrogens. Estrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organs. Ethinyl estradiol circulates in the blood largely bound to ... albumin. ... Although ethinyl estradiol does not bind to SHBG, it induces SHBG synthesis.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    Estradiol, estrone, and estriol are excreted in the urine along with glucuronide and sulfate conjugates.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    25 healthy women of reproductive age who had not previously used oral contraceptive steroids, were each given a single tablet containing 50, 80, or 100 ug of mestranol or 50 or 80 ug of ethinyl estradiol. Blood samples were obtained before taking the tablets and at intervals of 1, 2, 4, and 24 hours afterward. Anti-ethinyl-estradiol antibody in 1 to 100,000 initial dilution was used. Details of techniques employed are given. With ethinyl estradiol, the 1-hour sampling yielded the maximum plasma levels. At 24 hours, the plasma level was not detectable in 4 of 5 subjects given 50 ug or in 1 of 5 given 80 ug. With mestranol, the disappearance curve was more variable with the peak levels usually at 2 hours but occasionally at 4 hours. At all 3 dose levels of mestranol, measurable serum ethinyl estradiol levels were found at 24 hours. These levels were reached more slowly and were lower than when ethinyl estradiol was given. In contrast to natural estrogens ethinyl, estrogens are bound to plasma proteins chiefly by nonspecific binding and are therefore less likely to affect the metabolism of the ethinyl estrogens than are the endogenous steroids. Also, significant amounts of ethinyl estradiol are was given. In contrast to natural estrogens ethinyl, estrogens are bound di-ethynylated in vitro. The pharmacokinetics of ethinyl estrogens differ from those of natural estrogens. This complicates interpretation of plasma or urinary estrone and estradiol measurements.

    PMID:1154455 de la Pena A et al; Steroids 25 (6): 773-80 (1975)

    For more Absorption, Distribution and Excretion (Complete) data for ETHINYLESTRADIOL (7 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Ethinylestradiol can be glucuronidated by UGT1A1, UGT1A3, UGT1A4, UGT1A9, and UGT2B7. Ethinylestradiol is also sulfated by SULT1A1, SULT1A3, and SULT1E1. Ethinylestradiol can also be hydroxylated at positions 2, 4, 6, 7, and 16 by CYP3A4, CYP3A5, CYP2C8, CYP2C9, and CYP1A2. These hydroxylated metabolites can be methylated by catechol-O-methyltransferase. The methoxy metabolites can in turn be sulfated or glucuronidated.

    Exogenous estrogens are metabolized in the same manner as endogenous estrogens. Circulating estrogens exist in a dynamic equilibrium of metabolic interconversions. These transformations take place mainly in the liver. Estradiol is converted reversibly to estrone, and both can be converted to estriol, which is the major urinary metabolite. Estrogens also undergo enterohepatic recirculation via sulfate and glucuronide conjugation in the liver, biliary secretion of conjugates into the intestine, and hydrolysis in the gut followed by reabsorption. In postmenopausal women, a significant proportion of the circulating estrogens exist as sulfate conjugates, especially estrone sulfate, which serves as a circulating reservoir for the formation of more active estrogens.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    Ethinyl estradiol is extensively metabolized, both by oxidation and by conjugation with sulfate and glucuronide. Sulfates are the major circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The primary oxidative metabolite is 2-hydroxy ethinyl estradiol, formed by the CYP3A4 isoform of cytochrome P450. Part of the first-pass metabolism of ethinyl estradiol is believed to occur in gastrointestinal mucosa. Ethinyl estradiol may undergo enterohepatic circulation.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    Ethinyl estradiol is cleared much more slowly ... due to decreased hepatic metabolism.

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1420

    Studies on the metabolism of ethinylestradiol have been carried out in rats, rabbits, guinea-pigs, dogs and monkeys. It is very rapidly and effectively absorbed from rat intestine; no appreciable metabolic transformation is reported to take place during the absorption process. The main metabolic pathway of ethinylestradiol in rats is by aromatic 2-hydroxylation; hydroxylations at ring B (C-6/C-7) are of only minor importance. Rat liver forms 2-hydroxyethinylestradiol and the methyl ethers thereof, 2-methoxyethinylestradiol and 2-hydroxyethinylestradiol-3-methy1 ether, as its major metabolic products. This pathway is also important in humans. Metabolites of ethinylestradiol in rats are excreted almost exclusively in the feces.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V21 245 (1979)

    For more Metabolism/Metabolites (Complete) data for ETHINYLESTRADIOL (10 total), please visit the HSDB record page.

    Ethinylestradiol has known human metabolites that include 17-Ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-2,3,17-triol and 17-Ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,4,17-triol.

    Ethinylestradiol is a known human metabolite of Mestranol.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.7 Biological Half-Life

    A 30g oral dose has a half life of 8.44.8h and a 1.2mg topical dose has a half life of 27.734.2h.

    The pharmacokinetics of 19-nor-17 alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol (ethinylestradiol, Progynon C) (EE2) has been studied after intravenous administration of 0.1 or 0.01 mg/kg and after intragastric administration of 1 mg/kg in female rats, rabbits, beagle dogs, rhesus monkeys and baboons. After intravenous administration disposition of unchanged drug in the plasma was biphasic with initial half-lives between 0.3 and 0.5 hr and terminal half-lives between 2.3 and 3.0 hr. Total plasma clearance was of the same magnitude as total plasma liver flow or even higher rat) indicating a rapid biotransformation of the estrogen in the liver. Systemic availability of intragastric EE2 amounted to 3% in the rat, 0.3% in the rabbit, 9% in the dog, 0.6% in rhesus monkeys and 2% in the baboon and was considerably lower than in humans (40%). Differences in the pharmacokinetics and in the systemic availability of EE2 between laboratory animals and man should be taken into account in the retrospective interpretation of pharmacological and toxicological data and in the design of new studies.

    PMID:3778555 Dusterberg B et al; Arzneimittelforschung 36 (8): 1187-90 (1986)

    ... The elimination phase half-life has been reported ... to be 13 to 27 hours.

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1420

    5.8 Mechanism of Action

    Ethinylestradiol is a synthetic estrogenic compound. Use of estrogens have a number of effects on the body including reduced bone density. Combined oral contraceptives suppress ovulation by suppressing gonadotrophic hormone, thickening cervical mucus to prevent the travel of sperm, and preventing changes in the endometrium required for implantation of a fertilized egg. Ethinylestradiol decreases luteinizing hormone, decreasing vascularity in the endometrium. It also increases sex hormone binding globulin.

    Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites estrone and estriol at the receptor level. ... After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone by peripheral tissues. Thus, estrone and the sulfate conjugated form, estrone sulfate, are the most abundant circulating estrogens in postmenopausal women. The pharmacologic effects of ethinyl estradiol are similar to those of endogenous estrogens. Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date, two estrogen receptors have been identified. These vary in proportion from tissue to tissue. Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these hormones seen in postmenopausal women.

    US Natl Inst Health; DailyMed. Current Medication Information FEMHRT (norethindrone acetate/ethinyl estradiol) tablet (October 2008). Available from, as of March 10, 2010: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23194

    Estrogens have an important role in the reproductive, skeletal, cardiovascular, and central nervous systems in women, and act principally by regulating gene expression. Biologic response is initiated when estrogen binds to a ligand-binding domain of the estrogen receptor resulting in a conformational change that leads to gene transcription through specific estrogen response elements (ERE) of target gene promoters; subsequent activation or repression of the target gene is mediated through 2 distinct transactivation domains (ie, AF-1 and AF-2) of the receptor. The estrogen receptor also mediates gene transcription using different response elements (ie, AP-1) and other signal pathways. Recent advances in the molecular pharmacology of estrogen and estrogen receptors have resulted in the development of selective estrogen receptor modulators (eg, clomiphene, raloxifene, tamoxifen, toremifene), agents that bind and activate the estrogen receptor but that exhibit tissue-specific effects distinct from estrogen. Tissue-specific estrogen-agonist or -antagonist activity of these drugs appears to be related to structural differences in their estrogen receptor complex (eg, specifically the surface topography of AF-2 for raloxifene) compared with the estrogen (estradiol)-estrogen receptor complex. A second estrogen receptor also has been identified, and existence of at least 2 estrogen receptors (ER-alpha, ER-beta) may contribute to the tissue-specific activity of selective modulators. While the role of the estrogen receptor in bone, cardiovascular tissue, and the CNS continues to be studied, emerging evidence indicates that the mechanism of action of estrogen receptors in these tissues differs from the manner in which estrogen receptors function in reproductive tissue. /Estrogen General Statement/

    American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3130

    Intracellular cytosol-binding proteins for estrogens have been identified in estrogen-responsive tissues including the female genital organs, breasts, pituitary, and hypothalamus. The estrogen-binding protein complex (ie, cytosol-binding protein and estrogen) distributes into the cell nucleus where it stimulates DNA, RNA, and protein synthesis. The presence of these receptor proteins is responsible for the palliative response to estrogen therapy in women with metastatic carcinoma of the breast. /Estrogen General Statement/

    American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3130

    Estrogens have generally favorable effects on blood cholesterol and phospholipid concentrations. Estrogens reduce LDL-cholesterol and increase HDL-cholesterol concentrations in a dose-related manner. The decrease in LDL-cholesterol concentrations associated with estrogen therapy appears to result from increased LDL catabolism, while the increase in triglyceride concentrations is caused by increased production of large, triglyceride-rich, very-low-density lipoproteins (VLDLs); changes in serum HDL-cholesterol concentrations appear to result principally from an increase in the cholesterol and apolipoprotein A-1 content of HDL2- and a slight increase in HDL3-cholesterol. /Estrogen General Statement/

    American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 3130

    For more Mechanism of Action (Complete) data for ETHINYLESTRADIOL (7 total), please visit the HSDB record page.

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MAHARASHTRA","supplier":"ASPEN API","supplierCountry":"NETHERLANDS","foreign_port":"AMSTERDAM, SCHIPHOL","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.17","actualQuantity":"0.168","unit":"KGS","unitRateFc":"62500","totalValueFC":"11628.3","currency":"EUR","unitRateINR":"5778125","date":"18-Jun-2024","totalValueINR":"970725","totalValueInUsd":"11628.3","indian_port":"Bombay Air","hs_no":"29372300","bill_no":"4063977","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Micronized","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"KLOOSTERSTRAAT 6,5349 AB OSS.SDNFSDNF NETHERLANDS","customerAddress":"B\/2 MAHALAXMI CHAMBERS"}]
    19-Mar-2021
    18-Jun-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL-28 - 0.02MG;1MG

    USFDA APPLICATION NUMBER - 17354

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    DOSAGE - TABLET;ORAL-21 - 0.03MG;1.5MG

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    DOSAGE - TABLET;ORAL-21 - 0.03MG;1.5MG

    USFDA APPLICATION NUMBER - 17875

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    USFDA APPLICATION NUMBER - 17876

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    DOSAGE - TABLET;ORAL-28 - 0.035MG;1MG **Feder...DOSAGE - TABLET;ORAL-28 - 0.035MG;1MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

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    USFDA APPLICATION NUMBER - 18977

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    USFDA APPLICATION NUMBER - 18985

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    USFDA APPLICATION NUMBER - 19653

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    USFDA APPLICATION NUMBER - 19697

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    USFDA APPLICATION NUMBER - 20130

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    USFDA APPLICATION NUMBER - 20301

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    USFDA APPLICATION NUMBER - 203667

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    USFDA APPLICATION NUMBER - 204061

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    DOSAGE - CAPSULE;ORAL - 0.02MG;1MG

    USFDA APPLICATION NUMBER - 204426

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    USFDA APPLICATION NUMBER - 204654

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    DOSAGE - TABLET;ORAL - 0.02MG;0.1MG

    USFDA APPLICATION NUMBER - 208612

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    DOSAGE - RING;VAGINAL - 0.013MG/24HR;0.15MG/2...DOSAGE - RING;VAGINAL - 0.013MG/24HR;0.15MG/24HR

    USFDA APPLICATION NUMBER - 209627

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    DOSAGE - TABLET;ORAL - 0.0025MG;0.5MG

    USFDA APPLICATION NUMBER - 21065

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    USFDA APPLICATION NUMBER - 21065

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    DOSAGE - TABLET;ORAL-28 - 0.1MG,0.125MG,0.15M...DOSAGE - TABLET;ORAL-28 - 0.1MG,0.125MG,0.15MG;0.025MG,0.025MG,0.025MG

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    USFDA APPLICATION NUMBER - 21180

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    DOSAGE - RING;VAGINAL - 0.015MG/24HR;0.12MG/2...DOSAGE - RING;VAGINAL - 0.015MG/24HR;0.12MG/24HR

    USFDA APPLICATION NUMBER - 21187

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    USFDA APPLICATION NUMBER - 21241

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    USFDA APPLICATION NUMBER - 21490

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    DOSAGE - TABLET;ORAL - 3MG;0.02MG

    USFDA APPLICATION NUMBER - 21676

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    USFDA APPLICATION NUMBER - 21871

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    DOSAGE - TABLET;ORAL - 0.01MG,0.01MG;1MG,N/A

    USFDA APPLICATION NUMBER - 22501

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