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Chemistry

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Also known as: Ethyl alcohol, Alcohol, 64-17-5, Grain alcohol, Methylcarbinol, Ethyl hydroxide
Molecular Formula
C2H6O
Molecular Weight
46.07  g/mol
InChI Key
LFQSCWFLJHTTHZ-UHFFFAOYSA-N
FDA UNII
3K9958V90M

Ethanol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
1 2D Structure

Ethanol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
ethanol
2.1.2 InChI
InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
2.1.3 InChI Key
LFQSCWFLJHTTHZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCO
2.2 Other Identifiers
2.2.1 UNII
3K9958V90M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Absolute Alcohol

2. Alcohol, Absolute

3. Alcohol, Ethyl

4. Alcohol, Grain

5. Ethyl Alcohol

6. Grain Alcohol

2.3.2 Depositor-Supplied Synonyms

1. Ethyl Alcohol

2. Alcohol

3. 64-17-5

4. Grain Alcohol

5. Methylcarbinol

6. Ethyl Hydroxide

7. Ethyl Hydrate

8. Tecsol

9. Etoh

10. Algrain

11. Anhydrol

12. Hydroxyethane

13. Alkohol

14. Jaysol S

15. Potato Alcohol

16. Cologne Spirit

17. 1-hydroxyethane

18. Absolute Ethanol

19. Ethanol 200 Proof

20. Molasses Alcohol

21. Spirits Of Wine

22. Etanol

23. Aethylalkohol

24. Denatured Alcohol

25. Denatured Ethanol

26. Aethanol

27. Alcool Ethylique

28. Fermentation Alcohol

29. Alcohol, Diluted

30. Tecsol C

31. Dehydrated Ethanol

32. Alcool Etilico

33. Alcohol, Ethyl

34. Alcohols

35. Etanolo

36. Jaysol

37. Etylowy Alkohol

38. Absolute Alcohol

39. Ethanol Solution

40. Alcohol Dehydrated

41. Alkoholu Etylowego

42. Dehydrated Alcohol

43. Ethyl Alcohol Usp

44. Alcohol, Anhydrous

45. Synasol

46. Ethyl Alcohol Anhydrous

47. Denatured Alcohol Cd-5

48. Denatured Alcohol Sd-1

49. Alcohol Anhydrous

50. Distilled Spirits

51. Denatured Alcohol Cd-5a

52. Denatured Alcohol Sd-3a

53. Denatured Alcohol Cd-10

54. Denatured Alcohol Sd-17

55. Denatured Alcohol Sd-28

56. Denatured Alcohol Sd-30

57. Denatured Alcohol Sd-13a

58. Denatured Alcohol Sd-23a

59. Denatured Alcohol Sd-39b

60. Denatured Alcohol Sd-39c

61. Denatured Alcohol Sd-40m

62. Ethylalcohol

63. Spirit

64. Alcohol, Dehydrated

65. Sd Alchol 23-hydrogen

66. Alkohol [german]

67. Aethanol [german]

68. Etanolo [italian]

69. Ethyl Alcohol & Water, 5%

70. Thanol

71. Ethanol, Undenatured

72. Spirt

73. Alcare Hand Degermer

74. Ethyl Alcohol & Water, 10%

75. Ethyl Alcohol & Water, 20%

76. Ethyl Alcohol & Water, 30%

77. Ethyl Alcohol & Water, 40%

78. Ethyl Alcohol & Water, 50%

79. Ethyl Alcohol & Water, 60%

80. Ethyl Alcohol & Water, 70%

81. Ethyl Alcohol & Water, 80%

82. Ethyl Alcohol & Water, 95%

83. Ethyl Alcohol & Water, 96%

84. Ethyl Alc

85. Ethylalcohol [dutch]

86. Ethyl Alcohol And Water

87. Alcohol, Absolute

88. Nci-c03134

89. Alcohol (ethyl Alcohol)

90. Alcohol [usp]

91. Ethanol [jan]

92. Ethicap

93. Hinetoless

94. Alcohols, C1-3

95. Cologne Spirits

96. Caswell No. 430

97. Reagent Alcohol

98. Infinity Pure

99. Aethylalkohol [german]

100. Desinfektol El

101. Anhydrous Alcohol

102. Anhydrous Ethanol

103. Ethyl Alcohol In Alcoholic Beverages

104. Fema No. 2419

105. Fema Number 2419

106. Alcool Etilico [italian]

107. Etylowy Alkohol [polish]

108. Ethyl Alcohol, Undenatured

109. Alcool Ethylique [french]

110. C2h5oh

111. Alkoholu Etylowego [polish]

112. Hsdb 82

113. Sdm No. 37

114. Ai3-01706

115. Ccris 945

116. Ethylicum

117. Alcohol,ethyl

118. Edible Alcohol

119. Ethanol Vapor

120. Sd Alcohol 23-hydrogen

121. Alcohol Denatured

122. Alcohol,dehydrated

123. Ru-tuss Hydrocodone Liquid

124. Alcohol, Denatured

125. Ethanol, Denatured

126. Ethanol, Anhydrous

127. Nsc 85228

128. Ethanol, Dehydrated

129. Alcohol (usp)

130. Epa Pesticide Chemical Code 001501

131. Absolute Ethyl Alcohol

132. Ethyl Alcohol, Absolute

133. Punctilious Ethyl Alcohol

134. Ethyl Alcohol, Dehydrated

135. Ethanol Absolute

136. Ethanol, Anhydrous, Denatured

137. Alcohol Determination--alcohol

138. Chebi:16236

139. Nsc-85228

140. 3k9958v90m

141. Ethanol, Cda 19

142. Ethanol, 200 Proof

143. Ethyl Alcohol Denatured

144. Ethylol

145. Pm-6193-200

146. Ethanol Anhydrous

147. 68475-56-9

148. Eoh

149. Sekundasprit

150. Alcohol Etilico

151. Spiritus Vini

152. Mfcd00003568

153. Ethanol Denatured

154. 42845-45-4

155. Lux

156. Sy Fresh M

157. Esumiru Wk 88

158. Ethanol (9ci)

159. Ethanol, Silent Spirit

160. Alcohol Denat.

161. Anhydrol Pm 4085

162. Ethyl Alcohol, Anhydrous

163. Ethyl Alcohol (ethanol)

164. Higher Alcohol Distillate

165. Alcohol 5% In Dextrose 5%

166. Einecs 200-578-6

167. Cologne Spirits (alcohol)

168. Sda 3a

169. Alcoholum

170. Ethanolum

171. Silent Spirit

172. Diluted Alcohol

173. Ethanol In Alcoholic Beverages

174. Vodka

175. Alcohol,sda

176. Ethanol-

177. 100c.npa

178. Cda 19

179. Ims 99

180. Sd Alcohol

181. Ethanol, Dimer

182. Alcohol,denatured

183. Unii-3k9958v90m

184. Alcohol (ethyl)

185. Undenatured Ethanol

186. Ahd 2000

187. Sda 40-2

188. Vanilla Powder

189. Einecs 270-649-4

190. Eosin Y, Alcoholic

191. Ablysinol

192. Alcohol 95%

193. Alcohol 190 Proof

194. Cda 19-200

195. Ethyl Alcohol 40%

196. Ethyl Alcohol 70%

197. Ethyl Alcohol 75%

198. Ethyl Alcohol 80%

199. Ethyl Alcohol 90%

200. Alcohol [vandf]

201. Alcohol [hsdb]

202. Alcohol [inci]

203. Ethanol, 99.8%

204. Ethanol, Technical Grade

205. Fatty Alcohol C8-10

206. Reagent Alcohol, 70%

207. Reagent Alcohol, 80%

208. Reagent Alcohol, 95%

209. Alcohol [ii]

210. Ch3ch2oh

211. Dehydrated Ethanol (tn)

212. Ethyl Alcohol 47.5%

213. Ethylicum [hpus]

214. Dsstox_cid_584

215. Ethanol, Standard For Gc

216. Alcohol [usp-rs]

217. Alcohol [who-ip]

218. Ethanol [who-dd]

219. Ethanol [who-ip]

220. Industrial Alcohol (ims)

221. Bmse000297

222. Chembl545

223. Ec 200-578-6

224. Ethanol, >=99.5%

225. Aerosol™ Ot Solution

226. Anhydrous Ethanol (jp17)

227. Ethyl Alcohol [mi]

228. Reagent Alcohol, For Hplc

229. Ethanol, Analytical Standard

230. Dsstox_rid_75674

231. Sd 3a

232. Dsstox_gsid_20584

233. Ru-tuss Liquid (salt/mix)

234. Ethanol, Usp, 99.5%

235. Ethyl Alcohol [fhfi]

236. Wln: Q2

237. Ethanol, For Residue Analysis

238. Reagent Alcohol, Acs Reagent

239. Alcohol [orange Book]

240. Alcohol,ethyl [vandf]

241. B3324 [langual]

242. Duplicating Fluid 100c.npa

243. Ethanol, P.a., 99.8%

244. Reagent Alcohol, Reagent Grade

245. Sdm No. 37 (salt/mix)

246. Gtpl2299

247. Anhydrous Ethanol [jan]

248. Avagard Component Alcohol

249. Hbn-1 Component Ethanol

250. Alcohol Dehydrated, >=85.0%

251. Dtxsid9020584

252. Ethanol, Technical Grade, 93%

253. Ethanol, Technical Grade, 99%

254. Unii-7528n5h79b

255. Chebi:17246

256. Ethanol, 95.1-96.9%

257. Poly(vinyl Alcohol) Macromolecule

258. Ru-tuss Expectorant (salt/mix)

259. Alcohol, Dehydrated [ii]

260. Alcoholum [who-ip Latin]

261. Ethanolum [who-ip Latin]

262. Ethyl Alcohol (6ci,7ci,8ci)

263. Alcohol,dehydrated [vandf]

264. Ethanol Component Of Hbn-1

265. Ethanol, Technical Grade, 93.8%

266. Ethanol, Technical Grade, 99.5%

267. Alcohol Component Of Avagard

268. Alcohol, Dehydrated [vandf]

269. Dehydrated Alcohol [usp-rs]

270. Ethanol, >=99.5%, For Hplc

271. Nsc85228

272. Str05604

273. Ethanol 100 Microg/ml In Methanol

274. Ethyl Alcohol 95% Acs/usp Grade

275. Tox21_202510

276. Stl264245

277. Ethanol 1000 Microg/ml In Methanol

278. Ethanol 2000 Microg/ml In Methanol

279. Ethanol, 95.0%, (190 Proof)

280. Ethanol, P.a., Acs Reagent, 96%

281. Ethanol, Tested According To Ph.eur.

282. Ethanol, Usp, 70.0-72.0%

283. Ethanol, Usp, 94.9-96.0%

284. Akos009104571

285. Ethanol, Reagent (denatured Sda 3a)

286. 7528n5h79b

287. Db00898

288. Ethanol 10000 Microg/ml In Methanol

289. Ethanol, Absolute, >=99.8% (gc)

290. Ethanol, Uv Hplc Spectroscopic, 95%

291. Un 1170

292. Cas-64-17-5

293. Ethanol, Denatured, (uk Ida Standard)

294. Ethanol, Saj First Grade, >=99.5%

295. Ethyl Alcohol Absolute, Acs/usp Grade

296. Ethanol, Jis Special Grade, >=99.5%

297. Ethanol, P.a., Acs Reagent, 95.0%

298. Ethanol, Technical Grade, 92.6-93.8

299. Ncgc00091458-01

300. Ncgc00091458-02

301. Ncgc00260059-01

302. Reagent Alcohol, Spectrophotometric Grade

303. Dehydrated Alcohol [usp Monograph]

304. Ethanol, Anhydrous [ep Monograph]

305. Q153

306. Ethanol, Absolute, For Hplc, >=99.8%

307. Ethanol, Anhydrous, Denatured, Hplc Grade

308. Ethyl Alcohol 95% (synthetic) Fcc Grade

309. Ethanol, Acs Reagent, 99.8, 200 Proof

310. Ethanol, Jis First Grade, 94.8-95.8%

311. Ethyl Alcohol Absolute (organic) Usp Grade

312. E1510

313. Ethanol In Alcoholic Beverages [iarc]

314. Ethanol Solution, Ep, Bp, 69.5-70.4%

315. Ethanol, Denatured, Spectrophotometric Grade

316. Ethanol, Jis Special Grade, 94.8-95.8%

317. Ft-0625729

318. Ft-0625731

319. Ft-0625732

320. Ft-0668048

321. Ethanol, >=99.5%, Saj Super Special Grade

322. Reagent Alcohol, Anhydrous, <=0.003% Water

323. Reagent Alcohol, Anhydrous, <=0.005% Water

324. C00469

325. D00068

326. Ethanol, >=99.5%, Suitable For Fluorescence

327. Ethanol, Alcohol Reagent, Anhydrous, Denatured

328. Ethyl Alcohol 95% (grain Derived) Fcc Grade

329. Ethyl Alcohol 95% (synthetic) Acs/usp Grade

330. Ethyl Alcohol Absolute (synthetic) Acs/usp Grade

331. Sr-01000944357

332. Ethanol, Puriss. P.a., Absolute, >=99.8% (gc)

333. Sr-01000944357-1

334. Ethanol, Denatured (5 % Ipa, 5 % N-propylacetate)

335. Reagent Alcohol, Used For Histology Tissue Preparation

336. Ethanol, Anhydrous, Denatured, Spectrophotometric Grade

337. Ethyl Alcohol, Pure, 190 Proof, For Molecular Biology

338. Ethyl Alcohol, Pure, 200 Proof, Anhydrous, >=99.5%

339. Ethyl Alcohol, Pure, 200 Proof, For Molecular Biology

340. Ethanol 70%, Denatured With 1% Mek, 1% Ipa, 10 Mg/l

341. Ethanol, Absolute, >=99.8% (gc), Sales Not In Germany

342. Ethyl Alcohol Absolute (dehydrated) Usp, Bp/ep, Jp Grade

343. Ethyl Alcohol, Pure, 200 Proof, Acs Reagent, >=99.5%

344. Reagent Alcohol, 70%, Used For Histology Tissue Preparation

345. Reagent Alcohol, 80%, Used For Histology Tissue Preparation

346. 1e37b0d2-6209-4b03-a57d-500f3223c2da

347. Alcohol, United States Pharmacopeia (usp) Reference Standard

348. Ethanol, >=99.5%, Suitable For Absorption Spectrum Analysis

349. Ethanol-water Solutions, Nist(r) Srm(r) 1828b, Six Levels

350. Ethyl Alcohol, Pure, 200 Proof, Hplc/spectrophotometric Grade

351. Reagent Alcohol, 95%, Used For Histology Tissue Preparation

352. Ethanol Solution, Nist(r) Srm(r) 2897a, Nominal Mass Fraction 2%

353. Ethanol Solution, Nist(r) Srm(r) 2898a, Nominal Mass Fraction 6%

354. Ethanol Solution, Nist(r) Srm(r) 2899a, Nominal 25% By Mass

355. Ethanol, P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 99.9%

356. Ethanol, Suitable For 300 Per Jis, >=99.5%, For Residue Analysis

357. Ethyl Alcohol, Pure, 190 Proof, Meets Usp Testing Specifications

358. Ethyl Alcohol, Pure, 200 Proof, Anhydrous, Zero2(tm), >=99.5%

359. Ethyl Alcohol, Pure, 200 Proof, Meets Usp Testing Specifications

360. Specially Denatured Alcohol, 190 Proof, Sda 23a, Contains Acetone

361. Specially Denatured Alcohol, 190 Proof, Sda 2b-3, Contains Toluene

362. Specially Denatured Alcohol, 190 Proof, Sda 30, Contains Methanol

363. Specially Denatured Alcohol, 190 Proof, Sda 3a, Contains Methanol

364. Specially Denatured Alcohol, 200 Proof, Sda 23a, Contains Acetone

365. Specially Denatured Alcohol, 200 Proof, Sda 2b-3, Contains Toluene

366. Specially Denatured Alcohol, 200 Proof, Sda 30, Contains Methanol

367. Specially Denatured Alcohol, 200 Proof, Sda 3a, Contains Methanol

368. Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material

369. Dehydrated Alcohol, United States Pharmacopeia (usp) Reference Standard

370. Ethanol Fixative 80% V/v, Suitable For Fixing Solution (blood Films)

371. Ethanol Solution, Certified Reference Material, 2000 Mug/ml In Methanol

372. Ethanol Standards 10% (v/v), 10 % (v/v) In H2o, Analytical Standard

373. Ethanol, Absolute, For Gradient Elution, Sales Not In Germany, >=99.9%

374. Ethanol, Absolute, For Hplc, Sales Not In Germany1, >=99.8% (gc)

375. Ethanol, Absolute, Semiconductor Grade Puranal(tm) (honeywell 17826)

376. Ethanol, Suitable For 1000 Per Jis, >=99.5%, For Residue Analysis

377. Ethanol-water Solution, Nist(r) Srm(r) 2894, Nominal Mass Fraction 0.1%

378. Ethanol-water Solution, Nist(r) Srm(r) 2895, Nominal Mass Fraction 0.2%

379. Ethanol-water Solution, Nist(r) Srm(r) 2896, Nominal Mass Fraction 0.3%

380. Ethanol-water Solution, Nist(r) Srm(r) 2900, Nominal 95.6% By Mass

381. Ethyl Alcohol Absolute (dehydrated, Synthetic) Usp, Bp/ep, Jp Grade

382. Ethyl Alcohol, Pure, 140 Proof, Excise Tax-free, Permit For Use Required

383. Ethyl Alcohol, Pure, 160 Proof, Excise Tax-free, Permit For Use Required

384. Ethyl Alcohol, Pure, 190 Proof, Acs Spectrophotometric Grade, 95.0%

385. Specially Denatured Alcohol, 190 Proof, Sda 2b-4, Contains Heptanes

386. Specially Denatured Alcohol, 190 Proof, Sda 2b-4, Contains N-heptane

387. Specially Denatured Alcohol, 190 Proof, Sda 2b-5, Contains N-hexane

388. Specially Denatured Alcohol, 190 Proof, Sda 35a, Contains Ethyl Acetate

389. Specially Denatured Alcohol, 190 Proof, Sda 3c, Contains Isopropanol

390. Specially Denatured Alcohol, 200 Proof, Sda 2b-4, Contains Heptanes

391. Specially Denatured Alcohol, 200 Proof, Sda 2b-4, Contains N-heptane

392. Specially Denatured Alcohol, 200 Proof, Sda 2b-5, Contains N-hexane

393. Specially Denatured Alcohol, 200 Proof, Sda 35a, Contains Ethyl Acetate

394. Specially Denatured Alcohol, 200 Proof, Sda 3c, Contains Isopropanol

395. Alcohol Determination-alcohol, United States Pharmacopeia (usp) Reference Standard

396. Dehydrated Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material

397. Ethanol Calibration Kit, Ampule Of 10 X 1.2 Ml, Certified Reference Material

398. Ethanol, Absolute, Reag. Iso, Reag. Ph. Eur., >=99.8% (gc), Liquid (clear, Colorless)

399. Ethanol, Puriss. P.a., Acs Reagent, Absolute Alcohol, Without Additive, A15 O1, >=99.8%

400. Ethanol, Puriss. P.a., Acs Reagent, Prima Fine Spirit, Without Additive, F15 O1, ~96%

401. Ethanol, Puriss., Meets Analytical Specification Of Ph.??eur., Bp, 96% (v/v)

402. Ethanol, Puriss., Meets Analytical Specification Of Ph.??eur., Bp, 96.0-97.2%

403. Ethanol-10, 10 Mg/dl In H2o, Pack Of 10 X 1.2 Ml Ampules, Certified Reference Material

404. Ethanol-150, 150 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

405. Ethanol-25, 25 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

406. Ethanol-300, 300 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

407. Ethanol-40, 40 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

408. Ethanol-50, 50 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

409. Ethanol-500, 500 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

410. Ethanol-80, 80 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

411. Ethanol-80, 80 Mg/dl In H2o, Ampule Of 5 X 5 Ml, Certified Reference Material

412. Ethanol-water Solution, Nist(r) Srm(r) 2891, Nominal Mass Fraction 0.02%

413. Ethanol-water Solution, Nist(r) Srm(r) 2892, Nominal Mass Fraction 0.04%

414. Ethanol-water Solution, Nist(r) Srm(r) 2893, Nominal Mass Fraction 0.08%

415. Specially Denatured Alcohol, 190 Proof, Sda 39c, Contains Diethyl Phthalate

416. Specially Denatured Alcohol, 200 Proof, Sda 39c, Contains Diethyl Phthalate

417. Ethanol, Absolute, Denaturated With 0.5-1.5 Vol.% 2-butanone And Approx. 0.001% Bitrex (gc), >=98% (gc)

418. Ethanol, Absolute, Semiconductor Grade Puranal(tm) (honeywell 17833), Sales Not In Germany, >=99.8% (vol.)

419. Ethanol, Bioultra, For Molecular Biology, >=99.8%, (absolute Alcohol, Without Additive, A15 O1)

420. Ethanol, Puriss., Over Molecular Sieve (h2o <=0.01%), Absolute Alcohol, Without Additive, A15 O1, >=99.8%

421. Ethanol, Purum, Absolute Ethanol, Denaturated With 1% Cyclohexane, A15 Cyclo1, >=99.8% (based On Denaturant-free Substance)

422. Ethanol, Purum, Absolute Ethanol, Denaturated With 2% 2-butanone, A15 Mek1, >=99.8% (based On Denaturant-free Substance)

423. Ethanol, Purum, Absolute Ethanol, Denaturated With 4.8% Isopropanol, A15 Ipa1, >=99.8% (based On Denaturant-free Substance)

424. Ethanol, Purum, Fine Spirit, Denaturated With 2% 2-butanone, F25 Mek1, ~96% (based On Denaturant-free Substance)

425. Ethanol, Purum, Fine Spirit, Denaturated With 4.8% Methanol, F25 Methyl1, ~96% (based On Denaturant-free Substance)

426. Ethanol, Purum, Secunda Spirit, Denaturated With 2% 2-butanone And 0.5% 4-methyl-2-pentanone, S15, ~96% (based On Denaturant-free Substance)

427. Ethanol-100 (10 Ampules/kit), 100 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

428. Ethanol-100 (5 Ampules/kit), 100 Mg/dl In H2o, Ampule Of 5 X 5 Ml, Certified Reference Material

429. Ethanol-20 (10 Ampules/kit), 20 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

430. Ethanol-20 (5 Ampules/kit), 20 Mg/dl In H2o, Ampule Of 5 X 5 Ml, Certified Reference Material

431. Ethanol-200 (10 Ampules/kit), 200 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

432. Ethanol-200 (5 Ampules/kit), 200 Mg/dl In H2o, Ampule Of 5 X 5 Ml, Certified Reference Material

433. Ethanol-400 (10 Ampules/kit), 400 Mg/dl In H2o, Ampule Of 10 X 1.2 Ml, Certified Reference Material

434. Ethanol-400 (5 Ampules/kit), 400 Mg/dl In H2o, Ampule Of 5 X 5 Ml, Certified Reference Material

435. Ethyl Alcohol, Pure, 140 Proof, Meets Water Usp Testing Specifications, Excise Tax-free, Permit For Use Required

436. Ethyl Alcohol, Pure, 190 Proof, Acs Reagent, Meets Usp Testing Specifications, Excise Tax-free, Permit For Use Required

437. Ethyl Alcohol, Pure, 200 Proof, Acs Reagent, Meets Usp Testing Specifications, Excise Tax-free, Permit For Use Required

438. Specially Denatured Alcohol, 190 Proof, Sda 40 (40-2), Contains 0.14 % (v/v) Tert-butyl Alcohol And Brucine Sulfate

439. Specially Denatured Alcohol, 190 Proof, Sda 40b, Contains Tert-butyl Alcohol And Denatonium Benzoate

440. Specially Denatured Alcohol, 200 Proof, Sda 40 (40-2), Contains 0.14 % (v/v) Tert-butyl Alcohol And Brucine Sulfate

441. Specially Denatured Alcohol, 200 Proof, Sda 40b, Contains Tert-butyl Alcohol And Denatonium Benzoate

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 46.07 g/mol
Molecular Formula C2H6O
XLogP3-0.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass46.041864811 g/mol
Monoisotopic Mass46.041864811 g/mol
Topological Polar Surface Area20.2 Ų
Heavy Atom Count3
Formal Charge0
Complexity2.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

/EXPL THER/ Ethanol lock therapy (ELT) has emerged as an effective method for the prevention and treatment of central line-associated bloodstream infections (CLABSIs), but the safety of ELT in infants has not been established. The objective of this study was to determine blood alcohol concentration (BAC) and evidence of hepatic injury in infants after infusing a small one-time dose of ethanol, equivalent to the volume that would be flushed through the central venous catheter (CVC) after ELT is completed. This was a prospective pilot study in infants weighing

PMID:25632063 Chhim RF et al; Ann Pharmacother 49 (4): 431-6 (2015)


/The objective of the study was/ to evaluate the efficacy, safety, pain perception and health-related quality of life (QoL) of percutaneous ethanol injection treatment (PEIT) as an alternative to thyroid surgery in symptomatic thyroid cysts. Thirty consecutive patients (46 +/- 10 years; 82% women) with symptomatic benign thyroid cysts relapsed after drainage were included. In all cases, cytology prior to treatment, maximum cyst diameter and volume were determined. PEIT was conducted using the established procedure, and the volume of fluid removed and pain perceived by the patient were assessed. In each procedure, the volume of alcohol instilled was <2 mL. After follow-up, final cyst diameter and volume were determined and the persistence of symptoms and QoL were assessed by a questionnaire (SF-36). Mean symptom duration was 10 +/- 20 months. A single session of PEIT was required to complete the procedure in 45% of patients, two in 31% and three in 13%. Mean initial maximum cyst diameter was 3.5 +/- 1.0 cm and mean extracted liquid volume 61 +/- 36 mL. During PEIT, 39% of patients experienced virtually no pain, 43% mild pain and 17% moderate pain. No complications of PEIT were observed. After 12.1 +/- 1.4 months of follow-up, cysts were reduced more than 70% in volume in 86.3% of patients, more than 80% in 61.9% and more than 90% in 42%. On the health-related QoL SF-36 questionnaire, patient scores 6 months post-PEIT did not differ significantly from those of the healthy Spanish population. With respect to cosmetic complaints or local symptoms of compression, PEIT-treated patients presented an initial score of 22 +/- 8 and 13 +/- 5 after treatment (p < 0.05). In our experience, percutaneous ethanol injection has proved to be an effective, safe and well-tolerated first-line treatment of symptomatic thyroid cysts.

PMID:26610707 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661972 Reverter JL et al; BMC Endocr Disord 15: 73 (2015)


Because of the increased risk of surgery, thyroid nodules causing compression signs and/or hyperthyroidism are concerning during pregnancy. Six patients with nontoxic cystic, four with nontoxic solid, and three with overt hyperthyroidism caused by toxic nodules were treated with percutaneous ethanol injection therapy (PEI). An average of 0.68 mL ethanol per 1 mL nodule volume was administered. Mean number of PEI treatments for patients was 2.9. Success was defined as the shrinkage of the nodule by more than 50% of the pretreatment volume (V0) and the normalization of TSH and FT4 levels. The average V0 was 15.3 mL. Short-term success was measured prior to labor, whereas long-term success was determined during the final follow-up (an average of 6.8 years). The pressure symptoms decreased in all but one patient after PEI and did not worsen until delivery. The PEI was successful in 11 (85%) and 7 (54%) patients at short-term and long-term follow-up, respectively. Three patients underwent repeat PEI which was successful in 2 patients. PEI is a safe tool and seems to have good short-term results in treating selected symptomatic pregnant patients. Long-term success may require repeat PEI.

PMID:26697066 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677206 Solymosi T et al; Int J Endocrinol 2015: 765950 (2015)


Methanol poisoning outbreaks are a global public health issue, with delayed treatment causing poor outcomes. Out-of-hospital ethanol administration may improve outcome, but the difficulty of conducting research in outbreaks has meant that its effects have never been assessed. We study the effect of out-of-hospital ethanol in patients treated during a methanol outbreak in the Czech Republic between 2012 and 2014. This was an observational case-series study of 100 hospitalized patients with confirmed methanol poisoning. Out-of-hospital ethanol as a "first aid antidote" was administered by paramedic or medical staff before the confirmation of diagnosis to 30 patients; 70 patients did not receive out-of-hospital ethanol from the staff (12 patients self-administered ethanol shortly before presentation). The state of consciousness at first contact with paramedic or medical staff, delay to admission, and serum methanol concentration were similar among groups. The median serum ethanol level on admission in the patients with out-of-hospital administration by paramedic or medical staff was 84.3 mg/dL (interquartile range 32.7 to 129.5 mg/dL). No patients with positive serum ethanol level on admission died compared with 21 with negative serum ethanol level (0% versus 36.2%). Patients receiving out-of-hospital ethanol survived without visual and central nervous system sequelae more often than those not receiving it (90.5% versus 19.0%). A positive association was present between out-of-hospital ethanol administration by paramedic or medical staff, serum ethanol concentration on admission, and both total survival and survival without sequelae of poisoning. We found a positive association between out-of-hospital ethanol administration and improved clinical outcome. During mass methanol outbreaks, conscious adults with suspected poisoning should be considered for administration of out-of-hospital ethanol to reduce morbidity and mortality.

PMID:26875060 Zakharov S et al; Ann Emerg Med 68 (1): 52-61 (2016)


For more Therapeutic Uses (Complete) data for Ethanol (24 total), please visit the HSDB record page.


4.2 Drug Warning

Although there is a dose response relationship between alcohol consumption and liver damage, less than one-third of alcoholics develop alcoholic liver disease (ALD). This individual susceptibility to the development of alcoholic liver disease may be explained by genetic and environmental factors. Of the genetic factors, female sex is clearly a significant risk factor, human leukocyte antigen status is probably important but further studies are needed, abnormalities in alcohol metabolism have not been shown to be of primary pathogenic importance and the plethora of immunological disturbances reported appear to be mere epiphenomena. Of the environmental factors, no consistent evidence attests to the significance of hepatitis B viral infection in the susceptibility to developing alcoholic liver disease.

Johnson RD, Williams R; Alcohol 20 (2): 137-60 (1985)


Maternal Medication usually Compatible with Breast-Feeding: alcohol (ethanol): Reported Sign or Symptom in Infant or Effect on Lactation: With large amounts drowsiness, diaphoresis, deep sleep, weakness, decrease in linear growth, abnormal weight gain; maternal ingestion of 1 g/kg daily decreases milk ejection reflex. /from Table 6/

Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 140 (1994)


Two weeks after percutaneous ethanol injection therapy for hepatocellular carcinoma, performed by injecting 110 mL ethanol in a single session with general anesthesia, a 69-year-old woman with well-compensated liver cirrhosis developed an extensive thrombosis of the whole portal tree that caused severe uncorrectable ascites and progressive deterioration of her general condition, resulting in death 6 weeks after the procedure.

PMID:9922194 Lencioni R et al; Abdom Imaging 23 (6): 608-10 (1998)


Two patients developed hepatic infarction after undergoing percutaneous ethanol injection therapy (PEIT) for hepatocellular carcinoma (HCC). In both cases, liver function parameters deteriorated immediately after the ethanol injection, and enhanced computed tomography images showed a wedge-shaped avascular low-density area due to hepatic infarction. In one patient, PEIT was performed for a nodule treated with transcatheter arterial infusion (TAI) using a suspension of styrene maleic acid neocarzinostatin (SMANCS) 4 weeks before. In the other patient, TAI with SMANCS had been carried out 14 months previously for a different nodule in the same segment where the nodule treated with PEIT was located. When PEIT is used for patients with HCC who have previously undergone TAI, especially with SMANCS, PEIT may induce hepatic infarction.

PMID:9872612 Seki T et al; Eur J Gastroenterol Hepatol 10 (11): 915-8


Since 1990, percutaneous ethanol injection therapy (PEIT) has been clinically applied as a treatment for autonomous functioning nodules of the thyroid as well as for cystic lesions. Some additional indications are currently under consideration, e.g. inoperable advanced cancer of the thyroid. Since its inception, PEIT has generally been regarded as an effective, low-risk, inexpensive procedure which can be performed on an ambulatory basis. /The authors/ report the first case of severe ethyl toxic necrosis of the larynx combined with necrotic dermatitis in a patient treated with PEIT by a radiologist. The patient was admitted to hospital, where the necrosis and dermatitis were treated conservatively. A cyst which developed in the right false vocal fold was removed by microsurgery 10 months later. Voice was restored almost to normal but a significant reduction in nodular volume was not seen, probably due to the inexperience of the operator. PEIT for functional thyroid gland autonomy is an inexpensive method of treating hyperthyroidism with focal autonomy on an ambulatory basis if surgical intervention and radioiodine therapy are not feasible either for medical reasons or because of refusal by the patient. Severe complications must be taken into consideration and discussed with the patient. To avoid complications, substantial experience and a precise ultrasound-guided injection are required. In the case of complications the opinion of a specialist should be sought at an early stage.

PMID:15768823 Mauz PS et al; Acta Otolaryngol 124 (10): 1226-30 (2004)


4.3 Minimum/Potential Fatal Human Dose

... The fatal dose of ethanol is between 500 and 1000 mL of 100-proof liquor (50% ethanol), ingested in an hour or two. ...

PMID:4574410 McBay AJ; Clinical Chemistry 19 (4): 361-365 (1973)


4.4 Drug Indication

For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.


Treatment of congenital venous malformations


Treatment of uncontrolled primary hypertension


5 Pharmacology and Biochemistry
5.1 Pharmacology

Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm. This accounts for its bacteriocidal and antifungal action. When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis). Ninety to 98% of ethanol that enters the body is completely oxidized. Ethanol is also used as a cosolvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations. Ethanol also binds to GABA, glycine, NMDA receptors and modulates their effects. Ethanol is also metabolised by the hepatic enzyme alcohol dehydrogenase.


5.2 MeSH Pharmacological Classification

Anti-Infective Agents, Local

Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. (See all compounds classified as Anti-Infective Agents, Local.)


Central Nervous System Depressants

A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents). (See all compounds classified as Central Nervous System Depressants.)


Solvents

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant and Hackh's Chemical Dictionary, 5th ed) (See all compounds classified as Solvents.)


5.3 FDA Pharmacological Classification
5.3.1 Pharmacological Classes
Cell-mediated Immunity [PE]; Increased Histamine Release [PE]; Standardized Chemical Allergen [EPC]; Allergens [CS]
5.4 ATC Code

D08AX08

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


D - Dermatologicals

D08 - Antiseptics and disinfectants

D08A - Antiseptics and disinfectants

D08AX - Other antiseptics and disinfectants

D08AX08 - Ethanol


V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AB - Antidotes

V03AB16 - Ethanol


V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AZ - Nerve depressants

V03AZ01 - Ethanol


5.5 Absorption, Distribution and Excretion

Absorption

Rapidly absorbed.


After oral administration, ethanol is absorbed rapidly into the bloodstream from the stomach and small intestines and distributes into total body water (0.5-0.7 L/kg). Peak blood levels occur about 30 minutes after ingestion of ethanol when the stomach is empty. Because absorption occurs more rapidly from the small intestine than from the stomach, delays in gastric emptying (owing, e.g., to the presence of food) slow ethanol absorption. ... After oral consumption of alcohol, first-pass metabolism by gastric and liver alcohol dehydrogenase enzymes leads to lower blood alcohol levels than would be obtained if the same dose were administered intravenously.

Brunton, L. Chabner, B, Knollman, B. Goodman and Gillman's The Pharmaceutical Basis of Therapeutics, Twelth Edition, McGraw Hill Medical, New York, NY. 2011, p. 630


The distribution of alcohol between alveolar air and blood depends on its speed of diffusion, and its vapor pressure at the prevailing temp and concentration of alcohol in the lung capillaries. Empirical determinations have yielded rather different values for this distribution ratio, but a commonly accepted value is 1:2100.

International Encyclopedia of Pharmacology and Therapeutics. Vol 1 Section 20: 170 (1970)


Venous blood (orbital sinus) and brain ethanol levels were measured in long sleep and short sleep mice within the first 30 min following ethanol administration (2.5 to 6.0 g/kg). Ethanol was administered ip or intragastrically. For both lines of mice and for every dose, brain ethanol concentrations were significantly greater (as much as 100 mg/dL) than blood ethanol levels for the first 6 min, and peak blood and brain ethanol levels were reached 4 to 6 min after dosing. Approx 6 to 10 min (depending on dose and line of mouse) was required for blood and brain concn to reach equilibrium. At the time of loss of the righting response brain ethanol levels were significantly higher than blood ethanol levels. These results indicate that within the first 6 min after administration of ethanol, blood ethanol level is not suitable for the assessment of brain ethanol content.

PMID:2719816 Smolen TN, Smolen A; Alcohol 6 (1): 33-8 (1989)


The method of Pohorecky and Brick was modified for determination of ethanol concn in rebreathed air of rats. Female Sprague Dawley rats were injected with different doses (1 to 2 g/kg) of ethanol and both arterial blood and rebreathed air samples were collected at various time intervals (15 to 120 min) after administration. A good correlation (r= 0.96) was found between ethanol concn in arterial blood and in rebreathed air; the blood/breath conversion factor was 3241 + or - 55.

PMID:2719817 Hiltunen AJ et al; Alcohol 6 (1): 39-43 (1989)


For more Absorption, Distribution and Excretion (Complete) data for Ethanol (31 total), please visit the HSDB record page.


5.6 Metabolism/Metabolites

Hepatic. Metabolized by cytochrome P450 enzyme CYP2E1.


Ethanol metabolism in hepatocytes causes the generation of reactive oxygen species, endoplasmic reticulum stress and alterations in mitochondrial energy and REDOX metabolism. In ethanol-exposed liver disease, autophagy not only acts as a cleanser to remove damaged organelles and cytosolic components, but also selectively clears specific targets such as lipid droplets and damaged mitochondria. Moreover, ethanol appears to play a role in protecting hepatocytes from apoptosis at certain concentrations. This article describes the evidence, function and potential mechanism of autophagy in ethanol-exposed liver disease and the controversy surrounding the effects of ethanol on autophagy.

PMID:26186640 Wang LR et al; Expert Rev Gastroenterol Hepatol 9 (8): 1031-7 (2015)


There have been allegations in the courtroom that elevated serum lactic acid in trauma victims can yield a falsely elevated serum ethanol assay. Most hospitals utilize an indirect method of ethanol measurement where a serum sample is added to a mix of alcohol dehydrogenase and oxidized nicotinamide adenine dinucleotide (NAD+). This allows any ethanol in the patient's serum to be metabolized to acetaldehyde, and in the process results in the reduction of NAD+ to NADH. NADH is then measured using spectrophotometry. The courtroom allegation stems from the concept that oxidation of lactate to pyruvate by lactate dehydrogenase (LDH) results in the same molar-for-molar reduction of NAD+ to NADH, and could therefore theoretically cause patients with elevated lactate and LDH to have a falsely elevated ethanol concentration. Patients with elevated lactic acid and LDH concentrations who presented to a university hospital from 20 April 2015 to 13 December 2015 were identified to provide possible test specimens. If a sufficient amount of serum was available, the sample was used to re-run the lactate and LDH concentration simultaneously with an enzymatic ethanol assay. Any samples that had elevated lactic acid and LDH concentrations on this retesting, and also yielded a positive ethanol concentration, were sent for confirmatory gas chromatography testing of ethanol concentrations. A control group of 20 samples with normal lactate and LDH were included. A total of 37 samples were included in the final analysis. Only 4 patients had an elevated enzymatic ethanol concentration, and all 4 also had a measurable GC ethanol concentration. The lactate in this dataset ranged from 2.4 to 24.2 mmol/L, with a mean of 6.53 mmol/L (normal value 0.5-2.2). The LDH ranged from 242 to 8838 U/L with a mean of 1695 U/L (normal value 122-225 U/L). Twenty control samples were run on patients with normal lactate and LDH, none of which yielded a positive enzymatic ethanol result. This data does not support the contention that an elevated LDH and lactate can yield a false positive serum ethanol result as run by enzymatic ethanol assay in live patients presenting to the emergency department.

PMID:28812382 Nacca N et al; Clin Toxicol (Phila) 16: 1-4 (2017)


Ethanol is metabolized largely by sequential hepatic oxidation, first to acetaldehyde by alcohol dehydrogenase (ADE) and then to acetic acid by aldehyde dehydrogenase (ALDH). Each metabolic step requires NAD+; thus oxidation of 1 mol ethanol (46 g) to 1 mol acetic acid requires 2 mol NAD+ in the liver; indeed, NAD+ availability limits ethanol metabolism to about 8 gr or 10 mL (approximately 170 mmol) per hour in a 70-kg adult, or approximately 120 mg/kg per hour. Thus hepatic ethanol metabolism functionally saturates at relatively low blood levels compared with the high blood ethano levels (BELs) achieved, and ethanol metabolism is a zero-order process (constant amount per unit time). Small amounts of ethanol are excreted in urine, sweat, and breath, but metabolism to acetate accounts to 90-98% of ingested ethanol, mostly owing to hepatic metabolism by ADH and ADLH.

Brunton, L. Chabner, B, Knollman, B. Goodman and Gillman's The Pharmaceutical Basis of Therapeutics, Twelth Edition, McGraw Hill Medical, New York, NY. 2011, p. 630


Metabolism of ethanol, propanol, isopropanol, butanol, isobutanol, sec-butanol, and tert-butanol was studied after oral administration in rabbits. Blood pH was on the acid side with propanol, butanol, and isobutanol, and on the alkaline side with isopropanol and sec-butanol, but no change was observed with ethanol and tert-butanol. Butanol and isobutanol had the lowest rate of urinary excretion. Acetaldehyde and acetic acid were detected as the urinary metabolites of ethanol and propanol, whereas isobutyraldehyde and isovaleric acid were the metabolites of isobutanol.

Saito M; Nichidai Igaku Zasshi 34 (8-9): 569-85 (1975)


For more Metabolism/Metabolites (Complete) data for Ethanol (13 total), please visit the HSDB record page.


Ethanol has known human metabolites that include acetaldehyde.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


5.7 Biological Half-Life

... The concentrations of ethanol and methanol in blood were determined indirectly by analysis of end-expired alveolar air. In the morning when blood-ethanol dropped below the Km of liver alcohol dehydrogenase (ADH) of about 100 mg/L (2.2 mM), the disappearance half-life of ethanol was 21, 22, 18 and 15 min. in 4 test subjects respectively. ...

PMID:3588516 Jones AW; Pharmacol Toxicol. 60 (3): 217-20 (1987)


5.8 Mechanism of Action

Ethanol affects the brains neurons in several ways. It alters their membranes as well as their ion channels, enzymes, and receptors. Alcohol also binds directly to the receptors for acetylcholine, serotonin, GABA, and the NMDA receptors for glutamate. The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). It also inhibits NMDA receptor functioning. In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.


... Ethanol is known to affect a large number of membrane proteins that participate in signaling pathways such as neurotransmitter receptors, enzymes, and ion channels, and there is extensive evidence that ethanol interacts with a variety of neurotransmitters. The major actions of ethanol involve enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) at GABAa receptors and blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate, an excitatory amine acid (EAA) receptor. Animal studies indicate that the acute effects of ethanol result from competitive inhibition of glycine binding to NMDA receptor and disruption of glutamatergic neurotransmission by inhibiting the response of the NMDA receptor. Persistent glycine antagonism and attenuation of glutamatergic neurotransmission by chronic ethanol exposure results in tolerance to ethanol by enhancing EAA neurotransmission and NMDA receptor upregulation. The latter appears to involve selective increases in NMDA R2B subunit concentrations and other molecular changes in specific brain loci. The abrupt withdrawal of ethanol thus produces a hyperexcitable state that leads to the ethanol withdrawal syndrome and excitotoxic neuronal death. GABA-mediated inhibition, which normally acts to limit excitation, is eliminated during ethanol withdrawal syndrome and further intensifies this excitation. In addition, NMDA receptors function to inhibit the release of dopamine in the nucleus accumbens and mesolimbic structures, which modulate the reinforcing action of addictive xenobiotics such as ethanol. By inhibiting NMDA receptor activity, ethanol could increase dopamine release from the nucleus accumbens and ventral tegmental area and could thus create dependence. Chronic ethanol administration also results in tolerance, dependence, and an ethanol withdrawal syndrome, mediated, in part, by desensitization and or downregulation of GABAa receptors.

Goldfrank, L.R., Goldfrank's Toxicologic Emergencies 10th Ed. 2015., McGraw-Hill, New York, N.Y., p. 1085


The development of alcoholic ketoacidosis (AKA) requires that a combination of physical and physiologic events occur. The normal response to starvation and depletion of hepatic glycogen stores is for amino acids to be converted to pyruvate. Pyruvate can serve as a substrate for gluconeogenesis, be converted to acetyl-CoA, which can enter the Krebs cycle or can be utilized in various biosynthetic pathways (eg, fatty acid, ketone bodies, cholesterol, and acetylcholine) ... Ethanol metabolism generates NADH, resulting in an excess of reducing potential. This high redox state favors the conversion of pyruvate to lactate, diverting pyruvate from being a substrate for gluconeogenesis. To compensate for the lack of normal metabolic substrates, the body mobilizes fat from adipose tissue and increased fatty acid metabolism as an alternative source of energy. This response is mediated by a decrease in insulin and an increased secretion of glucagon, catecholamines, growth hormone, and cortisol. Fatty acid metabolism results in the formation of acetyl-CoA and it combines with the excess acetate that is generated from ethanol metabolism to form acetoacetate. Most of the acetoacetate is reduced to beta-hydroxybutyrate due to the excess reducing potential or high redox state of the cell. Volume depletion interferes with the renal elimination of acetoacetate and beta-hydroxybutyrate, and contributes to the acidosis. An elevated lactate concentration may result from shunting from pyruvate or from hypoperfusion or infection that may coexist with the underlying ketoacidosis.

Goldfrank, L.R., Goldfrank's Toxicologic Emergencies 10th Ed. 2015., McGraw-Hill, New York, N.Y., p. 1088


Adenosine may mediate many of the acute and chronic motor effects of ethanol on the brain. Ethanol, probably through its metabolite, acetate, prevents adenosine uptake, raising synaptic adenosine concentrations. Excessive stimulation of several adenosine receptors in the cerebellum may explain much of the motor impairment from low ethanol concentrations. In fact, animals made tolerant to ethanol develop cross-tolerance to adenosine agonists. In mice, adenosine receptor agonists increase ethanol-induced incoordination while adenosine antagonists decrease this intoxicating response.

Goldfrank, L.R. (ed). Goldfrank's Toxicologic Emergencies. 7th Edition McGraw-Hill New York, New York 2002., p. 162


Chronic ethanol (alcohol) administration has been associated with alterations in the binding and function of the gamma-aminobutyric acid (GABAA) receptor. To evaluate the mechanism underlying these changes, /the authors/ measured the steady state levels of the mRNAs for the alpha 1, alpha 2, alpha 3, alpha 5, and alpha 6 subunits of the GABAA receptor after chronic ethanol administration to rats and ethanol withdrawal for 24 hr. The results indicated that chronic ethanol administration resulted in a 61% decline in the level of the GABAA receptor alpha 1 subunit mRNAs [3.8 and 4.3 kilobases (kb)] in the cerebral cortex in rats. The levels of the alpha 2 subunit mRNAs (6 and 3 kb) and the alpha 5 subunit mRNA (2.8 kb) were also reduced, by 61, 45, and 51%, respectively, whereas there was no change in the level of the alpha 3 subunit mRNA (3 kb). Furthermore, the ethanol-induced decrease in receptor mRNA levels persisted for 24 hr, after withdrawal of ethanol and returned to control values at 36 hr of withdrawal. alpha 1 mRNA levels in cerebellum also decreased by 28%. The level of the alpha 6 subunit mRNA, which selectively encodes Ro15-4513 binding sites, was found to be increased by approximately 76% in the cerebellum. Also, the photoaffinity labeling studies using [3H]Ro15-4513 indicated an increase in the levels of various protein components of the GABAA receptor, in the cerebellum and the cerebral cortex (e.g., 50- and 55-kDa proteins in the cerebellum and 41- and 50-kDa proteins in the cortex), after chronic ethanol treatment. The increase in alpha 6 mRNA in the cerebellum might be related to the increased labeling of the 55-kDa (approximately 56-kDa) protein and partially responsible for the increased binding ... . Because the alpha 6 subunit is not expressed in cortex, involvement of an as yet unknown subunit in this region cannot be ruled out. The effect of chronic ethanol treatment appears to be specific for GABAA receptor subunit mRNAs, because the same treatment did not alter the levels of glyceraldehyde-3-dehydrogenase mRNA or poly(A)+ RNA. In summary, these data indicate that chronic ethanol treatment results in an alteration in the regulation of expression of GABAA receptor subunit-encoding mRNAs, which could be due to alterations in transcription or mRNA stability.

PMID:1383684 Mhatre MC et al; Mol Pharmacol 42 (3): 415-22 (1992)


For more Mechanism of Action (Complete) data for Ethanol (8 total), please visit the HSDB record page.


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WING,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"METHANOL METHANOL(METHYL ALCOHOL)","address":"SY NO 66 67,MIYAPUR","city":"HYDERABAD.AP","supplier":"SABIC ASIA PACIFIC PTE LTD","supplierCountry":"SINGAPORE","foreign_port":"JUBAIL","customer":"CHEMPHAR","customerCountry":"INDIA","quantity":"200000.00","actualQuantity":"200","unit":"MTS","unitRateFc":"351.9","totalValueFC":"71010.8","currency":"N\/A","unitRateINR":"30877","date":"28-Feb-2025","totalValueINR":"6175390","totalValueInUsd":"71010.8","indian_port":"Vizag Sea","hs_no":"29051100","bill_no":"8610941","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"JUBAIL","supplierAddress":"ONE TEMASEK AVENUE NO.06.01 MILLENIA TOWER SINGAPORE SDNF SINGAPORE","customerAddress":"SY NO 66 67,MIYAPUR"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"METHANOL (IN BULK) METHANOL (IN BULK)","address":"MAKUM ROAD,","city":"TINSUKIA, ASSAM.","supplier":"SABIC ASIA PACIFIC ","supplierCountry":"SINGAPORE","foreign_port":"AL JUBAYL INDUSTRIAL","customer":"GREENLAM INDUSTRIES LIMITED","customerCountry":"INDIA","quantity":"7273.00","actualQuantity":"7.273","unit":"MTS","unitRateFc":"347.7","totalValueFC":"2551.3","currency":"N\/A","unitRateINR":"30506.2","date":"28-Feb-2025","totalValueINR":"221871.92","totalValueInUsd":"2551.3","indian_port":"Kandla","hs_no":"29051100","bill_no":"8607504","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SINGAPORE","selfForZScoreResived":"Pharma Grade","supplierPort":"AL JUBAYL INDUSTRIAL","supplierAddress":"ONE TEMASEK AVENUE No 06-01 MILLENI A TOWER, SINGAPORE 039192. Singapo re, , Singapore Singapore","customerAddress":"MAKUM ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"METHANOL IN BULK METHANOL","address":"407 MEADOWS SAHAR PLAZA COMPLEX,AN","city":"MUMBAI,MAHARASHTRA","supplier":"SOLVENT ORGANICS FZE","supplierCountry":"UNITED ARAB EMIRATES","foreign_port":"SOHAR","customer":"INDISOL MARKETING PRIVATE ","customerCountry":"INDIA","quantity":"4898561.00","actualQuantity":"4898.561","unit":"MTS","unitRateFc":"335.6","totalValueFC":"1659058.4","currency":"AED","unitRateINR":"29453.2","date":"28-Feb-2025","totalValueINR":"144278492.8","totalValueInUsd":"1659058.4","indian_port":"Bombay Sea","hs_no":"29051100","bill_no":"8610742","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"SOHAR","supplierAddress":"P.O.BOX: 17467 , JEBEL ALI, DUBAI , U.A.E. SDNF United Arab Emirates","customerAddress":"407 MEADOWS SAHAR PLAZA COMPLEX,AN"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"METHANOL METHANOL","address":"MITTAL COURT92\/93, A WING 9TH FLR","city":"MUMBAI MAHARASHTRA","supplier":"SOLVENT ORGANICS FZE","supplierCountry":"UNITED ARAB EMIRATES","foreign_port":"SOHAR","customer":"JUPITER DYE CHEM PRIVATE LIMITED","customerCountry":"INDIA","quantity":"250000.00","actualQuantity":"250","unit":"MTS","unitRateFc":"337.3","totalValueFC":"85097.8","currency":"N\/A","unitRateINR":"29601.8","date":"28-Feb-2025","totalValueINR":"7400455.75","totalValueInUsd":"85097.8","indian_port":"Kandla","hs_no":"29051100","bill_no":"8610213","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"SOHAR","supplierAddress":"P.O. BOX: 17467, JEBEL ALI, DUBAI SDNF SDNF UNITED ARAB EMIRATES","customerAddress":"MITTAL COURT92\/93, A WING 9TH FLR"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"DIETHANOLAMINE ( ISO TANK ) DIETHANOLAMINE","address":"121 ATLANTA","city":"BOMBAY ,MAHARASHTRA","supplier":"THE DOW CHEMICAL COMPANY","supplierCountry":"UNITED ARAB EMIRATES","foreign_port":"JEBEL ALI","customer":"SIDDHARTH COLORCHEM PVT ","customerCountry":"INDIA","quantity":"23140.00","actualQuantity":"23140","unit":"KGS","unitRateFc":"0.7","totalValueFC":"15176.9","currency":"N\/A","unitRateINR":"57","date":"28-Feb-2025","totalValueINR":"1319847.75","totalValueInUsd":"15176.9","indian_port":"JNPT","hs_no":"29221200","bill_no":"8615497","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"JEBEL ALI","supplierAddress":"DUBAI BRANCH BCW JAFZA VIEW 18 DUBAI SDNF UNITED ARAB EMIRATES","customerAddress":"121 ATLANTA"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"ETHYLAMINOETHANOL - EAE ETHYLAMINOETHANOL - EAE","address":"SHIVSAGAR ESTATE, `D` BLDG, 6TH","city":"WORLI, MUMBAI. MAHARASHTRA","supplier":"TAMINCO US LLC","supplierCountry":"UNITED STATES","foreign_port":"NEW ORLEANS","customer":"AMINES AND PLASTICIZERS ","customerCountry":"INDIA","quantity":"39862.00","actualQuantity":"39.862","unit":"MTS","unitRateFc":"3700","totalValueFC":"148822.3","currency":"N\/A","unitRateINR":"324675","date":"28-Feb-2025","totalValueINR":"12942194.85","totalValueInUsd":"148822.3","indian_port":"JNPT","hs_no":"29221990","bill_no":"8624654","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW ORLEANS","supplierAddress":"A SUBSIDIARY OF EASTMAN CHEMICAL CO MPANY200 SOUTH WILCOX DRIVE KINGSPO RTTN 37660 USA U.S.A.","customerAddress":"SHIVSAGAR ESTATE, `D` BLDG, 6TH"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"THIOPHENE-2-ETHANOL THIOPHENE-2-ETHANOL","address":"2nd, 3rd & 4th FLOOR, PALLADIUM TOWER, ,? PLOT NO.181\/46, INDUSTRIAL AREA PHASE-1, ,? CHANDIGARH , ?CHANDIGARH ,? CHANDIGARH,? 160002","city":"","supplier":"ZHEJIANG UEASY BUSINESS ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SYNTHIMED LABS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"6000.00","actualQuantity":"6000","unit":"KGS","unitRateFc":"12.9","totalValueFC":"77796.8","currency":"N\/A","unitRateINR":"1127.6","date":"28-Feb-2025","totalValueINR":"6765525","totalValueInUsd":"77796.8","indian_port":"JNPT","hs_no":"29349990","bill_no":"8620406","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 302 NO.22 CHANGCHENG STREET, G ONGSHU DISTRICT, HANGZHOU SDNF China","customerAddress":"2nd, 3rd & 4th FLOOR, PALLADIUM TOWER, ,? PLOT NO.181\/46, INDUSTRIAL AREA PHASE-1, ,? CHANDIGARH , ?CHANDIGARH ,? CHANDIGARH,? 160002"}]
01-Jan-2021
28-Feb-2025
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ABOUT THIS PAGE

Looking for 64-17-5 / Ethanol API manufacturers, exporters & distributors?

Ethanol manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ethanol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ethanol manufacturer or Ethanol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ethanol manufacturer or Ethanol supplier.

PharmaCompass also assists you with knowing the Ethanol API Price utilized in the formulation of products. Ethanol API Price is not always fixed or binding as the Ethanol Price is obtained through a variety of data sources. The Ethanol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ethanol

Synonyms

Ethyl alcohol, Alcohol, 64-17-5, Grain alcohol, Methylcarbinol, Ethyl hydroxide

Cas Number

64-17-5

Unique Ingredient Identifier (UNII)

3K9958V90M

About Ethanol

A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.

Ethyl Alcohol Manufacturers

A Ethyl Alcohol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ethyl Alcohol, including repackagers and relabelers. The FDA regulates Ethyl Alcohol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ethyl Alcohol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ethyl Alcohol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ethyl Alcohol Suppliers

A Ethyl Alcohol supplier is an individual or a company that provides Ethyl Alcohol active pharmaceutical ingredient (API) or Ethyl Alcohol finished formulations upon request. The Ethyl Alcohol suppliers may include Ethyl Alcohol API manufacturers, exporters, distributors and traders.

click here to find a list of Ethyl Alcohol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ethyl Alcohol USDMF

A Ethyl Alcohol DMF (Drug Master File) is a document detailing the whole manufacturing process of Ethyl Alcohol active pharmaceutical ingredient (API) in detail. Different forms of Ethyl Alcohol DMFs exist exist since differing nations have different regulations, such as Ethyl Alcohol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Ethyl Alcohol DMF submitted to regulatory agencies in the US is known as a USDMF. Ethyl Alcohol USDMF includes data on Ethyl Alcohol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ethyl Alcohol USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Ethyl Alcohol suppliers with USDMF on PharmaCompass.

Ethyl Alcohol JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Ethyl Alcohol Drug Master File in Japan (Ethyl Alcohol JDMF) empowers Ethyl Alcohol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Ethyl Alcohol JDMF during the approval evaluation for pharmaceutical products. At the time of Ethyl Alcohol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Ethyl Alcohol suppliers with JDMF on PharmaCompass.

Ethyl Alcohol KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Ethyl Alcohol Drug Master File in Korea (Ethyl Alcohol KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ethyl Alcohol. The MFDS reviews the Ethyl Alcohol KDMF as part of the drug registration process and uses the information provided in the Ethyl Alcohol KDMF to evaluate the safety and efficacy of the drug.

After submitting a Ethyl Alcohol KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ethyl Alcohol API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Ethyl Alcohol suppliers with KDMF on PharmaCompass.

Ethyl Alcohol CEP

A Ethyl Alcohol CEP of the European Pharmacopoeia monograph is often referred to as a Ethyl Alcohol Certificate of Suitability (COS). The purpose of a Ethyl Alcohol CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ethyl Alcohol EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ethyl Alcohol to their clients by showing that a Ethyl Alcohol CEP has been issued for it. The manufacturer submits a Ethyl Alcohol CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ethyl Alcohol CEP holder for the record. Additionally, the data presented in the Ethyl Alcohol CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ethyl Alcohol DMF.

A Ethyl Alcohol CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ethyl Alcohol CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Ethyl Alcohol suppliers with CEP (COS) on PharmaCompass.

Ethyl Alcohol GMP

Ethyl Alcohol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ethyl Alcohol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ethyl Alcohol GMP manufacturer or Ethyl Alcohol GMP API supplier for your needs.

Ethyl Alcohol CoA

A Ethyl Alcohol CoA (Certificate of Analysis) is a formal document that attests to Ethyl Alcohol's compliance with Ethyl Alcohol specifications and serves as a tool for batch-level quality control.

Ethyl Alcohol CoA mostly includes findings from lab analyses of a specific batch. For each Ethyl Alcohol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ethyl Alcohol may be tested according to a variety of international standards, such as European Pharmacopoeia (Ethyl Alcohol EP), Ethyl Alcohol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ethyl Alcohol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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