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Ethylene Diamine Dihydro Iodide

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Synopsis

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Chemistry

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Also known as: 5700-49-2, Jodethamine, Ethane-1,2-diamine dihydroiodide, Ethanediamine dihydroiodide, Hydrodine, Eddi

Molecular Formula

C₂H₁₀I₂N₂

Molecular Weight

315.92 g/mol

InChI Key

IWNWLPUNKAYUAW-UHFFFAOYSA-N

FDA UNII

721M52NQ5L

1 2D Structure

Ethylene Diamine Dihydro Iodide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

ethane-1,2-diamine;dihydroiodide

2.1.2 InChI

InChI=1S/C2H8N2.2HI/c3-1-2-4;;/h1-4H2;2*1H

2.1.3 InChI Key

IWNWLPUNKAYUAW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C(CN)N.I.I

2.2 Other Identifiers

2.2.1 UNII

721M52NQ5L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1,2-diaminoethane

2. 1,2-ethanediamine

3. Edamine

4. Ethane-1,2-diamine

5. Ethyl Diamine

6. Ethylenediamine

7. Ethylenediamine (1:1) Sulfate

8. Ethylenediamine (1:1) Sulfite

9. Ethylenediamine Conjugate Acid

10. Ethylenediamine Dihydrobromide

11. Ethylenediamine Dihydrochloride

12. Ethylenediamine Dihydrogen Iodide

13. Ethylenediamine Dinitrate

14. Ethylenediamine Hydrochloride

15. Ethylenediamine Monohydrochloride

16. Ethylenediamine Phosphate

17. Ethylenediamine Sulfate

18. Ethylenediamine, 3h-labeled Cpd

2.3.2 Depositor-Supplied Synonyms

1. 5700-49-2

2. Jodethamine

3. Ethane-1,2-diamine Dihydroiodide

4. Ethanediamine Dihydroiodide

5. Hydrodine

6. Eddi

7. Ethylenediamine Dihydriodide

8. Orgadine

9. Ethylenediammonium Diiodide

10. Ethane-1,2-diamine;dihydroiodide

11. Ethylendiamine Dihydroiodide

12. 1,2-ethanediamine Dihydriodide

13. 1,2-ethanediamine Dihydroiodide

14. Chebi:81719

15. 721m52nq5l

16. Ethane-1,2-diammonium Iodide

17. Hiamine

18. Iomide

19. Hydriodide-boot

20. Iod-ethamine

21. Hy-odide

22. Hi-boot

23. Hydriodide-o-dide

24. Hi-o-dide

25. 1,2-ethanediamine, Dihydriodide

26. Unii-721m52nq5l

27. Hsdb 440

28. Ethane-1,2-diamine,dihydroiodide

29. Einecs 227-186-8

30. Hoffman Bonded E-d-d Iodine Compound

31. Whitmoyer Ethylene Diamine Dihydriodide

32. Dsstox_cid_24570

33. Dsstox_rid_80319

34. Dsstox_gsid_44570

35. Schembl1007637

36. Chembl3182879

37. Dtxsid5044570

38. 1,2-diaminoethane, Dihydroiodide

39. Tox21_302266

40. Mfcd00035535

41. Akos024334047

42. 1,2-ethanediamine, Hydriodide (1:2)

43. Ethane-1,2-diammonium Iodide, >=98%

44. Ncgc00255744-01

45. As-60979

46. Cas-5700-49-2

47. Db-052998

48. Ethylenediamine Dihydroiodide [hsdb]

49. E1222

50. Ft-0635813

51. C18382

52. T72638

53. 700e492

54. Q3027890

55. W-105492

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂H₁₀I₂N₂
Molecular Weight	315.92 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	315.89334 g/mol
Monoisotopic Mass	315.89334 g/mol
Topological Polar Surface Area	52 Å²
Heavy Atom Count	6
Formal Charge	0
Complexity	6
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Therapeutic Uses

VET: ...ETHYLENEDIAMINE DIHYDROIODIDE (EDDI), IS FED TO CATTLE TO PREVENT OR TREAT VARIOUS AILMENTS SUCH AS FOOT ROT, MILD RESP CONDITIONS, ACTINOMYCOSIS, MASTITIS, OTHER CHRONIC INFECTIONS, & IODINE DEFICIENCY.

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 1284

VET: EXPECTORANT & ANTIINFLAMMATORY AGENT

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 1284

(VET): FEED ADDITIVE

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 208

4.2 Drug Warning

VET: .../EDDI INTAKE/ SHOULD BE CURTAILED PRIOR TO CALVING, SHIPPING, VACCINATION, OR OTHER STRESSFUL SITUATIONS BECAUSE STRESS IS MAJOR FACTOR IN DEVELOPMENT OF EDDI-RELATED INFECTIONS.

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 1284

MORE RESEARCH IS NEEDED TO CHARACTERIZE DISEASE-ENHANCING ACTIONS OF EDDI REPORTED BY PRACTITIONERS & CATTLEMEN.

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 01284

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

IN CATTLE NORMAL TOTAL SERUM IODINE CONCN RANGES FROM 5.6 TO 14 UG/100 ML... IN SHEEP NORMAL TOTAL SERUM IODINE CONCN IS ABOUT 2.3-4.6 UG/100 ML... IN CASES OF EDDI-INDUCED IODISM &...INFECTION...TOTAL SERUM IODINE CONCN.../REPORTED/ 10-100 OR MORE TIMES NORMAL.

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 1285

IODIDES ARE READILY EXCRETED IN MILK /OF CATTLE/. ... IODIDES...ALSO SECRETED BY GLANDULAR CELLS IN RESP TRACT... SALIVARY & LACRIMAL GLANDS ALSO SECRETE IODIDES.

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 1284

5.2 Mechanism of Action

...REFLECTIONS OF PROSECRETORY ACTIONS OF IODIDE...SUSCEPTIBILITY OR PREDISPOSITION...TO MICROBIAL INFECTIONS /& FEVER/...ATTRIBUTED TO POSSIBLE ANTIINFLAMMATORY ACTION...ABILITY OF IODINE TO UNCOUPLE OXIDATIVE PHOSPHORYLATION.

Jones, L.M., et al. Veterinary Pharmacology & Therapeutics. 4th ed. Ames: Iowa State University Press, 1977., p. 1284

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API Reference Price

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