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ACTIVE PHARMA INGREDIENTS

3 API Suppliers, 1 CEP/COS, 1 JDMF, 1 Listed Suppliers

3 API Suppliers
1 CEP/COS
1 JDMF
1 Listed Suppliers

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

11 FDF Dossiers, 9 Europe, 1 South Africa, 1 Listed Dossiers

11 FDF Dossiers
9 Europe
1 South Africa
1 Listed Dossiers

GLOBAL SALES INFORMATION

6 Finished Drug Prices

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6 Finished Drug Prices

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4 APIs, 1 FDF Dossiers

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4 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM

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3 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

2INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

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US Patents

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Health Canada Patents

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Chemistry

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Also known as: 943-17-9, Circupon, Effontil, Etilefrine hcl, Etilefrin hydrochloride, Kertasin

Molecular Formula

C₁₀H₁₆ClNO₂

Molecular Weight

217.69 g/mol

InChI Key

KTNROWWHOBZQGK-UHFFFAOYSA-N

FDA UNII

ZBI6Q5FH3S

A phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.

1 2D Structure

Etilefrine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-[2-(ethylamino)-1-hydroxyethyl]phenol;hydrochloride

2.1.2 InChI

InChI=1S/C10H15NO2.ClH/c1-2-11-7-10(13)8-4-3-5-9(12)6-8;/h3-6,10-13H,2,7H2,1H3;1H

2.1.3 InChI Key

KTNROWWHOBZQGK-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCNCC(C1=CC(=CC=C1)O)O.Cl

2.2 Other Identifiers

2.2.1 UNII

ZBI6Q5FH3S

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Adrenam

2. Adrianol, Ethyl

3. Bioflutin

4. Cardanat

5. Circupon

6. Effortil

7. Efortil

8. Ethyl Adrianol

9. Ethyladrianol

10. Ethylnorphenylephrine

11. Ethylphenylephrine

12. Eti Puren

13. Eti-puren

14. Etil Von Ct

15. Etilefrin

16. Etilefrin Al

17. Etilefrin Ratiopharm

18. Etilefrin-ratiopharm

19. Etilefrine

20. Etilefrine Pivalate Hydrochloride

21. Fetanol

22. Hydrochloride, Etilefrine

23. Hydrochloride, Etilefrine Pivalate

24. Phetanol

25. Pivalate Hydrochloride, Etilefrine

26. Thomasin

2.3.2 Depositor-Supplied Synonyms

1. 943-17-9

2. Circupon

3. Effontil

4. Etilefrine Hcl

5. Etilefrin Hydrochloride

6. Kertasin

7. 534-87-2

8. Apocretin

9. Pulsamin

10. Phetanol

11. Updormin

12. Etilefrine (hydrochloride)

13. Cardanat

14. Efortil

15. Funasol

16. Thomasin

17. Ethyl Adrianol

18. Etilefrine Hydrochloride [jan]

19. 3-[2-(ethylamino)-1-hydroxyethyl]phenol Hydrochloride

20. Zbi6q5fh3s

21. 3-[2-(ethylamino)-1-hydroxyethyl]phenol;hydrochloride

22. Etilefrine Hydrochloride (tn)

23. Ethylephrine Hydrochloride

24. Alpha-((ethylamino)methyl)-m-hydroxybenzyl Alcohol Hydrochloride

25. 3-(2-(ethylamino)-1-hydroxyethyl)phenol Hydrochloride

26. 943-17-9 (hcl)

27. Dl-1-(3-hydroxyphenyl)-1-hydroxy-2-ethylaminoethane Hydrochloride

28. Effortilvet

29. Phetasin

30. Benzenemethanol, A-[(ethylamino)methyl]-3-hydroxy-, Hydrochloride

31. Tonus-forte

32. Eti-puren

33. Dl-effortil Hydrochloride

34. Dl-etilefrin Hydrochloride

35. Unii-zbi6q5fh3s

36. Dl-n-ethylnorphenylephrine Hydrochloride

37. Bioflutin

38. 2-ethylamino-1-(3-hydroxyphenyl)ethanol Hydrochloride

39. Dl-ethylphenylephrine Hydrochloride

40. Einecs 213-398-8

41. (+-)-ethylphenylephrine Hydrochloride

42. (+/-)-ethylphenylephrine Hydrochloride

43. (+-)-n-ethylnorphenylephrine Hydrochloride

44. Ncgc00016496-01

45. Cas-534-87-2

46. Dsstox_cid_25322

47. Dsstox_rid_80801

48. Dsstox_gsid_45322

49. Schembl207591

50. Etilefrin, Hydrochloride

51. 1-(3-hydroxyphenyl)-2-ethylaminoethanol Hydrochloride

52. Chembl3187408

53. Dl-1-(3-hydroxyphenyl-2-ethylaminoethanol Hydrochloride

54. Dtxsid1045322

55. Chebi:31582

56. Etilefrine Hydrochloride (jp17)

57. Hms1571k15

58. Etilefrin Hydrochloride [mi]

59. Tox21_110457

60. Benzenemethanol, Alpha-((ethylamino)methyl)-3-hydroxy-, Hydrochloride

61. Mfcd00060167

62. Akos005267166

63. Ccg-221017

64. Etilefrine Hydrochloride [mart.]

65. Etilefrine Hydrochloride [who-dd]

66. As-13925

67. Ethlyphenylephrine Hydrochloride, Dl

68. Db-057487

69. Cs-0030673

70. E0381

71. Ethylphenylephrine Hydrochloride, Dl-

72. Ft-0603527

73. Ft-0668420

74. En300-03375

75. D01573

76. D90499

77. Etilefrine Hydrochloride [ep Monograph]

78. 943e179

79. A844915

80. Sr-01000837506

81. (+/-)-n-ethylnorphenylephrine Hydrochloride

82. Q-201098

83. Sr-01000837506-2

84. 3-[2-(ethylamino)-1-hydroxyethyl]phenol,hydrochloride

85. Q27295283

86. 3-[2-(ethylamino)-1-hydroxy-ethyl]phenol Hydrochloride

87. (rs)-2-ethylamino-1-(3-hydroxyphenyl)ethanol Monohydrochloride

88. Benzyl Alcohol, Alpha-((ethylamino)methyl)-m-hydroxy-, Hydrochloride

89. Benzenemethanol, .alpha.-((ethylamino)methyl)-3-hydroxy-, Hydrochloride (1:1)

90. Benzyl Alcohol, .alpha.-((ethylamino)methyl)-m-hydroxy-, Hydrochloride

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₆ClNO₂
Molecular Weight	217.69 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	4
Exact Mass	217.0869564 g/mol
Monoisotopic Mass	217.0869564 g/mol
Topological Polar Surface Area	52.5 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	141
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Vasoconstrictor Agents

Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

Adrenergic alpha-Agonists

Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)

Adrenergic beta-1 Receptor Agonists

Compounds that bind to and activate ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Agonists.)

Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)

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