List of Drug Master Files (DMF) of Etofenamate Active Pharmaceutical Ingredient listed on PharmaCompass.com

Etofenamate

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ACTIVE PHARMA INGREDIENTS

11 API Suppliers, 1 USDMF, 4 CEP/COS, 1 EU WC, 7 Listed Suppliers, $ API Reference Price

11 API Suppliers
1 USDMF
4 CEP/COS
1 EU WC
7 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

17 FDF Dossiers, 15 Europe, 2 Listed Dossiers

17 FDF Dossiers
15 Europe
2 Listed Dossiers

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11 Finished Drug Prices

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11 Finished Drug Prices

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7 APIs, 1 FDF Dossiers

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7 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM

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3 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 30544-47-9, Bay d 1107, 2-(2-hydroxyethoxy)ethyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate, 2-(2-hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate, Tvx485, 2-(2-hydroxyethoxy)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}benzoate

Molecular Formula

C₁₈H₁₈F₃NO₄

Molecular Weight

369.3 g/mol

InChI Key

XILVEPYQJIOVNB-UHFFFAOYSA-N

FDA UNII

KZF0XM66JC

Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID).

1 2D Structure

Etofenamate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(2-hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate

2.1.2 InChI

InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2

2.1.3 InChI Key

XILVEPYQJIOVNB-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C(C(=C1)C(=O)OCCOCCO)NC2=CC=CC(=C2)C(F)(F)F

2.2 Other Identifiers

2.2.1 UNII

KZF0XM66JC

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(2-hydroxyethoxy)-ethyl-n-(alpha,alpha,alpha-trifluoro- M-tolyl)anthranilate

2. Algesalona E

3. Aspitopic

4. Bayro

5. Flogoprofen

6. Rheuma-gel-ratiopharm

7. Rheumon

8. Traumon

9. Zenavan

2.3.2 Depositor-Supplied Synonyms

1. 30544-47-9

2. Bay D 1107

3. 2-(2-hydroxyethoxy)ethyl 2-((3-(trifluoromethyl)phenyl)amino)benzoate

4. 2-(2-hydroxyethoxy)ethyl 2-[3-(trifluoromethyl)anilino]benzoate

5. Tvx485

6. 2-(2-hydroxyethoxy)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}benzoate

7. Whr-5020

8. Bayrogel

9. Rheumon

10. Kzf0xm66jc

11. Bayd-1107

12. Tvx-485

13. Bay-d-1107

14. 2-(2-hydroxyethoxy)ethyl-n-(alpha,alpha,alpha-trifluoro-m-tolyl)anthranilate

15. Benzoic Acid, 2-((3-(trifluoromethyl)phenyl)amino)-, 2-(2-hydroxyethoxy)ethyl Ester

16. Ncgc00016804-01

17. Rheumon Gel

18. Cas-30544-47-9

19. Benzoic Acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 2-(2-hydroxyethoxy)ethyl Ester

20. Dsstox_cid_25448

21. Dsstox_rid_80887

22. Dsstox_gsid_45448

23. Etofenamato

24. Etofenamatum

25. Etofenamatum [inn-latin]

26. Etofenamato [inn-spanish]

27. Tvx 485

28. Whr 5020

29. Einecs 250-231-8

30. Unii-kzf0xm66jc

31. Brn 2953263

32. Etofenamate [usan:inn:ban]

33. 2-(2-hydroxyethoxy)ethyl Fufenamate

34. 2-(2-hydroxyaethoxy)aethylester Der Flutenaminsaeure [german]

35. Etofenamate [mi]

36. Prestwick0_001014

37. Prestwick1_001014

38. Prestwick2_001014

39. Etofenamate [inn]

40. Etofenamate [jan]

41. Etofenamate (usan/inn)

42. Etofenamate [usan]

43. 2-(2-hydroxyethoxy)ethyl N-(alpha,alpha,alpha-trifluoro-m-tolyl)anthranilate

44. Etofenamate [mart.]

45. Schembl25152

46. Etofenamate [who-dd]

47. 2-(2-hydroxyaethoxy)aethylester Der Flutenaminsaeure

48. Spbio_003038

49. Chembl1451633

50. Dtxsid2045448

51. Chebi:94731

52. Ex-a275

53. Etofenamate [ep Monograph]

54. Etofenamate For Peak Identification

55. Hms1571k09

56. Hms3713h06

57. Bcp08746

58. Zinc2034516

59. Tox21_110618

60. Mfcd00242806

61. S6742

62. Akos026750534

63. Tox21_110618_1

64. Ccg-220592

65. Cs-0905

66. Db08984

67. Anthranilic Acid, N-(alpha,alpha,alpha-trifluoro-m-tolyl)-, 2-(2-hydroxyethoxy)ethyl Ester

68. Ncgc00016804-02

69. Ncgc00016804-03

70. Ac-35208

71. As-73948

72. Da-33632

73. Hy-17361

74. Ft-0668428

75. D04102

76. 544e479

77. Q414378

78. Sr-01000872640

79. J-018005

80. Sr-01000872640-1

81. Brd-k73541271-001-01-0

82. Z1248763315

83. 2-[3-(trifluoromethyl)anilino]benzoic Acid 2-(2-hydroxyethoxy)ethyl Ester

84. Tv-485;tv485;tv 485; Whr-5020; Whr 5020; Whr5020

85. 2-(2-hydroxyethoxy)ethyl N-(.alpha.,.alpha.,.alpha.-trifluoro-m-tolyl)anthranilate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₈F₃NO₄
Molecular Weight	369.3 g/mol
XLogP3	4.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	9
Exact Mass	369.11879254 g/mol
Monoisotopic Mass	369.11879254 g/mol
Topological Polar Surface Area	67.8 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	433
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

4.2 ATC Code

M02AA06

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

M - Musculo-skeletal system

M02 - Topical products for joint and muscular pain

M02A - Topical products for joint and muscular pain

M02AA - Antiinflammatory preparations, non-steroids for topical use

M02AA06 - Etofenamate

API SUPPLIERS

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USDMF

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CEP/COS

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API Reference Price

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