DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 8 USDMF, 6 CEP/COS, 2 EU WC, 2 NDC API, 6 Listed Suppliers, $ API Reference Price

13 API Suppliers
8 USDMF
6 CEP/COS
2 EU WC
2 NDC API
6 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

26 FDF Dossiers, 12 FDA Orange Book, 3 Canada, 2 South Africa, 9 Listed Dossiers

26 FDF Dossiers
12 FDA Orange Book
3 Canada
2 South Africa
9 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 BASF, 1 Finar, 1 Valens Pharmachem

relatedExcipients
1 Nanjing Well Pharmaceutical
1 BASF
1 Finar
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

3 Topical, 2 Film Formers & Plasticizers, 2 Solubilizers, 1 Emulsifying Agents, 1 Thickeners and Stabilizers, 1 Parenteral

excipientsByApplications
3 Topical
2 Film Formers & Plasticizers
2 Solubilizers
1 Emulsifying Agents
1 Thickeners and Stabilizers
1 Parenteral

DIGITAL CONTENT

7 NEWS #PharmaBuzz

media
7 NEWS #PharmaBuzz

MARKET PLACE

4 APIs, 4 FDF Dossiers

marketPlace
4 APIs
4 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 1 USP , 4 Others

otherSolutions
2 EDQM
1 USP
4 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

10EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 33125-97-2, Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate, Ethnor, Absele, 15301-65-2, C14h16n2o2

Molecular Formula

C₁₄H₁₆N₂O₂

Molecular Weight

244.29 g/mol

InChI Key

NPUKDXXFDDZOKR-UHFFFAOYSA-N

Etomidate is an imidazole derivative with short-acting sedative, hypnotic, and general anesthetic properties. Etomidate appears to have gamma-aminobutyric acid (GABA) like effects, mediated through GABA-A receptor. The action enhances the inhibitory effect of GABA on the central nervous system by causing chloride channel opening events which leads to membrane hyperpolarization.

1 2D Structure

Etomidate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

ethyl 3-(1-phenylethyl)imidazole-4-carboxylate

2.1.2 InChI

InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3

2.1.3 InChI Key

NPUKDXXFDDZOKR-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Absele

2. Ethnor

2.2.2 Depositor-Supplied Synonyms

1. 33125-97-2

2. Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

3. Ethnor

4. Absele

5. 15301-65-2

6. C14h16n2o2

7. Radenarcon

8. Amidate (pharmaceutical)

9. Mls000034952

10. 1h-imidazole-5-carboxylic Acid, 1-(1-phenylethyl)-, Ethyl Ester, (r)-

11. Smr000010931

12. Dsstox_cid_3033

13. 1h-imidazole-5-carboxylic Acid, 1-(1-phenylethyl)-, Ethyl Ester, (+-)-

14. Dsstox_rid_76841

15. Dsstox_gsid_23033

16. 1-(1-phenylethyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

17. Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate

18. Sr-01000325781

19. Rac-etomidate

20. Ncgc00016817-01

21. Cas-33125-97-2

22. Cpd000010931

23. Opera_id_1830

24. Prestwick0_001041

25. Prestwick1_001041

26. Prestwick2_001041

27. (+)-ethyl 1-(.alpha.-methylbenzyl)imidazole-5-carboxylate

28. Schembl39485

29. Mls001240191

30. Mls006011948

31. Chembl23731

32. Spbio_002901

33. Chebi:91759

34. Imidazole-5-carboxylic Acid, 1-(.alpha.-methylbenzyl)-, Ethyl Ester, (r)-(+)-

35. Bdbm238149

36. Dtxsid101347652

37. Hms1571a04

38. Hms1612g10

39. Hms2093p17

40. Hms2235k14

41. Hms3259f15

42. Hms3369p19

43. Hms3371k15

44. Hms3393p18

45. Hms3428l14

46. Hms3654n15

47. Pharmakon1600-01505599

48. Bcp21365

49. Us9394290, Eto (etomidate)

50. Tox21_110628

51. Nsc759160

52. S1329

53. Akos000548952

54. Akos021628930

55. Tox21_110628_1

56. Ac-5898

57. Ccg-266910

58. Nc00657

59. Ncgc00025176-02

60. Ncgc00036076-03

61. Ds-14867

62. Sbi-0206822.p001

63. Db-015827

64. Cs-0081287

65. Ft-0630568

66. Sw197275-2

67. En300-50290

68. Ab00439988-11

69. Ab00439988_13

70. Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate.

71. A821630

72. Ethyl1-(1-phenylethyl)-1h-imidazole-5-carboxylate

73. Sr-01000325781-1

74. Sr-01000325781-3

75. Sr-01000325781-5

76. Brd-a54880345-001-11-8

77. Q27163565

78. 3-(1-phenylethyl)-4-imidazolecarboxylic Acid Ethyl Ester

79. Z802671476

80. (-)-ethyl 1-(1-phenylethyl)-1h-imidazole- 5-carboxylate

81. (-)-ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

82. Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate, (+)-

83. R-(+) Ethyl 1-(1-phenylethyl)-1h-imidazole-5-carboxylate

84. 1-(.alpha.-methylbenzyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

85. (r)-(+)-1-(.alpha.-methylbenzyl)imidazole-5-carboxylic Acid Ethyl Ester

86. [r,(+)]-1-(alpha-methylbenzyl)-1h-imidazole-5-carboxylic Acid Ethyl Ester

87. 1h-imidazole-5-carboxylic Acid, 1-(.alpha.-methylbenzyl)-, Ethyl Ester, (+)-

88. R 16659 Pound>>r-16659 Pound>>r16659 Pound>>r 26490 Pound>>r-26490 Pound>>r26490

2.3 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₆N₂O₂
Molecular Weight	244.29 g/mol
XLogP3	3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	244.121177757 g/mol
Monoisotopic Mass	244.121177757 g/mol
Topological Polar Surface Area	44.1 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	277
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Amidate
Drug Label	Amidate (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The...
Active Ingredient	Etomidate
Dosage Form	Injectable
Route	Injection
Strength	2mg/ml
Market Status	Prescription
Company	Hospira

2 of 4
Drug Name	Etomidate
Drug Label	Etomidate Injection, USP is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The drug etom...
Active Ingredient	Etomidate
Dosage Form	Injectable
Route	Injection
Strength	2mg/ml
Market Status	Prescription
Company	Par Sterile Products; Bedford; Emcure Pharms; Luitpold; Zydus Pharms Usa; Agila Speclts

3 of 4
Drug Name	Amidate
Drug Label	Amidate (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The...
Active Ingredient	Etomidate
Dosage Form	Injectable
Route	Injection
Strength	2mg/ml
Market Status	Prescription
Company	Hospira

4 of 4
Drug Name	Etomidate
Drug Label	Etomidate Injection, USP is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0).It is intended for the induction of general anesthesia by intravenous injection.The drug etom...
Active Ingredient	Etomidate
Dosage Form	Injectable
Route	Injection
Strength	2mg/ml
Market Status	Prescription
Company	Par Sterile Products; Bedford; Emcure Pharms; Luitpold; Zydus Pharms Usa; Agila Speclts

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

General Anesthetic [EPC]; General Anesthesia [PE]

5.2 ATC Code

N01AX07

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

N - Nervous system

N01 - Anesthetics

N01A - Anesthetics, general

N01AX - Other general anesthetics

N01AX07 - Etomidate

API SUPPLIERS

01

ChemWerth Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI WW Frankfurt

Booth #12.1F43

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF

Click Us!

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Bachem AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFIT 2024

Attending

Bachem Group is a public, innovation-driven company specializing in the development and manufacturing of peptides and oligonucleotides.

Contact Supplier

Switzerland

Virtual Booth

Digital Content

USDMF

CEP/COS

JDMF EU-WC NDC

KDMF VMF Others AUDIT

03

Bachem AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFIT 2024

Attending

Bachem Group is a public, innovation-driven company specializing in the development and manufacturing of peptides and oligonucleotides.

Contact Supplier

Switzerland

Virtual Booth

Digital Content

USDMF

CEP/COS

JDMF EU-WC NDC

KDMF VMF Others AUDIT

04

Solara Active Pharma Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

05

GLAND PHARMA LIMITED

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

06

Pisgah Labs

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

07

Reliable Biopharmaceutical Corpora...

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

08

Johnson & Johnson Innovative Medic...

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

09

Jiangsu Nhwa Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

10

Solara Active Pharma Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health

Not Confirmed

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USDMF

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CEP/COS

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EU WC

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NDC API

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Listed Suppliers

01

ChemWerth Inc

U.S.A

CPhI WW Frankfurt

Booth #12.1F43

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

Etomidate

About the Company : Established in 1982, ChemWerth is a US-headquartered full-service generic active pharmaceutical ingredient (API) development and supply company. ChemWerth offers cGMP-quality APIs ...

Established in 1982, ChemWerth is a US-headquartered full-service generic active pharmaceutical ingredient (API) development and supply company. ChemWerth offers cGMP-quality APIs to regulated markets worldwide and has exclusive partnerships for new product development, compliance support and secure supply chain logistics. ChemWerth has access to over 500 APIs and more than 30 manufacturing facilities in the US, Europe, India and China. ChemWerth acts as a regulatory agent for over 25 FDA-approved facilities and sells more than 100 products. It has established its presence in 38 countries. In 2020, ChemWerth filed its 500th DMF with the FDA.

02

Bachem AG

Switzerland

13th Austrian Peptide

Presenting

Bachem Group is a public, innovation-driven company specializing in the development and manufacturing of peptides and oligonucleotides.

Contact Supplier

Switzerland

Virtual Booth

Digital Content

Etomidate

About the Company : With more than 50 years of experience and expertise, Bachem provides products for research, clinical development and commercial application to pharmaceutical and biotechnology comp...

With more than 50 years of experience and expertise, Bachem provides products for research, clinical development and commercial application to pharmaceutical and biotechnology companies worldwide, providing a wide range of services. Over the years, Bachem has established itself as a leading, innovation-driven company specializing in the development and manufacture of peptides and oligonucleotides. The company is headquartered in Switzerland and has offices in Europe, the US and Asia. The company is listed on the SIX Swiss Exchange.

03

Guangzhou Tosun Pharmaceutical

China

Medlab Asia & Asia Health

Not Confirmed

04

Jiangsu Nhwa Pharmaceutical

China

Medlab Asia & Asia Health

Not Confirmed

05

Medilux Laboratories

India

Medlab Asia & Asia Health

Not Confirmed

06

Solara Active Pharma Sciences

India

Medlab Asia & Asia Health

Not Confirmed

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API Reference Price

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