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Chemistry

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Also known as: 33419-42-0, Vepesid, Toposar, Trans-etoposide, Lastet, (-)-etoposide

Molecular Formula

C₂₉H₃₂O₁₃

Molecular Weight

588.6 g/mol

InChI Key

VJJPUSNTGOMMGY-MRVIYFEKSA-N

FDA UNII

6PLQ3CP4P3

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Etoposide is a Topoisomerase Inhibitor. The mechanism of action of etoposide is as a Topoisomerase Inhibitor.

1 2D Structure

Etoposide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

2.1.2 InChI

InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

2.1.3 InChI Key

VJJPUSNTGOMMGY-MRVIYFEKSA-N

2.1.4 Canonical SMILES

CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

2.1.5 Isomeric SMILES

C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

2.2 Other Identifiers

2.2.1 UNII

6PLQ3CP4P3

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Alpha-d-glucopyranosyl Isomer Etoposide

2. Celltop

3. Demethyl Epipodophyllotoxin Ethylidine Glucoside

4. Eposide

5. Eposin

6. Eto Gry

7. Eto-gry

8. Etomedac

9. Etopos

10. Etoposide Pierre Fabre

11. Etoposide Teva

12. Etoposide, (5a Alpha)-isomer

13. Etoposide, (5a Alpha,9 Alpha)-isomer

14. Etoposide, (5s)-isomer

15. Etoposide, Alpha D Glucopyranosyl Isomer

16. Etoposide, Alpha-d-glucopyranosyl Isomer

17. Etoposido Ferrer Farma

18. Exitop

19. Lastet

20. Nsc 141540

21. Nsc-141540

22. Nsc141540

23. Onkoposid

24. Riboposid

25. Teva, Etoposide

26. Toposar

27. Vpside Sandoz

28. Vpside-sandoz

29. Vepesid

30. Vp 16

31. Vp 16 213

32. Vp 16-213

33. Vp 16213

34. Vp-16

35. Vp16

2.3.2 Depositor-Supplied Synonyms

1. 33419-42-0

2. Vepesid

3. Toposar

4. Trans-etoposide

5. Lastet

6. (-)-etoposide

7. Vp-16

8. Zuyeyidal

9. Etoposidum

10. Etoposido

11. Etoposidum [inn-latin]

12. Vp-16-213

13. Etoposide (vp16)

14. Vp 16-213

15. Vepesid J

16. Sintopozid

17. 4-demethylepipodophyllotoxin Beta-d-ethylideneglucoside

18. Nsc-141540

19. Etoposide (vp-16)

20. Vp 16 (pharmaceutical)

21. 4'-demethylepipodophyllotoxin 9-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside)

22. Vp 16

23. 6plq3cp4p3

24. Epipodophyllotoxin Vp-16213

25. Chembl44657

26. Chebi:4911

27. Nk 171

28. Demethylepipodophyllotoxin-beta-d-ethylideneglucoside

29. Nsc 141540

30. 4'-demethylepipodophyllotoxin 9-(4,6-o-ethylidene-beta-d-glucopyranoside)

31. Etosid

32. [1,3]benzodioxol-8-one

33. Etoposido [inn-spanish]

34. (5s,5ar,8ar,9r)-5-[[(2r,4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

35. (5s,5ar,8ar,9r)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-o-[(1r)-ethylidene]-beta-d-glucopyranoside

36. Etopophos (phosphate Salt)

37. Etopol

38. Vp 16213

39. Nsc141540

40. 9-((4,6-o-ethylidine-beta-d-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5ah)-one

41. Smr000112002

42. Ccris 2392

43. Hsdb 6517

44. Vepesid (tn)

45. Einecs 251-509-1

46. Mfcd00869325

47. Unii-6plq3cp4p3

48. 4'-demethylepipodophyllotoxin Ethylidene-.beta.-d-glucoside

49. Dtxsid5023035

50. Etoposide,(s)

51. (5s,5ar,8ar,9r)-5-[[(2r,4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f]

52. (5s,5ar,8ar,9r)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-o-[(1r)-ethylidene]-beta-d-glucopyranoside

53. Evp

54. Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one, 9-[[4,6-o-(1r)-ethylidene-.beta.-d-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r,5ar,8ar,9s)-

55. 4'-o-demethyl-1-o-(4,6-o-ethylidene-beta-d-glucopyranosyl)epipodophyllotoxin

56. Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-o-ethylidene-beta-d-glucopyranoside)

57. Etoposide [usan:usp:inn:ban:jan]

58. Etoposide; Vp-16

59. Cpd000112002

60. Epipodophyllotoxin-beta-d-ethyliden-glucoside, 4'-demethyl-

61. Etoposide [inn]

62. Etoposide [jan]

63. Etoposide [mi]

64. Etoposide [hsdb]

65. Etoposide [iarc]

66. Etoposide [usan]

67. Prestwick3_000396

68. Etoposide [vandf]

69. Etoposide [mart.]

70. Epipodophyllotoxin, 4'-demethyl-, 4,6-o-ethylidene-beta-d-glucopyranoside

71. Etoposide Resolution Mixture

72. Etoposide [usp-rs]

73. Etoposide [who-dd]

74. Etoposide [who-ip]

75. Schembl4259

76. Bspbio_000611

77. 9-((4,6-o-ethylidene-beta-d-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, (5r-(5alpha,5abeta,8aalpha,9beta(r*)))-

78. 9-((4,6-o-ethylidine-beta-d-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4- Hydroxy-3,4-dimethyloxyphenyl)furo (3',4'':6,7) Naptho-(2,3-d)-1,3-dioxol-6 (5ah)-one

79. Mls000049957

80. Mls001074951

81. Mls001424283

82. Mls002153463

83. Mls002207239

84. Mls002222184

85. Etoposide (jp17/usp/inn)

86. Bpbio1_000673

87. Gtpl6815

88. Etoposide [ep Impurity]

89. Etoposide [orange Book]

90. Etoposide [ep Monograph]

91. Etoposide [usp Impurity]

92. Etoposide [usp Monograph]

93. Etoposidum [who-ip Latin]

94. Etoposide4-o-b-d-galactopyranoside

95. Hms2052n05

96. Hms2089f14

97. Hms2096o13

98. Hms2232l03

99. Hms3713o13

100. (5r,5ar,8ar,9s)-9-(((4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8h)-one

101. Ex-a1207

102. Zinc3938684

103. Bdbm50127140

104. S1225

105. Etoposide - Cas 33419-42-0

106. Akos007930275

107. Bcp9000669

108. Ccg-101165

109. Cs-1774

110. Db00773

111. Etoposide, Synthetic, >=98%, Powder

112. Nc00415

113. Sdccgsbi-0050405.p002

114. 4'-demethyl-epipodophyllotoxin 9-[4,6-o-(r)-ethylidene-beta-d-glucopyranoside

115. Ncgc00179504-02

116. As-35312

117. Be164434

118. Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, 9-((4,6-o-(1r)-ethylidene-beta-d-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r,5ar,8ar,9s)-

119. Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one-, 9-((4,6-o-ethylidene-beta-d-glucopyranosyl)oxy)5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl), (5r-(5alpha,5abeta,8aalpha,9beta(r*)))-

120. Hy-13629

121. Etoposide Impurity C [ep Impurity]

122. Sbi-0051910.p002

123. Ab00438905

124. C01576

125. D00125

126. Ab00438905-17

127. Ab00438905-18

128. Ab00438905_19

129. 419e420

130. Q418817

131. Sr-01000763196

132. Sr-01000763196-3

133. Brd-k37798499-001-02-5

134. Brd-k37798499-001-05-8

135. Brd-k37798499-001-10-8

136. Brd-k37798499-001-14-0

137. Brd-k37798499-001-27-2

138. Etoposide, British Pharmacopoeia (bp) Reference Standard

139. Etoposide, European Pharmacopoeia (ep) Reference Standard

140. Etoposide, United States Pharmacopeia (usp) Reference Standard

141. 4''-demethylepipodophyllotoxin 9-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside)

142. 4'-demethylepipodophyllotoxin 9-(4,6-o-(r)-ethylidene-.beta.-d-glucopyranoside)

143. Etoposide For System Suitability, European Pharmacopoeia (ep) Reference Standard

144. (10r,11r,15r,16s)-16-([(2r,4ar,7r,8r,8as)-7,8-dihydroxy-2-methyl-hexahydro-2h-pyrano[3,2-d][1,3]diox

145. (10r,11r,15r,16s)-16-{[(2r,4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methyl-hexahydro-2h-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one

146. (5r,5ar,8ar,9s)-9-(((2r,4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahy

147. (5r,5ar,8ar,9s)-9-(((2r,4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8h)-one

148. (5r,5ar,8ar,9s)-9-((4,6-o-((1r)-ethane-1,1-diyl)-.alpha.-d-glucopyranosyl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydro(2)benzofuro(5,6-f)(1,3)benzodioxol-6(5ah)-one

149. (5r,5ar,8ar,9s)-9-[[4,6-o-(1r)-ethylidene-beta-d-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one

150. (5s,5ar,8ar,9r)-5-[[(2r,4ar,6r,7r,8r,8as)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5h-isobenzofuro[5,6-f][1,3]benzodioxol-8-one

151. (5s,5ar,8ar,9r)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3'',4'':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-o-[(1r)-ethylidene]-beta-d-glucopyranoside

152. [5r-[5?,5a?,8a?,9?(r*)]]-9-[(4,6-?-ethylidene-?-d-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5ah)-one

153. 121471-01-0

154. 9-((4,6-o-ethylidine-beta-d-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3'',4'''':6,7)naptho-(2,3-d)-1,3-dioxol-6(5ah)-one

155. Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one-, 9-((4,6-o-ethylidene-.beta.-d-glucopyranosyl)oxy)5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl), (5r-(5.alpha.,5a.beta.,8a.alpha.,9.beta.(r*)))-

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₂₉H₃₂O₁₃
Molecular Weight	588.6 g/mol
XLogP3	0.6
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	5
Exact Mass	588.18429107 g/mol
Monoisotopic Mass	588.18429107 g/mol
Topological Polar Surface Area	161 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	969
Isotope Atom Count	0
Defined Atom Stereocenter Count	10
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Etoposide
PubMed Health	Etoposide
Drug Classes	Antineoplastic Agent
Drug Label	TOPOSAR (etoposide injection, USP) (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4'-demethylepipodophyllotoxin 9-[4,6-0-(R)-ethylidene--D-glucopyranoside]..
Active Ingredient	Etoposide
Dosage Form	Injectable; Capsule
Route	Injection; Oral
Strength	20mg/ml; 50mg
Market Status	Prescription
Company	Fresenius Kabi Usa; Accord Hlthcare; Teva Pharms Usa; Eurohlth Intl; Mylan

2 of 2
Drug Name	Etoposide
PubMed Health	Etoposide
Drug Classes	Antineoplastic Agent
Drug Label	TOPOSAR (etoposide injection, USP) (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4'-demethylepipodophyllotoxin 9-[4,6-0-(R)-ethylidene--D-glucopyranoside]..
Active Ingredient	Etoposide
Dosage Form	Injectable; Capsule
Route	Injection; Oral
Strength	20mg/ml; 50mg
Market Status	Prescription
Company	Fresenius Kabi Usa; Accord Hlthcare; Teva Pharms Usa; Eurohlth Intl; Mylan

4.2 Therapeutic Uses

Antineoplastic Agents, Phytogenic; Nucleic Acid Synthesis Inhibitors

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

Etoposide injection is indicated, in combination with other antineoplastics, for first-line treatment of testicular tumors (Evidence rating: 1A). /Included in US product labeling/

Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004., p. 1326

Etoposide is indicated in combination with other agents as first-line treatment of small cell lung carcinoma. /Included in US product labeling/

Etoposide also is indicated, alone and in combination with other agents, for treatment of Hodgkin's and non-Hodgkin"s lymphomas and acute nonlymphocytic (myelocytic) leukemia. /NOT included in US product labeling/

For more Therapeutic Uses (Complete) data for ETOPOSIDE (13 total), please visit the HSDB record page.

4.3 Drug Warning

The major and dose-limiting adverse effect of etoposide is hematologic toxicity. Myelosuppression, which is dose related, is manifested mainly by leukopenia (principally granulocytopenia). Myelosuppression resulting in death has been reported in patients receiving etoposide. Thrombocytopenia occurs less frequently, and anemia may also occur; pancytopenia has occurred in some patients. Myelosuppression apparently is not cumulative but may be more severe in patients previously treated with other antineoplastic agents or radiation therapy. Leukopenia has reportedly occurred in 60-91% of patients receiving etoposide and was severe (leukocyte count less than 1000/cu mm) in 3-17% of patients. Neutropenia (less than 2000 cu mm) occurred in 88% of patients treated with etoposide phosphate; severe neutropenia has reportedly occurred in 22-41% of patients receiving the drug and was severe (platelet count less than 50,000/cu mm) in 1-20% of patients. Anemia has occurred in up to 33% of patients receiving etoposide. Anemia (hemoglobin less than 11 g/dL) occurred in 72% of patients treated with etoposide phosphate; severe anemia (hemoglobin less than 8 g/dL) occurred in 19% of patients treated. Granulocyte and platelet nadirs usually occur within 7-14 and 9-16 days, respectively, after administration of etoposide, and within 12-19 and 10-15 days, respectively, after administration of etoposide phosphate; leukocyte nadir has been reported to occur within 15-22 days after administration of etoposide, phosphate. Bone marrow recovery is usually complete within 20 days after administration, but may occasionally require longer periods. Fever and infection have been reported in patients with drug-induced neutropenia.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 988

Pregnancy risk category: D /POSITIVE EVIDENCE OF RISK. Studies in humans, or investigational or post-marketing data, have demonstrated fetal risk. Nevertheless, potential benefits from the use of the drug may outweigh the potential risk. For example, the drug may be acceptable if needed in a life-threatening situation or serious disease for which safer drugs cannot be used or are ineffective./

Reversible alopecia, sometimes progressing to complete baldness, has occurred in 8-66% of patients receiving etoposide. The degree of alopecia may be dose related. Stevens-Johnson syndrome has been reported infrequently in patients receiving etoposide. Rash, pigmentation, urticaria, and severe pruritus have occurred infrequently, and cutaneous radiation-recall reactions associated with etoposide have been reported. ...

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 989

Anaphylactoid reactions consisting principally of chills, rigors, diaphoresis, pruritus, loss of consciousness, nausea, vomiting, fever, bronchospasm, dyspnea, tachycardia, hypertension, and/or hypotension have occurred during or immediately after administration of etoposide or etoposide phosphate in 0.7-3% of patients receiving the drug. Other manifestations have included flushing, rash, substernal chest pain, lacrimation, sneezing, coryza, throat pain, back pain, generalized body pain, abdominal cramps, and auditory impairment.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 989

For more Drug Warnings (Complete) data for ETOPOSIDE (24 total), please visit the HSDB record page.

4.4 Drug Indication

For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

Etoposide is an antineoplastic agent and an epipodophyllotoxin (a semisynthetic derivative of the podophyllotoxins). It inhibits DNA topoisomerase II, thereby ultimately inhibiting DNA synthesis. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases. Two different dose-dependent responses are seen. At high concentrations (10 µg/mL or more), lysis of cells entering mitosis is observed. At low concentrations (0.3 to 10 µg/mL), cells are inhibited from entering prophase. It does not interfere with microtubular assembly. The predominant macromolecular effect of etoposide appears to be the induction of DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals.

5.2 MeSH Pharmacological Classification

Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

ETOPOSIDE

5.3.2 FDA UNII

6PLQ3CP4P3

5.3.3 Pharmacological Classes

Topoisomerase Inhibitors [MoA]; Topoisomerase Inhibitor [EPC]

5.4 ATC Code

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01C - Plant alkaloids and other natural products

L01CB - Podophyllotoxin derivatives

L01CB01 - Etoposide

5.5 Absorption, Distribution and Excretion

Absorption

Absorbed well, time to peak plasma concentration is 1-1.5 hrs. Mean bioavailability is 50% (range of 25% - 75%). Cmax and AUC values for orally administered etoposide capsules display intra- and inter-subject variability. There is no evidence of first-pass effect for etoposide.

Route of Elimination

Etoposide is cleared by both renal and nonrenal processes, i.e., metabolism and biliary excretion. Glucuronide and/or sulfate conjugates of etoposide are also excreted in human urine. Biliary excretion of unchanged drug and/or metabolites is an important route of etoposide elimination as fecal recovery of radioactivity is 44% of the intravenous dose. 56% of the dose was in the urine, 45% of which was excreted as etoposide.

Volume of Distribution

The disposition of etoposide is a biphasic process with a distribution half-life of 1.5 hours. It does not cross into cerebrospinal fluid well. Volume of distribution, steady state = 18 - 29 L.

Clearance

Total body clearance = 33 - 48 mL/min [IV administration, adults]

Mean renal clearance = 7 - 10 mL/min/m^2

Excretion of etoposide in breast milk was demonstrated in a woman with acute promyelocytic leukemia receiving daily doses of 80 mg/sq m (route not stated). Peak concentrations of 0.6 to 0.8 ug/mL were measured immediately after dosing but had decreased to undetectable levels by 24 hr.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V76 214 (2000)

Thirty minutes after intravenous administration of etoposide to rats, the highest concentrations were found in the liver, kidneys and small intestine. By 24 hr after the dose, the tissue concentrations were negligible.

After intravenous infusion (5 min) of etoposide phosphate to beagle dogs at doses of 57-461 mg/sq m, a dose-proportional increase was seen in the maximal plasma concentration and AUC for etoposide. The total plasma clearance rate (342-435 mL/min per sq m) and the distribution volume (22-27 L/sq m) were not dose-dependent. The peak plasma concentration occurred at the end of the infusion of etoposide phosphate, indicating rapid conversion of the pro-drug to etoposide.

Less than 4% of a dose was recovered in the bile after 48 hr in patients with biliary drainage tubes. The fecal recovery of radiolabel after intravenous administration of 3(H)etoposide (130-290 mg/sq m) was variable, representing 0-16% of dose, but the collections were known to be incomplete because of fecal retention and other difficulties associated with the poor general condition of many of the patients). In a study reported as an abstract in four patients with small-cell lung cancer given 14(C)-glucopyranoside etoposide, 56% of the radiolabel was recovered in urine and 44% in feces over five days, for a total recovery of 100 +/- 6%.

For more Absorption, Distribution and Excretion (Complete) data for ETOPOSIDE (18 total), please visit the HSDB record page.

5.6 Metabolism/Metabolites

Primarily hepatic (through O-demethylation via the CYP450 3A4 isoenzyme pathway) with 40% excreted unchanged in the urine. Etoposide also undergoes glutathione and glucuronide conjugation which are catalyzed by GSTT1/GSTP1 and UGT1A1, respectively. Prostaglandin synthases are also responsible for the conversion of etoposide to O-demethylated metabolites (quinone).

The proposed hydroxy acid metabolite of etoposide, formed by opening of the lactone ring, has been detected in human urine, but only at low concentrations, accounting for 0.2-2.2% of the administered dose.

The major urinary metabolite of etoposide in humans is reported to be the glucuronide conjugate. Although urinary glucuronide and/or sulfate conjugates were reported to account for 5-22% of an intravenous dose of etoposide, other studies suggest that the glucuronide predominates. Etoposide glucuronide in the urine of treated patients accounted for 8-17% of a dose of 0.5-3.5 g/sq m etoposide and 29% of a dose of 100-800 mg/sq m etoposide, with no other metabolites other than etoposide glucuronide detected in the latter study. In patients with renal or liver impairment given somewhat lower doses of 70-150 mg/sq m, 3-17% of the dose was excreted in the urine within 72 hr as etoposide glucuronide.

Etoposide appears to be metabolized principally at the D ring to produce the resulting hydroxy acid (probably the trans-hydroxy acid); this metabolite appears to be pharmacologically inactive. The picrolactone isomer of etoposide has been detected in two concentrations in the plasma and urine of some patients but not in others. The aglycone of etoposide and/or its conjugates have not been detected to date in patients receiving the drug. In vitro, the picrolactone isomer and aglycone of etoposide have minimal cytotoxic activity.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 991

Generally, few or no etoposide metabolites have been detected in plasma. Etoposide is administered as the trans-lactone, but cis-etoposide can also be detected in human urine. This might be a storage phenomenon, since isomerization sometimes occurs during freezing of plasma samples under slightly basic conditions. The cis isomer accounts for < 1% of the dose. The catechol metabolite has also been reported in patients receiving 600 mg/sq m etoposide, with an AUC of around 2.5% that of etoposide. In patients given 90 mg/sq m etoposide, the catechol metabolite represented 1.4-7.1% of the urinary etoposide and < 2% of the administered dose.

In rat liver homogenates, liver microsomes and in rats in vivo, etoposide was extensively metabolized to only one major metabolite, which was not formally identified. In perfused isolated rat liver incubated with etoposide, the total recovery in bile was 60-85%, with roughly equal amounts of etoposide and two glucuronide metabolites, confirmed as glucuronide species by liquid chromatography and mass spectrometry. After intravenous injection of 3(H)etoposide to rabbits, the total urinary excretion of radiolabel was 30% after five days, with very little thereafter. A single glucuronide metabolite was identified in rabbit urine, which was present in larger amounts than etoposide. No hydroxy acid was identified in either species.

5.7 Biological Half-Life

4-11 hours

... In adults with normal renal and hepatic function, the half-life of etoposide averages 0.6-2 hours ... in the initial phase and 5.3-10.8 hours ... in the terminal phase. In one adult with impaired hepatic function, the terminal elimination half-life was reportedly 78 hours. In children with normal renal and hepatic function, the half-life of etoposide averages 0.6-1.4 hours in the initial phase and 3-5.8 hours in the terminal phase.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 991

... Elimination half-life of 3 to 7 hr in children and 4 to 8 hr in adults.

5.8 Mechanism of Action

Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA re-ligation. This causes critical errors in DNA synthesis at the premitotic stage of cell division and can lead to apoptosis of the cancer cell. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases of cell division. Inhibition of the topoisomerase II alpha isoform results in the anti-tumour activity of etoposide. The drug is also capable of inhibiting the beta isoform but inhibition of this target is not associated with the anti-tumour activity. It is instead associated with the carcinogenic effect.

The drug appears to produce its cytotoxic effects by damaging DNA and thereby inhibiting or altering DNA synthesis. ... Etoposide appears to be cell-cycle dependent and cycle-phase specific, inducing G2 phase arrest and preferentially filling cells in the G2 and late S phases.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 990

Etoposide has been shown to arrest metaphase in chick fibroblasts, but its principal effect in mammalian cells appears to be in the G2 phase. At etoposide concentrations of 0.3-10 ug/ml in vitro, cells are inhibited from entering prophase; at concentrations of 10 ug/ml or higher, lysis of cells entering mitosis occurs. ... Etoposide does not inhibit microtubule assembly. Etoposide has been shown to induce single-stranded DNA breaks in HeLa cells and in murine leukemia L1210 cells in vitro; the drug also induces double-stranded DNA breaks and DNA-protein crosslinks in L1210 cells. Etoposide induced DNA damage appears to correlate well with the cytotoxicity of the drug. ... Etoposide appears to induce single-stranded DNA breaks indirectly, possibly through endonuclease activation, inhibition of intranuclear type II topoisomerase, or formation of a free-radical metabolite via an enzymatic reaction involving the hydroxyl group at the C-4' position of the E ring. Etoposide also reversibly inhibits the facilitated diffusion of nucleosides into HeLa cells in a concentration dependent manner in vitro.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2004. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2004 (Plus Supplements)., p. 990

Etoposide may stabilize type II topoisomerase DNA complexes, preventing rejoining of single and double strand DNA breaks. Etoposide may also require cellular activation into intermediates, which then bind to DNA and disrupt cellular function.

PMID:2653712 Fleming RA et al; Clin Pharm 8 (4): 274-93 (1989)

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MINNEAPOLIS, MN 55413,SDNF UNITED STATES","customerAddress":"F 25, VIKRAM PLAZA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707330600,"product":"ETOPOSIDE - 78538AO -LOT#8538AO90423 (QTY 8 KG)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"TEVA API","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"VIATRIS","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"14938.4","totalValueFC":"120913.3","currency":"USD","unitRateINR":"1254078.7","date":"08-Feb-2024","totalValueINR":"10032629.44","totalValueInUsd":"120913.3","indian_port":"Bangalore Air","hs_no":"29389090","bill_no":"2051822","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"Piet Hein Building, Piet Heinkade 107 1019 GM Amsterdam The Netherlands Netherlands","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707330600,"product":"ETOPOSIDE RESOLUTION MIXTURE (QTY:2 X 10 MG, VALUE: USD 907\/EACH) (FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"USP","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00002","unit":"KGS","unitRateFc":"90700000","totalValueFC":"1985.8","currency":"USD","unitRateINR":"8238631000","date":"08-Feb-2024","totalValueINR":"164772.62","totalValueInUsd":"1985.8","indian_port":"Hyderabad Air","hs_no":"29389090","bill_no":"2041880","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD 21704 USA Frederick, , United States United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"78538AO ETOPOSIDE BATCH NO. 8538AO00424 (7PACKS)","address":"B-310, SOM DATT CHAMBERS, 1,","city":"NEW DELHI","supplier":"TEVA API","supplierCountry":"ITALY","foreign_port":"SEGRATE AIRPRT MILAN","customer":"FRESENIUS SE & CO. KGAA","customerCountry":"INDIA","quantity":"4.88","actualQuantity":"4877","unit":"GMS","unitRateFc":"15","totalValueFC":"73654.3","currency":"USD","unitRateINR":"1269","date":"01-Oct-2024","totalValueINR":"6188913","totalValueInUsd":"73654.3","indian_port":"Delhi Air","hs_no":"29095090","bill_no":"5893856","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"SEGRATE AIRPRT MILAN","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 1 07 1019 GM AMSTERDAM THE NETHERLAND S NETHERLANDS","customerAddress":"B-310, SOM DATT CHAMBERS, 1,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728844200,"product":"ETOPOSIDE - 78538AO","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"TEVA API","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"VIATRIS","customerCountry":"INDIA","quantity":"4.98","actualQuantity":"4.98","unit":"KGS","unitRateFc":"14938.4","totalValueFC":"75122.3","currency":"USD","unitRateINR":"1267523.2","date":"14-Oct-2024","totalValueINR":"6312265.57","totalValueInUsd":"75122.3","indian_port":"Bangalore Air","hs_no":"29389090","bill_no":"6115725","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"Piet Hein Building, Piet Heinkade 1 07 1019 GM Amsterdam SDNF Netherlands","customerAddress":"564\/A\/22, ROAD NO.92"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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FDA Orange Book

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Europe

01

Baxter Medical AB

Germany

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Not Confirmed

02

BRISTOL-MYERS SQUIBB Srl

U.S.A

Duphat

Not Confirmed

03

Fresenius Kabi Oncology Plc

Sweden

Duphat

Not Confirmed

04

Orifarm AB

Denmark

Duphat

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05

Orifarm AB

Denmark

Duphat

Not Confirmed

06

Orifarm AS

Denmark

Duphat

Not Confirmed

07

SANDOZ SpA

Switzerland

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08

Sandoz Pharmaceuticals AG

Switzerland

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09

Teva Sweden AB

Israel

Duphat

Not Confirmed

10

Paranova Läkemedel AB

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Listed Dossiers

01

Strides Pharma Science

India

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Strides Pharma Science: Pioneering IP-driven formulations for niche finished dosage forms.

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India

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Etoposide

Brand Name :

Dosage Form : Capsule

Dosage Strength : 50MG

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Registration Country : India

02

Strides Pharma Science

India

Duphat

Not Confirmed

Strides Pharma Science: Pioneering IP-driven formulations for niche finished dosage forms.

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Registration Country : India

Etoposide

Brand Name :

Dosage Form : Capsule

Dosage Strength : 100MG

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Application Number :

Regulatory Info :

Registration Country : India

03

Supriya Lifescience

India

Duphat

Not Confirmed

Supriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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Registration Country : India

Etoposide

Brand Name :

Dosage Form : Injection

Dosage Strength : 100MG

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Registration Country : India

04

Naprod Life Sciences

India

Duphat

Not Confirmed

Naprod is a top player in Oncology & Anesthesia FDF through excellent innovation, discovery of new processes & high-quality production.

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Registration Country : India

Etoposide

Brand Name :

Dosage Form : Liquid Injection

Dosage Strength : 20MG/ML

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Application Number :

Regulatory Info :

Registration Country : India

Product Web Link

Corporate PDF

05

Accure Labs Pvt. Ltd.

India

Duphat

Not Confirmed

06

GetWell Pharmaceutical

India

Duphat

Not Confirmed

07

GetWell Pharmaceutical

India

Duphat

Not Confirmed

08

Kremedine Health

India

Duphat

Not Confirmed

09

Sakar Healthcare

India

Duphat

Not Confirmed

10

Sakar Healthcare

India

Duphat

Not Confirmed

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ABOUT THIS PAGE

Etoposide Manufacturers

A Etoposide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Etoposide, including repackagers and relabelers. The FDA regulates Etoposide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Etoposide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Etoposide manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Etoposide Suppliers

A Etoposide supplier is an individual or a company that provides Etoposide active pharmaceutical ingredient (API) or Etoposide finished formulations upon request. The Etoposide suppliers may include Etoposide API manufacturers, exporters, distributors and traders.

click here to find a list of Etoposide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Etoposide USDMF

A Etoposide DMF (Drug Master File) is a document detailing the whole manufacturing process of Etoposide active pharmaceutical ingredient (API) in detail. Different forms of Etoposide DMFs exist exist since differing nations have different regulations, such as Etoposide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Etoposide DMF submitted to regulatory agencies in the US is known as a USDMF. Etoposide USDMF includes data on Etoposide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Etoposide USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Etoposide suppliers with USDMF on PharmaCompass.

Etoposide JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Etoposide Drug Master File in Japan (Etoposide JDMF) empowers Etoposide API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Etoposide JDMF during the approval evaluation for pharmaceutical products. At the time of Etoposide JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Etoposide suppliers with JDMF on PharmaCompass.

Etoposide CEP

A Etoposide CEP of the European Pharmacopoeia monograph is often referred to as a Etoposide Certificate of Suitability (COS). The purpose of a Etoposide CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Etoposide EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Etoposide to their clients by showing that a Etoposide CEP has been issued for it. The manufacturer submits a Etoposide CEP (COS) as part of the market authorization procedure, and it takes on the role of a Etoposide CEP holder for the record. Additionally, the data presented in the Etoposide CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Etoposide DMF.

A Etoposide CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Etoposide CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Etoposide suppliers with CEP (COS) on PharmaCompass.

Etoposide WC

A Etoposide written confirmation (Etoposide WC) is an official document issued by a regulatory agency to a Etoposide manufacturer, verifying that the manufacturing facility of a Etoposide active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Etoposide APIs or Etoposide finished pharmaceutical products to another nation, regulatory agencies frequently require a Etoposide WC (written confirmation) as part of the regulatory process.

click here to find a list of Etoposide suppliers with Written Confirmation (WC) on PharmaCompass.

Etoposide NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Etoposide as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Etoposide API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Etoposide as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Etoposide and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Etoposide NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Etoposide suppliers with NDC on PharmaCompass.

Etoposide GMP

Etoposide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Etoposide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Etoposide GMP manufacturer or Etoposide GMP API supplier for your needs.

Etoposide CoA

A Etoposide CoA (Certificate of Analysis) is a formal document that attests to Etoposide's compliance with Etoposide specifications and serves as a tool for batch-level quality control.

Etoposide CoA mostly includes findings from lab analyses of a specific batch. For each Etoposide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Etoposide may be tested according to a variety of international standards, such as European Pharmacopoeia (Etoposide EP), Etoposide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Etoposide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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ACTIVE PHARMA INGREDIENTS

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7 CEP/COS

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DEVELOPMENTS

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FINISHED DOSAGE FORMULATIONS

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55 Europe

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EXCIPIENTS BY APPLICATIONS

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9 Empty Capsules

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4 Vegetarian Capsules

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3 Granulation

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GLOBAL SALES INFORMATION

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