Find Evobrutinib manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 1415823-73-2, 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one, Evobrutinib [inn], Msc2364447c, M-2951, Msc-2364447c
Molecular Formula
C25H27N5O2
Molecular Weight
429.5  g/mol
InChI Key
QUIWHXQETADMGN-UHFFFAOYSA-N
FDA UNII
ZA45457L1K

Evobrutinib
Evobrutinib is an inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, evobrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.
1 2D Structure

Evobrutinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]piperidin-1-yl]prop-2-en-1-one
2.1.2 InChI
InChI=1S/C25H27N5O2/c1-2-22(31)30-14-12-18(13-15-30)16-27-25-23(24(26)28-17-29-25)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-11,17-18H,1,12-16H2,(H3,26,27,28,29)
2.1.3 InChI Key
QUIWHXQETADMGN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C=CC(=O)N1CCC(CC1)CNC2=NC=NC(=C2C3=CC=C(C=C3)OC4=CC=CC=C4)N
2.2 Other Identifiers
2.2.1 UNII
ZA45457L1K
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(4-(((6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl)amino)methyl)-1-piperidinyl)-2-propen-1-one

2. 2-propen-1-one, 1-(4-(((6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl)amino)methyl)-1-piperidinyl)-

2.3.2 Depositor-Supplied Synonyms

1. 1415823-73-2

2. 1-(4-(((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl)amino)methyl)piperidin-1-yl)prop-2-en-1-one

3. Evobrutinib [inn]

4. Msc2364447c

5. M-2951

6. Msc-2364447c

7. Za45457l1k

8. M2951

9. 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]piperidin-1-yl]prop-2-en-1-one

10. 1-(4-((6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino)-methyl)-piperidin-1-yl)-propenone

11. 2-propen-1-one, 1-(4-(((6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl)amino)methyl)-1-piperidinyl)-

12. 1-(4-(((6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl)amino)methyl)-1-piperidinyl)-2-propen-1-one

13. 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one

14. 1-[4-[[[6-amino-5-(4-phenoxyphenyl)-4-pyrimidinyl]amino]methyl]-1-piperidinyl]-2-propen-1-one

15. M-2951; Evobrutinib

16. Evobrutinib [who-dd]

17. Unii-za45457l1k

18. Gtpl9752

19. Chembl4072833

20. Schembl14165673

21. Bdbm291522

22. Us9580449, Example A39

23. Bcp28995

24. Ex-a2691

25. Us9580449, Example A250

26. Nsc800892

27. S8777

28. Zinc205623965

29. Ab90800

30. Cs-6303

31. Db15170

32. Nsc-800892

33. Msc 2364447

34. Ac-35533

35. Bs-15355

36. Db-126809

37. Hy-101215

38. A16824

39. D71175

40. A902526

41. A250 [wo2012170976]

42. Q27295200

43. M-2951; M 2951; M2951; Msc-2364447c; Msc 2364447c; Msc2364447c

44. N-[(1-acryloylpiperidin-4-yl)methyl]-5-(4-phenoxyphenyl)pyrimidine-4,6-diamine

2.4 Create Date
2013-06-10
3 Chemical and Physical Properties
Molecular Weight 429.5 g/mol
Molecular Formula C25H27N5O2
XLogP34.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass429.21647512 g/mol
Monoisotopic Mass429.21647512 g/mol
Topological Polar Surface Area93.4 Ų
Heavy Atom Count32
Formal Charge0
Complexity595
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of multiple sclerosis


Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Evobrutinib Manufacturers

A Evobrutinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Evobrutinib, including repackagers and relabelers. The FDA regulates Evobrutinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Evobrutinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Evobrutinib Suppliers

A Evobrutinib supplier is an individual or a company that provides Evobrutinib active pharmaceutical ingredient (API) or Evobrutinib finished formulations upon request. The Evobrutinib suppliers may include Evobrutinib API manufacturers, exporters, distributors and traders.

Evobrutinib GMP

Evobrutinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Evobrutinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Evobrutinib GMP manufacturer or Evobrutinib GMP API supplier for your needs.

Evobrutinib CoA

A Evobrutinib CoA (Certificate of Analysis) is a formal document that attests to Evobrutinib's compliance with Evobrutinib specifications and serves as a tool for batch-level quality control.

Evobrutinib CoA mostly includes findings from lab analyses of a specific batch. For each Evobrutinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Evobrutinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Evobrutinib EP), Evobrutinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Evobrutinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty