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ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 1 JDMF, 5 Listed Suppliers

6 API Suppliers
1 JDMF
5 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 Listed Dossiers

1 FDF Dossiers
1 Listed Dossiers

GLOBAL SALES INFORMATION

5 Annual Reports

globalSalesInformation
5 Annual Reports

MARKET PLACE

1 APIs

marketPlace
1 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

383

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 870964-67-3, Evocalcet [inn], Mt-4580, Khk-7580, Khk7580, E58mlh082p

Molecular Formula

C₂₄H₂₆N₂O₂

Molecular Weight

374.5 g/mol

InChI Key

RZNUIYPHQFXBAN-XLIONFOSSA-N

FDA UNII

E58MLH082P

Evocalcet is an orally available calcium receptor (CaR) modulator, with potential calcimimetic activity. Upon administration, evocalcet allosterically binds to and inhibits the activity of CaR, thereby suppressing the production of serum parathyroid hormone (PTH) and prevents the PTH-mediated efflux of calcium from bone and normalizes calcium levels.

1 2D Structure

Evocalcet

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid

2.1.2 InChI

InChI=1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/m1/s1

2.1.3 InChI Key

RZNUIYPHQFXBAN-XLIONFOSSA-N

2.1.4 Canonical SMILES

CC(C1=CC=CC2=CC=CC=C21)NC3CCN(C3)C4=CC=C(C=C4)CC(=O)O

2.1.5 Isomeric SMILES

C[C@H](C1=CC=CC2=CC=CC=C21)N[C@H]3CCN(C3)C4=CC=C(C=C4)CC(=O)O

2.2 Other Identifiers

2.2.1 UNII

E58MLH082P

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (4-((3s)-3-(((1r)-1-(1-naphthyl)ethyl)amino)-1-pyrrolidinyl)phenyl)acetic Acid

2.3.2 Depositor-Supplied Synonyms

1. 870964-67-3

2. Evocalcet [inn]

3. Mt-4580

4. Khk-7580

5. Khk7580

6. E58mlh082p

7. 4-[(3s)-3-[[(1r)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzeneaceticacid

8. 2-[4-[(3s)-3-[[(1r)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic Acid

9. 4-[(3s)-3-[[(1r)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzeneacetic Acid

10. Benzeneacetic Acid, 4-((3s)-3-(((1r)-1-(1-naphthalenyl)ethyl)amino)-1-pyrrolidinyl)-

11. 2-(4-((s)-3-(((r)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetic Acid

12. 2-[4-[(3s)-3-[[(1r)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic Acid

13. Unii-e58mlh082p

14. Evocalcet?

15. H43

16. Orkedia (tn)

17. Evocalcet (jan/inn)

18. Evocalcet [jan]

19. Evocalcet [mi]

20. Evocalcet [who-dd]

21. Gtpl9042

22. Chembl4297621

23. Schembl14668291

24. Khk7580khk7580

25. Dtxsid101132784

26. Vjb96467

27. Akos040741717

28. Db12388

29. Khk7580; Mt-4580

30. Hy-17613

31. Ms-26062

32. Cs-0014698

33. Ns00073438

34. D11063

35. G15959

36. Q27077250

37. (4-((3s)-3-(((1r)-1-(1-naphthyl)ethyl)amino)-1-pyrrolidinyl)phenyl)acetic Acid

2.4 Create Date

2013-03-21

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₆N₂O₂
Molecular Weight	374.5 g/mol
XLogP3	2.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	g/mol
Monoisotopic Mass	g/mol
Topological Polar Surface Area	52.6
Heavy Atom Count	28
Formal Charge	0
Complexity	517
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 ATC Code

H - Systemic hormonal preparations, excl. sex hormones and insulins

H05 - Calcium homeostasis

H05B - Anti-parathyroid agents

H05BX - Other anti-parathyroid agents

H05BX06 - Evocalcet

API SUPPLIERS

01

Shandong Loncom Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

Shandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Shandong Loncom Pharmaceutical company banner

02

ATK Chemical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

03

KareBay Biochem

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

04

J&H CHEM

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

05

Mitsubishi Tanabe Pharma

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

06

Sichuan Qingmu Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

JDMF

01

Mitsubishi Tanabe Pharma Factory, L...

Japan

Biotech Showcase

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

01

Shandong Loncom Pharmaceutical

China

Biotech Showcase

Not Confirmed

Shandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

Contact Supplier

China

Virtual Booth

Digital Content

Evocalcet

About the Company : Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development...

Established in May 2012, Shandong Loncom Pharmaceutical operates as a fully owned subsidiary of Shandong Bestcomm Pharmaceutical Co., Ltd. Situated in the Qihe Economic Development Zone, Shandong Province, Shandong Loncom has operational API pilot tests and production bases adhering to international standards. With 13 production lines dedicated to oral solid preparations, oral liquid preparations and API, it is actively expanding its preparation workshops for small-volume injections, soft capsules, eye drops, topical medicines and innovative drug R&D centres.