Find Evofosfamide manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Th-302, 918633-87-1, Th302, Th 302, Hap-302, N,n'-bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl ester
Molecular Formula
C9H16Br2N5O4P
Molecular Weight
449.04  g/mol
InChI Key
UGJWRPJDTDGERK-UHFFFAOYSA-N
FDA UNII
8A9RZ3HN8W

Evofosfamide
Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, such as those found in hypoxic tumors, the 2-nitroimidazole moiety of evofosfamide is reduced. This releases the DNA-alkylating Br-IPM moiety, which introduces intra- and inter-strand DNA crosslinks in nearby cells; the crosslinks inhibit both DNA replication and cell division, and may lead to apoptosis of cells in the tumor. The inactive form of the prodrug is stable under normoxic conditions, which may limit systemic toxicity.
1 2D Structure

Evofosfamide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-bromo-N-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine
2.1.2 InChI
InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/h6H,2-5,7H2,1H3,(H2,13,14,19)
2.1.3 InChI Key
UGJWRPJDTDGERK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr
2.2 Other Identifiers
2.2.1 UNII
8A9RZ3HN8W
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Th 302

2. Th-302

3. Th302 Cpd

2.3.2 Depositor-Supplied Synonyms

1. Th-302

2. 918633-87-1

3. Th302

4. Th 302

5. Hap-302

6. N,n'-bis(2-bromoethyl)phosphorodiamidic Acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl Ester

7. 2-bromo-n-[(2-bromoethylamino)-[(3-methyl-2-nitroimidazol-4-yl)methoxy]phosphoryl]ethanamine

8. 8a9rz3hn8w

9. Compound 3b

10. Th-302; Evofosfamide;hap-302

11. Phosphorodiamidic Acid, N,n'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1h-imidazol-5-yl)methyl Ester

12. Phosphorodiamidic Acid, N,n'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1h-imidazol-5-yl)methyl Ester.

13. Evofosfamide [usan:inn]

14. Unii-8a9rz3hn8w

15. Evofosfamide(th 302)

16. Evofosfamide(th-302)

17. Evofosfamide [inn]

18. Evofosfamide [jan]

19. Evofosfamide [usan]

20. Evofosfamide [who-dd]

21. Chembl260046

22. Evofosfamide (jan/usan/inn)

23. Gtpl8695

24. Schembl2357174

25. Schembl15691894

26. Dtxsid60238721

27. Amy16615

28. Bcp06074

29. Ex-a1740

30. Bdbm50543112

31. S2757

32. Zinc29053729

33. Akos026673946

34. Ccg-269225

35. Cs-0616

36. Db06091

37. Sb17116

38. Ac-29025

39. As-74462

40. Hy-10535

41. Ft-0696771

42. J3.504.735b

43. D10704

44. A901406

45. J-523214

46. Q7670203

47. (1-methyl-2-nitro-1h-imidazol-5-yl)methyl N,n'-bis(2-bromoethyl)diamidophosphate

48. (1-methyl-2-nitro-1h-imidazole-5-yl)methyl N,n'-bis(2-bromoethyl) Diamidophosphate

49. 1-methyl-2-nitro-l H-imidazole-5-yl) N,n-bis(2-bromoethyl)diamidophosphate

50. (2-bromoethyl)({[(2-bromoethyl)amino][(1-methyl-2-nitro-1h-imidazol-5-yl)methoxy]phosphoryl})amine

51. Th302n,n'-bis(2-bromoethyl)phosphorodiamidic Acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl Ester

2.4 Create Date
2007-01-10
3 Chemical and Physical Properties
Molecular Weight 449.04 g/mol
Molecular Formula C9H16Br2N5O4P
XLogP30.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass448.92862 g/mol
Monoisotopic Mass446.93067 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count21
Formal Charge0
Complexity374
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in solid tumors.


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

TH-302 combines a 2-nitroimidazole oxygen-sensing trigger with a masked DNA crosslinker. Upon activation in oxygen deficient zones, TH-302 is converted selectively to the drug's active form, dibromo isophosphoramide mustard, a potent alkylator. TH-302 targets levels of severe hypoxia that are found in tumors but are rare in normal tissues - this is how selective targeting of the tumor occurs. After conversion to the active form of the drug, the hypoxic cells are exposed to high concentrations of released cytotoxic agent, which can also diffuse into the adjacent regions of the tumor.


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ABOUT THIS PAGE

Looking for 918633-87-1 / Evofosfamide API manufacturers, exporters & distributors?

Evofosfamide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Evofosfamide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Evofosfamide manufacturer or Evofosfamide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Evofosfamide manufacturer or Evofosfamide supplier.

PharmaCompass also assists you with knowing the Evofosfamide API Price utilized in the formulation of products. Evofosfamide API Price is not always fixed or binding as the Evofosfamide Price is obtained through a variety of data sources. The Evofosfamide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Evofosfamide

Synonyms

Th-302, 918633-87-1, Th302, Th 302, Hap-302, N,n'-bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1h-imidazol-5-yl)methyl ester

Cas Number

918633-87-1

Unique Ingredient Identifier (UNII)

8A9RZ3HN8W

About Evofosfamide

Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, such as those found in hypoxic tumors, the 2-nitroimidazole moiety of evofosfamide is reduced. This releases the DNA-alkylating Br-IPM moiety, which introduces intra- and inter-strand DNA crosslinks in nearby cells; the crosslinks inhibit both DNA replication and cell division, and may lead to apoptosis of cells in the tumor. The inactive form of the prodrug is stable under normoxic conditions, which may limit systemic toxicity.

Evofosfamide Manufacturers

A Evofosfamide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Evofosfamide, including repackagers and relabelers. The FDA regulates Evofosfamide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Evofosfamide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Evofosfamide Suppliers

A Evofosfamide supplier is an individual or a company that provides Evofosfamide active pharmaceutical ingredient (API) or Evofosfamide finished formulations upon request. The Evofosfamide suppliers may include Evofosfamide API manufacturers, exporters, distributors and traders.

Evofosfamide GMP

Evofosfamide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Evofosfamide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Evofosfamide GMP manufacturer or Evofosfamide GMP API supplier for your needs.

Evofosfamide CoA

A Evofosfamide CoA (Certificate of Analysis) is a formal document that attests to Evofosfamide's compliance with Evofosfamide specifications and serves as a tool for batch-level quality control.

Evofosfamide CoA mostly includes findings from lab analyses of a specific batch. For each Evofosfamide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Evofosfamide may be tested according to a variety of international standards, such as European Pharmacopoeia (Evofosfamide EP), Evofosfamide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Evofosfamide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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