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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 1 KDMF, 4 Listed Suppliers, $ API Reference Price

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Chemistry

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Also known as: Da-1229, Evogliptin [inn], 1222102-29-5, Chembl1779710, Evogliptin (inn), Da1229

Molecular Formula

C₁₉H₂₆F₃N₃O₃

Molecular Weight

401.4 g/mol

InChI Key

LCDDAGSJHKEABN-MLGOLLRUSA-N

FDA UNII

09118300L7

Evogliptin has been used in trials studying the treatment and screening of Osteoporosis, Renal Impairment, Type 2 Diabetes Mellitus, Diabetes Mellitis Type 2, and Diabetes Mellitus, Type 2.

1 2D Structure

Evogliptin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one

2.1.2 InChI

InChI=1S/C19H26F3N3O3/c1-19(2,3)28-10-16-18(27)24-4-5-25(16)17(26)8-12(23)6-11-7-14(21)15(22)9-13(11)20/h7,9,12,16H,4-6,8,10,23H2,1-3H3,(H,24,27)/t12-,16-/m1/s1

2.1.3 InChI Key

LCDDAGSJHKEABN-MLGOLLRUSA-N

2.1.4 Canonical SMILES

CC(C)(C)OCC1C(=O)NCCN1C(=O)CC(CC2=CC(=C(C=C2F)F)F)N

2.1.5 Isomeric SMILES

CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N

2.2 Other Identifiers

2.2.1 UNII

09118300L7

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one

2. Da 1229

3. Da-1229

4. Da1229

2.3.2 Depositor-Supplied Synonyms

1. Da-1229

2. Evogliptin [inn]

3. 1222102-29-5

4. Chembl1779710

5. Evogliptin (inn)

6. Da1229

7. (r)-4-((r)-3-amino-4-(2,4,5-trifluorophenyl)-butanoyl)-3-(t-butoxymethyl)-piperazin-2-one

8. (r)-4-((r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one

9. 2-piperazinone, 4-((3r)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-3-((1,1-dimethylethoxy)methyl)-, (3r)-

10. 09118300l7

11. (r)-4-((r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazine-2-one

12. Unii-09118300l7

13. Evogliptin [who-dd]

14. Schembl343846

15. Dtxsid00153545

16. Bdbm50344779

17. Db12625

18. Hy-117985

19. Cs-0068793

20. C92448

21. D11023

22. Q25103700

23. (r)-4-[(r)-3-amino-4-(2,4,5-trifluorophenyl) Butanoyl]-3-(t-butoxymethyl)piperazin-2-one

24. (r)-4-[(r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(t-butoxymethy)piperazin-2-one

25. (3r)-4-[(3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(tert-butoxymethyl)piperazin-2-one

26. (3r)-4-[(3r)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one

27. (r)-4-[(r)-3-amino-4-(2,4,5-trifluorophenyl) Butanoyl]-3-(t-butoxymethyl)piperazine-2-one

28. 8vu

2.4 Create Date

2008-11-10

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₆F₃N₃O₃
Molecular Weight	401.4 g/mol
XLogP3	1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	401.19262619 g/mol
Monoisotopic Mass	401.19262619 g/mol
Topological Polar Surface Area	84.7 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	558
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 ATC Code

A - Alimentary tract and metabolism

A10 - Drugs used in diabetes

A10B - Blood glucose lowering drugs, excl. insulins

A10BH - Dipeptidyl peptidase 4 (dpp-4) inhibitors

A10BH07 - Evogliptin

API SUPPLIERS

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Listed Suppliers

01

02

SimSon Pharma

India

Antibody Engineering

Not Confirmed

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India

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Digital Content

Evogliptin Tatrate

About the Company : "SimSon Pharma, a renowned name in pharmaceutical sector, has build high its reputation as a complete solution provider in contract research arena. We are leading manufacturer and ...

"SimSon Pharma, a renowned name in pharmaceutical sector, has build high its reputation as a complete solution provider in contract research arena. We are leading manufacturer and supplier of pharmaceutical Reference materials like Drug working standard, Drug impurity standards, Drug metabolites and Stable Isotope Labelled compounds. Our expertise in this area has made us one of the the most trusted companies in the industry. We are the front runner in manufacturing complicated Drug impurity standards or Reference materials and the complete solution provider in identifying, synthesizing and qualifying any Unknown impurity. We have scaled up our operations to make the company a holistic solution provider and would be supplying all reference chemicals and materials for research requirements . In short, we are one stop solutions for Chemical development, Formulation development, Analytical development and Regulatory services. SimSon Pharma not only synthesize and supply molecules but also provides cost effective & innovative approach to help companies achieve success. We work closely with our clients for understanding their requirements and offer them time bound solutions. Vision: To become a leading pharma company and a preferred partner for the global pharma industry for Reference materials, Research chemicals and R&D services. Mission: We strive to provide a cost-effective and time-bound research solutions in the area of custom synthesis, formulation development and analytical development."

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03

ST Pharma

South Korea

Antibody Engineering

Not Confirmed

04

Vivan Life Sciences

India

Antibody Engineering

Not Confirmed

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API Reference Price

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