Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

12 API Suppliers, 6 USDMF, 7 Listed Suppliers, $ API Reference Price

12 API Suppliers
6 USDMF
7 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

5 Intermediates Suppliers

5 Intermediates Suppliers

DIGITAL CONTENT

3 NEWS #PharmaBuzz

media
3 NEWS #PharmaBuzz

MARKET PLACE

2 APIs

marketPlace
2 APIs

Cohance Exatecan

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 171335-80-1, Exatecan [inn], Dx-8951f, Oc71pp0f89, Dx-8951, (1s,9s)-1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10h,13h-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione

Molecular Formula

C₂₄H₂₂FN₃O₄

Molecular Weight

435.4 g/mol

InChI Key

ZVYVPGLRVWUPMP-FYSMJZIKSA-N

FDA UNII

OC71PP0F89

Exatecan has been used in trials studying the treatment of Sarcoma, Leukemia, Lymphoma, Lung Cancer, and Liver Cancer, among others.

1 2D Structure

Exatecan

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione

2.1.2 InChI

InChI=1S/C24H22FN3O4/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19/h6-7,16,31H,3-5,8-9,26H2,1-2H3/t16-,24-/m0/s1

2.1.3 InChI Key

ZVYVPGLRVWUPMP-FYSMJZIKSA-N

2.1.4 Canonical SMILES

CCC1(C2=C(COC1=O)C(=O)N3CC4=C5C(CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O

2.1.5 Isomeric SMILES

CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O

2.2 Other Identifiers

2.2.1 UNII

OC71PP0F89

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (1s,9s)-1-amino-9-ethyl-5-fluoro-2,3-dihydro-9-hydroxy-4-methyl-1h,12h-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9h,15h)dione Methanesulfonate

2. Dx 8951

3. Dx 8951f

4. Dx-8951

5. Dx-8951a

6. Dx-8951f

7. Exatecan Mesilate Hydrate

8. Exatecan Mesylate

9. Exatecan Methanesulfonate Dihydrate

2.3.2 Depositor-Supplied Synonyms

1. 171335-80-1

2. Exatecan [inn]

3. Dx-8951f

4. Oc71pp0f89

5. Dx-8951

6. (1s,9s)-1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10h,13h-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione

7. Dx 8951

8. Unii-oc71pp0f89

9. Exatecan-mesylate

10. (1s,9s)-1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10h,13h-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione

11. Exatecan [mi]

12. Exatecan [who-dd]

13. Schembl2512959

14. Chembl1614650

15. Dtxsid60169061

16. Chebi:135709

17. Ex-a2683

18. Zinc3800855

19. Nsc829066

20. Akos005146469

21. At33978

22. Bcp9000674

23. Db12185

24. Nsc-829066

25. 10h,13h-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1s,9s)-

26. 10h,13h-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1s-trans)-

27. Ac-32495

28. Bp-27996

29. Hy-13631

30. Db-064817

31. Dx8951;dx 8951;dx-8951

32. 335e801

33. J-521361

34. Q5419343

35. (10s,23s)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₂FN₃O₄
Molecular Weight	435.4 g/mol
XLogP3	0.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	435.15943435 g/mol
Monoisotopic Mass	435.15943435 g/mol
Topological Polar Surface Area	106 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	950
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Topoisomerase I Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)

API SUPPLIERS

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

01

Cohance Lifesciences

India

CPhI India 2024

Attending

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

Contact Supplier

India

Virtual Booth

Digital Content

Exatecan

About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.

02

Chongqing Sintaho Pharmaceutical

China

euroPLX 86 Munich

Not Confirmed

Chongqing Sintaho Pharma: A trusted partner globally for chemosynthetic APIs.

Contact Supplier

China

Virtual Booth

Digital Content

Exatecan

About the Company : Sintaho Pharmaceutical Co., Ltd., located in Chongqing, China, contributes to being the most dependable partner for global pharmaceutical companies. Sintaho specializes in chemosyn...

Sintaho Pharmaceutical Co., Ltd., located in Chongqing, China, contributes to being the most dependable partner for global pharmaceutical companies. Sintaho specializes in chemosynthetic APIs (application contains oncology, nervous system, and metabolic diseases and etc.,) with a product portfolio ranging from small molecule APIs, ADC compounds (linkers and payloads) to polypeptides, also provides CDMO services of cytotoxic and OEB4/5 grade APIs.

Corporate PDF

03

Shanghai Minbiotech

China

Pharmtech & Ingredients

Booth #B4103

Shanghai Minbiotech is the leading producer of biopharmaceuticals and a variety of high-end generic & innovative drugs.

Contact Supplier

China

Virtual Booth

Digital Content

Exatecan Mesylate

About the Company : Headquartered in Fengxian District, Shanghai Minbiotech Co., Ltd. is a company specializing in the R&D and production of advanced pharmaceutical intermediates and biological API...

Headquartered in Fengxian District, Shanghai Minbiotech Co., Ltd. is a company specializing in the R&D and production of advanced pharmaceutical intermediates and biological APIs. There are more than 1000 square meters of R&D centers in Nantong, Jiangsu and Jinan, Shandong, with more than 13,000㎡ of production sites. While supplying products to customers, the company also provides services such as technology development, technology transfer and technology exchange, aiming to provide customers with comprehensive supply and solutions in the biomedical industry.

Product Web Link

Corporate PDF

04

Sichuan Elixir Pharmaceuticals

China

euroPLX 86 Munich

Not Confirmed

Sichuan Elixir Pharmaceutical, a manufacturer of small molecule APIs & a CMO/CDMO service provider for anti-tumor characteristic APIs..

Contact Supplier

China

Virtual Booth

Digital Content

Exatecan

About the Company : Specializing in natural & oncology APIs, we establish R&D and production platforms for new salt, crystal form & synthetic biology research. We cooperate with clients for IND, NDA, ...

Specializing in natural & oncology APIs, we establish R&D and production platforms for new salt, crystal form & synthetic biology research. We cooperate with clients for IND, NDA, ANDA, 505b(2) and P-IV challenges. Exploring macromolecular APIs, we focus on Glycans & polypeptides. Expertise in XDC drugs drives innovative research & payload production. With a global registration platform & international cGMP system, we offer API CMO/CDMO services worldwide. Our strategy combines FDF and APIs. Our labs meet GMP standards with a stable R&D team, over 10 years of experience, we've delivered 20+ successful projects.

05

Jin Dun Medical

China

euroPLX 86 Munich

Not Confirmed

06

Sichuan Xieli Pharmaceutical

China

euroPLX 86 Munich

Not Confirmed

07

Zhejiang Huida Biotech

China

euroPLX 86 Munich

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

[{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713983400,"product":"EXATECAN MESYLATE","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"SYNGENE INTERNATIONAL LIMITED","supplierCountry":"INDIA","foreign_port":"LEOLA","customer":"XXBREXX 2","customerCountry":"UNITED STATES","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"61295.5","totalValueFC":"60702.9","currency":"USD","unitRateINR":5069138,"date":"25-Apr-2024","totalValueINR":"5069138","totalValueInUsd":"60702.9","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"4002097","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Biocon-SEZ","supplierAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3, ","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1715106600,"product":"EXATECAN MESYLATE DIHYDRATE (QTY:10 GM,VALUE: USD 300\/GM)","address":"AVRA HOUSE, 7-102\/54, SAI ENCLAVE","city":"HYDERABAD, AP","supplier":"AVRA LABORATORIES PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BEIJING","customer":"PHARMARON BEIJING CO..LTD","customerCountry":"CHINA","quantity":"0.01","actualQuantity":"0.01","unit":"KGS","unitRateFc":"300000","totalValueFC":"2762.4","currency":"USD","unitRateINR":23025484,"date":"08-May-2024","totalValueINR":"230254.84","totalValueInUsd":"2762.4","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"9728612","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"AVRA HOUSE, 7-102\/54, SAI ENCLAVE, HYDERABAD, AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719513000,"product":"EXATECAN MESYLATE DIHYDRATE (QTY:150 GM,VALUE: USD 250\/GM)","address":"AVRA HOUSE, 7-102\/54, SAI ENCLAVE","city":"HYDERABAD, AP","supplier":"AVRA LABORATORIES PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BEIJING","customer":"PHARMARON BEIJING CO..LTD","customerCountry":"CHINA","quantity":"0.15","actualQuantity":"0.15","unit":"KGS","unitRateFc":"250000","totalValueFC":"37105","currency":"USD","unitRateINR":20650000,"date":"28-Jun-2024","totalValueINR":"3097500","totalValueInUsd":"37105","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"2012749","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"AVRA HOUSE, 7-102\/54, SAI ENCLAVE, HYDERABAD, AP","customerAddress":""},{"dataSource":"API Import","activeIngredients":"EXATECAN","year":"2021","qtr":"Q1","strtotime":1612981800,"product":"EXATECAN MESYLATE","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"ARBOR CHEMICAL CO. LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"4500","totalValueFC":"4561.4","currency":"USD","unitRateINR":"332100","date":"11-Feb-2021","totalValueINR":"332100","totalValueInUsd":"4561.4","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1001820","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"ROOM 401, UNIT 3, BUILDING 10 NO 128, MINGDONG RD, CAOLU TOWN PUDONG SHANGHAI CHINA","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1661970600,"product":"EXATECAN MESYLATE","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"NANJING HABO MEDICAL TECHNOLOGY CO LTD","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"5","unit":"GMS","unitRateFc":"454","totalValueFC":"2280.2","currency":"USD","unitRateINR":"36547","date":"01-Sep-2022","totalValueINR":"182735","totalValueInUsd":"2280.2","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1013143","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"ADD:NO.9,WEIDI ROAD CN","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1697135400,"product":"EXATECAN MESYLATE","address":"AVRA HOUSE, 7-102\/54, SAI ENCLAVE","city":"HYDERABAD, AP","supplier":"ZHEJIANG HUIDA BIOTECH","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"AVRA LABORATORIES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.002","unit":"KGS","unitRateFc":"274000","totalValueFC":"554.1","currency":"USD","unitRateINR":"23057100","date":"13-Oct-2023","totalValueINR":"46114.2","totalValueInUsd":"554.1","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"8284577","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"FLOOR 3 ,BUILDING 94 NO.700SDNFSDNF China","customerAddress":"AVRA HOUSE, 7-102\/54, SAI ENCLAVE"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702924200,"product":"EXATECAN","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"PHARMATECH","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"52","unit":"GMS","unitRateFc":"106.3","totalValueFC":"5598.2","currency":"USD","unitRateINR":"8961.7","date":"19-Dec-2023","totalValueINR":"466010","totalValueInUsd":"5598.2","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1017219","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706553000,"product":"EXATECAN MESYLATE","address":"CORPORATE HOUSE, NR. SOLA BRIDGE,,","city":"AHMEDABAD,GUJARAT","supplier":"BIOBETTA PHARMACEUTICALS SHANGHAI ","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"0.02","unit":"KGS","unitRateFc":"135000","totalValueFC":"2732.1","currency":"USD","unitRateINR":"11353500","date":"30-Jan-2024","totalValueINR":"227070","totalValueInUsd":"2732.1","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"9903479","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"Suite 506-507, No. 2777 East JinxiuRoad,Pudong New Area, Shanghai 201206 China","customerAddress":"CORPORATE HOUSE, NR. SOLA BRIDGE,,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707503400,"product":"EXATECAN MESYLATE","address":"2ND FLOOR, CHINUBHAI CENTRE,","city":"AHMEDABAD, GUJARAT","supplier":"ABYDOS SCIENTIFIC","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"INTAS PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"150","totalValueFC":"1517.6","currency":"USD","unitRateINR":"12592.5","date":"10-Feb-2024","totalValueINR":"125925","totalValueInUsd":"1517.6","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"2080245","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"NO.9 BUILDING, R&D ZONE 1, NO. 699-8 XUANWU DISTRICT NANJING Nanjing -210042, , China China","customerAddress":"2ND FLOOR, CHINUBHAI CENTRE,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

Upgrade, download data, analyse, strategize, subscribe with us contact

Drugs in Development

01 Cybrexa Therapeutics

U.S.A

euroPLX 86 Munich

Not Confirmed

China

BioFlorida Conference

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Digital Content

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

Market Place

Do you need sourcing support? Ask us

APIs

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

ABOUT THIS PAGE

Find Exatecan manufacturers, exporters & distributors on PharmaCompass

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

12 API Suppliers

6 USDMF

7 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

INTERMEDIATES

5 Intermediates Suppliers

DIGITAL CONTENT

3 NEWS #PharmaBuzz

MARKET PLACE

2 APIs

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 88,595

MARKET PLACE

FINISHED DOSAGE FORMULATIONS

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

01

02

03

04

05

06

07

Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

01

01

02

03

04

05

What are you looking for?