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Chemistry

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Also known as: 196612-93-8, Bibx 1382, Bibx1382, Bibx-1382, Falnidamol [inn], N8-(3-chloro-4-fluorophenyl)-n2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine
Molecular Formula
C18H19ClFN7
Molecular Weight
387.8  g/mol
InChI Key
FTFRZXFNZVCRSK-UHFFFAOYSA-N
FDA UNII
0MU316797D

Falnidamol
Falnidamol is a pyrimido-pyrimidine with antitumor activity. BIBX 1382 inhibits the intracellular tyrosine kinase domain of the Epidermal Growth Factor Receptor (EGFR) thus specifically reversing the aberrant enzymatic activity from overexpressed and constitutively activated EGFR, and subsequently inhibiting cell proliferation and inducing cell differentiation.
1 2D Structure

Falnidamol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-N-(3-chloro-4-fluorophenyl)-6-N-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-4,6-diamine
2.1.2 InChI
InChI=1S/C18H19ClFN7/c1-27-6-4-11(5-7-27)25-18-21-9-15-16(26-18)17(23-10-22-15)24-12-2-3-14(20)13(19)8-12/h2-3,8-11H,4-7H2,1H3,(H,21,25,26)(H,22,23,24)
2.1.3 InChI Key
FTFRZXFNZVCRSK-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl
2.2 Other Identifiers
2.2.1 UNII
0MU316797D
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bibx 1382bs

2. Bibx-1382bs

3. Bibx1382bs

2.3.2 Depositor-Supplied Synonyms

1. 196612-93-8

2. Bibx 1382

3. Bibx1382

4. Bibx-1382

5. Falnidamol [inn]

6. N8-(3-chloro-4-fluorophenyl)-n2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine

7. Chembl258940

8. 0mu316797d

9. 4-n-(3-chloro-4-fluorophenyl)-6-n-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-4,6-diamine

10. Bibx 1382bs

11. 8-(3-chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-d)pyrimidine

12. N4-(3-chloro-4-fluorophenyl)-n6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine

13. Ncgc00161422-01

14. Unii-0mu316797d

15. Falnidamol [who-dd]

16. Bibx-1382bs

17. Bibx-1382bx

18. Schembl158563

19. Gtpl7646

20. Dtxsid0048399

21. Chebi:93243

22. Ex-a570

23. Bcp09515

24. Zinc1494443

25. Bdbm50375639

26. Mfcd09838900

27. Cs-0691

28. Db12966

29. Ncgc00161422-03

30. Ncgc00161422-09

31. Ac-30284

32. As-16894

33. Hy-10322

34. Db-014915

35. Ft-0700465

36. Brd-k70914287-300-01-0

37. Q27077274

38. 8-(3-chloro-4-fluorophenylamino)-2-(1-methylpiperidin-4-ylamino)pyrimido[5,4-d]pyrimidine

39. N-(3-chloro-4-fluorophenyl)-n'-(1-methylpiperidin-4-yl)pyrimido[4,5-e]pyrimidine-4,6-diamine

40. N4-(3-chloro-4-fluoro-phenyl)-n6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine

41. Pyrimido(5,4-d)pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-n2-(1-methyl-4-piperidinyl)-

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 387.8 g/mol
Molecular Formula C18H19ClFN7
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass387.1374495 g/mol
Monoisotopic Mass387.1374495 g/mol
Topological Polar Surface Area78.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Falnidamol Manufacturers

A Falnidamol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Falnidamol, including repackagers and relabelers. The FDA regulates Falnidamol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Falnidamol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Falnidamol Suppliers

A Falnidamol supplier is an individual or a company that provides Falnidamol active pharmaceutical ingredient (API) or Falnidamol finished formulations upon request. The Falnidamol suppliers may include Falnidamol API manufacturers, exporters, distributors and traders.

Falnidamol GMP

Falnidamol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Falnidamol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Falnidamol GMP manufacturer or Falnidamol GMP API supplier for your needs.

Falnidamol CoA

A Falnidamol CoA (Certificate of Analysis) is a formal document that attests to Falnidamol's compliance with Falnidamol specifications and serves as a tool for batch-level quality control.

Falnidamol CoA mostly includes findings from lab analyses of a specific batch. For each Falnidamol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Falnidamol may be tested according to a variety of international standards, such as European Pharmacopoeia (Falnidamol EP), Falnidamol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Falnidamol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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