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Chemistry

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Also known as: Farudodstat, 1035688-66-4, Aslan-003, I58we41h6x, 2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid, 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-3-pyridinecarboxylic acid
Molecular Formula
C19H14F2N2O3
Molecular Weight
356.3  g/mol
InChI Key
OMPATGZMNFWVOH-UHFFFAOYSA-N
FDA UNII
I58WE41H6X

Farudodstat
Farudodstat is an orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential antineoplastic activity. Upon administration, farudodstat specifically targets, binds to and prevents the activation of DHODH, thereby preventing the fourth enzymatic step in de novo pyrimidine synthesis. This prevents uridine monophosphate (UMP) formation, DNA synthesis, cell division and cellular proliferation, causes reactive oxygen species (ROS) formation, enables differentiation and induces apoptosis in susceptible tumor cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO) to orotate in the endogenous synthesis of UMP.
1 2D Structure

Farudodstat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic acid
2.1.2 InChI
InChI=1S/C19H14F2N2O3/c1-26-13-5-2-4-11(8-13)12-9-15(20)17(16(21)10-12)23-18-14(19(24)25)6-3-7-22-18/h2-10H,1H3,(H,22,23)(H,24,25)
2.1.3 InChI Key
OMPATGZMNFWVOH-UHFFFAOYSA-N
2.1.4 Canonical SMILES
COC1=CC=CC(=C1)C2=CC(=C(C(=C2)F)NC3=C(C=CC=N3)C(=O)O)F
2.2 Other Identifiers
2.2.1 UNII
I58WE41H6X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-((3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino)nicotinic Acid

2.3.2 Depositor-Supplied Synonyms

1. Farudodstat

2. 1035688-66-4

3. Aslan-003

4. I58we41h6x

5. 2-[2,6-difluoro-4-(3-methoxyphenyl)anilino]pyridine-3-carboxylic Acid

6. 2-[(3,5-difluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]-3-pyridinecarboxylic Acid

7. 2-(3,5-difluoro-3'-methoxybiphenyl-4-ylamino)nicotinic Acid

8. 2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinic Acid

9. 2-((3,5-difluoro-3'-methoxy(1,1'-biphenyl)-4-yl)amino)-3-pyridinecarboxylic Acid

10. 3-pyridinecarboxylic Acid, 2-((3,5-difluoro-3'-methoxy(1,1'-biphenyl)-4-yl)amino)-

11. Farudodstat [inn]

12. Asaln003

13. Unii-i58we41h6x

14. Schembl355081

15. Chembl2263632

16. Gtpl12106

17. Bdbm119812

18. 2-[(3,5-difluoro-3'-methoxy-4-biphenylyl)amino]nicotinic Acid

19. Ex-a4313

20. Las186323

21. Mfcd32215342

22. S9721

23. Ac-36562

24. Sy270741

25. Hy-129239

26. Cs-0104387

27. Us8691852, 20

28. 2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)nicotinicacid

29. 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic Acid

30. 2-[(3,5-difluoro-3 Inverted Exclamation Mark -methoxy-4-biphenylyl)amino]nicotinic Acid

2.4 Create Date
2008-10-27
3 Chemical and Physical Properties
Molecular Weight 356.3 g/mol
Molecular Formula C19H14F2N2O3
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass356.09724864 g/mol
Monoisotopic Mass356.09724864 g/mol
Topological Polar Surface Area71.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity470
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Farudodstat Manufacturers

A Farudodstat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Farudodstat, including repackagers and relabelers. The FDA regulates Farudodstat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Farudodstat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Farudodstat Suppliers

A Farudodstat supplier is an individual or a company that provides Farudodstat active pharmaceutical ingredient (API) or Farudodstat finished formulations upon request. The Farudodstat suppliers may include Farudodstat API manufacturers, exporters, distributors and traders.

Farudodstat GMP

Farudodstat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Farudodstat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Farudodstat GMP manufacturer or Farudodstat GMP API supplier for your needs.

Farudodstat CoA

A Farudodstat CoA (Certificate of Analysis) is a formal document that attests to Farudodstat's compliance with Farudodstat specifications and serves as a tool for batch-level quality control.

Farudodstat CoA mostly includes findings from lab analyses of a specific batch. For each Farudodstat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Farudodstat may be tested according to a variety of international standards, such as European Pharmacopoeia (Farudodstat EP), Farudodstat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Farudodstat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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