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Chemistry

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Also known as: 23062-06-8, Fasedienol, Aloradine, 4,16-androstadien-3-beta-ol, 4,16-androstadien-3beta-ol, Dtw1nj7ijh
Molecular Formula
C19H28O
Molecular Weight
272.4  g/mol
InChI Key
NYVFCEPOUVGTNP-DYKIIFRCSA-N
FDA UNII
DTW1NJ7IJH

Fasedienol
PH94B is being developed by Pherin Pharmaceuticals, Inc. for the treatment of social phobias (generalized anxiety disorder). It is a member of a new family of pharmaceutical compounds called vomeropherins.
1 2D Structure

Fasedienol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3S,8S,9S,10R,13R,14S)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
2.1.2 InChI
InChI=1S/C19H28O/c1-18-9-3-4-16(18)15-6-5-13-12-14(20)7-11-19(13,2)17(15)8-10-18/h3,9,12,14-17,20H,4-8,10-11H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
2.1.3 InChI Key
NYVFCEPOUVGTNP-DYKIIFRCSA-N
2.1.4 Canonical SMILES
CC12CCC3C(C1CC=C2)CCC4=CC(CCC34C)O
2.1.5 Isomeric SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC=C2)CCC4=C[C@H](CC[C@]34C)O
2.2 Other Identifiers
2.2.1 UNII
DTW1NJ7IJH
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 23062-06-8

2. Fasedienol

3. Aloradine

4. 4,16-androstadien-3-beta-ol

5. 4,16-androstadien-3beta-ol

6. Dtw1nj7ijh

7. (3s,8s,9s,10r,13r,14s)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol

8. Androsta-4,16-dien-3-ol, (3b)-

9. (3s,8s,9s,10r,13r,14s)-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15-decahydro-1h-cyclopenta[a]phenanthren-3-ol

10. (3as,3bs,7s,9ar,9bs,11ar)-9a,11a-dimethyl-3h,3ah,3bh,4h,5h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-7-ol

11. 4-androstadienol

12. Unii-dtw1nj7ijh

13. Fasedienol [inn]

14. Aloradine [who-dd]

15. Ph94b

16. Androsta-4,16-dien-3beta-ol

17. Schembl4075431

18. Androsta-4,16-diene-3beta-ol

19. Dtxsid901032322

20. (3b)-androsta-4,16-dien-3-ol

21. Yaa06206

22. Mfcd00271236

23. Zinc34031047

24. Akos028109412

25. As-60043

26. Androsta-4,16-dien-3-ol, (3.beta.)-

27. Hy-145567

28. Cs-0376082

29. Q20707597

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 272.4 g/mol
Molecular Formula C19H28O
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass272.214015512 g/mol
Monoisotopic Mass272.214015512 g/mol
Topological Polar Surface Area20.2 Ų
Heavy Atom Count20
Formal Charge0
Complexity476
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Intended for the acute treatment of social phobia.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Vomeropherin compounds are directly delivered to the nasal passages using either a metered nasal spray or a metered nasal aerosol. By virtue of the chemoreceptors location in the nasal passages, direct connections to the hypothalamus and limbic system and the ability of our compounds to act locally, vomeropherins do not need to achieve systemic absorption and distribution. This provides a significant therapeutic advantage over traditional therapeutics targeted at the hypothalamus and limbic system that require access to systemic circulation and must cross the blood-brain barrier followed by uptake into the brain to exert effects.


5.2 Absorption, Distribution and Excretion

Absorption

Absorbed following nasal administration.


5.3 Mechanism of Action

There is little information available on the mechanism of action of vomeropherins. These compounds are delivered to the nasal passages and bind to chemoreceptors that in turn affect the hypothalamus and the limbic system.


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ABOUT THIS PAGE

Fasedienol Manufacturers

A Fasedienol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fasedienol, including repackagers and relabelers. The FDA regulates Fasedienol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fasedienol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Fasedienol Suppliers

A Fasedienol supplier is an individual or a company that provides Fasedienol active pharmaceutical ingredient (API) or Fasedienol finished formulations upon request. The Fasedienol suppliers may include Fasedienol API manufacturers, exporters, distributors and traders.

Fasedienol GMP

Fasedienol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fasedienol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fasedienol GMP manufacturer or Fasedienol GMP API supplier for your needs.

Fasedienol CoA

A Fasedienol CoA (Certificate of Analysis) is a formal document that attests to Fasedienol's compliance with Fasedienol specifications and serves as a tool for batch-level quality control.

Fasedienol CoA mostly includes findings from lab analyses of a specific batch. For each Fasedienol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fasedienol may be tested according to a variety of international standards, such as European Pharmacopoeia (Fasedienol EP), Fasedienol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fasedienol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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