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Synopsis

ACTIVE PHARMA INGREDIENTS

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REF. STANDARDS OR IMPURITIES

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Chemistry

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Also known as: 105628-07-7, Fasudil hcl, Eril, Fasudil (ha-1077) hcl, 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline hydrochloride, Fasudil (hydrochloride)
Molecular Formula
C14H18ClN3O2S
Molecular Weight
327.8  g/mol
InChI Key
LFVPBERIVUNMGV-UHFFFAOYSA-N
FDA UNII
SQ04N8S7BR

Fasudil
1 2D Structure

Fasudil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
2.1.2 InChI
InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
2.1.3 InChI Key
LFVPBERIVUNMGV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
2.2 Other Identifiers
2.2.1 UNII
SQ04N8S7BR
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(5-isoquinolinesulfonyl)homopiperazine

2. At 877

3. At-877

4. At877

5. Fasudil

6. Fasudil Mesylate

7. Ha 1077

8. Ha-1077

2.3.2 Depositor-Supplied Synonyms

1. 105628-07-7

2. Fasudil Hcl

3. Eril

4. Fasudil (ha-1077) Hcl

5. 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline Hydrochloride

6. Fasudil (hydrochloride)

7. At-877

8. Fasudil Monohydrochloride

9. Ha-1077

10. Sq04n8s7br

11. Fasudil, Monohydrochloride Salt

12. 105628-07-7 (hcl)

13. 1h-1,4-diazepine, Hexahydro-1-(5-isoquinolinylsulfonyl)-, Monohydrochloride

14. Dsstox_cid_25615

15. Dsstox_rid_81004

16. Dsstox_gsid_45615

17. Fasudil Hydrochloride (jan)

18. 1-(5-isoquinolinesulfonyl)homopiperazine Hydrochloride

19. Chembl541388

20. Ha-1077 Hydrochloride

21. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride

22. 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline Xhydrochloride

23. At 877 Hydrochloride

24. Fasudil Hydrochloride [jan]

25. Ha 1077 Hydrochloride

26. Ha-1077 Dihydrochloride

27. 133337-43-6

28. Cas-105628-07-7

29. Ncgc00018100-04

30. Unii-sq04n8s7br

31. C14h17n3o2s.hcl

32. Fasdil

33. Fasudil-ha

34. Calciumcyclamate

35. Fasudil, Monohcl

36. Hexahydro-1-(5-isoquinolinylsulfonyl)-1h-1,4-diazepine Monohydrochloride

37. Regid_for_cid_4917

38. Bmk1-e2

39. Mls000069344

40. Schembl317082

41. Fasudil Hcl (ha-1077)

42. Fasudil Hcl - Ha-1077

43. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline Hydrochloride

44. Dtxsid1045615

45. Regid_for_cid_163751

46. Chebi:31593

47. Fasudil Hydrochloride [mi]

48. Act06296

49. Bcp26351

50. Tox21_110824

51. Mfcd00943198

52. S1573

53. Fasudil Hydrochloride [mart.]

54. Akos015897321

55. Fasudil Hydrochloride [who-dd]

56. Tox21_110824_1

57. Ac-4515

58. Ccg-267783

59. Cs-0225

60. Ncgc00018100-08

61. Ncgc00180915-01

62. 111ge018

63. As-17751

64. Hy-10341

65. Smr000058993

66. Am20050635

67. F0839

68. Ft-0631034

69. Sw218155-2

70. A21128

71. D01840

72. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline Hcl

73. Sr-01000000005

74. 1-(5isoquinolinesulfonyl)homopiperazine Hydrochloride

75. Sr-01000000005-2

76. Q27289337

77. 1-(5-isoquinolinesulfonyl)homopiperazine Dihydrochloride

78. 5-(1-homopiperazinyl)sulfonylisoquinoline Hydrochloride

79. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydron;chloride

80. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline Hydrochloride (1:1)

81. 5-(hexahydro-1h-1,4-diazepine-1-ylsulfonyl)isoquinoline Hydrochloride

82. Isoquinoline, 5-((hexahydro-1h-1,4-diazepin-1-yl)sulfonyl)-, Hydrochloride (1:1)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 327.8 g/mol
Molecular Formula C14H18ClN3O2S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass327.0808257 g/mol
Monoisotopic Mass327.0808257 g/mol
Topological Polar Surface Area70.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity421
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Treatment of non-traumatic subarachnoid haemorrhage


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)


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ABOUT THIS PAGE

Fasudil Manufacturers

A Fasudil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fasudil, including repackagers and relabelers. The FDA regulates Fasudil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fasudil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Fasudil manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Fasudil Suppliers

A Fasudil supplier is an individual or a company that provides Fasudil active pharmaceutical ingredient (API) or Fasudil finished formulations upon request. The Fasudil suppliers may include Fasudil API manufacturers, exporters, distributors and traders.

click here to find a list of Fasudil suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Fasudil USDMF

A Fasudil DMF (Drug Master File) is a document detailing the whole manufacturing process of Fasudil active pharmaceutical ingredient (API) in detail. Different forms of Fasudil DMFs exist exist since differing nations have different regulations, such as Fasudil USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Fasudil DMF submitted to regulatory agencies in the US is known as a USDMF. Fasudil USDMF includes data on Fasudil's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Fasudil USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Fasudil suppliers with USDMF on PharmaCompass.

Fasudil GMP

Fasudil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fasudil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fasudil GMP manufacturer or Fasudil GMP API supplier for your needs.

Fasudil CoA

A Fasudil CoA (Certificate of Analysis) is a formal document that attests to Fasudil's compliance with Fasudil specifications and serves as a tool for batch-level quality control.

Fasudil CoA mostly includes findings from lab analyses of a specific batch. For each Fasudil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fasudil may be tested according to a variety of international standards, such as European Pharmacopoeia (Fasudil EP), Fasudil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fasudil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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