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Fenoldopam (mesylate)

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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 4 USDMF, 1 NDC API, $ API Reference Price

4 API Suppliers
4 USDMF
1 NDC API
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

6 FDF Dossiers, 5 FDA Orange Book, 1 Europe

6 FDF Dossiers
5 FDA Orange Book
1 Europe

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 2 Actylis, 1 BASF, 1 Finar, 1 Valens Pharmachem

relatedExcipients
1 Nanjing Well Pharmaceutical
2 Actylis
1 BASF
1 Finar
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

3 Topical, 2 Film Formers & Plasticizers, 2 Solubilizers, 2 Controlled & Modified Release, 1 Parenteral, 1 Emulsifying Agents, 1 Thickeners and Stabilizers

excipientsByApplications
3 Topical
2 Film Formers & Plasticizers
2 Solubilizers
2 Controlled & Modified Release
1 Parenteral
1 Emulsifying Agents
1 Thickeners and Stabilizers

GLOBAL SALES INFORMATION

1 Finished Drug Prices

globalSalesInformation
1 Finished Drug Prices

REF. STANDARDS & IMPURITIES

2 USP , 3 Others

otherSolutions
2 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

12EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 67227-57-0, Corlopam, Fenoldopam methanesulfonate, Fenoldopam (mesylate), Fenoldopam mesilate, Corlopam mesylate

Molecular Formula

C₁₇H₂₀ClNO₆S

Molecular Weight

401.9 g/mol

InChI Key

CVKUMNRCIJMVAR-UHFFFAOYSA-N

FDA UNII

HA3R0MY016

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.

1 2D Structure

Fenoldopam Mesylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid

2.1.2 InChI

InChI=1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)

2.1.3 InChI Key

CVKUMNRCIJMVAR-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CS(=O)(=O)O.C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O

2.2 Other Identifiers

2.2.1 UNII

HA3R0MY016

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Corlopam

2. Fenoldopam

3. Fenoldopam Hydrobromide

4. Hydrobromide, Fenoldopam

5. Sk And F 82526

6. Sk And F 82526j

7. Sk And F-82526

8. Sk And F-82526j

9. Sk And F82526

10. Sk And F82526j

11. Skf 82526

12. Skf 82526j

13. Skf-82526

14. Skf-82526j

15. Skf82526

16. Skf82526j

2.3.2 Depositor-Supplied Synonyms

1. 67227-57-0

2. Corlopam

3. Fenoldopam Methanesulfonate

4. Fenoldopam (mesylate)

5. Fenoldopam Mesilate

6. Corlopam Mesylate

7. Sk&f 82526-j

8. Fendolopam Mesylate

9. Nsc-759860

10. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;methanesulfonic Acid

11. Ha3r0my016

12. Sk&f-82526j

13. 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Methanesulfonate (salt)

14. Fenoldopam Methanesulfonate;skf-82526 Mesylate

15. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol,methanesulfonic Acid

16. 1h-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, Methanesulfonate (salt)

17. Mls001401388

18. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-benzo[d]azepine-7,8-diol Methanesulfonate

19. Einecs 266-612-7

20. Fenoldopam Mesylate [usan]

21. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol; Methanesulfonic Acid

22. Fenoldopam Monomethanesulfonate

23. Sk-82526-j

24. Skf 82526-j

25. Smr000469190

26. Unii-ha3r0my016

27. Skf 82526 (mesylate)

28. Fenoldopam Mesylate [usan:usp]

29. Corlopam (tn)

30. Skf-82526 Mesylate

31. Fenoldopam Mesylate (usp)

32. Chembl1026

33. Schembl41213

34. 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1h-3-benzazepinium Methanesulphonate

35. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol; Methanesulfonic Acid

36. Chebi:5003

37. Hy-b0735a

38. Dtxsid00904650

39. Hms2051p09

40. Hms2230j03

41. Hms3264b10

42. Hms3371l12

43. Hms3393p09

44. Hms3885l10

45. Pharmakon1600-01505539

46. Fenoldopam Mesylate [vandf]

47. Fenoldopam Mesilate [mart.]

48. Fenoldopam Mesilate [who-dd]

49. Fenoldopam Mesylate [usp-rs]

50. Nsc759860

51. S4618

52. Sk&f-82526-j

53. Akos030254549

54. Fenoldopam Mesylate, >=98% (hplc)

55. Ccg-100942

56. Ccg-213480

57. M27f569

58. Nc00192

59. Nsc 759860

60. Fenoldopam Methanesulfonate [mi]

61. Fenoldopam Mesylate [orange Book]

62. Ac-32753

63. As-57125

64. Fenoldopam Mesylate [usp Monograph]

65. Db-054999

66. Ft-0626401

67. C76117

68. D00613

69. A835665

70. W-104725

71. Q27279818

72. Z2210694608

73. Fenoldopam Mesylate, United States Pharmacopeia (usp) Reference Standard

74. 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Mesylate

75. 1h-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, Methanesulphonate (salt)

76. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;methanesulfonic Acid

77. 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Methanesulphonate (salt)

78. 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine Methane Sulfonate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₀ClNO₆S
Molecular Weight	401.9 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	401.0699862 g/mol
Monoisotopic Mass	401.0699862 g/mol
Topological Polar Surface Area	136 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	441
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Corlopam
PubMed Health	Fenoldopam (Injection)
Drug Classes	Antihypertensive
Drug Label	Corlopam (Fenoldopam Mesylate Injection, USP) is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-...
Active Ingredient	Fenoldopam mesylate
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml
Market Status	Prescription
Company	Hospira

2 of 4
Drug Name	Fenoldopam mesylate
Drug Label	Fenoldopam Mesylate Injection, USP is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-7,8-diol me...
Active Ingredient	Fenoldopam mesylate
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml
Market Status	Prescription
Company	Eurohlth Intl; Sandoz

3 of 4
Drug Name	Corlopam
PubMed Health	Fenoldopam (Injection)
Drug Classes	Antihypertensive
Drug Label	Corlopam (Fenoldopam Mesylate Injection, USP) is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-...
Active Ingredient	Fenoldopam mesylate
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml
Market Status	Prescription
Company	Hospira

4 of 4
Drug Name	Fenoldopam mesylate
Drug Label	Fenoldopam Mesylate Injection, USP is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-7,8-diol me...
Active Ingredient	Fenoldopam mesylate
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml
Market Status	Prescription
Company	Eurohlth Intl; Sandoz

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Dopaminergic Agonist [EPC]; Dopamine Agonists [MoA]

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