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Chemistry

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Also known as: 67227-57-0, Corlopam, Fenoldopam methanesulfonate, Fenoldopam (mesylate), Fenoldopam mesilate, Corlopam mesylate
Molecular Formula
C17H20ClNO6S
Molecular Weight
401.9  g/mol
InChI Key
CVKUMNRCIJMVAR-UHFFFAOYSA-N
FDA UNII
HA3R0MY016

Fenoldopam Mesylate
A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
1 2D Structure

Fenoldopam Mesylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid
2.1.2 InChI
InChI=1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
2.1.3 InChI Key
CVKUMNRCIJMVAR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)O.C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O
2.2 Other Identifiers
2.2.1 UNII
HA3R0MY016
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Corlopam

2. Fenoldopam

3. Fenoldopam Hydrobromide

4. Hydrobromide, Fenoldopam

5. Sk And F 82526

6. Sk And F 82526j

7. Sk And F-82526

8. Sk And F-82526j

9. Sk And F82526

10. Sk And F82526j

11. Skf 82526

12. Skf 82526j

13. Skf-82526

14. Skf-82526j

15. Skf82526

16. Skf82526j

2.3.2 Depositor-Supplied Synonyms

1. 67227-57-0

2. Corlopam

3. Fenoldopam Methanesulfonate

4. Fenoldopam (mesylate)

5. Fenoldopam Mesilate

6. Corlopam Mesylate

7. Sk&f 82526-j

8. Fendolopam Mesylate

9. Nsc-759860

10. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;methanesulfonic Acid

11. Ha3r0my016

12. Sk&f-82526j

13. 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Methanesulfonate (salt)

14. Fenoldopam Methanesulfonate;skf-82526 Mesylate

15. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol,methanesulfonic Acid

16. 1h-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, Methanesulfonate (salt)

17. Mls001401388

18. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-benzo[d]azepine-7,8-diol Methanesulfonate

19. Einecs 266-612-7

20. Fenoldopam Mesylate [usan]

21. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol; Methanesulfonic Acid

22. Fenoldopam Monomethanesulfonate

23. Sk-82526-j

24. Skf 82526-j

25. Smr000469190

26. Unii-ha3r0my016

27. Skf 82526 (mesylate)

28. Fenoldopam Mesylate [usan:usp]

29. Corlopam (tn)

30. Skf-82526 Mesylate

31. Fenoldopam Mesylate (usp)

32. Chembl1026

33. Schembl41213

34. 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1h-3-benzazepinium Methanesulphonate

35. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol; Methanesulfonic Acid

36. Chebi:5003

37. Hy-b0735a

38. Dtxsid00904650

39. Hms2051p09

40. Hms2230j03

41. Hms3264b10

42. Hms3371l12

43. Hms3393p09

44. Hms3885l10

45. Pharmakon1600-01505539

46. Fenoldopam Mesylate [vandf]

47. Fenoldopam Mesilate [mart.]

48. Fenoldopam Mesilate [who-dd]

49. Fenoldopam Mesylate [usp-rs]

50. Nsc759860

51. S4618

52. Sk&f-82526-j

53. Akos030254549

54. Fenoldopam Mesylate, >=98% (hplc)

55. Ccg-100942

56. Ccg-213480

57. M27f569

58. Nc00192

59. Nsc 759860

60. Fenoldopam Methanesulfonate [mi]

61. Fenoldopam Mesylate [orange Book]

62. Ac-32753

63. As-57125

64. Fenoldopam Mesylate [usp Monograph]

65. Db-054999

66. Ft-0626401

67. C76117

68. D00613

69. A835665

70. W-104725

71. Q27279818

72. Z2210694608

73. Fenoldopam Mesylate, United States Pharmacopeia (usp) Reference Standard

74. 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Mesylate

75. 1h-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, Methanesulphonate (salt)

76. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;methanesulfonic Acid

77. 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Methanesulphonate (salt)

78. 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine Methane Sulfonate

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 401.9 g/mol
Molecular Formula C17H20ClNO6S
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass401.0699862 g/mol
Monoisotopic Mass401.0699862 g/mol
Topological Polar Surface Area136 Ų
Heavy Atom Count26
Formal Charge0
Complexity441
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameCorlopam
PubMed HealthFenoldopam (Injection)
Drug ClassesAntihypertensive
Drug LabelCorlopam (Fenoldopam Mesylate Injection, USP) is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-...
Active IngredientFenoldopam mesylate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyHospira

2 of 4  
Drug NameFenoldopam mesylate
Drug LabelFenoldopam Mesylate Injection, USP is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-7,8-diol me...
Active IngredientFenoldopam mesylate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyEurohlth Intl; Sandoz

3 of 4  
Drug NameCorlopam
PubMed HealthFenoldopam (Injection)
Drug ClassesAntihypertensive
Drug LabelCorlopam (Fenoldopam Mesylate Injection, USP) is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-...
Active IngredientFenoldopam mesylate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyHospira

4 of 4  
Drug NameFenoldopam mesylate
Drug LabelFenoldopam Mesylate Injection, USP is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-7,8-diol me...
Active IngredientFenoldopam mesylate
Dosage FormInjectable
RouteInjection
Strengtheq 10mg base/ml
Market StatusPrescription
CompanyEurohlth Intl; Sandoz

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Dopaminergic Agonist [EPC]; Dopamine Agonists [MoA]

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