Synopsis
Synopsis
0
USDMF
0
CEP/COS
0
JDMF
0
EU WC
0
KDMF
0
NDC API
0
VMF
0
FDF
0
FDF Dossiers
0
FDA Orange Book
0
Europe
0
Canada
0
Australia
0
South Africa
0
Listed Dossiers
DRUG PRODUCT COMPOSITIONS
0
EDQM
0
USP
0
JP
0
Others
0
US Patents
0
US Exclusivities
0
Health Canada Patents
0
Data Compilation #PharmaFlow
0
Stock Recap #PipelineProspector
0
Weekly News Recap #Phispers
0
News #PharmaBuzz
US Medicaid
NA
Annual Reports
NA
Finished Drug Prices
NA
1. Fenproporex Monohydrochloride
2. Fenproporex Monohydrochloride, (+-)-isomer
3. Fenproporex, (+-)-isomer
4. Ifa Diety
1. Desobesi
2. 16397-28-7
3. Femproporex
4. Fenorex
5. 3-(1-phenylpropan-2-ylamino)propanenitrile
6. 3-[(1-methyl-2-phenylethyl)amino]propiononitrile
7. W0194s5foa
8. Fenproporex (inn)
9. J268.797f
10. Fenproporex [inn]
11. Fenproporex [inn:dcf]
12. Femproporex [inn-spanish]
13. Fenproporexum [inn-latin]
14. 3-((1-methyl-2-phenylethyl)amino)propiononitrile
15. Einecs 239-772-0
16. Unii-w0194s5foa
17. Dea No. 1575
18. Einecs 240-444-4
19. Fenorex (tn)
20. Fenproporex [mi]
21. N-2-cyanoethylamphetamine
22. N-(2-cyanoethyl)amphetamine
23. Fenproporex [who-dd]
24. 15686-61-0
25. Schembl157687
26. Chembl2105566
27. Dtxsid0043921
28. Chebi:134837
29. (.+/-.)-n-2-cyanoethylamphetamine
30. Db01550
31. D07947
32. 3-[(1-methyl-2-phenylethyl)amino]propanenitrile #
33. Q5443577
34. (.+/-.)-3-[(.alpha.-methylphenethyl)amino]propionitrile
35. (+/-)-3-((.alpha.-methylphenethyl)amino)propionitrile
36. Propanenitrile, 3-[(1-methyl-2-phenylethyl)amino]-, (.+/-.)-
37. Propionitrile, 3-((.alpha.-methylphenethyl)amino)-, (.+/-.)-
| Molecular Weight | 188.27 g/mol |
|---|---|
| Molecular Formula | C12H16N2 |
| XLogP3 | 1.9 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 5 |
| Exact Mass | 188.131348519 g/mol |
| Monoisotopic Mass | 188.131348519 g/mol |
| Topological Polar Surface Area | 35.8 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 186 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Fenproporex is used as an appetite suppressant, and anti-obesity agent [2]; however, due to substance abuse potential, it is an illicit substance in many countries. In some countries, such as Brazil, it is still prescribed -- often in the form of diet pills (ie. Brazilian Diet Pills) which combine amphetamines, benzodiazepines, antidepressants, diuretics and laxatives. In the United States the sale of such diet pills has been banned due to concerns over side effects, and the risk of potentially fatal overdose. However, internet sales and illicit markets has lead to international availability. It has been found by primary care physicians that Brazilian immigrant women utilized imported diet pills at particularly high rates, and sometimes suffered from side effects requiring hospitalization or experienced a loss of employment. [3]
Fenproporex was first claimed to not exert a stimulant effect on the body, however research into its metabolism has shown that it is converted into a considerable amount of amphetamine in the body, which leads to stimulant effects. [9]
Route of Elimination
Renally eliminated in the urine, mainly as amphetamine, but 5-9% as unchanged drug.
Clearance
The amphetamine metabolite can be detected for several days after the administration of forproporex (up to 119h, in one study). [2]
A large portion, 60-80%, of fenproporex is rapidly converted into amphetamine. Besides amphetamine, and unchanged fenproporex, 14 other metabolites were identified from urine samples. Two interacting metabolic pathways are believed to exist. The major pathway is believed to involve ring-degradation by aromatic hydroxylation, methylation, and side chain degradation by N-dealkyation to form amphetamine. The minor pathway involves the beta-hydroxylation of amphetamine to form norephedrine. [6]
Fenproporex is an amphetamine based anorectic which is rapidly metabolized into amphetamine in the body. Both acute and chronic fenproporex administration has been shown to increase brain energy metabolism in young rats, by increasing the activity of citrate synthase, malate dehydrogenase, succinate dehydrogenase, creatine kinase and complexes I,II, III, and IV. [8] Amphetamine based drugs are also known to reduce food intake. They are addictive substances due to their ability to increase dopamine release, however their anorectic effects are believed to be a result of noradrenergic neurotransmission. Activation of the alpha 1 and beta 2 adrenoceptors has been shown to decrease food intake, and drugs which release norepinephrine or block norepinephrine reuptake can activate these receptors. [3] The alpha 1 and beta 2 adrenoceptors are noted to be clinically important receptors in weight regulation. [3]
Market Place
ABOUT THIS PAGE
A Fenproporex manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fenproporex, including repackagers and relabelers. The FDA regulates Fenproporex manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fenproporex API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of Fenproporex manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A Fenproporex supplier is an individual or a company that provides Fenproporex active pharmaceutical ingredient (API) or Fenproporex finished formulations upon request. The Fenproporex suppliers may include Fenproporex API manufacturers, exporters, distributors and traders.
click here to find a list of Fenproporex suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
Fenproporex Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Fenproporex GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fenproporex GMP manufacturer or Fenproporex GMP API supplier for your needs.
A Fenproporex CoA (Certificate of Analysis) is a formal document that attests to Fenproporex's compliance with Fenproporex specifications and serves as a tool for batch-level quality control.
Fenproporex CoA mostly includes findings from lab analyses of a specific batch. For each Fenproporex CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Fenproporex may be tested according to a variety of international standards, such as European Pharmacopoeia (Fenproporex EP), Fenproporex JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fenproporex USP).
LOOKING FOR A SUPPLIER?
