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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 20287-37-0, Idrolone, M.g. 13054, Lj1u13r8ik, 7-chloro-4-oxo-2-phenyl-2,3-dihydro-1h-quinazoline-6-sulfonamide, Mg-13054

Molecular Formula

C₁₄H₁₂ClN₃O₃S

Molecular Weight

337.8 g/mol

InChI Key

DBDTUXMDTSTPQZ-UHFFFAOYSA-N

FDA UNII

LJ1U13R8IK

Fenquizone is a quinazolinone sulphonamide-based diuretic, structurally related to metolazone, with thiazide-like activity. As a thiazide-like diuretic, fenquizone acts by blocking reabsorption of sodium in the proximal tubule and the ascending branch of the loop of Henle. This causes an increase in diuresis with the elimination of chloride and sodium.

1 2D Structure

Fenquizone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-chloro-4-oxo-2-phenyl-2,3-dihydro-1H-quinazoline-6-sulfonamide

2.1.2 InChI

InChI=1S/C14H12ClN3O3S/c15-10-7-11-9(6-12(10)22(16,20)21)14(19)18-13(17-11)8-4-2-1-3-5-8/h1-7,13,17H,(H,18,19)(H2,16,20,21)

2.1.3 InChI Key

DBDTUXMDTSTPQZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C(C=C1)C2NC3=CC(=C(C=C3C(=O)N2)S(=O)(=O)N)Cl

2.2 Other Identifiers

2.2.1 UNII

LJ1U13R8IK

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Idrolone

2. Mg 13054

2.3.2 Depositor-Supplied Synonyms

1. 20287-37-0

2. Idrolone

3. M.g. 13054

4. Lj1u13r8ik

5. 7-chloro-4-oxo-2-phenyl-2,3-dihydro-1h-quinazoline-6-sulfonamide

6. Mg-13054

7. Fenchizone

8. Fenquizona

9. Fenquizonum

10. Fenchizone [dcit]

11. Fenquizone [usan:inn]

12. Fenquizonum [inn-latin]

13. Fenquizona [inn-spanish]

14. Unii-lj1u13r8ik

15. Einecs 243-689-5

16. Fenquizone [mi]

17. Fenquizone [inn]

18. Fenquizone (usan/inn)

19. Fenquizone [usan]

20. Fenquizone [mart.]

21. Fenquizone [who-dd]

22. Schembl309550

23. Chembl2106186

24. Dtxsid10864933

25. Chebi:135435

26. Ex-a6134

27. (+-)-7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-6-quinazolinesulfonamide

28. Db13708

29. Hy-126179

30. Cs-0092520

31. D04161

32. Q3742488

33. 2-phenyl-7-chloro-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone

34. 2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolidone

35. 7-chloro-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

36. (+/-)-7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-6-quinazolinesulfonamide

37. 6-quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-, (+-)-

38. 6-quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-, (+/-)-

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₂ClN₃O₃S
Molecular Weight	337.8 g/mol
XLogP3	1.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	337.0287901 g/mol
Monoisotopic Mass	337.0287901 g/mol
Topological Polar Surface Area	110 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	530
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1