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Chemistry

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Also known as: 10028-22-5, Iron(iii) sulfate, Iron persulfate, Ferric persulfate, Iron sesquisulfate, Iron tersulfate
Molecular Formula
Fe2O12S3
Molecular Weight
399.9  g/mol
InChI Key
RUTXIHLAWFEWGM-UHFFFAOYSA-H
FDA UNII
4YKQ1X5E5Y

Ferric Sulfate
1 2D Structure

Ferric Sulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
iron(3+);trisulfate
2.1.2 InChI
InChI=1S/2Fe.3H2O4S/c;;3*1-5(2,3)4/h;;3*(H2,1,2,3,4)/q2*+3;;;/p-6
2.1.3 InChI Key
RUTXIHLAWFEWGM-UHFFFAOYSA-H
2.1.4 Canonical SMILES
[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Fe+3].[Fe+3]
2.2 Other Identifiers
2.2.1 UNII
4YKQ1X5E5Y
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ferric Sulfate Heptahydrate

2. Ferric Sulfate Hexahydrate

3. Ferric Sulfate Hydrate

4. Ferric Sulfate Monohydrate

5. Ferric Sulfate Nonahydrate

6. Ferric Sulfate Tetrahydrate

7. Ferric Sulfate Trihydrate

8. Ferric Sulfate, Basic

9. Polyferric Sulfate

2.3.2 Depositor-Supplied Synonyms

1. 10028-22-5

2. Iron(iii) Sulfate

3. Iron Persulfate

4. Ferric Persulfate

5. Iron Sesquisulfate

6. Iron Tersulfate

7. Iron(3+) Sulfate

8. Diiron Tris(sulphate)

9. Diiron Trisulfate

10. Ferric Tersulfate

11. Ferric Sesquisulfate

12. Iron(3+);trisulfate

13. Iron Sulfate (fe2(so4)3)

14. 4ykq1x5e5y

15. Coquimbite Mineral

16. Iron Sulfate (2:3)

17. Ccris 7885

18. Iron(3+) Sulfate, (2:3)

19. Hsdb 6311

20. Einecs 233-072-9

21. Mfcd00011007

22. Unii-4ykq1x5e5y

23. Sulfuric Acid, Iron(3+) Salt

24. Iron-s-hydrate

25. Iron(iii)sulphate

26. Ferric Sulfate (usp)

27. Sulfuric Acid,iron Salt

28. Iron(iii) Sulfate(vi)

29. Diiron Trissulfate Hydrate

30. Polyferric Sulfate(spfs)

31. Diiron Trissulphate Hydrate

32. Ec 233-072-9

33. Iron(iii) Sulphate Hydrate

34. Ferric Sulfate [mi]

35. Ferric Sulfate [inci]

36. Ferric Sulfate Anhydrous

37. Dtxsid5029712

38. Ferric Sulfate [who-dd]

39. Chebi:53438

40. Iron(iii) Sulfate (fe2(so4)3)

41. Ferric Sulfate Hydrate 500gm

42. Akos015903761

43. Ft-0627289

44. D08922

45. Q409021

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 399.9 g/mol
Molecular Formula Fe2O12S3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count12
Rotatable Bond Count0
Exact Mass399.725060 g/mol
Monoisotopic Mass399.725060 g/mol
Topological Polar Surface Area266 Ų
Heavy Atom Count17
Formal Charge0
Complexity62.2
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count5
4 Drug and Medication Information
4.1 Therapeutic Uses

Seventy primary molar teeth, carious exposed, symptom free, without any sign of root resorption in children aged from 3 to 6 years (main age 4.3 yr) were treated with conventional pulpotomy procedures. Ferric sulfate 15.5% solution (applied for 15 second for 35 teeth) and formocresol solution (five minute procedure of Buckley's formula for next 35 teeth) have been used as pulpotomy agents. In both groups, pulp stumps were covered with zinc-oxide eugenol paste. Permanent restorations were stainless steel crowns. Clinical check up was every three-months and radiographic follow-up time was six and twenty months after treatment. Our results within this period revealed 100% clinical success rate in both groups. Radiographic success rate was in both groups 97.2%, while in 2.8% cases has shown internal root resorption.

PMID:11314410 Ibricevic H, al-Jame Q; J Clin Pediatr Dent 24 (4): 269-72 (2000)


The hemostatic efficacy, as well as the cardiovascular effects, of two hemostatic agents currently used during endodontic surgery was examined. The hemostatic agents used were epinephrine pellets (Racellet pellets) or 20% ferric sulfate (Viscostat). Patients were assigned to one of two experimental groups. Blood pressure and pulse rate were recorded pre- and postoperatively and at three additional times during the surgery (root-end resection, root-end preparation, and filling). The adequacy of hemostasis was rated by the surgical operator. Results indicated that there is no significant change in cardiovascular effects when using either of these hemostatic agents. Except in one case where ferric sulfate was the agent, both agents produced surgical hemostasis that allowed for a dry field for root-end filling.

PMID:12043873 Vickers FJ et al; J Endod 28 (4): 322-3 (2002)


5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Pharmacological Classes
Parenteral Iron Replacement [EPC]; Phosphate Binder [EPC]; Phosphate Chelating Activity [MoA]; Iron [CS]
5.2 Absorption, Distribution and Excretion

The bioavailability of ferrous and ferric iron following cecal infusion was compared by assessing the hemoglobin regeneration method in ileally fistulated anemic rats. Rats were fed an iron-deficient diet (8 mg Fe/kg diet) for 14 days after recovery from surgery. The anemic rats were then divided into three groups of 11 rats. Group 1 (control) was fed an iron-adequate diet (45 mg Fe/kg diet) and infused with NaCl solution (150 mM). Group 2 and 3 were fed an iron-deficient diet and infused with ferrous sulfate [Fe(II)] suspension or ferric sulfate [Fe(III)] solution (800 ppm as Fe, pH 6.8) to provide the same amount of iron as that consumed one day before by the control group. NaCl, Fe(II) and Fe(III) were infused through the fistula as two times (1000 hr and 1800 hr) for 14 days. The volume of NaCl infused was about equal to the volume of Fe(II) suspension and Fe(III) solution infused. Hemoglobin regeneration efficiency, hematocrit, plasma iron concentration, transferrin saturation, total iron-binding capacity, iron contents in organs (liver, spleen and kidney), body weight gain and food intake were almost the same among groups.

Kiyoshi E, Jun O; Nutr Res 15 (6): 889-897 (1995)


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ABOUT THIS PAGE

Ferric Sulfate Manufacturers

A Ferric Sulfate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ferric Sulfate, including repackagers and relabelers. The FDA regulates Ferric Sulfate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ferric Sulfate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Ferric Sulfate Suppliers

A Ferric Sulfate supplier is an individual or a company that provides Ferric Sulfate active pharmaceutical ingredient (API) or Ferric Sulfate finished formulations upon request. The Ferric Sulfate suppliers may include Ferric Sulfate API manufacturers, exporters, distributors and traders.

Ferric Sulfate GMP

Ferric Sulfate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ferric Sulfate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ferric Sulfate GMP manufacturer or Ferric Sulfate GMP API supplier for your needs.

Ferric Sulfate CoA

A Ferric Sulfate CoA (Certificate of Analysis) is a formal document that attests to Ferric Sulfate's compliance with Ferric Sulfate specifications and serves as a tool for batch-level quality control.

Ferric Sulfate CoA mostly includes findings from lab analyses of a specific batch. For each Ferric Sulfate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ferric Sulfate may be tested according to a variety of international standards, such as European Pharmacopoeia (Ferric Sulfate EP), Ferric Sulfate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ferric Sulfate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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