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Ferriprox

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Chemistry

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Also known as: 30652-11-0, 3-hydroxy-1,2-dimethyl-4(1h)-pyridone, Ferriprox, 3-hydroxy-1,2-dimethylpyridin-4(1h)-one, Cp20, 1,2-dimethyl-3-hydroxy-4-pyridone

Molecular Formula

C₇H₉NO₂

Molecular Weight

139.15 g/mol

InChI Key

TZXKOCQBRNJULO-UHFFFAOYSA-N

FDA UNII

2BTY8KH53L

A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.

Deferiprone is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.

1 2D Structure

Deferiprone

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-hydroxy-1,2-dimethylpyridin-4-one

2.1.2 InChI

InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

2.1.3 InChI Key

TZXKOCQBRNJULO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C(=O)C=CN1C)O

2.2 Other Identifiers

2.2.1 UNII

2BTY8KH53L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1,2 Dimethyl 3 Hydroxy 4 Pyridinone

2. 1,2 Dimethyl 3 Hydroxypyrid 4 One

3. 1,2 Dimethyl 3 Hydroxypyridin 4 One

4. 1,2-dimethyl-3-hydroxy-4-pyridinone

5. 1,2-dimethyl-3-hydroxypyrid-4-one

6. 1,2-dimethyl-3-hydroxypyridin-4-one

7. 3 Hydroxy 1,2 Dimethyl 4 Pyridinone

8. 3-hydroxy-1,2-dimethyl-4-pyridinone

9. Dmohpo

10. Ferriprox

11. Hdmpp

2.3.2 Depositor-Supplied Synonyms

1. 30652-11-0

2. 3-hydroxy-1,2-dimethyl-4(1h)-pyridone

3. Ferriprox

4. 3-hydroxy-1,2-dimethylpyridin-4(1h)-one

5. Cp20

6. 1,2-dimethyl-3-hydroxy-4-pyridone

7. 1,2-dimethyl-3-hydroxypyrid-4-one

8. Apo-66

9. 1,2-dimethyl-3-hydroxypyridine-4-one

10. 4(1h)-pyridinone, 3-hydroxy-1,2-dimethyl-

11. Apo-066

12. Dn-180-01-af

13. 3-hydroxy-1,2-dimethylpyridin-4-one

14. Deferipron

15. Mfcd00134497

16. Deferiprone (inn)

17. Pl-1

18. L1

19. Chebi:68554

20. 1,2-dimethyl-3-hydroxy-4(1h)-pyridinone

21. Cp-20

22. Dn-18001af

23. Nsc-758880

24. 2bty8kh53l

25. Mls000069481

26. Hk-1

27. Pl1

28. 4(1h)-pyridinone, 1,2-dimethyl-3-hydroxy-

29. Smr000059136

30. Deferiprone [inn]

31. L-1

32. Cp20 (chelating Agent)

33. Ferriprox (tn)

34. Unii-2bty8kh53l

35. Brn 1447108

36. Deferidone

37. Deferiprona

38. Deferum

39. Deferiprone [usan:inn:ban]

40. Ccris 8318

41. 1,2-dimethyl-3-hydroxy-4-pyridinone

42. 3-hydroxy-1,2-dimethyl-4-pyridinone

43. L-1[chelating Agent]

44. Opera_id_366

45. 3-hydroxy-1,2-dimethyl-4(1h)-pyridinone

46. Deferiprone [mi]

47. 4(1h)-pyridone, 3-hydroxy-1,2-dimethyl-

48. Deferiprone (usan/inn)

49. Deferiprone [usan]

50. Deferiprone [vandf]

51. Deferiprone [mart.]

52. Dsstox_cid_20666

53. Dsstox_rid_79529

54. Dsstox_gsid_40666

55. Schembl94474

56. Deferiprone [who-dd]

57. Mls000758227

58. Mls001424029

59. Mls006011689

60. Chembl70927

61. Deferiprone [ema Epar]

62. Crmd-001

63. Gtpl7456

64. Zinc6226

65. Dtxsid6040666

66. Hsdb 8335

67. Tzxkocqbrnjulo-uhfffaoysa-

68. Deferiprone [orange Book]

69. Ex-a972

70. Cp020

71. Deferiprone [ep Monograph]

72. Hms2051c05

73. Hms2232e24

74. Hms3264p17

75. Hms3393c05

76. Hms3873l13

77. Pharmakon1600-01504512

78. Bcp09606

79. Hy-b0568

80. 3-hydroxy-1,2-dimethylpyrid-4-one

81. Tox21_112429

82. Bbl036482

83. Bdbm50525976

84. Cgp-37391

85. Nsc758880

86. S4067

87. Stl559018

88. 1,2-dimetyl-3-hydroxy-4-pyridinone

89. Akos015902286

90. Ccg-100760

91. Cs-5240

92. Db08826

93. Ds-5493

94. Nc00010

95. Nsc 758880

96. 3-hydroxy-1,2-dimethyl-4- Pyridinone

97. 3-hydroxy-1,2-dimethyl-pyridin-4-one

98. Ncgc00090548-01

99. Ncgc00090548-02

100. Ncgc00090548-04

101. Ncgc00090548-05

102. Ac-33026

103. Bp-12415

104. Sy052576

105. Sbi-0207041.p001

106. Cas-30652-11-0

107. Db-047826

108. 1,2-dimethyl-3-hydroxy-4-pyridone, 99+%

109. Ft-0606424

110. H0944

111. D07416

112. 3-hydroxy-1,2-dimethyl-4(1h)-pyridone, 98%

113. Ab00572605_11

114. Ab00572605_12

115. A820470

116. Q749664

117. Sr-01000721891

118. Deferiprone 1,2-dimethyl-3-hydroxy-4-pyridone

119. Sr-01000721891-4

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₇H₉NO₂
Molecular Weight	139.15 g/mol
XLogP3	0.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	139.063328530 g/mol
Monoisotopic Mass	139.063328530 g/mol
Topological Polar Surface Area	40.5 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	228
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Ferriprox
PubMed Health	Deferiprone (By mouth)
Drug Classes	Heavy Metal Chelator
Drug Label	Ferriprox (deferiprone) tablets contain 500mg deferiprone (3-hydroxy-1,2-dimethylpyridin-4-one), a synthetic, orally active, iron-chelating agent. Deferiprone has the following structural formula:Deferiprone is a white to pinkish-white crystallin...
Active Ingredient	Deferiprone
Dosage Form	Tablet
Route	Oral
Strength	500mg
Market Status	Prescription
Company	Apopharma

2 of 2
Drug Name	Ferriprox
PubMed Health	Deferiprone (By mouth)
Drug Classes	Heavy Metal Chelator
Drug Label	Ferriprox (deferiprone) tablets contain 500mg deferiprone (3-hydroxy-1,2-dimethylpyridin-4-one), a synthetic, orally active, iron-chelating agent. Deferiprone has the following structural formula:Deferiprone is a white to pinkish-white crystallin...
Active Ingredient	Deferiprone
Dosage Form	Tablet
Route	Oral
Strength	500mg
Market Status	Prescription
Company	Apopharma

4.2 Therapeutic Uses

Iron Chelating Agents

National Library of Medicine's Medical Subject Headings. Deferiprone. Online file (MeSH, 2016). Available from, as of June 24, 2016: https://www.nlm.nih.gov/mesh/2016/mesh_browser/MBrowser.html

/CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Deferiprone is included in the database.

NIH/NLM; ClinicalTrials.Gov. Available from, as of July 6, 2016: https://clinicaltrials.gov/search/intervention=DEFERIPRONE

Ferriprox (deferiprone) is indicated for the treatment of patients with transfusional iron overload due to thalassemia syndromes when current chelation therapy is inadequate. /Included in US product label/

NIH; DailyMed. Current Medication Information for Ferriprox (Deferiprone) Tablet, Film-coated (Updated: February 2015). Available from, as of July 14, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dc8cbc3d-026c-0db5-42e8-8e93d374dd23

/EXPL THER/ Friedreich ataxia is an inherited disorder characterized by degeneration of the peripheral and central nervous system and hypertrophic cardiomyopathy. Homozygous mutations in the frataxine (FXN) gene reduce expression of frataxin and cause accumulation of iron in the mitochondria. Deferiprone, an oral iron chelator, has been shown effective in cell and animal models of Friedreich ataxia. The results of a 6-month randomized, double blind placebo-controlled study suggested that deferiprone 20 mg/kg/day may reduce disease progression. The authors present their experience of 5 Friedreich ataxia patients treated with deferiprone (20 mg/kg/day), in addition to idebenone treatment, followed over a period of 10-24 months, under off-label authorization. The patients were monitored for laboratory parameters, cardiac assessment, neurological evaluations, and quality of life. The authors conclude that combined therapy of a low dose of deferiprone with idebenone is relatively safe, might improve neurological function, and seems to improve heart hypertrophy, warranting further studies.

PMID:27029487 Elincx-Benizri S et al; J Child Neurol 31 (8): 1036-40 (2016)

/EXPL THER/ Growing body of evidence suggests that Parkinson's disease (PD) is associated with oxidative damage via iron accumulation in the substantia nigra (SN). Low ceruloplasmin (CP)-ferroxidase activity has been identified in the SN and the cerebrospinal fluid (CSF) of patients with PD. The iron chelator, deferiprone, reduces the abnormally high levels of iron in the SN. In order to determine CP's involvement in iron accumulation in SN and PD progression, we aim to compare the ability of iron chelation treatment to reducing both SN iron levels and motor handicap in PD patients according to the level of ceruloplasmin activity. We used a moderate chelation protocol with deferiprone (DFP) based on a, 6-month delayed-start paradigm, randomized placebo controlled clinical trial in 40 PD patients. CP-ferroxidase activity was determined in blood and CSF together with the D544E gene polymorphism (rs701753). Iron levels were determined by R2* MRI sequence and the motor handicap by the UPDRS motor score. After 6 to 12 months of DFP treatment, greater reductions in SN iron levels and UPDRS motor scores were obtained in patients with higher serum and CSF levels of CP-ferroxidase activity. After 6 months of DFP treatment, the AT genotype group displayed greater reduction of iron level in the SN with greater CSF and serum levels of CP activity than the AA genotype group. Although most of the DFP-treated patients displayed clinical and radiological improvements, those with the lower CP activity appeared to respond better to iron chelation. Larger RCTs are now needed to establish whether pharmacological modulation of CP activity could be an innovative neuroprotective strategy in PD.

PMID:25943368 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429376 Grolez G et al; BMC Neurol 15:74 (2015)

4.3 Drug Warning

/BOXED WARNING/ WARNING: AGRANULOCYTOSIS/NEUTROPENIA: Ferriprox can cause agranulocytosis that can lead to serious infections and death. Neutropenia may precede the development of agranulocytosis. Measure the absolute neutrophil count (ANC) before starting Ferriprox therapy and monitor the ANC weekly on therapy. Interrupt Ferriprox therapy if neutropenia develops. Interrupt Ferriprox if infection develops, and monitor the ANC more frequently. Advise patients taking Ferriprox to report immediately any symptoms indicative of infection.

Based on evidence of genotoxicity and developmental toxicity in animal studies, Ferriprox can cause fetal harm when administered to a pregnant woman. ... If Ferriprox is used during pregnancy or if the patient becomes pregnant while taking Ferriprox, the patient should be apprised of the potential hazard to the fetus.

It is not known whether deferiprone is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for adverse reactions in nursing infants from Ferriprox, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Safety and effectiveness in elderly individuals have not been established. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

For more Drug Warnings (Complete) data for Deferiprone (13 total), please visit the HSDB record page.

4.4 Drug Indication

Deferiprone is indicated in thalassemia syndromes when first line chelation agents are not adequate to treat transfusional iron overload.

FDA Label

Ferriprox monotherapy is indicated for the treatment of iron overload in patients with thalassaemia major when current chelation therapy is contraindicated or inadequate.

Ferriprox in combination with another chelator is indicated in patients with thalassaemia major when monotherapy with any iron chelator is ineffective, or when prevention or treatment of life-threatening consequences of iron overload (mainly cardiac overload) justifies rapid or intensive correction.

Deferiprone Lipomed monotherapy is indicated for the treatment of iron overload in patients with thalassaemia major when current chelation therapy is contraindicated or inadequate.

Deferiprone Lipomed in combination with another chelator is indicated in patients with thalassaemia major when monotherapy with any iron chelator is ineffective, or when prevention or treatment of life-threatening consequences of iron overload justifies rapid or intensive correction.

Treatment of chronic iron overload

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Iron Chelating Agents

Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems. (See all compounds classified as Iron Chelating Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Active Moiety

DEFERIPRONE

5.2.2 FDA UNII

2BTY8KH53L

5.2.3 Pharmacological Classes

Iron Chelator [EPC]; Iron Chelating Activity [MoA]

5.3 ATC Code

V03AC02

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AC - Iron chelating agents

V03AC02 - Deferiprone

5.4 Absorption, Distribution and Excretion

Absorption

Deferiprone is absorbed in the upper gastrointestinal tract. Absorption is rapid with maximum plasma concentrations occurring after 1 hour in the fasted state and after 2 hours in the fed state.

Route of Elimination

Within 5-6 hours of administration, more than 90% of deferiprone is eliminated from the plasma. 75 to 90% of deferiprone is excreted in the urine as the metabolite.

Volume of Distribution

In healthy patients, the volume of distribution is 1L/kg, and in thalassemia patients, the volume of distribution is 1.6L/kg.

In healthy subjects, the mean maximum concentration (Cmax) of deferiprone in serum was 20 ug/mL, and the mean total area under the concentration-time curve (AUC) was 53 ug*hr/mL following oral administration of a 1,500 mg dose of Ferriprox tablets in the fasting state. Dose proportionality over the labeled dosage range of 25 to 33 mg/kg three times per day (75 to 99 mg/kg per day) has not been studied. The elimination half life of deferiprone was 1.9 hours. The accumulation of deferiprone and its glucuronide metabolite at the highest approved dosage level of 33 mg/kg three times per day has not been studied. The volume of distribution of deferiprone is 1.6 L/kg in thalassemia patients, and approximately 1 L/kg in healthy subjects. The plasma protein binding of deferiprone in humans is less than 10%.

Deferiprone is rapidly absorbed from the upper part of the gastrointestinal tract, appearing in the blood within 5 to 10 minutes of oral administration. Peak serum concentrations occur approximately 1 hour after a single dose in fasted healthy subjects and patients, and up to 2 hours after a single dose in the fed state. Administration with food decreased the Cmax of deferiprone by 38% and the AUC by 10%. While a food effect cannot be ruled out, the magnitude of the exposure change does not warrant dose adjustment.

More than 90% of deferiprone is eliminated from plasma within 5 to 6 hours of ingestion. Following oral administration, 75% to 90% is recovered in the urine in the first 24 hours, primarily as metabolite.

/MILK/ It is not known whether deferiprone is excreted in human milk.

For more Absorption, Distribution and Excretion (Complete) data for Deferiprone (8 total), please visit the HSDB record page.

5.5 Metabolism/Metabolites

Deferiprone is mainly metabolized by UGT1A6 to the 3-O-glucuronide metabolite. This metabolite cannot chelate iron.

In humans, the majority of the deferiprone is metabolized, primarily by UGT1A6. The contribution of extrahepatic (e.g., renal) UGT1A6 is unknown. The major metabolite of deferiprone is the 3-O-glucuronide, which lacks iron binding capability. Peak serum concentration of the glucuronide occurs 2 to 4 hours after administration of deferiprone in fasting subjects.

5.6 Biological Half-Life

The half-life is 1.9 hours.

The pharmacokinetics of deferiprone in children was assessed in 7 patients with thalassemia and iron overload aged 11 to 18 years (mean age= 15 + or - 2.7 years; median=16 years). These patients were on long term therapy with deferiprone and were thus considered to be at steady state. ... Serum levels of deferiprone were maximal approximately 2 hours after dosing and declined with a half-life of 1.8 hours; levels of deferiprone glucuronide peaked at approximately 3 hours and fell with a half-life of 2.0 hours. ...

Health Canada; Product Monograph for Ferriprox (Deferiprone) Tablets (500 mg and 1000 mg) Deferiprone Oral Solution (100 mg/mL). Drug Identification Number (DIN): 02436531 p.17 (Date of Preparation: January 22, 2015). Available from, as of July 14, 2016: https://webprod5.hc-sc.gc.ca/dpd-bdpp/start-debuter.do?lang=eng

In healthy subjects ... following oral administration of a 1,500 mg dose of Ferriprox tablets in the fasting state ... the elimination half life ... was 1.9 hours.

5.7 Mechanism of Action

Deferiprone is an iron chelator that binds to ferric ions (iron III) and forms a 3:1 (deferiprone:iron) stable complex and is then eliminated in the urine. Deferiprone is more selective for iron in which other metals such as zinc, copper, and aluminum have a lower affinity for deferiprone.

Deferiprone is a chelating agent with an affinity for ferric ion (iron III). Deferiprone binds with ferric ions to form neutral 3:1 (deferiprone:iron) complexes that are stable over a wide range of pH values. Deferiprone has a lower binding affinity for other metals such as copper, aluminum and zinc than for iron.

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Deferiprone

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 39766

Submission : 2024-04-16

Status : Active

Type : II

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Deferiprone

Certificate Number : CEP 2024-124 - Rev 00

Status : Valid

Issue Date : 2024-10-09

Type : Chemical

Substance Number : 2236

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Deferiprone EP

Date of Issue : 2024-05-20

Valid Till : 2027-05-20

Written Confirmation Number : WC-295

Address of the Firm : D-53, Phase II, Kalyan Shill Road, Dombivli (E.), Dombivli - 421204, Taluka: Dom...

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DEFERIPRONE

NDC Package Code : 15308-2908

Start Marketing Date : 2023-04-16

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (360kg/360kg)

Marketing Category : BULK INGREDIENT

02

B.V. KATWIJK CHEMIE

Netherlands

Antibody Engineering

Not Confirmed

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Listed Suppliers

01

Aarti Pharmalabs

India

Antibody Engineering

Not Confirmed

Aarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

Contact Supplier

India

Virtual Booth

Digital Content

Deferiprone

About the Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, corticosteroids, cyto...

Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, corticosteroids, cytotoxic & oncology products. It has 2 R&D centers & 3 cGMP plants successfully audited by the USFDA, EUGMP, EDQM, KFDA & COFEPRIS. It offers CDMO services for generic APIs & NCEs, intermediates & key building blocks.Note: None of the products will be supplied to countries in which this could be in conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer

02

Macsen Labs

India

Antibody Engineering

Not Confirmed

Macsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

Contact Supplier

India

Virtual Booth

Digital Content

Deferiprone

About the Company : Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our c...

Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our comprehensive offerings extend to Contract Research & Custom Synthesis. With a legacy of over seven decades, Macsen combines tradition with innovation to meet the evolving needs of the chemical and pharmaceutical sectors. Our commitment to quality is evident in every aspect of our operations, from state-of-the-art manufacturing facilities to advanced analytical capabilities.

Portfolio PDF

Product Web Link

Virtual Booth

India

Antibody Engineering

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

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PEX\/0315\/24-25 DT. 26.06.2024)","address":"2ND FLOOR, GODOWN No. 204","city":"MUMBAI","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"ATHENS","customer":"TO ORDER","customerCountry":"GREECE","quantity":"756.66","actualQuantity":"756.66","unit":"KGS","unitRateFc":"190","totalValueFC":"137888.1","currency":"USD","unitRateINR":15212.666243755451,"date":"29-Jun-2024","totalValueINR":"11510816.04","totalValueInUsd":"137888.1","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"2042942","productDescription":"API","marketType":"REGULATED MARKET","country":"GREECE","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"2ND FLOOR, GODOWN No. 204, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724869800,"product":"DEFERIPRONE","address":"TYPE-C,PLOT NO.10,ROAD NO.8FILM NAGAR,JUBILEE HILLS","city":"HYD-A.P.","supplier":"SRINI PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"TORONTO","customer":"APOTEX INC","customerCountry":"CANADA","quantity":"871.25","actualQuantity":"871.25","unit":"KGS","unitRateFc":"105","totalValueFC":"79979.8","currency":"USD","unitRateINR":7699.9615954088949,"date":"29-Aug-2024","totalValueINR":"6708591.54","totalValueInUsd":"79979.8","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"3586710","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"TYPE-C,PLOT NO.10,ROAD NO.8FILM NAGAR,JUBILEE HILLS, HYD-A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725215400,"product":"DEFERIPRONE","address":"TYPE-C,PLOT NO.10,ROAD NO.8FILM NAGAR,JUBILEE HILLS","city":"HYD-A.P.","supplier":"SRINI PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"TORONTO","customer":"APOTEX INC","customerCountry":"CANADA","quantity":"872.33","actualQuantity":"872.33","unit":"KGS","unitRateFc":"105","totalValueFC":"80150.3","currency":"USD","unitRateINR":7699.7185124895395,"date":"02-Sep-2024","totalValueINR":"6716695.45","totalValueInUsd":"80150.3","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"3677134","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"TYPE-C,PLOT NO.10,ROAD NO.8FILM NAGAR,JUBILEE HILLS, HYD-A.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725906600,"product":"ACTIVE PHARMACEUTICAL INGREDIENTS OTHERORGANIC COMPOUNDS- DEFERIPRONE PH. EUR","address":"SETHNA BUILDING, 4TH FLR,","city":"LINES, MUMBAI ,MAHARASHTRA","supplier":"MEGAFINE PHARMA (P) LIMITED","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"TO THE ORDER OF,","customerCountry":"INDONESIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"199.3","totalValueFC":"161600","currency":"USD","unitRateINR":13542.2754,"date":"10-Sep-2024","totalValueINR":"13542275.4","totalValueInUsd":"161600","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"3879687","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"SETHNA BUILDING, 4TH FLR,, LINES, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726684200,"product":"DEFERIPRONE EP (PHARMACEUTICAL RAW MATERIALS)(INV NO.PEX\/0626\/24-25 DT.13.09.2024)","address":"2ND FLOOR, GODOWN No. 204","city":"MUMBAI","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"JAKARTA SOEKARNO-HA","customer":"TO ORDER","customerCountry":"INDONESIA","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"140","totalValueFC":"34081","currency":"USD","unitRateINR":11424.120000000001,"date":"19-Sep-2024","totalValueINR":"2856030","totalValueInUsd":"34081","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"4165743","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"2ND FLOOR, GODOWN No. 204, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1727721000,"product":"PHARMACEUTICAL RAW MATERIAL-BULK DRUG FOR USE IN PHARMACEUTICAL INDUSTRIES - DEFERIPRONE EP","address":"708, TIMES SQUARE ARCADE,","city":"AHMEDABAD","supplier":"SKJ HEALTHCARE PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"TO THE ORDER OF","customerCountry":"INDONESIA","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"140","totalValueFC":"33989.1","currency":"USD","unitRateINR":11423.9516,"date":"01-Oct-2024","totalValueINR":"2855987.9","totalValueInUsd":"33989.1","indian_port":"Ahmedabad Air","hs_no":"29420090","bill_no":"4494053","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"708, TIMES SQUARE ARCADE,, AHMEDABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730140200,"product":"DEFERIPRONE (PHARMACEUTICAL RAW MATERIALS) (INV NO: PEX\/0824\/24-25 DT: 25.10.2024)","address":"2ND FLOOR, GODOWN No. 204","city":"MUMBAI","supplier":"AARTI PHARMALABS","supplierCountry":"INDIA","foreign_port":"LAHORE","customer":"TO ORDER","customerCountry":"PAKISTAN","quantity":"63.95","actualQuantity":"63.95","unit":"KGS","unitRateFc":"105","totalValueFC":"6441","currency":"USD","unitRateINR":8463.0836591086772,"date":"29-Oct-2024","totalValueINR":"541214.2","totalValueInUsd":"6441","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"5251512","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"2ND FLOOR, GODOWN No. 204, MUMBAI","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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FDF Dossiers

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FDA Orange Book

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Europe

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Canada

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Australia

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Listed Dossiers

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Related Excipient Companies

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Excipients by Applications

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Fillers, Diluents & Binders

01

Gangwal Healthcare

India

Cosmoprof India

Not Confirmed

Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

Dosage Form : Capsule, Tablet

Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Disintegrants & Superdisintegrants, Fillers, Diluents & Binders, Lubricants & Glidants

Brand Name : ProBlend®

Application : Co-Processed Excipients, Direct Compression, Disintegrants & Superdisintegrants, Fillers, Diluents & Binders, Lubricants & Glidants

Excipient Details : ProBlend (Microcrystalline Cellulose) is used as a filler, binder, glidant, DC & co-processed excipient in tablets, capsules, and MUPS formulations.

Pharmacopoeia Ref : USP-NF

Technical Specs : NA

Ingredient(s) : Microcrystalline Cellulose

02

Gangwal Healthcare

India

Cosmoprof India

Not Confirmed

Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

Dosage Form : Capsule, Tablet

Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Brand Name : DiCOM-DC® PL009 P60

Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Excipient Details : DiCOM-DC PL009 P60 is used as a filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

Pharmacopoeia Ref : IH

Technical Specs : NA

Ingredient(s) : Maize Starch

03

Gangwal Healthcare

India

Cosmoprof India

Not Confirmed

Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

Dosage Form : Capsule, Tablet

Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Thickeners and Stabilizers

Brand Name : DiCOM-DC® SP204

Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders, Thickeners and Stabilizers

Excipient Details : DiCOM-DC SP204 is used as a stabilizer, filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

Pharmacopoeia Ref : In-house

Technical Specs : NA

Ingredient(s) : Corn Starch, Pregelatinized

04

Gangwal Healthcare

India

Cosmoprof India

Not Confirmed

Gangwal Healthcare is powered by innovation, driving health, wellness & healing.

Dosage Form : Capsule, Tablet

Grade : Oral

Category : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Brand Name : Microlose™ M60 P60

Application : Co-Processed Excipients, Direct Compression, Fillers, Diluents & Binders

Excipient Details : Microlose M60 P60 is used as a filler, binder, directly compressible, and co-processed excipient in tablets and capsules.

Pharmacopoeia Ref : In-house

Technical Specs : Lactose Monohydrate – 40%, Microcrystalline cellulose – 60%

Ingredient(s) : Lactose Monohydrate

Excipients Web Link

India

Cosmoprof India

Not Confirmed

Only 10 entries up to this point, click to access all

Thickeners and Stabilizers

Direct Compression

Lubricants & Glidants

Co-Processed Excipients

Coating Systems & Additives

Parenteral

Disintegrants & Superdisintegrants

Film Formers & Plasticizers

Taste Masking

Granulation

Topical

Controlled & Modified Release

Rheology Modifiers

Emulsifying Agents

Coloring Agents

Chewable & Orodispersible Aids

API Stability Enhancers

Digital Content

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DATA COMPILATION #PharmaFlow

NEWS #PharmaBuzz

Global Sales Information

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US Medicaid Prescriptions

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Finished Drug Prices

01

Brand Name : Ferriprox

Canada

Italy

Cosmoprof India

Not Confirmed

07

Brand Name : DEFERIPRONE DOC

Italy

Cosmoprof India

Not Confirmed

08

Brand Name : Ferriprox

Italy

Cosmoprof India

Not Confirmed

09

Brand Name : Deferipron Lipomed

Switzerland

Cosmoprof India

Not Confirmed

10

Brand Name : Ferriprox

Canada

Cosmoprof India

Not Confirmed

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Market Place

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APIs

Various APIs needed in India [ENA12513]

A WHO-GMP accredited company that deals in contract manufacturing services, P2P (product to procurement) manufacturing and branded ethical formulation is looking for suppliers of Various APIs for commercial purpose. The suppliers must support this enquiry with open & closed part of DMF, GMP & CoA. 1. Pregabalin API 2. Gliclazide API 3. Levetiracetam API 4. Rosuvastatin Calcium API 5. Metformin Hydrochloride API 6. Duloxetine (22%) API 7. Ledipasvir API 8. Deferiprone API 9. Sofosbuvir API

25 Jan 2022

Deferiprone (MOQ) API needed in Germany [ENA12502]

A compounding pharmacy that offers desired hormone formulations is looking for suppliers of Deferiprone (MOQ) API for development purpose. The suppliers must support this enquiry with CoA.

24 Jan 2022

Various APIs needed in Thailand [ENA07403]

A distributor based in Thailand is looking for Various APIs. The suppliers must support this enquiry with USDMF, CEP/COS and JDMF preferably. 1. Nevirapine (9 MT) 2. Deferasirox (200 kg) 3. Deferiprone (15 MT) 4. Finasteride (35 kg) 5. Folic Acid (2 MT) 6. Furosemide (3 MT)

27 May 2020

Deferiprone (MOQ) API needed in Vietnam [ENA05702]

One of the leading companies in applying high technology in the manufacturing process of pharmaceuticals is looking for suppliers of Deferiprone (MOQ) API. The supplier must support this enquiry with CoA.

08 Nov 2019

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FDF DOSSIERS

Tender// Various Finished Dosage Formulations needed in France [ENA09560]

22 Jan 2021

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DEFERIPRONE

Cosmoprof India

Not Confirmed

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US Exclusivities

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ABOUT THIS PAGE

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Market Place

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ACCESS ALL DATA

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

11 API Suppliers

6 USDMF

2 CEP/COS

3 EU WC

2 NDC API

7 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

FINISHED DOSAGE FORMULATIONS

35 FDF Dossiers

9 FDA Orange Book

15 Europe

4 Canada

6 Australia

1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

1 SPI Pharma

6 DKSH

1 Pharm-RX Chemical

2 Faran Shimi Pharmaceutical

7 Gangwal Healthcare

1 Nanjing Well Pharmaceutical

3 Actylis

3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 Bioplus Life Sciences

2 DFE Pharma

5 Gangwal Chemicals

1 Ideal Cures Pvt Ltd

4 Kerry

7 Microlex e.U

1 Pharmatrans-Sanaq

3 Pluviaendo

2 Prachin Chemical

9 Roquette

2 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

8 Sigachi Industries

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

20 Fillers, Diluents & Binders

14 Thickeners and Stabilizers

13 Direct Compression

12 Lubricants & Glidants

8 Co-Processed Excipients

8 Coating Systems & Additives

5 Parenteral

5 Disintegrants & Superdisintegrants

5 Film Formers & Plasticizers

5 Taste Masking

5 Granulation

5 Topical

5 Controlled & Modified Release

4 Rheology Modifiers

3 Emulsifying Agents

2 Coloring Agents

2 Chewable & Orodispersible Aids

1 API Stability Enhancers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow

11 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions

10 Finished Drug Prices

MARKET PLACE

4 APIs

1 FDF Dossiers

PATENTS & EXCLUSIVITIES

8 US Patents

20 US Exclusivities

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 139

MARKET PLACE