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Chemistry

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Also known as: Iron(ii) fumarate, 141-01-5, Feostat, Palafer, Galfer, Ircon

Molecular Formula

C₄H₂FeO₄

Molecular Weight

169.90 g/mol

InChI Key

PMVSDNDAUGGCCE-TYYBGVCCSA-L

FDA UNII

R5L488RY0Q

Ferrous Fumarate is the fumarate salt form of the mineral iron. Administration of ferrous fumarate results in elevation of serum iron concentration, which is then assimilated into hemoglobin, required for the transport of oxygen, or trapped in the reticuloendothelial cells for storage. This agent is used as a dietary supplement, and to prevent or treat iron deficiency related syndromes.

1 2D Structure

Ferrous Fumarate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(E)-but-2-enedioate;iron(2+)

2.1.2 InChI

InChI=1S/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;

2.1.3 InChI Key

PMVSDNDAUGGCCE-TYYBGVCCSA-L

2.1.4 Canonical SMILES

C(=CC(=O)[O-])C(=O)[O-].[Fe+2]

2.1.5 Isomeric SMILES

C(=C/C(=O)[O-])\C(=O)[O-].[Fe+2]

2.2 Other Identifiers

2.2.1 UNII

R5L488RY0Q

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Feostat

2. Ferrocap

3. Fersaday

4. Fersamal

5. Ferval

6. Fumar

7. Galfer

8. Ircon

9. Nephro-fer

10. Palafer

11. Rulofer N

2.3.2 Depositor-Supplied Synonyms

1. Iron(ii) Fumarate

2. 141-01-5

3. Feostat

4. Palafer

5. Galfer

6. Ircon

7. Ercoferro

8. Ferrofume

9. Tolferain

10. Cpiron

11. Hemoton

12. Toleron

13. Tolifer

14. Erco-fer

15. Ferrousfumarate

16. Iron(2+) Fumarate

17. Iron Fumarate

18. 2-butenedioic Acid (2e)-, Iron(2+) Salt (1:1)

19. Fumaric Acid, Iron(2+) Salt (1:1)

20. 2-butenedioic Acid (e)-, Iron(2+) Salt (1:1)

21. R5l488ry0q

22. 2-butenedioic Acid, (e)-, Iron(2+) Salt

23. Fersamal

24. Fumar

25. (e)-but-2-enedioate;iron(2+)

26. Feroton

27. Ferronat

28. Ferrone

29. Ferrotemp

30. Fumafer

31. Fumiron

32. Firon

33. One-iron

34. Fumar-f

35. Ferrocite

36. Fumaric Acid, Iron(2+) Salt

37. Ccris 6896

38. Einecs 205-447-7

39. Unii-r5l488ry0q

40. Ferrofumarate

41. Heferol

42. Orgasal

43. Ferrous Fumarate [usp:jan]

44. Feostat (tn)

45. Ferrum (tn)

46. Iron (as Fumarate)

47. Meterfer

48. Iron (as Ferrous Fumarate)

49. Schembl24284

50. Schembl24286

51. Ferrous Fumarate (jan/usp)

52. Ferrous Fumarate [ii]

53. Ferrous Fumarate [mi]

54. Ferrous Fumarate [fcc]

55. Ferrous Fumarate [jan]

56. Ferrous Fumarate [inci]

57. Dtxsid7047148

58. Ferrous Fumarate [vandf]

59. Chebi:31607

60. Amy8976

61. Ferrous Fumarate [mart.]

62. Ferrous Fumarate [who-dd]

63. Ferrous Fumarate [who-ip]

64. Hy-b1651

65. Einecs 231-731-5

66. Mfcd00058315

67. Akos015918237

68. Ferrous Fumarate [orange Book]

69. Db14491

70. Ferrosi Fumaras [who-ip Latin]

71. Ferrous Fumarate [ep Monograph]

72. Ferrous Fumarate [usp Monograph]

73. Iron (as Ferrous Fumarate) [vandf]

74. 2-butenedioic Acid (2e)-, Iron(2+) Salt

75. Cs-0013603

76. Norquest Fe Component Ferrous Fumarate

77. D01194

78. Ferrous Fumarate Component Of Norquest Fe

79. Lo Minastrin Fe Component Ferrous Fumarate

80. Minastrin 24 Fe Component Ferrous Fumarate

81. Q416370

82. 2-butenedioic Acid (2e)-, Iron(2+) Salt (1:?)

83. J-007445

84. J-521364

85. 7705-12-6

2.4 Create Date

2006-04-28

3 Chemical and Physical Properties

Molecular Formula	C₄H₂FeO₄
Molecular Weight	169.90 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	169.930244 g/mol
Monoisotopic Mass	169.930244 g/mol
Topological Polar Surface Area	80.3 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	108
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Ferrous fumarate
Active Ingredient	Ferrous fumarate
Dosage Form	Tablet
Route	oral
Strength	75mg
Market Status	Tentative Approval
Company	Barr Labs

2 of 2
Drug Name	Ferrous fumarate
Active Ingredient	Ferrous fumarate
Dosage Form	Tablet
Route	oral
Strength	75mg
Market Status	Tentative Approval
Company	Barr Labs

4.2 Drug Indication

Used in preventing and treating iron-deficiency anemia.

5 Pharmacology and Biochemistry

5.1 Pharmacology

The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.

5.2 MeSH Pharmacological Classification

Trace Elements

A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Trace Elements.)

5.3 ATC Code

B - Blood and blood forming organs

B03 - Antianemic preparations

B03A - Iron preparations

B03AA - Iron bivalent, oral preparations

B03AA02 - Ferrous fumarate

B - Blood and blood forming organs

B03 - Antianemic preparations

B03A - Iron preparations

B03AD - Iron in combination with folic acid

B03AD02 - Ferrous fumarate

5.4 Absorption, Distribution and Excretion

Absorption

The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.

5.5 Mechanism of Action

Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Granulation

Parenteral

Film Formers & Plasticizers

Topical

Lubricants & Glidants

Co-Processed Excipients

Chewable & Orodispersible Aids

Emulsifying Agents

Empty Capsules

API Stability Enhancers

Rheology Modifiers

Vegetarian Capsules

Surfactant & Foaming Agents

Coloring Agents

Soft Gelatin

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Ferrous Fumarate

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

25 API Suppliers

6 USDMF

3 CEP/COS

1 JDMF

20 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

FINISHED DOSAGE FORMULATIONS

30 FDF Dossiers

8 FDA Orange Book

2 Europe

4 Canada

2 Australia

4 South Africa

10 Listed Dossiers

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1 Evonik

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18 Microlex e.U

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4 Novo Excipients

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11 Sigachi Industries

4 The Dow Chemical Company

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EXCIPIENTS BY APPLICATIONS

91 Fillers, Diluents & Binders

60 Coating Systems & Additives

46 Direct Compression

43 Disintegrants & Superdisintegrants