Find FHD-286 manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Fhd-286, 2671128-05-3, Fhd286, 1h-pyrrole-3-carboxamide, n-((1s)-2-((4-(6-((2r,6s)-2,6-dimethyl-4-morpholinyl)-2-pyridinyl)-2-thiazolyl)amino)-1-(methoxymethyl)-2-oxoethyl)-1-(methylsulfonyl)-, Unii-qha5xla4sa, Gtpl11967
Molecular Formula
C24H30N6O6S2
Molecular Weight
562.7  g/mol
InChI Key
JBLQNFBXKOAIHG-FCEWJHQRSA-N
FDA UNII
QHA5XLA4SA

FHD-286
BRG1/BRM Inhibitor FHD-286 is an orally bioavailable, allosteric, small molecule inhibitor of transcription activator BRG1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SMARCA4) and BRM (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; SMARCA2), with potential antineoplastic activity. Upon oral administration, BRG1/BRM inhibitor FHD-286 targets, binds to, and inhibits the activity of BRG1 and/or BRM, the primary ATPase components and mutually exclusive subunits of the BRG1/BRM-associated factor (BAF) complexes. This may lead to the inhibition of the SWI/SNF chromatin remodeling complex, disrupt chromatin remodeling and gene expression, and result in the downregulation of oncogenic pathways and the inhibition of tumor cell proliferation. BAF is an important regulator of transcriptional programs and gene expression. Mutations in BAF or its transcription factor partners are found in certain diseases including cancers.
1 2D Structure

FHD-286

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(2S)-1-[[4-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide
2.1.2 InChI
InChI=1S/C24H30N6O6S2/c1-15-10-29(11-16(2)36-15)21-7-5-6-18(25-21)20-14-37-24(27-20)28-23(32)19(13-35-3)26-22(31)17-8-9-30(12-17)38(4,33)34/h5-9,12,14-16,19H,10-11,13H2,1-4H3,(H,26,31)(H,27,28,32)/t15-,16+,19-/m0/s1
2.1.3 InChI Key
JBLQNFBXKOAIHG-FCEWJHQRSA-N
2.1.4 Canonical SMILES
CC1CN(CC(O1)C)C2=CC=CC(=N2)C3=CSC(=N3)NC(=O)C(COC)NC(=O)C4=CN(C=C4)S(=O)(=O)C
2.1.5 Isomeric SMILES
C[C@@H]1CN(C[C@@H](O1)C)C2=CC=CC(=N2)C3=CSC(=N3)NC(=O)[C@H](COC)NC(=O)C4=CN(C=C4)S(=O)(=O)C
2.2 Other Identifiers
2.2.1 UNII
QHA5XLA4SA
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Fhd-286

2. 2671128-05-3

3. Fhd286

4. 1h-pyrrole-3-carboxamide, N-((1s)-2-((4-(6-((2r,6s)-2,6-dimethyl-4-morpholinyl)-2-pyridinyl)-2-thiazolyl)amino)-1-(methoxymethyl)-2-oxoethyl)-1-(methylsulfonyl)-

5. Unii-qha5xla4sa

6. Gtpl11967

7. Ex-a6082

8. Nsc840947

9. Nsc-840947

10. Hy-144835

11. Cs-0435579

12. F78342

13. N-((s)-1-(4-(6-((2s,6r)-2,6-dimethylmorpholino)pyridin-2-yl)thiazol-2-ylamino)-3-methoxy-1-oxopropan-2-yl)-1-(methylsulfonyl)-1h-pyrrole-3-carboxamide

14. N-[(2s)-1-[[4-[6-[(2s,6r)-2,6-dimethylmorpholin-4-yl]pyridin-2-yl]-1,3-thiazol-2-yl]amino]-3-methoxy-1-oxopropan-2-yl]-1-methylsulfonylpyrrole-3-carboxamide

2.4 Create Date
2021-11-10
3 Chemical and Physical Properties
Molecular Weight 562.7 g/mol
Molecular Formula C24H30N6O6S2
XLogP31.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass562.16682505 g/mol
Monoisotopic Mass562.16682505 g/mol
Topological Polar Surface Area181 Ų
Heavy Atom Count38
Formal Charge0
Complexity926
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

FHD-286 Manufacturers

A FHD-286 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of FHD-286, including repackagers and relabelers. The FDA regulates FHD-286 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. FHD-286 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

FHD-286 Suppliers

A FHD-286 supplier is an individual or a company that provides FHD-286 active pharmaceutical ingredient (API) or FHD-286 finished formulations upon request. The FHD-286 suppliers may include FHD-286 API manufacturers, exporters, distributors and traders.

FHD-286 GMP

FHD-286 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of FHD-286 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right FHD-286 GMP manufacturer or FHD-286 GMP API supplier for your needs.

FHD-286 CoA

A FHD-286 CoA (Certificate of Analysis) is a formal document that attests to FHD-286's compliance with FHD-286 specifications and serves as a tool for batch-level quality control.

FHD-286 CoA mostly includes findings from lab analyses of a specific batch. For each FHD-286 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

FHD-286 may be tested according to a variety of international standards, such as European Pharmacopoeia (FHD-286 EP), FHD-286 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (FHD-286 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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