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Also known as: 247257-48-3, Kanarb, Fimasartan [inn], 2-(1-((2'-(2h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-n,n-dimethylethanethioamide, Chembl1951143, Fimasartan (inn)
Molecular Formula
C27H31N7OS
Molecular Weight
501.6  g/mol
InChI Key
AMEROGPZOLAFBN-UHFFFAOYSA-N
FDA UNII
P58222188P

Fimasartan
Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the brand name Kanarb by Boryung Pharmaceuticals.
1 2D Structure

Fimasartan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide
2.1.2 InChI
InChI=1S/C27H31N7OS/c1-5-6-11-24-28-18(2)23(16-25(36)33(3)4)27(35)34(24)17-19-12-14-20(15-13-19)21-9-7-8-10-22(21)26-29-31-32-30-26/h7-10,12-15H,5-6,11,16-17H2,1-4H3,(H,29,30,31,32)
2.1.3 InChI Key
AMEROGPZOLAFBN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCCCC1=NC(=C(C(=O)N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CC(=S)N(C)C)C
2.2 Other Identifiers
2.2.1 UNII
P58222188P
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Br-a657

2.3.2 Depositor-Supplied Synonyms

1. 247257-48-3

2. Kanarb

3. Fimasartan [inn]

4. 2-(1-((2'-(2h-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-n,n-dimethylethanethioamide

5. Chembl1951143

6. Fimasartan (inn)

7. P58222188p

8. 2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-n,n-dimethylethanethioamide

9. 2-(2-butyl-4-methyl-6-oxo-1-{[2'-(1h-tetrazol-5-yl)-4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)-n,n-dimethylethanethioamide

10. Br-a657

11. Br-a-657.k

12. Unii-p58222188p

13. 5-pyrimidineethanethioamide, 2-butyl-1,6-dihydro-n,n,4-trimethyl-6-oxo-1-((2'-(2h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

14. 5-pyrimidineethanethioamide, 2-butyl-1,6-dihydro-n,n,4-trimethyl-6-oxo-1-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

15. Fimasartan [who-dd]

16. Schembl2229436

17. Schembl20126833

18. Dtxsid80179460

19. Chebi:136044

20. Bcp11616

21. Ex-a3997

22. Hy-b0780

23. Zinc3842872

24. Bdbm50364573

25. Mfcd13194795

26. S4975

27. Zb1816

28. Akos016011331

29. Akos037643761

30. Ccg-269705

31. Cs-3509

32. Db09279

33. Ncgc00390600-01

34. Ac-30631

35. As-35179

36. D10556

37. 257f483

38. A919293

39. L019170

40. Q8563179

41. 2-((2-butyl-4-methyl-6-oxo-1-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)-1,6-dihydropyrimidin-5-yl))-n,n-dimethylthioacetamide

42. 2-(1-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-n,n-dimethylethanethioamide

43. 2-(1-((2-(2h-tetrazol-5-yl)-[1,1-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-n,n-dimethylethanethioamide

44. 2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]met Hyl]pyrimidin-5-yl]-n,n-dimethylethanethioamide

45. 2-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3h)-one

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 501.6 g/mol
Molecular Formula C27H31N7OS
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass501.23107981 g/mol
Monoisotopic Mass501.23107981 g/mol
Topological Polar Surface Area123 Ų
Heavy Atom Count36
Formal Charge0
Complexity849
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used for the treatment of hypertension and heart failure.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Fimasartan is a selective angiotensin receptor 1 (AR1) inhibitor. It acts to lower blood pressure by inhibiting vasoconstriction


5.2 ATC Code

C - Cardiovascular system

C09 - Agents acting on the renin-angiotensin system

C09C - Angiotensin ii receptor blockers (arbs), plain

C09CA - Angiotensin ii receptor blockers (arbs), plain

C09CA10 - Fimasartan


5.3 Absorption, Distribution and Excretion

Absorption

Tmax is 0.5-1.3 h.


Route of Elimination

Most is eliminated unchangd in bile with less than 3% in the urine.


5.4 Biological Half-Life

The half life of elimination is 7-10 h.


5.5 Mechanism of Action

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at 1-adrenergic receptors. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.


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Virtual BoothAMI Lifesciences is Driven by Chemistry. Powered by People.

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Fimasartan

About the Company : Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory thera...

Ami Lifesciences, established in 2006, is one of the fastest growing API manufacturing companies in India. Specializing in cardiovascular, anti-diabetic, CNS, and respiratory therapeutic areas, Ami offers a wide range of APIs, intermediates, key starting materials, as well as contract bulk manufacturing services. Ami's manufacturing units in Gujarat and Karnataka feature dedicated clean rooms for APIs and adhere to international standards like EU-GMP, WHO-GMP, PMDA, and COFEPRIS. Ami serves as a reliable partner for contract development and manufacturing, offering generic APIs to global pharma companies across more than 60 countries.
AMI Lifesciences

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Fimasartan

About the Company : Aurore Life Sciences is a pure-play API manufacturer with a diverse portfolio of capabilities in delivering efficiencies to generic players globally. Founded in 2017 by a team with...

Aurore Life Sciences is a pure-play API manufacturer with a diverse portfolio of capabilities in delivering efficiencies to generic players globally. Founded in 2017 by a team with vast experience across the pharmaceutical value chain, the company is on a mission to become the most preferred partner for pharmaceuticals. At Aurore, we aim to push the boundaries to manufacture and deliver high quality products that can be relied upon by both customers and regulators. Our thrust on rapidly adding capabilities have led us to acquire, integrate and expand our reach across the geographies.
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fimasartan potassium hydrate

About the Company : Boryung Pharmaceutical, aiming at the best not the biggest, started from the pharmacy since 1957 and has put a strong presence in Korean market as one of TOP leading pharmaceutical...

Boryung Pharmaceutical, aiming at the best not the biggest, started from the pharmacy since 1957 and has put a strong presence in Korean market as one of TOP leading pharmaceutical companies. Boryung has invested continually on research and development and made continuous efforts to produce high-quality products. Lately by developing new drug of Fimasartan(new chemical entity by Boryung's technology) with its own R&D, Boryung is accelerating its R&D activity to become global health care company. Also, synthetic API's & oncology formulation are core competence and have been attractive to many customers in regulated & non-regulated markets.
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Fimasartan

About the Company : Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Ex...

Guangzhou Tosun Pharmaceutical was founded in 1999, which mainly focuses on importation & exportation of Active Pharmaceutical Ingrediants, Chemical Raw Materials, Intermediate, Excipients, Herbal extracts, Formulation of Chinese & Western Medicine. With abundant economic strength, the group has successfully developed to a pharmaceutical group enterprise wich intergrets operation of medicine & related products, processing & manufacturing, and importation & exportation together.
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Fimasartan

About the Company : Kimia Biosciences, established in 1993, is focused on manufacturing bulk drugs for various therapeutic segments. With a strong emphasis on excellence and advanced technologies, Kim...

Kimia Biosciences, established in 1993, is focused on manufacturing bulk drugs for various therapeutic segments. With a strong emphasis on excellence and advanced technologies, Kimia aims to become a globally recognized company in both APIs and FDFs while upholding clean business practices. Kimia's state-of-the-art facilities at Village Bhondsi, Gurugram enable it to produce a wide range of APIs. Kimia also plans to establish its own facilities for lifestyle segments, adhering to international regulatory standards. Kimia aims to provide the best pharmaceutical products and support to consumers and healthcare professionals.
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Fimasartan

About the Company : Kukjeon Pharmaceutical has been contributing towards advancing Korea’s pharmaceutical industry with its active pharmaceutical ingredients (API) based on professional capacity bui...

Kukjeon Pharmaceutical has been contributing towards advancing Korea’s pharmaceutical industry with its active pharmaceutical ingredients (API) based on professional capacity built up over the course of 50 years. Currently, we supply API to over 200 pharmaceutical and electronics companies at home and abroad. We are a chemical total solution provider that offers a whole range of chemical-based products and services, equipped with an organizational system and capacity to conduct research and development as well as foundational businesses.
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Fimasartan

About the Company : Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry since our inception in 1988. Our resources are dedicated to promoting better health ...

Medilux Laboratories has been providing quality back-end support to the pharmaceutical industry since our inception in 1988. Our resources are dedicated to promoting better health through products that offer superior value. Located in Pithampur, Madhya Pradesh, Medilux Laboratories is committed to strategic research, delivering a complex range of globally benchmarked chemistries. Our products and services are rapidly making strides in the global pharmaceutical space, giving us the impetus to constantly strive for excellence and provide quality customer service.
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Fimasartan

About the Company : Prajna is an innovation driven pharmaceutical company. We dedicated to Research, Process development and Manufacturing APIs and Advanced Intermediates for Active Pharmaceutical Ing...

Prajna is an innovation driven pharmaceutical company. We dedicated to Research, Process development and Manufacturing APIs and Advanced Intermediates for Active Pharmaceutical Ingredients (APIs) for the global pharmaceutical companies. It provides value-added services in Contract Research, Custom Synthesis, and Specialties Scientific technology (Green Process, APIs Process Development, Polymorphism, Crystallisation and Purification) for Pharmaceutical and Life Sciences industry.
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Fimasartan

About the Company : Synaptics Labs Private Limited is a young Pharmaceutical Company with a fully integrated and globally specialized in the development, production and marketing of API’s "Active Ph...

Synaptics Labs Private Limited is a young Pharmaceutical Company with a fully integrated and globally specialized in the development, production and marketing of API’s "Active Pharmaceuticals Ingredients" and its advanced Intermediates, thanks to our focus on satisfying our customers' requirements and supporting the consolidation of a robust infrastructure. The Company promoted by a team of technocrats holding a master’s degree in pharmaceuticals and who have been involved in different Pharmaceutical companies since 24years.
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BHONDSI, TEHSIL SOHNA,,KHASR A NO. 214, DAMDAMA LAKE ROAD,, GURGAON,HARYANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1643826600,"product":"FIMASARTAN POTASSIUM TRIHYDRATE","address":"2ND FLOOR, PRESTIGE PLAZA, 40 URMI NEAR URMI CROSSING, BPC ROAD, AKOTA","city":"VADODARA","supplier":"AMI LIFESCIENCES PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"KOREA","customerCountry":"KOREA, REPUBLIC OF","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"2600","totalValueFC":"2454.7","currency":"USD","unitRateINR":184000,"date":"03-Feb-2022","totalValueINR":"184000","totalValueInUsd":"2454.7","indian_port":"BOMBAY AIR","hs_no":"29335990","bill_no":"7962241","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"2ND FLOOR, PRESTIGE PLAZA, 40 URMI NEAR URMI CROSSING, BPC ROAD, AKOTA, VADODARA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1648233000,"product":"FIMASARTAN","address":"JUBILEE HEIGHTS PLOT NO 68 & 69,2N D FLOOR SY NOS 66 & 67 MADHAPUR","city":"HYDERABAD,TELANGANA","supplier":"AURORE LIFE SCIENCES","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"KEB HANA BANK","customerCountry":"KOREA, REPUBLIC OF","quantity":"70.00","actualQuantity":"70","unit":"KGS","unitRateFc":"1000","totalValueFC":"68368.3","currency":"USD","unitRateINR":74442.857142857145,"date":"26-Mar-2022","totalValueINR":"5211000","totalValueInUsd":"68368.3","indian_port":"HYDERABAD AIR","hs_no":"29335990","bill_no":"9246995","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"JUBILEE HEIGHTS PLOT NO 68 & 69,2N D FLOOR SY NOS 66 & 67 MADHAPUR, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1654021800,"product":"FIMASARTAN POTASSIUM TRIHYDRATE BN.KB\/FI","address":"VILL. 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13-Feb-2021
17-Sep-2024
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ABOUT THIS PAGE

Fimasartan Manufacturers

A Fimasartan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fimasartan, including repackagers and relabelers. The FDA regulates Fimasartan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fimasartan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Fimasartan manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Fimasartan Suppliers

A Fimasartan supplier is an individual or a company that provides Fimasartan active pharmaceutical ingredient (API) or Fimasartan finished formulations upon request. The Fimasartan suppliers may include Fimasartan API manufacturers, exporters, distributors and traders.

click here to find a list of Fimasartan suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Fimasartan KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Fimasartan Drug Master File in Korea (Fimasartan KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Fimasartan. The MFDS reviews the Fimasartan KDMF as part of the drug registration process and uses the information provided in the Fimasartan KDMF to evaluate the safety and efficacy of the drug.

After submitting a Fimasartan KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Fimasartan API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Fimasartan suppliers with KDMF on PharmaCompass.

Fimasartan WC

A Fimasartan written confirmation (Fimasartan WC) is an official document issued by a regulatory agency to a Fimasartan manufacturer, verifying that the manufacturing facility of a Fimasartan active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Fimasartan APIs or Fimasartan finished pharmaceutical products to another nation, regulatory agencies frequently require a Fimasartan WC (written confirmation) as part of the regulatory process.

click here to find a list of Fimasartan suppliers with Written Confirmation (WC) on PharmaCompass.

Fimasartan GMP

Fimasartan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fimasartan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fimasartan GMP manufacturer or Fimasartan GMP API supplier for your needs.

Fimasartan CoA

A Fimasartan CoA (Certificate of Analysis) is a formal document that attests to Fimasartan's compliance with Fimasartan specifications and serves as a tool for batch-level quality control.

Fimasartan CoA mostly includes findings from lab analyses of a specific batch. For each Fimasartan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fimasartan may be tested according to a variety of international standards, such as European Pharmacopoeia (Fimasartan EP), Fimasartan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fimasartan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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