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Chemistry

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Also known as: Qgc-001, 648927-86-0, Rb-150, Qgc001, Rb150, 638ky4573i
Molecular Formula
C8H20N2O6S4
Molecular Weight
368.5  g/mol
InChI Key
HJPXZXVKLGEMGP-YUMQZZPRSA-N
FDA UNII
638KY4573I

Firibastat
QGC001 has been used in trials studying the treatment of Essential Hypertension.
1 2D Structure

Firibastat

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3S)-3-amino-4-[[(2S)-2-amino-4-sulfobutyl]disulfanyl]butane-1-sulfonic acid
2.1.2 InChI
InChI=1S/C8H20N2O6S4/c9-7(1-3-19(11,12)13)5-17-18-6-8(10)2-4-20(14,15)16/h7-8H,1-6,9-10H2,(H,11,12,13)(H,14,15,16)/t7-,8-/m0/s1
2.1.3 InChI Key
HJPXZXVKLGEMGP-YUMQZZPRSA-N
2.1.4 Canonical SMILES
C(CS(=O)(=O)O)C(CSSCC(CCS(=O)(=O)O)N)N
2.1.5 Isomeric SMILES
C(CS(=O)(=O)O)[C@@H](CSSC[C@H](CCS(=O)(=O)O)N)N
2.2 Other Identifiers
2.2.1 UNII
638KY4573I
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4,4'-dithio(bis(3-aminobutyl Sulfonic Acid))

2. Rb 150

3. Rb-150

4. Rb150

5. Rb150 Cpd

2.3.2 Depositor-Supplied Synonyms

1. Qgc-001

2. 648927-86-0

3. Rb-150

4. Qgc001

5. Rb150

6. 638ky4573i

7. 1-butanesulfonic Acid, 4,4'-dithiobis(3-amino-, (3s,3's)-

8. (s)-3-amino-4-(((s)-2-amino-4-sulfobutyl)disulfaneyl)butane-1-sulfonic Acid

9. Unii-638ky4573i

10. Qgc 001

11. Firibastat [inn]

12. Firibastat [who-dd]

13. Schembl1694944

14. Chembl4297511

15. (3s,3's)-4,4'-dithiobis(3-aminobutane-1-sulfonic Acid)

16. Glxc-25368

17. Db13107

18. Hy-109058

19. Cs-0032985

20. 4,4'-dithio(bis(3-aminobutyl Sulfonic Acid))

21. Q27263587

22. (3s,3's)-4,4'-disulfanediylbis(3-aminobutane-1-sulfonicacid)

23. (3s,3s')-4,4'-disulfanediylbis(3-aminobutane-1-sulfonic Acid)

24. (3s)-3-amino-4-[[(2s)-2-amino-4-sulfobutyl]disulfanyl]butane-1-sulfonic Acid

25. 1601301-49-8

2.4 Create Date
2008-07-14
3 Chemical and Physical Properties
Molecular Weight 368.5 g/mol
Molecular Formula C8H20N2O6S4
XLogP3-6.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count10
Rotatable Bond Count11
Exact Mass368.02042106 g/mol
Monoisotopic Mass368.02042106 g/mol
Topological Polar Surface Area228 Ų
Heavy Atom Count20
Formal Charge0
Complexity410
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


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ABOUT THIS PAGE

Firibastat Manufacturers

A Firibastat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Firibastat, including repackagers and relabelers. The FDA regulates Firibastat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Firibastat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Firibastat Suppliers

A Firibastat supplier is an individual or a company that provides Firibastat active pharmaceutical ingredient (API) or Firibastat finished formulations upon request. The Firibastat suppliers may include Firibastat API manufacturers, exporters, distributors and traders.

Firibastat GMP

Firibastat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Firibastat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Firibastat GMP manufacturer or Firibastat GMP API supplier for your needs.

Firibastat CoA

A Firibastat CoA (Certificate of Analysis) is a formal document that attests to Firibastat's compliance with Firibastat specifications and serves as a tool for batch-level quality control.

Firibastat CoA mostly includes findings from lab analyses of a specific batch. For each Firibastat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Firibastat may be tested according to a variety of international standards, such as European Pharmacopoeia (Firibastat EP), Firibastat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Firibastat USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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