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    Chemistry

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    Also known as: 3717-88-2, Flavoxate hcl, Urispas, Dw-61, Flavoxate (hydrochloride), Bladderon
    Molecular Formula
    C24H26ClNO4
    Molecular Weight
    427.9  g/mol
    InChI Key
    XOEVKNFZUQEERE-UHFFFAOYSA-N
    FDA UNII
    9C05J6089W
    Flavoxate
    A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist.
    1 2D Structure

    Flavoxate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate;hydrochloride
    2.1.2 InChI
    InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H
    2.1.3 InChI Key
    XOEVKNFZUQEERE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(OC2=C(C1=O)C=CC=C2C(=O)OCCN3CCCCC3)C4=CC=CC=C4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    9C05J6089W
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bladuril

    2. Flavoxate

    3. Hydrochloride, Flavoxate

    4. Spasuret

    5. Urispas

    6. Uronid

    2.3.2 Depositor-Supplied Synonyms

    1. 3717-88-2

    2. Flavoxate Hcl

    3. Urispas

    4. Dw-61

    5. Flavoxate (hydrochloride)

    6. Bladderon

    7. Peflate

    8. Spasmal

    9. Nsc-114649

    10. Dw 61 (flavoxate)

    11. 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4h-chromene-8-carboxylate Hydrochloride

    12. Rec 7/0040

    13. Rec-7-0040;dw61

    14. Flavoxate Hydrochloride

    15. Chebi:5089

    16. 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylate Hydrochloride

    17. 9c05j6089w

    18. Piperidinoethyl-3-methylflavone-8-carboxylate Hydrochloride

    19. Spasuret Hydrochloride

    20. Dsstox_cid_27764

    21. Dsstox_rid_82541

    22. Dsstox_gsid_47784

    23. 4h-1-benzopyran-8-carboxylic Acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl Ester, Hydrochloride

    24. Genurin

    25. Spasuret

    26. Urispadol

    27. Verrispasmin Amp.

    28. 2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate;hydrochloride

    29. Ak 123

    30. Nsc114649

    31. Rec-7-0040

    32. Ncgc00016636-01

    33. Cas-3717-88-2

    34. Ccris 1950

    35. Sr-01000872667

    36. Unii-9c05j6089w

    37. Prestwick_884

    38. Einecs 223-066-4

    39. Mfcd00072099

    40. Nsc 114649

    41. Rec 7-0040

    42. Flavoxate Hydrochloride [usan:usp:jan]

    43. Rec-7-0040 Hcl

    44. Mls002154247

    45. Schembl124540

    46. Dw61

    47. Chembl1200875

    48. Dtxsid1047784

    49. Hy-b0549a

    50. 1-piperidinoethanol, Hydrochloride

    51. Hms1568b06

    52. Bcp13298

    53. Flavoxate Hydrochloride [mi]

    54. Tox21_110537

    55. Flavoxate Hydrochloride (jp17/usp)

    56. Flavoxate Hydrochloride [jan]

    57. S4027

    58. Flavoxate Hydrochloride [usan]

    59. Akos025310107

    60. Tox21_110537_1

    61. Ac-1093

    62. Ccg-220242

    63. Flavoxate Hydrochloride [mart.]

    64. 1-piperidineethanol, 3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylate, Hydrochloride

    65. 2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate Hydrochloride

    66. Flavoxate Hydrochloride [usp-rs]

    67. Flavoxate Hydrochloride [who-dd]

    68. Dw-61;rec-7-0040;dw61

    69. Ncgc00016636-05

    70. 4h-1-benzopyran-8-carboxylic Acid, 3-methyl-4-oxo-2-phenyl-, 2-piperidinoethyl Ester, Hydrochloride

    71. As-12321

    72. Smr000499576

    73. F0717

    74. Flavoxate Hydrochloride [ep Impurity]

    75. Flavoxate Hydrochloride [orange Book]

    76. Ft-0658191

    77. Ft-0668549

    78. Sw197005-3

    79. Flavoxate Hydrochloride [ep Monograph]

    80. D00718

    81. D90684

    82. Flavoxate Hydrochloride [usp Monograph]

    83. Flavoxate Hydrochloride, >=98% (hplc), Solid

    84. J-521367

    85. Sr-01000872667-1

    86. Q27106648

    87. Wln: T66 Bo Evj Cr& D1 Jvo2- At6ntj &gh

    88. 4h-1-benzopyran-8-carboxylic Acid, 2-piperidinoethyl Ester, Hydrochloride

    89. Flavoxate Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    90. Flavoxate Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    91. 1-(2-{[(3-methyl-4-oxo-2-phenyl-4h-chromen-8-yl)carbonyl]oxy}ethyl)piperidinium Chloride

    92. 2-(piperidin-1-yl)ethyl3-methyl-4-oxo-2-phenyl-4h-chromene-8-carboxylatehydrochloride

    93. 2-piperidinoethyl-3-methyl-4-oxo-2-phenyl-4h-1-benzopyran-8-carboxylate Hydrochloride

    94. 4h-1-benzopyran-8-carboxylic Acid, 2-(1-piperidinyl)ethyl Ester, Hydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 427.9 g/mol
    Molecular Formula C24H26ClNO4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count6
    Exact Mass427.1550360 g/mol
    Monoisotopic Mass427.1550360 g/mol
    Topological Polar Surface Area55.8 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity631
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFlavoxate hydrochloride
    Drug LabelFlavoxate hydrochloride tablets contain flavoxate hydrochloride, a synthetic urinary tract spasmolytic.Chemically, flavoxate hydrochloride is 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate hydrochloride. The empirical formula...
    Active IngredientFlavoxate hydrochloride
    Dosage FormTablet
    RouteOral
    Strength100mg
    Market StatusPrescription
    CompanyImpax Pharms; Epic Pharma; Paddock

    2 of 2  
    Drug NameFlavoxate hydrochloride
    Drug LabelFlavoxate hydrochloride tablets contain flavoxate hydrochloride, a synthetic urinary tract spasmolytic.Chemically, flavoxate hydrochloride is 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate hydrochloride. The empirical formula...
    Active IngredientFlavoxate hydrochloride
    Dosage FormTablet
    RouteOral
    Strength100mg
    Market StatusPrescription
    CompanyImpax Pharms; Epic Pharma; Paddock

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

    Urological Agents

    Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Cholinergic Muscarinic Antagonists [MoA]; Cholinergic Muscarinic Antagonist [EPC]

    API Reference Price

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AP","supplier":"SRIAM LABS","supplierCountry":"INDIA","foreign_port":"DUBAI","customer":"GULF AGENCY COMPANY DUBAI LLC","customerCountry":"UNITED ARAB EMIRATES","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"145","totalValueFC":"28391.3","currency":"USD","unitRateINR":11896.129150000001,"date":"11-Sep-2024","totalValueINR":"2379225.83","totalValueInUsd":"28391.3","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"3917812","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UNITED ARAB EMIRATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"3RD FLOOR, SDE SERENE CHAMBERS,, HYDERABAD. AP","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730831400,"product":"FLAVOXATE HCL BP","address":"70, PRINCESS STREET,","city":"MUMBAI, MAHARASHTRA.","supplier":"PREMIER DRUG HOUSE","supplierCountry":"INDIA","foreign_port":"BIRGUNJ","customer":"TO THE ORDER OF","customerCountry":"NEPAL","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"5720","totalValueFC":"1694.6","currency":"INR","unitRateINR":5720,"date":"06-Nov-2024","totalValueINR":"143000","totalValueInUsd":"1694.6","indian_port":"Raxaul","hs_no":"29321990","bill_no":"5401408","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NEPAL","selfForZScoreResived":"Pharma Grade","supplierPort":"Raxaul","supplierAddress":"70, PRINCESS STREET,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731004200,"product":"FLAVOXATE HCL BP","address":"29-B, RABINDRA SARANI,,2ND FLOOR,","city":"KOLKATA,WEST BENGAL","supplier":"K KUMAR & ","supplierCountry":"INDIA","foreign_port":"BHAIRAWA","customer":"ASIAN PHARMACEUTICALS PVT LTD","customerCountry":"NEPAL","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"6500","totalValueFC":"3861.9","currency":"INR","unitRateINR":6518,"date":"08-Nov-2024","totalValueINR":"325900","totalValueInUsd":"3861.9","indian_port":"Sonauli","hs_no":"29321990","bill_no":"5440714","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NEPAL","selfForZScoreResived":"Pharma Grade","supplierPort":"Sonauli","supplierAddress":"29-B, RABINDRA SARANI,,2ND FLOOR,, KOLKATA,WEST BENGAL","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1731695400,"product":"FLAVOXATE HYDROCHLORIDE BP","address":"KAMALA BHUVAN NO.2, 1ST FLR. 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D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.000075","unit":"KGS","unitRateFc":"410133.3","totalValueFC":"32.1","currency":"USD","unitRateINR":"35097733.3","date":"06-Apr-2023","totalValueINR":"2632.33","totalValueInUsd":"32.1","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"5392222","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1680719400,"product":"FLAVOXATE HYDROCHLORIDE (QTY:3 X 1.5 GMS, VALUE:USD 373.83\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"INDIA","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0045","unit":"KGS","unitRateFc":"249220","totalValueFC":"1171.1","currency":"USD","unitRateINR":"21327326.7","date":"06-Apr-2023","totalValueINR":"95972.97","totalValueInUsd":"1171.1","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"5392222","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"}]
    11-Jan-2021
    16-Nov-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    INTERMEDIATES SUPPLIERS

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    01

    Ocimum Labs

    India
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    Ocimum Labs

    India
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    3-Methylflavone -8-Carboxylic Acid

    CAS Number : 3468-01-7

    End Use API : Flavoxate

    About The Company : Ocimum Labs was founded in 2018 and started its R&D activities with a cutting-edge facility. The Hyderabad-based firm focuses on process research and developmen...

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    Ocimum Labs

    India
    Duphat
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    Ocimum Labs

    India
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    1-(2-Chloroethyl)-piperidine hydrochloride

    CAS Number : 2008-75-5

    End Use API : Flavoxate

    About The Company : Ocimum Labs was founded in 2018 and started its R&D activities with a cutting-edge facility. The Hyderabad-based firm focuses on process research and developmen...

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    USP

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    ABOUT THIS PAGE

    Flavoxate Manufacturers

    A Flavoxate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Flavoxate, including repackagers and relabelers. The FDA regulates Flavoxate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Flavoxate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Flavoxate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Flavoxate Suppliers

    A Flavoxate supplier is an individual or a company that provides Flavoxate active pharmaceutical ingredient (API) or Flavoxate finished formulations upon request. The Flavoxate suppliers may include Flavoxate API manufacturers, exporters, distributors and traders.

    click here to find a list of Flavoxate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Flavoxate USDMF

    A Flavoxate DMF (Drug Master File) is a document detailing the whole manufacturing process of Flavoxate active pharmaceutical ingredient (API) in detail. Different forms of Flavoxate DMFs exist exist since differing nations have different regulations, such as Flavoxate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Flavoxate DMF submitted to regulatory agencies in the US is known as a USDMF. Flavoxate USDMF includes data on Flavoxate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Flavoxate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Flavoxate suppliers with USDMF on PharmaCompass.

    Flavoxate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Flavoxate Drug Master File in Japan (Flavoxate JDMF) empowers Flavoxate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Flavoxate JDMF during the approval evaluation for pharmaceutical products. At the time of Flavoxate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Flavoxate suppliers with JDMF on PharmaCompass.

    Flavoxate KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Flavoxate Drug Master File in Korea (Flavoxate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Flavoxate. The MFDS reviews the Flavoxate KDMF as part of the drug registration process and uses the information provided in the Flavoxate KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Flavoxate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Flavoxate API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Flavoxate suppliers with KDMF on PharmaCompass.

    Flavoxate WC

    A Flavoxate written confirmation (Flavoxate WC) is an official document issued by a regulatory agency to a Flavoxate manufacturer, verifying that the manufacturing facility of a Flavoxate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Flavoxate APIs or Flavoxate finished pharmaceutical products to another nation, regulatory agencies frequently require a Flavoxate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Flavoxate suppliers with Written Confirmation (WC) on PharmaCompass.

    Flavoxate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Flavoxate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Flavoxate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Flavoxate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Flavoxate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Flavoxate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Flavoxate suppliers with NDC on PharmaCompass.

    Flavoxate GMP

    Flavoxate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Flavoxate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Flavoxate GMP manufacturer or Flavoxate GMP API supplier for your needs.

    Flavoxate CoA

    A Flavoxate CoA (Certificate of Analysis) is a formal document that attests to Flavoxate's compliance with Flavoxate specifications and serves as a tool for batch-level quality control.

    Flavoxate CoA mostly includes findings from lab analyses of a specific batch. For each Flavoxate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Flavoxate may be tested according to a variety of international standards, such as European Pharmacopoeia (Flavoxate EP), Flavoxate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Flavoxate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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