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Chemistry

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Also known as: 112859-71-9, R7m5ugd04g, 156680-74-9, Chembl4441355, 16alpha-fluoro-5-androsten-17-one, (8r,9s,10r,13s,14s,16r)-16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
Molecular Formula
C19H27FO
Molecular Weight
290.4  g/mol
InChI Key
VHZXNQKVFDBFIK-NBBHSKLNSA-N
FDA UNII
R7M5UGD04G

Fluasterone
Has antiproliferative effects on HIV-1 and reduces HIV-1 replication.
1 2D Structure

Fluasterone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8R,9S,10R,13S,14S,16R)-16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
2.1.2 InChI
InChI=1S/C19H27FO/c1-18-9-4-3-5-12(18)6-7-13-14(18)8-10-19(2)15(13)11-16(20)17(19)21/h6,13-16H,3-5,7-11H2,1-2H3/t13-,14+,15+,16-,18+,19+/m1/s1
2.1.3 InChI Key
VHZXNQKVFDBFIK-NBBHSKLNSA-N
2.1.4 Canonical SMILES
CC12CCCCC1=CCC3C2CCC4(C3CC(C4=O)F)C
2.1.5 Isomeric SMILES
C[C@]12CCCCC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3C[C@H](C4=O)F)C
2.2 Other Identifiers
2.2.1 UNII
R7M5UGD04G
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-androstene-16-fluoro-17-one

2. 5-androstene-16alpha-fluoro-17-one

3. Dhea Analog 8354

4. He2500

2.3.2 Depositor-Supplied Synonyms

1. 112859-71-9

2. R7m5ugd04g

3. 156680-74-9

4. Chembl4441355

5. 16alpha-fluoro-5-androsten-17-one

6. (8r,9s,10r,13s,14s,16r)-16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

7. 16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

8. 16-fluoro-5-androsten-17-one

9. He2500

10. Unii-r7m5ugd04g

11. Ccris 4216

12. 8354 Compound

13. Schembl1418930

14. Niosh/bv8387230

15. Dtxsid90920920

16. Zinc3778181

17. Bdbm50507597

18. 16-alpha-fluoro-5-androsten-17-one

19. Db06250

20. Bv83872300

21. 16.alpha.-fluoroandrost-5-en-17-one

22. Androst-5-en-17-one, 16-fluoro-, (16alpha)-

23. Androst-5-en-17-one, 16-fluoro-, (16-alpha)-

24. J-002855

25. Androst-5-en-17-one, 16-fluoro-, (16.alpha.)-

26. Q27287895

27. (2r,3as,3br,9ar,9bs,11as)-2-fluoro-9a,11a-dimethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-1-one

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 290.4 g/mol
Molecular Formula C19H27FO
XLogP35.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass290.20459364 g/mol
Monoisotopic Mass290.20459364 g/mol
Topological Polar Surface Area17.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity510
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity.


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

Fluasterone is a synthetically stable adrenocortical steroid fluorinated analogue of dehydroepiandrosterone (DHEA), a powerful anti-inflammatory molecule with androgenic or estrogenic side effects. It is proposed that fluasterone inhibits NF-kB activation and reduces oxidative stress, but other mechanisms may play a role. Fluasterone suppresses inflammation and is effective in preclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. Fluasterone has anti-inflammatory effects inpreclinical models of chronic inflammatory disease including psoriasis, asthma, rheumatoid arthritis, multiple sclerosis and lupus erythematosus. [Aeson Pharmaceuticals Executive Report]


ABOUT THIS PAGE

Looking for 112859-71-9 / Fluasterone API manufacturers, exporters & distributors?

Fluasterone manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Fluasterone API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Fluasterone manufacturer or Fluasterone supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Fluasterone manufacturer or Fluasterone supplier.

PharmaCompass also assists you with knowing the Fluasterone API Price utilized in the formulation of products. Fluasterone API Price is not always fixed or binding as the Fluasterone Price is obtained through a variety of data sources. The Fluasterone Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Fluasterone

Synonyms

112859-71-9, R7m5ugd04g, 156680-74-9, Chembl4441355, 16alpha-fluoro-5-androsten-17-one, (8r,9s,10r,13s,14s,16r)-16-fluoro-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one

Cas Number

112859-71-9

Unique Ingredient Identifier (UNII)

R7M5UGD04G

About Fluasterone

Has antiproliferative effects on HIV-1 and reduces HIV-1 replication.

Fluasterone Manufacturers

A Fluasterone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fluasterone, including repackagers and relabelers. The FDA regulates Fluasterone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fluasterone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Fluasterone Suppliers

A Fluasterone supplier is an individual or a company that provides Fluasterone active pharmaceutical ingredient (API) or Fluasterone finished formulations upon request. The Fluasterone suppliers may include Fluasterone API manufacturers, exporters, distributors and traders.

Fluasterone GMP

Fluasterone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fluasterone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fluasterone GMP manufacturer or Fluasterone GMP API supplier for your needs.

Fluasterone CoA

A Fluasterone CoA (Certificate of Analysis) is a formal document that attests to Fluasterone's compliance with Fluasterone specifications and serves as a tool for batch-level quality control.

Fluasterone CoA mostly includes findings from lab analyses of a specific batch. For each Fluasterone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fluasterone may be tested according to a variety of international standards, such as European Pharmacopoeia (Fluasterone EP), Fluasterone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fluasterone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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