1. 6 Alpha-fluorodihydroxy-16 Alpha,17 Alpha-isopropylidenedioxy-1,4-pregnadiene-3,20- Dione
2. 6alpha-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16, 17-acetal With Acetone
3. Aerobid
4. Aerospan
5. Apo-flunisolide
6. Flunisolide 21-acetate
7. Flunisolide Acetate
8. Flunisolide Anhydrous
9. Flunisolide Hemihydrate
10. Flunisolide Hemihydrate, (6alpha,11beta,16alpha)-isomer
11. Flunisolide Hfa
12. Flunisolide Hydrofluoroalkane
13. Flunisolide, (6beta,11beta,16alpha)-isomer
14. Inhacort
15. Nasalide
16. Nasarel
17. Ratio-flunisolide
18. Rhinalar
19. Rs-1320
20. Rs-3999
21. Rs1320
22. Syntaris
1. 3385-03-3
2. Aerobid
3. Rhinalar
4. Synaclyn
5. Flunisolide Anhydrous
6. Nasarel
7. Syntaris
8. Flunisolide Hfa
9. Nasalide
10. Aerospan
11. Bronalide
12. Flunisolide [inn]
13. Flunisolida
14. Flunisolidum
15. Aerospan Hfa
16. Lunis
17. Rs-3999
18. Chebi:5106
19. Flunisolide Hemihydrate
20. Nisolid
21. Soluzione
22. Mls002153928
23. 78m02aa8kf
24. Pregna-1,4-diene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-
25. Aerobid M
26. Dsstox_cid_25534
27. Dsstox_rid_80936
28. Dsstox_gsid_45534
29. (1s,2s,4r,8s,9s,11s,12s,13r,19s)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
30. Flunisolide [anhydrous]
31. Cas-3385-03-3
32. Nsc-757871
33. Flunisolidum [inn-latin]
34. Flunisolida [inn-spanish]
35. Syntaris Hayfever
36. Ncgc00016983-01
37. Lunisolide Anhydrous
38. Prestwick_223
39. Einecs 222-193-2
40. Rs 3999
41. Flunisolide [mi]
42. Prestwick0_000643
43. Prestwick1_000643
44. Prestwick2_000643
45. Prestwick3_000643
46. Schembl4351
47. Chembl1512
48. Unii-78m02aa8kf
49. Bspbio_000645
50. Flunisolide [who-dd]
51. 6alpha-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16, 17-acetal With Acetone
52. Spbio_002566
53. Bpbio1_000711
54. Gtpl7076
55. Dtxsid1045534
56. Hms1570a07
57. Hms2097a07
58. Hms2236a06
59. Hms3259l10
60. Hms3714a07
61. Hy-b1121
62. Zinc4097305
63. Tox21_110725
64. Bdbm50248007
65. Akos025402038
66. Tox21_110725_1
67. Ac-3514
68. Bcp9000696
69. Ccg-220643
70. Cs-4713
71. Db00180
72. Nc00716
73. 6-fluoro-11,21-dihydroxy-16,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
74. Ncgc00179492-01
75. Ncgc00179492-03
76. Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, Cyclic 16,17-acetal With Acetone
77. Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
78. Smr001233272
79. Flunisolide 100 Microg/ml In Acetonitrile
80. F0437
81. (6a,11b,16a)-6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione
82. C07005
83. D78324
84. 385f033
85. Q3746835
86. Brd-k49577446-001-03-1
87. (1s,2s,4r,8s,9s,11s,12s,13r,19s)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one
88. 6.alpha.-fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-acetal With Acetone
89. 6alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
90. Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))- (6.alpha.,11.beta.,16.alpha.)-
| Molecular Weight | 434.5 g/mol |
|---|---|
| Molecular Formula | C24H31FO6 |
| XLogP3 | 2.5 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 2 |
| Exact Mass | 434.21046687 g/mol |
| Monoisotopic Mass | 434.21046687 g/mol |
| Topological Polar Surface Area | 93.1 Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 910 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 9 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
| 1 of 4 | |
|---|---|
| Drug Name | Aerospan hfa |
| PubMed Health | Flunisolide |
| Drug Classes | Anti-Inflammatory |
| Drug Label | Flunisolide hemihydrate, the active component of AEROSPANTM (flunisolide HFA, 80 mcg) Inhalation Aerosol, is a corticosteroid having the chemical name 6-Fluoro-11, 16, 17, 21 tetrahydroxylpregna-1, 4-diene-3, 20-dione cyclic-16, 17-acetal wi... |
| Active Ingredient | Flunisolide |
| Dosage Form | Aerosol, metered |
| Route | Inhalation |
| Strength | 0.078mg/inh |
| Market Status | Prescription |
| Company | Meda Pharms |
| 2 of 4 | |
|---|---|
| Drug Name | Flunisolide |
| Active Ingredient | Flunisolide |
| Dosage Form | Spray, metered |
| Route | Nasal |
| Strength | 0.025mg/spray; 0.029mg/spray |
| Market Status | Prescription |
| Company | Apotex; Hi Tech Pharma; Bausch And Lomb |
| 3 of 4 | |
|---|---|
| Drug Name | Aerospan hfa |
| PubMed Health | Flunisolide |
| Drug Classes | Anti-Inflammatory |
| Drug Label | Flunisolide hemihydrate, the active component of AEROSPANTM (flunisolide HFA, 80 mcg) Inhalation Aerosol, is a corticosteroid having the chemical name 6-Fluoro-11, 16, 17, 21 tetrahydroxylpregna-1, 4-diene-3, 20-dione cyclic-16, 17-acetal wi... |
| Active Ingredient | Flunisolide |
| Dosage Form | Aerosol, metered |
| Route | Inhalation |
| Strength | 0.078mg/inh |
| Market Status | Prescription |
| Company | Meda Pharms |
| 4 of 4 | |
|---|---|
| Drug Name | Flunisolide |
| Active Ingredient | Flunisolide |
| Dosage Form | Spray, metered |
| Route | Nasal |
| Strength | 0.025mg/spray; 0.029mg/spray |
| Market Status | Prescription |
| Company | Apotex; Hi Tech Pharma; Bausch And Lomb |
For the maintenance treatment of asthma as a prophylactic therapy.
FDA Label
Flunisolide is a synthetic corticosteroid. It is administered either as an oral metered-dose inhaler for the treatment of asthma or as a nasal spray for treating allergic rhinitis. Corticosteroids are naturally occurring hormones that prevent or suppress inflammation and immune responses. When given as an intranasal spray, flunisolide reduces watery nasal discharge (rhinorrhea), nasal congestion, postnasal drip, sneezing, and itching oat the back of the throat that are common allergic symptoms.
Anti-Asthmatic Agents
Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)
Anti-Inflammatory Agents
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
R - Respiratory system
R01 - Nasal preparations
R01A - Decongestants and other nasal preparations for topical use
R01AD - Corticosteroids
R01AD04 - Flunisolide
R - Respiratory system
R03 - Drugs for obstructive airway diseases
R03B - Other drugs for obstructive airway diseases, inhalants
R03BA - Glucocorticoids
R03BA03 - Flunisolide
Absorption
Absorbed rapidly
Primarily hepatic, converted to the S beta-OH metabolite.
1.8 hours
Flunisolide is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flunisolide binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
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