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ACTIVE PHARMA INGREDIENTS

11 API Suppliers, 7 USDMF, 1 CEP/COS, 2 NDC API, 7 Listed Suppliers, $ API Reference Price

11 API Suppliers
7 USDMF
1 CEP/COS
2 NDC API
7 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers, 2 FDA Orange Book, 4 Europe, 2 South Africa, 4 Listed Dossiers

12 FDF Dossiers
2 FDA Orange Book
4 Europe
2 South Africa
4 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.25%, SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3%

drugProductComposition
SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.25%
SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3%

RELATED EXCIPIENT COMPANIES

1 DKSH, 1 Faran Shimi Pharmaceutical, 1 Boai NKY Pharmaceuticals Ltd, 1 Gangwal Healthcare, 1 Actylis, 9 BASF, 1 Gangwal Chemicals, 1 Microlex e.U, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 1 Pluviaendo

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1 DKSH
1 Faran Shimi Pharmaceutical
1 Boai NKY Pharmaceuticals Ltd
1 Gangwal Healthcare
1 Actylis
9 BASF
1 Gangwal Chemicals
1 Microlex e.U
1 Novo Excipients
1 Pharmatrans-Sanaq
1 Pluviaendo

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7 Fillers, Diluents & Binders, 6 Solubilizers, 5 Granulation, 4 Direct Compression, 3 Controlled & Modified Release, 3 Parenteral, 1 Topical, 1 Film Formers & Plasticizers, 1 Co-Processed Excipients, 1 Coating Systems & Additives, 1 Disintegrants & Superdisintegrants, 1 Thickeners and Stabilizers

excipientsByApplications
7 Fillers, Diluents & Binders
6 Solubilizers
5 Granulation
4 Direct Compression
3 Controlled & Modified Release
3 Parenteral
1 Topical
1 Film Formers & Plasticizers
1 Co-Processed Excipients
1 Coating Systems & Additives
1 Disintegrants & Superdisintegrants
1 Thickeners and Stabilizers

DIGITAL CONTENT

5 NEWS #PharmaBuzz

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2 Finished Drug Prices

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MARKET PLACE

9 APIs, 1 FDF Dossiers

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9 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 US Patents

patents
3 US Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 2 USP , 3 Others

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1 EDQM
2 USP
3 Others

Macsen Fluorescein

Synopsis

ACTIVE PHARMA INGREDIENTS

11

API Suppliers

7

USDMF

1

CEP/COS

CEP/COS Certifications

0

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2

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7

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API REF. PRICE (USD/KG)

$

$ 94,129

MARKET PLACE

9

API

1

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

12

FDF Dossiers

2

FDA Orange Book

FDA (Orange Book)

4

Europe

0

Canada

0

Australia

2

South Africa

4

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

1

EDQM

2

USP

0

JP

3

Others

PATENTS & EXCLUSIVITIES

3

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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5

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Finished Drug Prices

19 RELATED EXCIPIENT COMPANIES

34EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 2321-07-5, Solvent yellow 94, Resorcinolphthalein, Yellow fluorescein, Fluoresceine, 3',6'-dihydroxy-3h-spiro[isobenzofuran-1,9'-xanthen]-3-one

Molecular Formula

C₂₀H₁₂O₅

Molecular Weight

332.3 g/mol

InChI Key

GNBHRKFJIUUOQI-UHFFFAOYSA-N

FDA UNII

TPY09G7XIR

Fluorescein

A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.

Fluorescein is a Diagnostic Dye. The mechanism of action of fluorescein is as a Dye.

1 2D Structure

Fluorescein

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

2.1.2 InChI

InChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H

2.1.3 InChI Key

GNBHRKFJIUUOQI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O

2.2 Other Identifiers

2.2.1 UNII

TPY09G7XIR

2.3 Synonyms

2.3.1 MeSH Synonyms

1. C.i. 45350

2. Colircusi Fluoresceina

3. D And C Yellow No. 7

4. D And C Yellow No. 8

5. Diofluor

6. Dipotassium Salt, Fluorescein

7. Disodium Fluorescein

8. Disodium Salt, Fluorescein

9. Fluor I Strip A.t.

10. Fluor-i-strip A.t.

11. Fluorescine Sodique Faure

12. Fluorescein Dipotassium Salt

13. Fluorescein Disodium Salt

14. Fluorescein Monosodium Salt

15. Fluorescein Sodium, Minims

16. Fluorescein, Disodium

17. Fluorescein, Sodium

18. Fluoresceina, Colircusi

19. Fluoresceine, Minims

20. Fluorescite

21. Fluorets

22. Ful Glo

23. Ful-glo

24. Funduscein

25. Minims Fluorescein Sodium

26. Minims Fluoresceine

27. Minims Stains

28. Monosodium Salt, Fluorescein

29. Optifluor Diba

30. Sodium Fluorescein

31. Sodium, Fluorescein

32. Uranine

2.3.2 Depositor-Supplied Synonyms

1. 2321-07-5

2. Solvent Yellow 94

3. Resorcinolphthalein

4. Yellow Fluorescein

5. Fluoresceine

6. 3',6'-dihydroxy-3h-spiro[isobenzofuran-1,9'-xanthen]-3-one

7. 3,6-fluorandiol

8. D&c Yellow No. 7

9. Japan Yellow 201

10. D And C Yellow No. 7

11. C.i. Solvent Yellow 94

12. 3',6'-dihydroxyfluoran

13. Fluorescein Acid

14. Fluoreszein

15. Soap Yellow F

16. Hidacid Fluorescein

17. Resorcinol Phthalein

18. D & C Yellow No. 7

19. D+c Yellow No. 7

20. 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone

21. Fluorescein (free Acid)

22. 11712 Yellow

23. Chebi:31624

24. 9-(o-carboxyphenyl)-6-hydroxy-3h-xanthen-3-one

25. Japan Yellow No. 201

26. Zlut Kysela 73

27. 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one

28. Fluoran, 3',6'-dihydroxy-

29. Nsc 667256

30. 3',6'-fluorandiol

31. C.i. 45350:1

32. Mfcd00005050

33. Tpy09g7xir

34. Spiro[isobenzofuran-1(3h),9'-[9h]xanthen]-3-one, 3',6'-dihydroxy-

35. Chembl1057

36. Ci 45350:1

37. 3h-xanthen-3-one, 9-(o-carboxyphenyl)-6-hydroxy-

38. Nsc667256

39. Benzoic Acid, O-(6-hydroxy-3-oxo-3h-xanthen-9-yl)-

40. Nsc-667256

41. Nsc-759114

42. Benzoic Acid, 2-(6-hydroxy-3-oxo-3h-xanthen-9-yl)-

43. Ncgc00161643-03

44. 3',6'-dihydroxyspiro(isobenzofuran-1(3h),9'(9h)-xanthen)-3-one

45. 3',6'-dihydroxyspiro(isobenzofuran-1(3h),9'-(9h)xanthen)-3-one

46. Spiro(isobenzofuran-1(3h),9'-(9h)xanthen)-3-one, 3',6'-dihydroxy-

47. 3,6-dihydroxyspiro(xanthene-9,3'-phthalide)

48. Dsstox_cid_18887

49. Dsstox_rid_79416

50. Dsstox_gsid_38887

51. 3',6'-dihydroxy-3h-spiro[2-benzofuran-1,9'-xanthen]-3-one

52. Fluorescein Red

53. Cas-2321-07-5

54. 3,6-dihydroxyspiro[xanthene-9,3'-phthalide]

55. Zlut Kysela 73 [czech]

56. Fluorecein

57. Diofluor

58. Ccris 7076

59. Hsdb 2128

60. Fluorescite (tn)

61. Diresorcinolphthalein

62. Einecs 219-031-8

63. Brn 0094324

64. Fluorescite (salt/mix)

65. 3',6' Dihydroxyfluoran

66. Fluorescein (jan/usp)

67. Fluorescein [ii]

68. Fluorescein [mi]

69. Unii-tpy09g7xir

70. Fluorescein [jan]

71. Fluorescein [hsdb]

72. Epitope Id:137337

73. Upcmld-dp087

74. Yellow 7 [inci]

75. Fluorescein [vandf]

76. Fluorescein [mart.]

77. Schembl16533

78. Fluorescein [usp-rs]

79. Fluorescein [who-dd]

80. Fluorescein [usp:ban:jan]

81. Ki201 [inci]

82. Dtxsid0038887

83. Upcmld-dp087:001

84. Acid Yellow 73 [inci]

85. Gnbhrkfjiuuoqi-uhfffaoysa-

86. Fluorescein (solvent Yellow 94)

87. C.i. 45350 (salt/mix)

88. Fluorescein [ep Monograph]

89. Hms2093f21

90. Hms3744c17

91. Moli001003

92. Pharmakon1600-01505396

93. Fluorescein [usp Monograph]

94. Amy22388

95. Hy-d0251

96. Zinc3860453

97. Tox21_113500

98. Tox21_303508

99. Bdbm50237588

100. C.i. Acid Yellow 73 (salt/mix)

101. Nsc759114

102. S5488

103. Spiro(isobenzofuran-1(3h),9'-(9h)xanthen)-3-one,3'6'-dihydroxy-

104. Akos015903296

105. Ccg-213417

106. Cs-7537

107. Db00693

108. C.i. 45350a

109. Fluorescein, For Fluorescence, Free Acid

110. Ncgc00161643-01

111. Ncgc00161643-02

112. Ncgc00257491-01

113. D & C Yellow No. 7 K7133

114. Sy012645

115. Sbi-0206827.p001

116. F0095

117. Fluorescein (free Acid), Dye Content 95 %

118. Ft-0668579

119. D01261

120. D70685

121. Ec 219-031-8

122. Ab00643381_02

123. 5-19-06-00456 (beilstein Handbook Reference)

124. Q410922

125. Sr-05000001696

126. Sr-05000001696-1

127. W-107417

128. Brd-k21913543-001-01-6

129. 3',6'-dihydroxyspiro[isobenzofuran-3,9'-xanthene]-1-one

130. E89fa0b4-4844-46a2-af9b-29eca50e5599

131. Fluorescein, European Pharmacopoeia (ep) Reference Standard

132. 3',6'-dihydroxy-3h-spiro[isobenzo[b]furan-1,9'-xanthen]-3-one

133. Fluorescein, United States Pharmacopeia (usp) Reference Standard

134. Fluorescein Low Range Dna Standard, Fluorescein-labeled Marker For Dna Electrophoresis

135. Spiro[isobenzofuran-1(3h),9'-[9h]xanthene]-ar-carboxylicacid, 3',6'-dihydroxy-3-oxo-

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₁₂O₅
Molecular Weight	332.3 g/mol
XLogP3	3.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	0
Exact Mass	332.06847348 g/mol
Monoisotopic Mass	332.06847348 g/mol
Topological Polar Surface Area	76 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	522
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Fluorescite
PubMed Health	Fluorescein (Injection)
Drug Classes	Disclosing Agent
Drug Label	FLUORESCITE (fluorescein injection, USP) 10% contains fluorescein sodium (equivalent to fluorescein 10% w/v). It is a sterile solution for use intravenously as a diagnostic aid. Its chemical name is spiro[isobenzofuran-1(3H), 9'-[9H]xanthene]-3-one..
Active Ingredient	Fluorescein sodium
Dosage Form	Injectable
Route	Intravenous
Strength	eq 500mg base/5ml (eq 100mg base/ml)
Market Status	Prescription
Company	Alcon Pharms

2 of 2
Drug Name	Fluorescite
PubMed Health	Fluorescein (Injection)
Drug Classes	Disclosing Agent
Drug Label	FLUORESCITE (fluorescein injection, USP) 10% contains fluorescein sodium (equivalent to fluorescein 10% w/v). It is a sterile solution for use intravenously as a diagnostic aid. Its chemical name is spiro[isobenzofuran-1(3H), 9'-[9H]xanthene]-3-one..
Active Ingredient	Fluorescein sodium
Dosage Form	Injectable
Route	Intravenous
Strength	eq 500mg base/5ml (eq 100mg base/ml)
Market Status	Prescription
Company	Alcon Pharms

4.2 Therapeutic Uses

Contrast Medium

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

VET: Deep corneal ulcers, descemetocele, and iris prolapse are seen with some frequency in dogs, cats, and horses. ... Important diagnostic aids are the Schirmer tear test to measure aqueous tear production and topical fluorescein to examine the corneal ulcer. ...

Kahn, C.M. (Ed.); The Merck Veterinary Manual 9th ed. Merck & Co. Whitehouse Station, NJ. 2005, p. 1416

Fluorescein is now sometimes used for determination of circulation time, adequacy of blood supply, and viability of tissue.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1004

In determination of circulation time, ... by rapid iv ... appearance of fluorescence in lips, eyes, or intact skin or in wheals (histamine or scratch) ... is taken as end point.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1004

Measurement of arm-to-retina circulation time is employed for diagnosis of carotid artery occlusion.

American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 985

4.3 Drug Warning

Adverse effects following topical administration to the eye may include irritation and rash. Fluorescein may cause yellow discoloration of skin or eyes. urine may attain a bright yellow color. Adverse effects following intravenous administration include nausea, vomiting, headache, dizziness, fainting, and low blood pressure.

United States Pharmacopeial Convention, Inc (USP); MSDS Database Online; Material Safety Data Sheet: Fluorescein; Catalog Number: 1277004; (Revision Date: January 31, 2005)

4.4 Drug Indication

For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Contrast Media

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

Fluorescent Dyes

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)

5.2 FDA Pharmacological Classification

5.2.1 Active Moiety

FLUORESCEIN

5.2.2 FDA UNII

TPY09G7XIR

5.2.3 Pharmacological Classes

Dyes [MoA]; Diagnostic Dye [EPC]

5.3 ATC Code

S01JA01

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

S - Sensory organs

S01 - Ophthalmologicals

S01J - Diagnostic agents

S01JA - Colouring agents

S01JA01 - Fluorescein

5.4 Absorption, Distribution and Excretion

Absorption

Rapidly distributed

Route of Elimination

Fluorescein and its metabolites are mainly eliminated via renal excretion.

Volume of Distribution

0.5 L/kg

Clearance

renal cl=1.75 mL/min/kg [After IV administration]

hepatic cl=1.50 mL/min/kg [After IV administration]

Fluorescence of skin persists for several hr, and dye appears in urine for as long as 30 hr.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1004

Within 7 to 14 seconds after IV administration into antecubital vein, fluorescein usually appears in the central artery of the eye. Within a few minutes of IV administration of fluorescein sodium, a yellowish discoloration of the skin occurs, which begins to fade after 6 to 12 hours of dosing. Various estimates of volume of distribution indicate that fluorescein distributes well into interstitial space (0.5 L/ kg).

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium

Fluorescein and its metabolites are mainly eliminated via renal excretion. After IV administration, the urine remains slightly fluorescent for 24 to 36 hours. A renal clearance of 1.75 mL/min/kg and a hepatic clearance (due to conjugation) of 1.50 mL/min/kg have been estimated. The systemic clearance of fluorescein was essentially complete by 48 to 72 hours after administration of 500 mg fluorescein.

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium

Fluorescein sodium has been demonstrated to be excreted in human milk.

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium

The permeability of the blood-retinal and blood-aqueous barriers to fluorescein and the rate of aqueous flow can be estimated by measurements of fluorescein in the vitreous, aqueous, and plasma after systemic administration. Fluorescein is commonly measured by fluorescence, but fluorescein glucuronide, a metabolite of fluorescein, also fluoresces. To assess the influence of fluorescein glucuronide on the quantitation of fluorescein by fluorescence, we studied the pharmacokinetics of fluorescein and fluorescein glucuronide for 38 hr in the plasma of five normal subjects given 14 mg/kg of sodium fluorescein intravenously. The plasma and the plasma ultrafiltrate were measured by fluorescence and by high performance liquid chromatography. In our fluorophotometer, fluorescein glucuronide was 0.124 times as fluorescent as fluorescein. Fluorescein was rapidly converted to fluorescein glucuronide, and within 10 min the concentration of unbound fluorescein glucuronide exceeded that of unbound fluorescein. The terminal half-lives of fluorescein and fluorescein glucuronide in the plasma ultrafiltrate were 23.5 and 264 min, respectively, so that fluorescein glucuronide contributed almost all of the plasma fluorescence after 4-5 hr. Because fluorescein glucuronide was less bound in the plasma than fluorescein, the ratio of the fluorescence of the plasma ultrafiltrate to that of the plasma increased with time. The greatest proportion of the total fluorescein available to penetrate into the ocular compartments occurred shortly after injection. ...

PMID:3721789 Blair NP et al; Invest Ophthalmol Vis Sci 27 (7): 1107-14 (1986).

5.5 Metabolism/Metabolites

The permeability of the blood-retinal and blood-aqueous barriers to fluorescein and the rate of aqueous flow can be estimated by measurements of fluorescein in the vitreous, aqueous, and plasma after systemic administration. Fluorescein is commonly measured by fluorescence, but fluorescein glucuronide, a metabolite of fluorescein, also fluoresces. To assess the influence of fluorescein glucuronide on the quantitation of fluorescein by fluorescence, we studied the pharmacokinetics of fluorescein and fluorescein glucuronide for 38 hr in the plasma of five normal subjects given 14 mg/kg of sodium fluorescein intravenously. The plasma and the plasma ultrafiltrate were measured by fluorescence and by high performance liquid chromatography. In our fluorophotometer, fluorescein glucuronide was 0.124 times as fluorescent as fluorescein. Fluorescein was rapidly converted to fluorescein glucuronide, and within 10 min the concentration of unbound fluorescein glucuronide exceeded that of unbound fluorescein. The terminal half-lives of fluorescein and fluorescein glucuronide in the plasma ultrafiltrate were 23.5 and 264 min, respectively, so that fluorescein glucuronide contributed almost all of the plasma fluorescence after 4-5 hr. Because fluorescein glucuronide was less bound in the plasma than fluorescein, the ratio of the fluorescence of the plasma ultrafiltrate to that of the plasma increased with time. The greatest proportion of the total fluorescein available to penetrate into the ocular compartments occurred shortly after injection. ...

PMID:3721789 Blair NP et al; Invest Ophthalmol Vis Sci 27 (7): 1107-14 (1986).

Fluorescein undergoes rapid metabolism to fluorescein monoglucuronide. After IV administration of fluorescein sodium (14 mg/kg) to 7 healthy subjects, approximately 80% of fluorescein in plasma was converted to glucuronide conjugate after a period of 1 hour post dose, indicating relatively rapid conjugation.

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium

Fluorescein is a known human metabolite of zinc15020070.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

5.6 Biological Half-Life

... The pharmacokinetics of fluorescein and fluorescein glucuronide /were studied/ for 38 hr in the plasma of five normal subjects given 14 mg/kg of sodium fluorescein intravenously. ... The terminal half-lives of fluorescein and fluorescein glucuronide in the plasma ultrafiltrate were 23.5 and 264 min, respectively, ... .

PMID:3721789 Blair NP et al; Invest Ophthalmol Vis Sci 27 (7): 1107-14 (1986).

5.7 Mechanism of Action

Fluorescein sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.

Fluorescein sodium responds to electromagnetic radiation and light between the wavelengths of 465-490 nm and fluoresces, i.e., emits light at wavelengths of 520-530 nm. Thus, the hydrocarbon is excited by blue light and emits light that appears yellowish-green. Following intravenous injection of fluorescein sodium in an aqueous solution, the unbound fraction of the fluorescein can be excited with a blue light flash from a fundus camera as it circulates through the ocular vasculature, and the yellowish green fluorescence of the dye is captured by the camera. In the fundus, the fluorescence of the dye demarcates the retinal and/or choroidal vasculature under observation, distinguishing it from adjacent areas/structures. /Fluorescein sodium/

US Natl Inst Health; DailyMed. Current Medication Information for Fluorescite (fluorescein sodium) injection, solution (2009). Available from, as of October 19, 2009: https://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Fluorescein+sodium

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CEP/COS

01

ICROM S.R.L. Concorezzo IT

Italy

Duphat

Not Confirmed

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NDC API

01

DELMAR CHEMICALS INC

Canada

Duphat

Not Confirmed

Minakem is manufacturing small molecules APIs including corticosteroids

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Canada

Digital Content

FLUORESCEIN

NDC Package Code : 11712-375

Start Marketing Date : 2004-08-25

End Marketing Date : 2025-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

Portfolio PDF

Product Web Link

Digital Content

Corporate PDF

02

Abbey Color Incorporated

U.S.A

Duphat

Not Confirmed

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Listed Suppliers

01

Macsen Labs

India

Duphat

Not Confirmed

Macsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

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India

Digital Content

Fluorescein

About the Company : Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our c...

Macsen is a USFDA registered, TGA GMP & WHO-GMP certified manufacturer and supplier of Active Pharmaceutical Ingredients (APIs), Biological Stains & Specialty Fine Chemicals. Our comprehensive offerings extend to Contract Research & Custom Synthesis. With a legacy of over seven decades, Macsen combines tradition with innovation to meet the evolving needs of the chemical and pharmaceutical sectors. Our commitment to quality is evident in every aspect of our operations, from state-of-the-art manufacturing facilities to advanced analytical capabilities.

Macsen Company Banner

Product Web Link

Digital Content

02

Minakem

France

Minakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

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France

Digital Content

Fluorescein

About the Company : MINAKEM is a cGMP custom manufacturer of small molecule API, HPAPI and steroids. All development and manufacturing activities are supported by highly skilled R&D teams, supported b...

MINAKEM is a cGMP custom manufacturer of small molecule API, HPAPI and steroids. All development and manufacturing activities are supported by highly skilled R&D teams, supported by strong analytical and regulatory affairs services. The R&D team has an expertise in process development, organic synthesis, and works under a secrecy agreement to protect your IP. With 3 production sites in Europe and 1 in Canada, Minakem is ready to support your strategic sourcing projects or your reshoring activities. Recently launched commercial generic API: Apixaban, Mirabegron, Fulvestrant, remifentanil, esmolol,

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Digital Content

03

Minakem (formerly Delmar Chemicals)

Canada

Duphat

Not Confirmed

Minakem is manufacturing small molecules APIs including corticosteroids

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Canada

Digital Content

Fluorescein

About the Company : Minakem Montreal is developing and manufacturing small molecules APIs and advanced intermediates, including corticosteroids. Following efficient processes and methodologies, our em...

Minakem Montreal is developing and manufacturing small molecules APIs and advanced intermediates, including corticosteroids. Following efficient processes and methodologies, our employees operate a regularly inspected cGMP facility equipped with reactors ranging from 40 to 7,600 litres. Located in Montreal, Canada, we have contributed to the success of our North-American and international clients since 1964.

Portfolio PDF

Product Web Link

Digital Content

Corporate PDF

04

Jai Radhe Sales

India

Duphat

Not Confirmed

Jai Radhe Sales is your partner for all your sourcing needs.

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India

Digital Content

Fluorescein

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

Jai Radhe Sales

Product Web Link

Digital Content

05

Guangzhou Tosun Pharmaceutical

China

Duphat

Not Confirmed

06

Icrom

Italy

Duphat

Not Confirmed

07

Unipex

France

Duphat

Not Confirmed

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API Reference Price

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ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"UNITED STATES","foreign_port":"","customer":"UNITED STATES PHARMACOPEIA ","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0004","unit":"KGS","unitRateFc":"1225000","totalValueFC":"515.1","currency":"USD","unitRateINR":"93750875","date":"26-Feb-2021","totalValueINR":"37500.35","totalValueInUsd":"515.1","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"2925115","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q1","strtotime":1614709800,"product":"6-FAM, SINGLE ISOMER (6-CARBOXYFLUORESCEIN-AMINOHEXYL AMIDITE)","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"LGC BIOSEARCH TECHNOLOGIES","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"1725","totalValueFC":"1746.3","currency":"USD","unitRateINR":"127133","date":"03-Mar-2021","totalValueINR":"127133","totalValueInUsd":"1746.3","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1002793","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"2189 S MCDOWELL BLVD FETALUMA CA , UNITED STATES","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"FLUORESCEIN","year":"2021","qtr":"Q1","strtotime":1616092200,"product":"L09319.03 FLUORESCEIN ISOTHIOCYANATE, ISOMER 1, 95%","address":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN EXPRESS","city":"HIGH WAY, SION(E) MUMBA,MAHARASHTRA","supplier":"THERMO FISHER SCIENTIFIC","supplierCountry":"UNITED KINGDOM","foreign_port":"MANCHESTER","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.001","unit":"KGS","unitRateFc":"99000","totalValueFC":"141.4","currency":"GBP","unitRateINR":"10291690","date":"19-Mar-2021","totalValueINR":"10291.69","totalValueInUsd":"141.4","indian_port":"HYDERABAD AIR","hs_no":"29322090","bill_no":"3207859","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"MANCHESTER","supplierAddress":"","customerAddress":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN EXPRESS"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1624559400,"product":"DIACETYLFLUORESCEIN (QTY: 1 X 0.05 GMS, VALUE: USD 10.39)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"UNITED KINGDOM","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00005","unit":"KGS","unitRateFc":"207800","totalValueFC":"10.8","currency":"USD","unitRateINR":"15906200","date":"25-Jun-2021","totalValueINR":"795.31","totalValueInUsd":"10.8","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"4452094","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1624559400,"product":"DIACETYLFLUORESCEIN (QTY: 1 X 0.35 GMS, VALUE: USD 12.05)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"UNITED KINGDOM","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00035","unit":"KGS","unitRateFc":"34428.6","totalValueFC":"12.5","currency":"USD","unitRateINR":"2635371.4","date":"25-Jun-2021","totalValueINR":"922.38","totalValueInUsd":"12.5","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"4452094","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1624559400,"product":"DIACETYLFLUORESCEIN (QTY: 2 X 200 MG, VALUE: USD 245\/EACH)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"UNITED KINGDOM","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0004","unit":"KGS","unitRateFc":"1225000","totalValueFC":"510","currency":"USD","unitRateINR":"93768875","date":"25-Jun-2021","totalValueINR":"37507.55","totalValueInUsd":"510","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"4452094","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q2","strtotime":1624559400,"product":"DIACETYLFLUORESCEIN (QTY: 3 X 0.2 GMS, VALUE: USD 11.22\/EACH)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"THE U.S PHARMACOPEIAL ","supplierCountry":"UNITED KINGDOM","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0006","unit":"KGS","unitRateFc":"56100","totalValueFC":"35","currency":"USD","unitRateINR":"4294233.3","date":"25-Jun-2021","totalValueINR":"2576.54","totalValueInUsd":"35","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"4452094","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1633372200,"product":"BP-25594 DIFLUOROCARBOXYFLUORESCEIN NHS ESTER, 5-ISOMER (100MG) (LAB MATERIAL FOR RESEARCH USE)","address":"PLOT 1A, SECTOR-16A, INSTITUTIONAL Contact No:","city":"NOIDA","supplier":"BROADPHARM","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"JUBILANT GENERICS","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0001","unit":"KGS","unitRateFc":"7950000","totalValueFC":"1092.3","currency":"USD","unitRateINR":"818262400","date":"05-Oct-2021","totalValueINR":"81826.24","totalValueInUsd":"1092.3","indian_port":"DELHI AIR","hs_no":"29339990","bill_no":"5710164","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT 1A, SECTOR-16A, INSTITUTIONAL Contact No:"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1634927400,"product":"FLUORESCEIN ISOTHIOCYANATE ISOMER I, TECH GRADE (CHINA), CAS3326-32-7, (LAB CHEMICAL FOR RESEARCH & TESTING PURPOSE)","address":"7\/28, VARDAAN HOUSE MAHABIR,STRE ET ANSARI ROAD DARYAGANJ","city":"NEW DELHI,DELHI","supplier":"COMBI BLOCKS INC.","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"CENTRAL DRUG HOUSE P LTD.","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"0.005","unit":"KGS","unitRateFc":"64000","totalValueFC":"327.4","currency":"USD","unitRateINR":"4905776","date":"23-Oct-2021","totalValueINR":"24528.88","totalValueInUsd":"327.4","indian_port":"DELHI AIR","hs_no":"29420090","bill_no":"5969421","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"7\/28, VARDAAN HOUSE MAHABIR,STRE ET ANSARI ROAD DARYAGANJ"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1665513000,"product":"FLUORESCEIN 6-ISOTHIOCYANATE-VALUE FOR CUSTOM PURPOSE(FOC)","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"ASTATECH","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"1","unit":"GMS","unitRateFc":"355.4","totalValueFC":"356.1","currency":"USD","unitRateINR":"29304","date":"12-Oct-2022","totalValueINR":"29304","totalValueInUsd":"356.1","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1015344","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1668969000,"product":"5-AMINOFLUORESCEIN","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"COMBI BLOCKS INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.02","actualQuantity":"20","unit":"GMS","unitRateFc":"37.2","totalValueFC":"752.1","currency":"USD","unitRateINR":"3069","date":"21-Nov-2022","totalValueINR":"61380","totalValueInUsd":"752.1","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1017574","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677263400,"product":"DIACETYLFLUORESCEIN (Q TY:1 X 0.45 GMS, PRICE USD:20.50)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00045","unit":"KGS","unitRateFc":"45555.6","totalValueFC":"21.4","currency":"USD","unitRateINR":"3927355.6","date":"25-Feb-2023","totalValueINR":"1767.31","totalValueInUsd":"21.4","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"4803483","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677263400,"product":"DIACETYLFLUORESCEIN (Q TY:1 X 1.1 GMS, PRICE USD:31.76)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0011","unit":"KGS","unitRateFc":"28872.7","totalValueFC":"33.2","currency":"USD","unitRateINR":"2489118.2","date":"25-Feb-2023","totalValueINR":"2738.03","totalValueInUsd":"33.2","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"4803483","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1677263400,"product":"DIACETYLFLUORESCEIN (Q TY:3 X 0.05 GMS, PRICE USD:13.57\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"UNITED STATES PHARMACOPEIAL ","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00015","unit":"KGS","unitRateFc":"271400","totalValueFC":"42.5","currency":"USD","unitRateINR":"23397400","date":"25-Feb-2023","totalValueINR":"3509.61","totalValueInUsd":"42.5","indian_port":"HYDERABAD AIR","hs_no":"29329990","bill_no":"4803483","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716402600,"product":"FLUORESCEIN RELATED COMPOUND C(QTY:2 X 25 MG, VALUE: USD 838\/EACH) (FOC)","address":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,","city":"TURKAPALLY(V),SHAMEERPET, HYDERABAD","supplier":"USP","supplierCountry":"INDIA","foreign_port":"WASHINGTON, DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00005","unit":"KGS","unitRateFc":"33520000","totalValueFC":"1731.4","currency":"USD","unitRateINR":"2886422600","date":"23-May-2024","totalValueINR":"144321.13","totalValueInUsd":"1731.4","indian_port":"Hyderabad Air","hs_no":"29189990","bill_no":"3620237","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON, DULLES I","supplierAddress":"7135 ENGLISH MUFFIN WAY FREDERICK,MD, US 21704, UNITED STATES OF AMERICA United States","customerAddress":"P.NO. D6 D8, SY.NO. 234\/2,234\/3,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717353000,"product":"6-CARBOXYFLUORESCEIN","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"SUZHOU SIBIAN CHEMICAL ","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"23.5","totalValueFC":"237.4","currency":"USD","unitRateINR":"1982.2","date":"03-Jun-2024","totalValueINR":"19822","totalValueInUsd":"237.4","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1006853","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722969000,"product":"AG00BXOF 5-AMINOFLUORESCEIN CAS:3326-34-9 (CHEMICALS ARE ONLY USED FOR CHEMISTRY RESEARCH)","address":"RH-13, GOOD HOUSE KEEPING CHS,","city":"AIROLI NAVIMUMBAI","supplier":"ANGENE INTERNATIONAL","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"SYNSMART RASAYAN RESEARCH PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.03","actualQuantity":"0.025","unit":"KGS","unitRateFc":"10640","totalValueFC":"325","currency":"USD","unitRateINR":"1090299.6","date":"07-Aug-2024","totalValueINR":"27257.49","totalValueInUsd":"325","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"4921365","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"WORKSHOP 27 ON 8\/F THRIVING INDUSTRIAL CENTRE NOS 26-38 SHATSUI ROAD TSUEN WAN NT Hong Kong","customerAddress":"RH-13, GOOD HOUSE KEEPING CHS,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

01

Alcon Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

02

Alcon Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

03

Alcon Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

04

Alcon Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

05

Altaire Pharmaceuticals

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

06

Aurolab

India

Pharma, Lab & Chemical Expo

Not Confirmed

07

Bausch & Lomb Incorporated

Canada

Pharma, Lab & Chemical Expo

Not Confirmed

08

Laboratorios Poen

Argentina

Pharma, Lab & Chemical Expo

Not Confirmed

09

Laboratorios Poen

Argentina

Pharma, Lab & Chemical Expo

Not Confirmed

10

Polifarma

Turkey

Pharma, Lab & Chemical Expo

Not Confirmed

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FDA Orange Book

01

ALTAIRE PHARMS INC

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

02

BAUSCH LOMB IRELAND

Canada

Pharma, Lab & Chemical Expo

Not Confirmed

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Europe

01

Alcon Nordic A / S,

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

02

Alcon Nordic A/S

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

03

Bausch & Lomb UK, Ltd.

Canada

Pharma, Lab & Chemical Expo

Not Confirmed

04

MONICO SpA

Country

Pharma, Lab & Chemical Expo

Not Confirmed

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South Africa

01

Alcon Laboratories (Sa) (Pty) Ltd

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

02

Alcon Laboratories (Sa) (Pty) Ltd

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

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Listed Dossiers

01

Aurolab

India

Duphat

Not Confirmed

02

Laboratorios Poen

Argentina

Duphat

Not Confirmed

03

Laboratorios Poen

Argentina

Duphat

Not Confirmed

04

Polifarma

Turkey

Duphat

Not Confirmed

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.2...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.25%

USFDA APPLICATION NUMBER - 208582

DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3...DOSAGE - SOLUTION/DROPS;OPHTHALMIC - 0.4%;0.3%

USFDA APPLICATION NUMBER - 211039

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Finished Drug Prices

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APIs

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FDF DOSSIERS

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Patents & EXCLUSIVITIES

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US Patents

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REF. STANDARDS & IMPURITIES

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ABOUT THIS PAGE

Fluorescein, Sodium Manufacturers

A Fluorescein, Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fluorescein, Sodium, including repackagers and relabelers. The FDA regulates Fluorescein, Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fluorescein, Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Fluorescein, Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Fluorescein, Sodium Suppliers

A Fluorescein, Sodium supplier is an individual or a company that provides Fluorescein, Sodium active pharmaceutical ingredient (API) or Fluorescein, Sodium finished formulations upon request. The Fluorescein, Sodium suppliers may include Fluorescein, Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Fluorescein, Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Fluorescein, Sodium USDMF

A Fluorescein, Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Fluorescein, Sodium active pharmaceutical ingredient (API) in detail. Different forms of Fluorescein, Sodium DMFs exist exist since differing nations have different regulations, such as Fluorescein, Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Fluorescein, Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Fluorescein, Sodium USDMF includes data on Fluorescein, Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Fluorescein, Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Fluorescein, Sodium suppliers with USDMF on PharmaCompass.

Fluorescein, Sodium CEP

A Fluorescein, Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Fluorescein, Sodium Certificate of Suitability (COS). The purpose of a Fluorescein, Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Fluorescein, Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Fluorescein, Sodium to their clients by showing that a Fluorescein, Sodium CEP has been issued for it. The manufacturer submits a Fluorescein, Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Fluorescein, Sodium CEP holder for the record. Additionally, the data presented in the Fluorescein, Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Fluorescein, Sodium DMF.

A Fluorescein, Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Fluorescein, Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Fluorescein, Sodium suppliers with CEP (COS) on PharmaCompass.

Fluorescein, Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Fluorescein, Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Fluorescein, Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Fluorescein, Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Fluorescein, Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Fluorescein, Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Fluorescein, Sodium suppliers with NDC on PharmaCompass.

Fluorescein, Sodium GMP

Fluorescein, Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fluorescein, Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fluorescein, Sodium GMP manufacturer or Fluorescein, Sodium GMP API supplier for your needs.

Fluorescein, Sodium CoA

A Fluorescein, Sodium CoA (Certificate of Analysis) is a formal document that attests to Fluorescein, Sodium's compliance with Fluorescein, Sodium specifications and serves as a tool for batch-level quality control.

Fluorescein, Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Fluorescein, Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fluorescein, Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Fluorescein, Sodium EP), Fluorescein, Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fluorescein, Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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