Synopsis
Synopsis
0
CEP/COS
0
JDMF
0
EU WC
0
KDMF
0
NDC API
0
VMF
0
Listed Suppliers
0
API
0
FDF
0
FDA Orange Book
0
Europe
0
Canada
0
Australia
0
Listed Dossiers
DRUG PRODUCT COMPOSITIONS
0
EDQM
0
USP
0
JP
0
Others
0
US Patents
0
US Exclusivities
0
Health Canada Patents
0
Data Compilation #PharmaFlow
0
Stock Recap #PipelineProspector
0
Weekly News Recap #Phispers
0
News #PharmaBuzz
US Medicaid
NA
Annual Reports
NA
Finished Drug Prices
NA
1. Fluoride-18 Anion
2. 18f-fluoride
3. (18f)-fluoride
4. Fluorine-18(1-)
5. 67862-54-8
6. 4m4we5n2ge
7. Unii-4m4we5n2ge
8. Fluoride-18f
9. Fluoride-18
10. Fluoride F-18
11. Fluoride Ion F 18
12. Fluoride Ion, F-18
13. Fluoride (18f1-)
14. Fluorine-18 Ion(1-)
15. Dtxsid80218101
16. Db09398
17. Q27260079
| Molecular Weight | 18.000937 g/mol |
|---|---|
| Molecular Formula | F- |
| XLogP3 | 0.6 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 18.000937 g/mol |
| Monoisotopic Mass | 18.000937 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 1 |
| Formal Charge | -1 |
| Complexity | 0 |
| Isotope Atom Count | 1 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
18F is used as a bone imaging agent to define areas of altered osteogenic activity. It has been indicated for back pain and otherwise unexplained bone pain, child abuse, abnormal radiographic or laboratory findings, osteomyelitis, trauma, inflammatory and degenerative arthritis, avascular necrosis. Osteonecrosis of the mandible, condylar hyperplasia, and metabolic bone disease are also among the indications for fluoride imaging.
Deposition of 18F fluoride in bone appears to be primarily a function of blood flow to the bone and the efficiency of the bone in extracting the 18F from the blood perfusing the bone. Increased fluorine F 18 ion deposition around joints can occur in arthritis or following trauma; increased deposition has also been documented in bone around fracture sites, in osteomyelities, fibrous dysplasia, spondylitis tuberculosa, Paget's disease, hyperstosis frontalis interna, myositis, ossificans, and in rapidly growing epiphyses. The tendency for fluorine F 18 ions to accumulate in the vicinity of primary and metastatic malignancy in bone has proven clinically useful in detection of such lesions
Absorption
Following intravenous administration, Sodium Fluoride F 18 injection provides fluorine F 18 ions that rapidly equilibrate, primarily within the extracellular fluid space.
Route of Elimination
Fluorine F 18 ions are rapidly eliminated via the renal system. 20% or more of the fluorine F 18 ions are cleared from the body in the urine within the first 2 hours after intravenous administration.
Volume of Distribution
0.5-0.7 L/Kg
Clearance
Renal clearance for fluoride is 48-147 mL/min, depending upon urinary flow and pH.
First, the 18F- exchanges for an OH- ion on the surface of the hydroxyapatite matrix of bone and this is followed by migration of the 18F- into the crystalline matrix of the bone where it is retained until the bone is remodelled.
110 min.
18F-fluoride is a highly sensitive bone-seeking PET tracer used for detection of skeletal abnormalities. The uptake mechanism of 18F-fluoride has better pharmacokinetic characteristics (compared to other elements) including faster blood clearance and 2-fold higher uptake in bone. Uptake of 18F-fluoride reflects blood flow and bone remodeling.
Related Excipient Companies
ABOUT THIS PAGE
A Fluoride Ion F-18 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fluoride Ion F-18, including repackagers and relabelers. The FDA regulates Fluoride Ion F-18 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fluoride Ion F-18 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Fluoride Ion F-18 supplier is an individual or a company that provides Fluoride Ion F-18 active pharmaceutical ingredient (API) or Fluoride Ion F-18 finished formulations upon request. The Fluoride Ion F-18 suppliers may include Fluoride Ion F-18 API manufacturers, exporters, distributors and traders.
click here to find a list of Fluoride Ion F-18 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Fluoride Ion F-18 DMF (Drug Master File) is a document detailing the whole manufacturing process of Fluoride Ion F-18 active pharmaceutical ingredient (API) in detail. Different forms of Fluoride Ion F-18 DMFs exist exist since differing nations have different regulations, such as Fluoride Ion F-18 USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Fluoride Ion F-18 DMF submitted to regulatory agencies in the US is known as a USDMF. Fluoride Ion F-18 USDMF includes data on Fluoride Ion F-18's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Fluoride Ion F-18 USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Fluoride Ion F-18 suppliers with USDMF on PharmaCompass.
Fluoride Ion F-18 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Fluoride Ion F-18 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fluoride Ion F-18 GMP manufacturer or Fluoride Ion F-18 GMP API supplier for your needs.
A Fluoride Ion F-18 CoA (Certificate of Analysis) is a formal document that attests to Fluoride Ion F-18's compliance with Fluoride Ion F-18 specifications and serves as a tool for batch-level quality control.
Fluoride Ion F-18 CoA mostly includes findings from lab analyses of a specific batch. For each Fluoride Ion F-18 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Fluoride Ion F-18 may be tested according to a variety of international standards, such as European Pharmacopoeia (Fluoride Ion F-18 EP), Fluoride Ion F-18 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fluoride Ion F-18 USP).
LOOKING FOR A SUPPLIER?
