Find Fluorothymidine F-18 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 18f-flt, Alovudine f-18, 3'-deoxy-3'-(18f)fluorothymidine, (18f)flt, Flt f-18, 287114-80-1
Molecular Formula
C10H13FN2O4
Molecular Weight
243.22  g/mol
InChI Key
UXCAQJAQSWSNPQ-ZIVQXEJRSA-N
FDA UNII
2X1K91UT6N

Fluorothymidine F-18
Fluorothymidine F-18 is a radioconjugate consisting of a thymidine analogue radiolabeled with fluorine F 18, a positron emitting isotope. Phosphorylated by S-phase-specific thymidine kinase 1, 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) is trapped intracellularly by entering the salvage pathway of DNA synthesis without incorporation into DNA. 18F-FLT serves a marker of tumor cell proliferation for imaging with positron emission tomography (PET); as a marker of proliferation rather than metabolism, it is more specific to tumor tissue than 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG). This agent is metabolically stable, accumulates in the normal bone marrow and the liver, and does not cross the blood-brain barrier.
1 2D Structure

Fluorothymidine F-18

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(2R,4S,5R)-4-(18F)fluoranyl-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
2.1.2 InChI
InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1/i11-1
2.1.3 InChI Key
UXCAQJAQSWSNPQ-ZIVQXEJRSA-N
2.1.4 Canonical SMILES
CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)F
2.1.5 Isomeric SMILES
CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)[18F]
2.2 Other Identifiers
2.2.1 UNII
2X1K91UT6N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (18)flt Cpd

2. (18f)3'-deoxy-3'-fluorothymidine

3. (18f)flt

4. 1-(3'-fluoro-3'-deoxy-beta-d-erythropentofuranosyl)thymine

5. 18f-flt

6. 3'-(f-18)fluoro-3'-deoxythymidine

7. 3'-deoxy-3'-(18f)fluorothymidine

8. 3'-deoxy-3'-fluorothymidine

9. 3'-fluoro-2',3'-dideoxythymidine

10. 3'-fluoro-3'-deoxythymidine

11. 3'-fluorothymidine

12. Alovudine

13. Fddt

2.3.2 Depositor-Supplied Synonyms

1. 18f-flt

2. Alovudine F-18

3. 3'-deoxy-3'-(18f)fluorothymidine

4. (18f)flt

5. Flt F-18

6. 287114-80-1

7. Thymidine, 3'-deoxy-3'-(18f)fluoro-

8. 2x1k91ut6n

9. [18f]flt

10. F-18 Fluorothymidine

11. Unii-2x1k91ut6n

12. 3'-deoxy-3'-18f-fluorothymidine

13. Schembl14461296

14. (18f) Flt

15. (18f)-flt

16. (f-18)flt

17. Dtxsid90182869

18. Db14930

19. Fluorothymidine (18f) [who-dd]

20. Q27255730

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 243.22 g/mol
Molecular Formula C10H13FN2O4
XLogP3-0.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass243.088469 g/mol
Monoisotopic Mass243.088469 g/mol
Topological Polar Surface Area78.9 Ų
Heavy Atom Count17
Formal Charge0
Complexity385
Isotope Atom Count1
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)


ABOUT THIS PAGE

Fluorothymidine F-18 Manufacturers

A Fluorothymidine F-18 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Fluorothymidine F-18, including repackagers and relabelers. The FDA regulates Fluorothymidine F-18 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Fluorothymidine F-18 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Fluorothymidine F-18 Suppliers

A Fluorothymidine F-18 supplier is an individual or a company that provides Fluorothymidine F-18 active pharmaceutical ingredient (API) or Fluorothymidine F-18 finished formulations upon request. The Fluorothymidine F-18 suppliers may include Fluorothymidine F-18 API manufacturers, exporters, distributors and traders.

click here to find a list of Fluorothymidine F-18 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Fluorothymidine F-18 USDMF

A Fluorothymidine F-18 DMF (Drug Master File) is a document detailing the whole manufacturing process of Fluorothymidine F-18 active pharmaceutical ingredient (API) in detail. Different forms of Fluorothymidine F-18 DMFs exist exist since differing nations have different regulations, such as Fluorothymidine F-18 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Fluorothymidine F-18 DMF submitted to regulatory agencies in the US is known as a USDMF. Fluorothymidine F-18 USDMF includes data on Fluorothymidine F-18's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Fluorothymidine F-18 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Fluorothymidine F-18 suppliers with USDMF on PharmaCompass.

Fluorothymidine F-18 GMP

Fluorothymidine F-18 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Fluorothymidine F-18 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Fluorothymidine F-18 GMP manufacturer or Fluorothymidine F-18 GMP API supplier for your needs.

Fluorothymidine F-18 CoA

A Fluorothymidine F-18 CoA (Certificate of Analysis) is a formal document that attests to Fluorothymidine F-18's compliance with Fluorothymidine F-18 specifications and serves as a tool for batch-level quality control.

Fluorothymidine F-18 CoA mostly includes findings from lab analyses of a specific batch. For each Fluorothymidine F-18 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Fluorothymidine F-18 may be tested according to a variety of international standards, such as European Pharmacopoeia (Fluorothymidine F-18 EP), Fluorothymidine F-18 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Fluorothymidine F-18 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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