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Also known as: 51529-01-2, Flupenthixol dihydrochloride, Emergil, Cis-(z)-flupenthixol dihydrochloride, 2413-38-9, Flupentixol hcl
Molecular Formula
C23H27Cl2F3N2OS
Molecular Weight
507.4  g/mol
InChI Key
IOVDQEIIMOZNNA-MHKBYHAFSA-N
FDA UNII
96L0Z069N1

Flupentixol Dihydrochloride
A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)
1 2D Structure

Flupentixol Dihydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol;dihydrochloride
2.1.2 InChI
InChI=1S/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;;/h1-2,4-8,16,29H,3,9-15H2;2*1H/b18-5-;;
2.1.3 InChI Key
IOVDQEIIMOZNNA-MHKBYHAFSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
2.1.5 Isomeric SMILES
C1CN(CCN1CC/C=C\2/C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
96L0Z069N1
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Alpha-flupenthixol

2. Cis-flupenthixol

3. Emergil

4. Fluanxol

5. Flupenthixol

6. Flupentixol

2.3.2 Depositor-Supplied Synonyms

1. 51529-01-2

2. Flupenthixol Dihydrochloride

3. Emergil

4. Cis-(z)-flupenthixol Dihydrochloride

5. 2413-38-9

6. Flupentixol Hcl

7. Cis-(z)-flupentixol Dihydrochloride

8. Fupentixol Dihydrochloride

9. (z)-flupenthixol Dihydrochloride

10. Flupenthixol 2hcl

11. (e/z)-flupentixol Dihydrochloride

12. Flupenthixol, Dihydrochloride

13. Fx 703

14. Flupentixol Dihydrochloride Cis-(z)

15. 96l0z069n1

16. Cis-(z)-flupentixol (dihydrochloride)

17. Flupentixol Hydrochloride

18. (z)-4-[3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Dihydrochloride

19. 2-[4-[(3z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol;dihydrochloride

20. N 7009

21. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Dihydrochloride, (z)-

22. (z)-4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-1-piperazineethanol Dihydrochloride

23. Einecs 219-321-4

24. Nsc 170952

25. Unii-96l0z069n1

26. Prestwick_902

27. Cis-flupenthixol 2hcl

28. Unii-hat84mlq6z

29. Hat84mlq6z

30. 1-piperazineethanol, 4-(3-(2-trifluoromethylthioxanth-9-ylidene)propyl)-, Dihydrochloride

31. 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethanol Dihydrochloride

32. Cis-flupenthixol Hydrochloride

33. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Dihydrochloride

34. Cis-flupenthixol Dihydrochloride

35. (z)-flupentixol Dihydrochloride

36. Schembl1153162

37. Chembl1496351

38. Ex-a352

39. Chebi:180489

40. Flupentixol Dihydrochloride (jan)

41. Cis-(z)-flupentixoldihydrochloride

42. Dtxsid501017247

43. Hms1569c21

44. Cis(z)-flupentixol Dihydrochloride

45. 4-[3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Dihydrochloride

46. Cis-flupentixol Hydrochloride

47. Tox21_500528

48. Mfcd00069278

49. S3664

50. Akos025401529

51. Ac-2136

52. Ccg-221832

53. Lp00528

54. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-, Dihydrochloride

55. Ncgc00093921-01

56. Ncgc00261213-01

57. .alpha.-flupenthixol Hydrochloride

58. 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)piperazine-1-ethanol Dihydrochloride

59. Bs-16961

60. Flupentixol Dihydrochloride, (z)-

61. Hy-15856

62. Thioxanthene, 9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-trifluoromethyl-, Dihydrochloride

63. B7578

64. Cs-0009393

65. Eu-0100528

66. F-114

67. D02236

68. 529f012

69. Sr-01000076232

70. J-015359

71. Sr-01000076232-1

72. Q27271910

73. Cis-(z)-flupenthixol Dihydrochloride, >=98% (hplc), Solid

74. (z)-2-(4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethanol Dihydrochloride

75. (z)-4-[3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazine-ethanol Dihydrochloride

76. 1-(2-hydroxyethyl)-4-{(3z)-3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl}piperazinediium Dichloride

77. 1-piperazineethanol, 4-((3z)-3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Dihydrochloride

78. 1-piperazineethanol, 4-(3-((3z)-2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Hydrochloride (1:2)

79. 2-(4-{(3z)-3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethan-1-ol--hydrogen Chloride (1/2)

80. 2-(4-{(3z)-3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol Dihydrochloride

81. 4-[3-[(3z)-2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Hydrochloride

2.4 Create Date
2005-10-11
3 Chemical and Physical Properties
Molecular Weight 507.4 g/mol
Molecular Formula C23H27Cl2F3N2OS
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass506.1173245 g/mol
Monoisotopic Mass506.1173245 g/mol
Topological Polar Surface Area52 Ų
Heavy Atom Count32
Formal Charge0
Complexity592
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


API Reference Price

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12-Jan-2021
18-Nov-2024
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ABOUT THIS PAGE

Flupentixol Dihydrochloride Manufacturers

A Flupentixol Dihydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Flupentixol Dihydrochloride, including repackagers and relabelers. The FDA regulates Flupentixol Dihydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Flupentixol Dihydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Flupentixol Dihydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Flupentixol Dihydrochloride Suppliers

A Flupentixol Dihydrochloride supplier is an individual or a company that provides Flupentixol Dihydrochloride active pharmaceutical ingredient (API) or Flupentixol Dihydrochloride finished formulations upon request. The Flupentixol Dihydrochloride suppliers may include Flupentixol Dihydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Flupentixol Dihydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Flupentixol Dihydrochloride WC

A Flupentixol Dihydrochloride written confirmation (Flupentixol Dihydrochloride WC) is an official document issued by a regulatory agency to a Flupentixol Dihydrochloride manufacturer, verifying that the manufacturing facility of a Flupentixol Dihydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Flupentixol Dihydrochloride APIs or Flupentixol Dihydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Flupentixol Dihydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Flupentixol Dihydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Flupentixol Dihydrochloride GMP

Flupentixol Dihydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Flupentixol Dihydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Flupentixol Dihydrochloride GMP manufacturer or Flupentixol Dihydrochloride GMP API supplier for your needs.

Flupentixol Dihydrochloride CoA

A Flupentixol Dihydrochloride CoA (Certificate of Analysis) is a formal document that attests to Flupentixol Dihydrochloride's compliance with Flupentixol Dihydrochloride specifications and serves as a tool for batch-level quality control.

Flupentixol Dihydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Flupentixol Dihydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Flupentixol Dihydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Flupentixol Dihydrochloride EP), Flupentixol Dihydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Flupentixol Dihydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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