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Fluphenazine Decanoate

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ACTIVE PHARMA INGREDIENTS

14 API Suppliers, 9 USDMF, 1 CEP/COS, 1 JDMF, 3 EU WC, 4 NDC API, 7 Listed Suppliers, $ API Reference Price

14 API Suppliers
9 USDMF
1 CEP/COS
1 JDMF
3 EU WC
4 NDC API
7 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

18 FDF Dossiers, 11 FDA Orange Book, 2 Canada, 5 Listed Dossiers

18 FDF Dossiers
11 FDA Orange Book
2 Canada
5 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Nanjing Well Pharmaceutical, 1 Actylis, 1 Finar

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1 Nanjing Well Pharmaceutical
1 Actylis
1 Finar

EXCIPIENTS BY APPLICATIONS

2 Topical, 1 Parenteral, 1 Solubilizers

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2 Topical
1 Parenteral
1 Solubilizers

DIGITAL CONTENT

7 NEWS #PharmaBuzz

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7 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 2 Finished Drug Prices

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1 US Medicaid Prescriptions
2 Finished Drug Prices

MARKET PLACE

3 APIs, 4 FDF Dossiers

marketPlace
3 APIs
4 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

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1 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

9,231,722

Annual Reports (USD Million)

Finished Drug Prices

4EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 5002-47-1, Modecate, Fluphenazine depot, Moditen depot, Dapotum d, Lyogen

Molecular Formula

C₃₂H₄₄F₃N₃O₂S

Molecular Weight

591.8 g/mol

InChI Key

VIQCGTZFEYDQMR-UHFFFAOYSA-N

FDA UNII

FMU62K1L3C

Fluphenazine Decanoate is the decanoate salt form of fluphenazine, a phenothiazine with antipsychotic activity. Fluphenazine decanoate exerts its actions by blocking postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia.

1 2D Structure

Fluphenazine Decanoate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate

2.1.2 InChI

InChI=1S/C32H44F3N3O2S/c1-2-3-4-5-6-7-8-14-31(39)40-24-23-37-21-19-36(20-22-37)17-11-18-38-27-12-9-10-13-29(27)41-30-16-15-26(25-28(30)38)32(33,34)35/h9-10,12-13,15-16,25H,2-8,11,14,17-24H2,1H3

2.1.3 InChI Key

VIQCGTZFEYDQMR-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCCCCCCC(=O)OCCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F

2.2 Other Identifiers

2.2.1 UNII

FMU62K1L3C

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Fluphenazine Depot

2. Ftorphenazine Decanoate

3. Liogen

4. Mirenil

5. Modecate

6. Moditen Depot

7. Moditen-depot

2.3.2 Depositor-Supplied Synonyms

1. 5002-47-1

2. Modecate

3. Fluphenazine Depot

4. Moditen Depot

5. Dapotum D

6. Lyogen

7. Prolixin Decanoate

8. Flufenazine Decanoate

9. Fluorophenazine Decanoate

10. Fluphenazine O-decanoate

11. Fluphenaline Decanoate

12. Sq 10,733

13. 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl Decanoate

14. 2-(4-{3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl Decanoate

15. Nsc-169510

16. Fmu62k1l3c

17. 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Decanoate

18. Decanoic Acid, 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Ester

19. Decanoic Acid, 2-[4-[3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl Ester

20. Qd-10733

21. Sq-10733

22. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl Decanoate

23. Decanoic Acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Ester

24. Decanoic Acid, 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl Ester

25. Moditen-depo

26. Fluphenazinedecanoate

27. Ccris 3954

28. Prolixin Decanoate (tn)

29. Einecs 225-672-4

30. Unii-fmu62k1l3c

31. Nsc 169510

32. Brn 0599852

33. Dapotum Depot

34. Fluphenazine Decanoate (jan/usp)

35. Anatensol Decanoate

36. Fluphenazini Decanoas

37. Depot

38. Fluphenazine-decanoate

39. Fluphenazine Decanoate [usp:ban:jan]

40. Schembl41288

41. Mls006010097

42. Chebi:5124

43. Chembl1200854

44. Dtxsid7023069

45. Fluphenazine Decanoate [mi]

46. Bcp18078

47. Hy-b1904

48. Fluphenazine Decanoate [jan]

49. Mfcd00798504

50. Nsc169510

51. Zinc22816725

52. Fluphenazine Decanoate [vandf]

53. Akos003589045

54. Fluphenazine Decanoate [mart.]

55. Fluphenazine Decanoate [who-dd]

56. Fluphenazine Decanoate [who-ip]

57. Ncgc00386699-01

58. As-11646

59. Smr004701239

60. Fluphenazine Decanoate [orange Book]

61. Cs-0013962

62. Fluphenazine Decanoate [ep Monograph]

63. Fluphenazine Decanoate [usp Impurity]

64. Fluphenazini Decanoas [who-ip Latin]

65. Fluphenazine Decanoate [usp Monograph]

66. C07956

67. D00793

68. 002f471

69. A827938

70. Fluphenazine Enanthate Impurity C [ep Impurity]

71. Q27278080

72. Wln: T C666 Bn Isj Exfff B3- At6n Dntj D2ov9

73. Decanoic Acid, 2-(4-(3-(2-(trifluoromethyl)-10h-decanoate Phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Ester

74. Decanoic Acid, 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl Ester (7ci,8ci)

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₃₂H₄₄F₃N₃O₂S
Molecular Weight	591.8 g/mol
XLogP3	9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	16
Exact Mass	591.31063331 g/mol
Monoisotopic Mass	591.31063331 g/mol
Topological Polar Surface Area	61.3 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	765
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Fluphenazine decanoate
Drug Label	Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect and has the following structural formula:Fluphenazine Decanoate Injection...
Active Ingredient	Fluphenazine decanoate
Dosage Form	Injectable
Route	Injection
Strength	25mg/ml
Market Status	Prescription
Company	Par Sterile Products; Fresenius Kabi Usa; Eurohlth Intl

2 of 2
Drug Name	Fluphenazine decanoate
Drug Label	Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect and has the following structural formula:Fluphenazine Decanoate Injection...
Active Ingredient	Fluphenazine decanoate
Dosage Form	Injectable
Route	Injection
Strength	25mg/ml
Market Status	Prescription
Company	Par Sterile Products; Fresenius Kabi Usa; Eurohlth Intl

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Phenothiazines [CS]; Phenothiazine [EPC]

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