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Chemistry

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Also known as: Flurazepam dihydrochloride, 1172-18-5, Dalmane, Dalmadorm, Dalmate, Felison
Molecular Formula
C21H25Cl3FN3O
Molecular Weight
460.8  g/mol
InChI Key
ZIIJJOPLRSCQNX-UHFFFAOYSA-N
FDA UNII
756RDM536M

Flurazepam Dihydrochloride
A benzodiazepine derivative used mainly as a hypnotic.
1 2D Structure

Flurazepam Dihydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;dihydrochloride
2.1.2 InChI
InChI=1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H
2.1.3 InChI Key
ZIIJJOPLRSCQNX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
756RDM536M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apo Flurazepam

2. Apo-flurazepam

3. Dalmadorm

4. Dalmane

5. Dihydrochloride, Flurazepam

6. Dormodor

7. Flurazepam

8. Flurazepam Dihydrochloride

9. Flurazepam Mono Perchlorate

10. Flurazepam Mono-perchlorate

11. Flurazepam Monohydrochloride

12. Hydrochloride, Flurazepam

13. Mono-perchlorate, Flurazepam

14. Monohydrochloride, Flurazepam

15. Staurodorm

2.3.2 Depositor-Supplied Synonyms

1. Flurazepam Dihydrochloride

2. 1172-18-5

3. Dalmane

4. Dalmadorm

5. Dalmate

6. Felison

7. Linzac

8. Natam

9. Nsc-78559

10. Ro 5-6901

11. Insumin Dihydrochloride

12. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Dihydrochloride

13. Flurazepam Hydrochloride Civ

14. Id 480

15. 756rdm536m

16. 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one Dihydrochloride

17. Ro-5-6901

18. Benozil

19. Lunipax

20. Somlan

21. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3h-1,4-benzodiazepin-2-one;dihydrochloride

22. Dea No. 2767

23. Einecs 214-630-0

24. Unii-756rdm536m

25. Dalmane (tn)

26. Flurazepam Hydrochloride [usan:usp:jan]

27. Schembl29792

28. Chebi:5129

29. Flurazepam Hydrochloride (usp)

30. Chembl3989724

31. Dtxsid3025334

32. Flurazepam Dihydrochloride, Solid

33. Flurazepam Hydrochloride [jan]

34. Flurazepam Dihydrochloride [mi]

35. Flurazepam Hydrochloride [usan]

36. Flurazepam Hydrochloride [vandf]

37. Flurazepam Hydrochloride [who-dd]

38. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, Dihydrochloride

39. Flurazepam Dihydrochloride [mart.]

40. Db-041356

41. Flurazepam Hydrochloride Civ [usp-rs]

42. Flurazepam Hydrochloride [orange Book]

43. D00695

44. Flurazepam Hydrochloride [usp Monograph]

45. W-108568

46. Q27266355

47. Flurazepam Dihydrochloride, Drug Standard, 1.0 Mg/ml In Methanol

48. Flurazepam Hydrochloride, United States Pharmacopeia (usp) Reference Standard

49. 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one, Dihydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 460.8 g/mol
Molecular Formula C21H25Cl3FN3O
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass459.104724 g/mol
Monoisotopic Mass459.104724 g/mol
Topological Polar Surface Area35.9 Ų
Heavy Atom Count29
Formal Charge0
Complexity540
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameFlurazepam hydrochloride
Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active IngredientFlurazepam hydrochloride
Dosage FormCapsule
RouteOral
Strength30mg; 15mg
Market StatusPrescription
CompanyMylan Pharms

2 of 2  
Drug NameFlurazepam hydrochloride
Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active IngredientFlurazepam hydrochloride
Dosage FormCapsule
RouteOral
Strength30mg; 15mg
Market StatusPrescription
CompanyMylan Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)


GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)


Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Benzodiazepines [CS]; Benzodiazepine [EPC]

ABOUT THIS PAGE

Flurazepam Dihydrochloride Manufacturers

A Flurazepam Dihydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Flurazepam Dihydrochloride, including repackagers and relabelers. The FDA regulates Flurazepam Dihydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Flurazepam Dihydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Flurazepam Dihydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Flurazepam Dihydrochloride Suppliers

A Flurazepam Dihydrochloride supplier is an individual or a company that provides Flurazepam Dihydrochloride active pharmaceutical ingredient (API) or Flurazepam Dihydrochloride finished formulations upon request. The Flurazepam Dihydrochloride suppliers may include Flurazepam Dihydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Flurazepam Dihydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Flurazepam Dihydrochloride WC

A Flurazepam Dihydrochloride written confirmation (Flurazepam Dihydrochloride WC) is an official document issued by a regulatory agency to a Flurazepam Dihydrochloride manufacturer, verifying that the manufacturing facility of a Flurazepam Dihydrochloride active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Flurazepam Dihydrochloride APIs or Flurazepam Dihydrochloride finished pharmaceutical products to another nation, regulatory agencies frequently require a Flurazepam Dihydrochloride WC (written confirmation) as part of the regulatory process.

click here to find a list of Flurazepam Dihydrochloride suppliers with Written Confirmation (WC) on PharmaCompass.

Flurazepam Dihydrochloride GMP

Flurazepam Dihydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Flurazepam Dihydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Flurazepam Dihydrochloride GMP manufacturer or Flurazepam Dihydrochloride GMP API supplier for your needs.

Flurazepam Dihydrochloride CoA

A Flurazepam Dihydrochloride CoA (Certificate of Analysis) is a formal document that attests to Flurazepam Dihydrochloride's compliance with Flurazepam Dihydrochloride specifications and serves as a tool for batch-level quality control.

Flurazepam Dihydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Flurazepam Dihydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Flurazepam Dihydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Flurazepam Dihydrochloride EP), Flurazepam Dihydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Flurazepam Dihydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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