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Flurazepam Dihydrochloride

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Chemistry

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Also known as: Flurazepam dihydrochloride, 1172-18-5, Dalmane, Dalmadorm, Dalmate, Felison

Molecular Formula

C₂₁H₂₅Cl₃FN₃O

Molecular Weight

460.8 g/mol

InChI Key

ZIIJJOPLRSCQNX-UHFFFAOYSA-N

FDA UNII

756RDM536M

A benzodiazepine derivative used mainly as a hypnotic.

1 2D Structure

Flurazepam Dihydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;dihydrochloride

2.1.2 InChI

InChI=1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H

2.1.3 InChI Key

ZIIJJOPLRSCQNX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

756RDM536M

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Apo Flurazepam

2. Apo-flurazepam

3. Dalmadorm

4. Dalmane

5. Dihydrochloride, Flurazepam

6. Dormodor

7. Flurazepam

8. Flurazepam Dihydrochloride

9. Flurazepam Mono Perchlorate

10. Flurazepam Mono-perchlorate

11. Flurazepam Monohydrochloride

12. Hydrochloride, Flurazepam

13. Mono-perchlorate, Flurazepam

14. Monohydrochloride, Flurazepam

15. Staurodorm

2.3.2 Depositor-Supplied Synonyms

1. Flurazepam Dihydrochloride

2. 1172-18-5

3. Dalmane

4. Dalmadorm

5. Dalmate

6. Felison

7. Linzac

8. Natam

9. Nsc-78559

10. Ro 5-6901

11. Insumin Dihydrochloride

12. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Dihydrochloride

13. Flurazepam Hydrochloride Civ

14. Id 480

15. 756rdm536m

16. 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one Dihydrochloride

17. Ro-5-6901

18. Benozil

19. Lunipax

20. Somlan

21. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3h-1,4-benzodiazepin-2-one;dihydrochloride

22. Dea No. 2767

23. Einecs 214-630-0

24. Unii-756rdm536m

25. Dalmane (tn)

26. Flurazepam Hydrochloride [usan:usp:jan]

27. Schembl29792

28. Chebi:5129

29. Flurazepam Hydrochloride (usp)

30. Chembl3989724

31. Dtxsid3025334

32. Flurazepam Dihydrochloride, Solid

33. Flurazepam Hydrochloride [jan]

34. Flurazepam Dihydrochloride [mi]

35. Flurazepam Hydrochloride [usan]

36. Flurazepam Hydrochloride [vandf]

37. Flurazepam Hydrochloride [who-dd]

38. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, Dihydrochloride

39. Flurazepam Dihydrochloride [mart.]

40. Db-041356

41. Flurazepam Hydrochloride Civ [usp-rs]

42. Flurazepam Hydrochloride [orange Book]

43. D00695

44. Flurazepam Hydrochloride [usp Monograph]

45. W-108568

46. Q27266355

47. Flurazepam Dihydrochloride, Drug Standard, 1.0 Mg/ml In Methanol

48. Flurazepam Hydrochloride, United States Pharmacopeia (usp) Reference Standard

49. 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one, Dihydrochloride

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₅Cl₃FN₃O
Molecular Weight	460.8 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	459.104724 g/mol
Monoisotopic Mass	459.104724 g/mol
Topological Polar Surface Area	35.9 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	540
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Flurazepam hydrochloride
Drug Label	Flurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active Ingredient	Flurazepam hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	30mg; 15mg
Market Status	Prescription
Company	Mylan Pharms

2 of 2
Drug Name	Flurazepam hydrochloride
Drug Label	Flurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active Ingredient	Flurazepam hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	30mg; 15mg
Market Status	Prescription
Company	Mylan Pharms

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Benzodiazepines [CS]; Benzodiazepine [EPC]

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